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9370586 Methods of preparing pre-mixed, ready-to-use pharmaceutical compositions  
Provided herein are ready-to-use premixed pharmaceutical compositions of nicardipine or a pharmaceutically acceptable salt and methods for use in treating cardiovascular and cerebrovascular...
9364564 Pre-mixed, ready-to-use pharmaceutical compositions  
Provided herein are ready-to-use premixed pharmaceutical compositions of nicardipine or a pharmaceutically acceptable salt and methods for use in treating cardiovascular and cerebrovascular...
9290478 Substituted quinoxalines as FGFR kinase inhibitors  
The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to...
9290533 β-L-2′-deoxy-nucleosides for the treatment of hepatitis B  
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active...
9181191 Heterobicyclic sphingosine 1-phosphate analogs  
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
9163043 Oxazolidinone derivatives  
The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone...
9132130 Purine derivative and antitumor agent using same  
Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed...
9126941 Treatment of hyperproliferative disorders with diarylhydantoin compounds  
The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
9127083 Neurturin molecules  
Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host...
9119801 Cancer vaccine composition  
A cancer vaccine composition for human leukocyte antigen (HLA)-A*0206-positive persons, comprising a protein product of the tumor suppressor gene WT1 or a partial peptide thereof.
9115143 Substituted indole derivatives as gamma secretase modulators  
The present invention is concerned with novel substituted indole derivatives of Formula (I) wherein R1, R2, R3, A1, A2, A3, Y and X have the meaning defined in the claims. The compounds according...
9115090 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors  
Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.
9107852 Uses of agonists of delta opioid receptor in cosmetic and dermocosmetic field  
The present invention relates to the use of a DOR ligand for stimulating pigmentation in a cosmetic composition and to the use of rubiscolin-6 or its derivatives in a cosmetic composition.
9107441 Composition for reducing absorption of dietary fat  
This invention relates to compositions for reducing the absorption or bioavailability of lipids in the gastrointestinal tract, and to methods for the preparation and use of these compositions. The...
9109004 Progesterone receptor antagonists  
The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for...
9095599 O-(substituted benzyl) phosphoramidate compounds and therapeutic use  
This application discloses novel phosphoramidate and phosphonoamidate prodrugs of nucleosides, nucleotides, C-nucleosides, C-nucleotides, phosphonates, and other alcohol-containing drugs; use of...
9079914 Fused aminodihydro-oxazine derivatives  
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like...
9072700 Methods of using derivatives of (−)-venlafaxine  
Methods of preparing, and compositions comprising, derivatives of (−)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not...
9073919 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors  
The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or...
9067973 Peptide vaccines for cancers expressing tumor-associated antigens  
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80, 100, 101, 110, 111, 387, 112, 394, 114,...
9061165 Solution for forming double eyelid and method for forming double eyelid using same  
To provide a solution for forming a double eyelid which enables extremely easy formation of a natural and ideal double eyelid without giving a displeased feeling or an uncomfortable feeling to a...
9061016 Aqueous solution comprising 3-quinuclidinones for the treatment hyperproliferative, autoimmune and heart disease  
A liquid composition that is an aqueous solution of a compound of formula (I), wherein the aqueous solution has a pH from about 3.0 to about 5.0. The liquid composition may be used in the...
9062298 Antidotes for factor XA inhibitors and methods of using the same  
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially...
9051334 Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse  
The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
9051277 Phenyl(oxy/thio)alkanol derivatives  
The present invention relates to novel phenyl(oxy/thio)alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically...
9040589 Continuous administration of dopa decarboxylase inhibitors and compositions for same  
Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome,...
9040550 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
9040498 1,2,3-Triazolyl purine derivatives  
The present invention relates to novel 1,2,3-triazolyl purine derivatives. The invention also relates to using the derivatives to treat cancer and various viral infections. An example of a...
9040545 Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors  
The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK...
9040529 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity  
The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a...
9040489 Nanocrystalline photocatalytic colloid, a method of producing it and its use  
The present invention relates to a nanocrystalline photocatalyst active upon visible light irradiation, with a high degree of dispersion, stable in the form of a transparent colloidal solution in...
9040050 Combination treatment of CD38-expressing tumors  
The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
9040514 Chlorobis copper (I) complex compositions and methods of manufacture and use  
A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple...
9040527 Pyrimidinediamine kinase inhibitors  
Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions...
9040491 Compositions, methods and kits based on small nuclear RNAs  
The present invention includes methods for modulating the expression of a gene or mRNA in a cell using small nuclear RNAs comprising specific sequence and structural features and further...
9040591 Methods and compositions comprising at least one α3 βA4 nAChR antagonist or pharmaceutically acceptable salt thereof  
The present invention is directed to methods and formulations for treating, modifying, and/or managing gastrointestinal secretion, and intestinal conditions that cause the same. Methods of using...
9040507 Method for treating inflammatory conditions  
A method for treating an autoimmune disease in a subject includes administering to the subject a therapeutically effective amount of an agent comprising an imidazole, an estrogen receptor agonist,...
9040578 Continuous administration of L-dopa, dopa decarboxylase inhibitors, catechol-O-methyl transferase inhibitors and compositions for same  
Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically...
9040562 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, whereineach dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is...
9040534 [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators  
The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are...
9040492 Double-stranded lipid-modified RNA having high RNA interference effect  
An object of the present invention is to provide a novel double-stranded RNA that has high resistance to nuclease and cellular uptake efficiency and that can produce an excellent RNA interference...
9040553 Phenoxyisobutyric acid compounds and method of synthesis  
The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced...
9040068 Control of bed bugs  
A method of combating bed bugs and/or other insects in a locus containing or susceptible to presence of same, in which a DMSO-containing formulation is applied to the locus. Various pesticidal...
9040548 Quinazoline derivatives as VEGF inhibitors  
The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the...
9040520 Noribogaine salt ansolvates  
Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated...
9040516 Uracil derivative and use thereof for medical purposes  
The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl...
9040480 Synthesis of glucagon-like peptide  
A new method of synthesizing GLP-1 peptide is devised.
9040456 Method for controlling noxious organisms  
To provide a method which exerts excellent controlling effects on noxious organisms in a field of soybean, corn or cotton. A method for controlling noxious organisms in a field of soybean, corn or...
9040530 1,2,4-triazine-6-carboxamide kinase inhibitors  
Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for...
9040535 Crystalline molecular comlpexes of tadalafil  
Crystalline molecular complexes of tadalafil are disclosed. The crystalline molecular complexes include those of tadalafil and oxalic acid, tadalafil and 4-hydroxybenzoic acid, tadalafil and...