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8178617 |
Antimicrobial constructs
The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the...
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8173115 |
Particle compositions with a pre-selected cell internalization mode
A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface...
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8173597 |
Modified recombinant factor VIII and von Willebrand factor and methods of use
The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of...
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8143347 |
Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
The present invention relates to a proteinaceous construct comprising a blood coagulation factor, e.g., Factor VIII (FVIII), being bound to at least one water soluble polymer, including a...
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8138308 |
Modified peptide substrate
The invention provides novel reagents and methodologies for detecting free versus bound compounds. It is particularly useful to detect thrombin when it is not bound to A2M in the presence of...
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8137688 |
Hydroxyphenyl cross-linked macromolecular network and applications thereof
A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic...
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8138265 |
Hydroxyphenyl cross-linked macromolecular network and applications thereof
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network...
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8119392 |
Biocompatible resists
This invention relates to biomaterials, biocompatible photoresists, and electroactive photoresists, and methods to engineer the interactions between biomaterials and cells. In one aspect, this...
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8105391 |
Merhods of treatment with devices having a coating containing pegylated hyaluronic acid and a pegylated non-hyaluronic acid polymer
Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid...
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8106098 |
Protein conjugates with a water-soluble biocompatible, biodegradable polymer
The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods...
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8088340 |
Polymer compound for biomedical use and biochip substrate using such a polymer compound
A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of...
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8088365 |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small...
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8080260 |
Molecular enhancement of extracellular matrix and methods of use
A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury,...
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8076412 |
Water-soluble polymer alkanals
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
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8076463 |
Polymer-von Willebrand factor-conjugates
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at...
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8071678 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs ...
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8058411 |
Method for producing mature VWF from VWF pro-peptide
The present invention relates to a method for producing a mature von Willebrand Factor (VWF) from von Willebrand Factor pro-peptide comprising the steps: immobilizing VWF pro-peptide on an ion...
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8052990 |
Biocompatible crosslinked gel
The invention relates to a method for producing a biocompatible crosslinked gel consisting in crosslinking a determined quantity of at least one type of liquid biocompatible polymer by adding a...
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8053520 |
Conjugation reactions
An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl...
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8029774 |
Wound healing polymeric networks
A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing...
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8021350 |
Hydroxyphenyl cross-linked macromolecular network and applications thereof
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network...
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8003089 |
Y shape branched hydrophilic polymer derivatives, their preparation methods, conjugates of the derivatives and drug molecules, and pharmaceutical compositions comprising the conjugates
The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules,...
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7989554 |
Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
A new method of preparing a tertiary alkyl ester of a polyalkylene oxide is provided. The new method employs milder conditions that avoid the back reaction to the starting polyalkylene oxide. The...
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7922929 |
Cellulosic fabric with silk peptide/building block nanopolymer
The present invention relates a method of making a coated cellulosic textile, whereby a silk peptide is polymerized with a building block to develop a silk peptide/building block nanoparticle, said...
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7897684 |
Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the...
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7884075 |
Polymer-factor VIII-von Willebrand factor-conjugates
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at...
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7872072 |
Branched polymers and their conjugates
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core...
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7868087 |
Graft copolymers, methods for grafting hydrophilic chains onto hydrophobic polymers, and articles thereof
The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride)...
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7863406 |
Unsaturated poly(ester-amide) biomaterials
Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from...
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7863376 |
Thermally controlled particulate core migration within polymer matrix
A composition is provided that includes a polymer matrix. A core having a core surface is embedded within the polymer matrix. A polymeric ligand passivates the core surface and has a moiety Y,...
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7863408 |
Body fluid compatible and biocompatible resin
A body fluid compatible and biocompatible resin for use in a medical treatment involving a contact of said resin with at least one member selected from the group consisting of a body fluid and a...
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7858079 |
Tissue adhesives and sealants and method for their use
Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses.
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7858108 |
Elutable surface coating
Elutable coatings comprising protein resistant components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved under controlled...
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7851565 |
Stabilized polymeric thiol reagents
Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol...
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7851052 |
Coating system for sag resistant formaldehyde-free fibrous panels
A coating system on a fibrous substrate, such as a fibrous ceiling panel, having a first surface and a second surface. A first coating is disposed on the first surface of the substrate and includes...
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7847019 |
Functionalized polymers using protected thiols
A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided....
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7838595 |
Water-soluble polymer alkanals
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
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7834088 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs ...
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7833979 |
Toxin peptide therapeutic agents
Disclosed is a composition of matter of the formula (X1)a—(F1)d—(X2)b—(F2)e—(X3)c (I) and multimers thereof, in which F1 and F2 are half-life extending moieties, and d and e are each indepen...
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7833978 |
Thrombomodulin derivatives and conjugates
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured...
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7820759 |
Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer
A novel micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration...
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7786213 |
Biomacromolecule polymer conjugates
Chemical polymerization procedures initiated by, and proceeding from, a biomolecule, particularly a protein, for the formation of biomolecule-polymer conjugates, particularly protein-polymer...
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7767756 |
Composite materials containing keratin
The application describes materials derived from keratin proteins in combination with polymers, either as intimate mixtures with water soluble polymers, or as chemically bound copolymers. The...
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7749957 |
Clay-binding peptides and methods of use
Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.
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7728069 |
Reactive cyclic carbonates and ureas used for modifying biomolecules, polymers, and surfaces
Disclosed are reactive cyclic carbonates and ureas of formula (I) or (II), wherein R and X have the meaning indicated in the description. Said carbonates and ureas allow functional groups to be...
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7713637 |
Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
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7714063 |
Solid support for Fmoc-solid phase synthesis of peptides
The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing...
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7687608 |
Methods for reducing the mitogenicity of lectin compositions
Methods for reducing the T-cell mitogenicity of lectin compositions are provided. In one aspect this is achieved by chemically modifying mitogenic lectin compositions under optimized conditions....
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7635734 |
Photochemical activation of surfaces for attaching biomaterial
A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble...
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7629437 |
Fluorogenic materials and uses thereof
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general substrate libraries to rapidly identify the primary and extended...
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