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9023402 Method for treating a mammal by administration of a compound having the ability to release CO  
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases...
8623823 Methods for treatment of stroke or cerebrovascular accidents using an ETB receptor agonist  
Methods of using an ETB receptor agonist, such as IRL-1620, for the treatment of stroke or cerebrovascular accidents are disclosed. The ETB receptor agonist is used alone or in combination with a...
8603519 Topical delivery of L-arginine to cause beneficial effects  
A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissue lacking sufficient hair, restoring normal...
8586634 Therapeutic compounds  
The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for...
8524226 Methods of prolonging patency of hemodialysis access  
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
8445536 Arginine-containing compositions and methods for increasing blood flow using same  
A composition for increasing blood flow is provided, wherein side effects such as lowering of blood pressure are reduced and blood flow is effectively increased in the capillaries. A composition...
8383650 Organic compounds  
The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a...
8333997 Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof  
The invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous...
8211947 Composition and method for treating and preventing musculoskeletal and connective tissue disorders  
The present invention relates to a pharmaceutical composition and method for treating and preventing musculoskeletal and connective tissue diseases of unknown etiology, such as different forms of...
8168232 Formulations and methods of using nitric oxide mimetics in cancer treatment  
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics,...
7964220 Method for treating a mammal by administration of a compound having the ability to release CO  
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases...
7923455 Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic  
The present invention relates to a method for the prevention or the treatment of heart failure comprising administration of a therapeutically effective amount of an anticholinergic 1, medicaments...
7883699 Methods for enlarging the lumen of an obstructed biological conduit  
The invention provides methods to for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
7872040 Receptor blocker and vasodilator comprising indole derivative as active ingredient  
It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine. The present invention...
7776354 Remedies for glomerular diseases  
The present invention relates to a preventive or therapeutic agent for a glomerular disease which comprises an anti-thrombocytic agent and an HMG-CoA reductase inhibitor as active ingredients. The...
7678391 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype  
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics,...
7629384 Topical delivery of L-arginine to cause beneficial effects  
The application of L-arginine and its derivatives to the skin causes beneficial effects of wound healing, increasing erectile function and increased growth of hair when applied in sufficient...
7270838 Composition for treating chronic venous insufficiencies using an extract of red vine leaves  
The invention relates to a dietary supplement consisting of an aqueous extract of red vine leaves and an acceptable carrier which prevents and reduces the discomfort relating to mild-to-moderate...
7265087 Exendin improves β-cell response in subjects with impaired glucose tolerance  
A composition for the treatment of impaired glucose tolerance (IGT) including a compound which binds to a receptor for glucagon-like peptide-1, and a pharmaceutical carrier. The amount of the...
7235264 Cerebral protection with a gas comprising xenon  
Xenon or xenon-containing gases and, where appropriate, an NO source are employed as medicament for cerebral protection. Cerebral protection is defined as reducing or preventing impairments of...
7189761 Nitric oxide donor composition and method for treatment of anal disorders  
A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal...
7045152 Treating pulmonary disorders with gaseous agent causing repletion of GSNO  
Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas,...
6825234 Compositions and methods for amelioration of human female sexual dysfunction  
The invention provides compositions and methods suitable for ameliorating female sexual dysfunction, and in particular, female sexual arousal disorder. In one embodiment, the invention provides a...
6784179 Tetracyclic derivatives, process of preparation and use  
A compound of formula (I) and salts and solvates thereof, in which:R0 represents hydrogen, halogen or C1-6 alkyl;R1 represents hydrogen, C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, halo C1-6alkyl,...
6762202 Infrared thermography and methods of use  
The present invention describes rapid noninvasive methods for measuring vasodilation or changes in blood flow in a patient following administration of at least one compound that donates, transfers...
6753338 Methods for treating hypertension, angina, and congestive heart failure using of optically pure (-) amlodipine  
Methods and compositions are disclosed utilizing the optically pure (−) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant...
6562372 Tocotrienol-containing powder, a process for preparing it and a tablet comprising compressed said powder into a tablet form  
A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a...
6544946 Inhibitors for use in hemostasis and immune function  
The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a...
6514934 Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use  
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with at...
6462016 Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method  
There are provided a method to screen agonist or antagonist of the maxadilan receptor participating in vasodilating action, wherein a receptor of maxadilan is used, compounds which specifically...
6358536 Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal  
The invention relates to compositions, methods, apparatus, and kits for alleviating or preventing vasoconstriction or vasospasm in a mammal. The compositions, methods, apparatus, and kits are also...
6340480 Natural composition for the treatment of circulatory conditions  
A composition and method for treating circulatory conditions by promoting systemic vascular relaxation and dilation. Exemplary circulatory conditions are disclosed and include wound healing and/or...
6335039 Pharmaceutical formulations comprising vegetal material selected from trichilia  
The present invention refers to a method for producing vasodilation or analgesia in a mammal, comprising the use of vegetal material derived from the bark of a Trichilia species.
6323211 Compositions and methods for treating sexual dysfunctions  
The present invention describes methods for preventing and treating sexual dysfunctions in patients by orally administering at least one α-adrenergic receptor antagonist and at least one compound...
6294517 Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use  
The present invention describes novel compositions and kits comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels...
6288110 Pharmaceutical compositions comprising disulfiram  
Disulfiram (tetraethylthiuram disulfide) is shown to inhibit angiogenesis and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and to prevent cell...
6284140 Dialysis solution for peritoneal dialysis  
The present invention relates to dialysis solutions for peritoneal dialysis, containing hydroxyethyl starch as the osmotically-active substance, electrolytes and, optionally, conventional...
6210343 Use of misoprostol or/and misoprostol acid for diagnosis of vascular damage in a subject with erectile dysfunction  
A method is provided for diagnosing vascular damage in a subject with erectile dysfunction that includes applying an effective dose of a therapeutic formulation having an excipient and at least...
6103769 Pharmaceutical composition containing nitric oxide  
Disclosed are pharmaceutical composition of a sterile, injectable physiologically acceptable solution containing nitric oxide (NO), processes for preparing the compositions and a process for...
6066649 Drug for cardiovascular diseases  
The invention relates to a drug, which contains one or more inhibitors for the cGMP-stimulated phosphodiesterase (PDE II) together with conventional substrates and/or diluents. Preferably the drug...
6054462 Intranasal antimigraine compositions  
The present invention relates to a composition comprising an antimigraine compound of formula (I) and chitosan, which is particularly suited for intranasal administration. ##STR1## Process for...
6042849 Unit dosage forms for treatment of vasoconstriction and related conditions  
Magnesium is formulated in combination with vitamin E, vitamin C, folate, selenium, and optionally melatonin a unit dosage form for oral administration, for the treatment of vasoconstriction and...
6036977 Drug preparations for treating sexual dysfunction  
Topical gelled compositions comprising a drug for treating sexual dysfunction dispersed within a polymer matrix and methods and treatments using said compositions.
6027713 Composition and method for the treatment of exercise induced pulmonary hemorrhage  
A composition for the treatment of exercise induced pulmonary hemorrhage, particularly in horses. The composition comprises arginine and is formulated for inhalation. The invention includes an...
6020308 Methods for improving therapeutic effectiveness of treatment of vascularization disorders  
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue...
6007813 Method and composition for treating ulcers and secretion of gastric acid  
Secretion of gastric acid and development of ulcers can be inhibited by administering to a patient in need thereof an effective amount of a hot water extract of the cultivated mycelia of Cordyceps...
5989558 Method of using rosmarinus officinalis for treating various diseases  
A method for treating various diseases with a dried total extract of Rosmarinus officinalis. The dried total extract is obtained by macerating Rosmarinus officinalis leaves in hydrated ethyl...
5958877 Method for counteracting vasospasms, ischemia, renal failure, and treating male impotence using calcitonin gene related peptide  
The present invention provides a method for counteracting vasospasms and treating male impotence using calcitonin gene-related peptide (CGRP). CGRP is a naturally occurring substance in the human...
5958413 Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor  
A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or...
5958427 Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications  
The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a...