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3915998 |
Disubstituted carboxylic acids and disubstituted ethyl malonates for use as intermediates
The present invention relates to substituted tetrahydrofurfuryl aminoesters. The novel tetrahydrofurfuryl dialkyl aminoesters are represented by the formula ##EQU1## in which R is a member of the...
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3912741 |
1-(Benzo[b]thienylalkyl)piperidines
A group of benzthienyl compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described....
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3910884 |
S-Substituted-2-thioadenosines and process for producing the same
Novel S-substituted-2-thioadenosines which are useful as a coronary vascular vasodilator and a platelet aggregation inhibitor, a process for producing S-substituted-2-thioadenosines by reacting...
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3910937 |
Certain bis-(hydroxyalkyl)esters of 1,4-dihydro-2,6-diloweralkyl-4-(2-trifluoromethylphenyl)pyridine-3, 5 dicarboxylic acid and the N-methyl derivative thereof
The compounds are 1,4-dihydropyridines having anti-hypertensive activity. A particular compound of this invention is 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)pyridine
-3,5-dicarboxy lic...
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3910932 |
1-Pyridylalkyl piperidines
A group of pyridine compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These...
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3910927 |
3-Hydroxyisoquinoline ethers
New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action....
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3911123 |
Pharmaceutical compositions utilizing 2-amino-1,4-dihydropyridine derivatives and method of effecting coronary vessel dilation and treating hypertension in humans and animals utilizing said compounds
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding...
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3907864 |
Amino acid esters and amides of disubstituted phenethylamines
Amino acid amides of disubstituted phenethylamines represented by the formula ##EQU1## wherein each R 1 is hydrogen or benzyl; R 2 is hydrogen or loweralkyl and R 3 is an amino acid selected...
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3907807 |
Benzoquinolizine derivatives and process for their preparation and use
6,7,7a,8,9,10-Hexahydro-1H,5H-benzo?i,j!quinolizines bearing a lower alkyl, phenyl, substituted phenyl or a heterocyclic group in the 1-position and a carbonyl function in the 2-position, and being...
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3906030 |
New amino ether derivatives of orthothymotic esters
Amino ethers of the general formula: ##SPC1## In which R is a lower alkyl radical having 1-4 carbon atoms, R 2 and R 3 which may be the same or different are hydrogen or a lower alkyl radical or,...
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3901941 |
New oxyacetic ether derivatives of ortho-thymotic esters
New derivatives of the formula: ##EQU1## in which R represents a lower alkyl radical having 1-4 carbon atoms; n is an integer from 1 to 4; R 2 is hydrogen or a lower alkyl radical, the various R 2...
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3901884 |
Bases and salts of 2-aminomethyal-4,4-dialkyl-4H-1,3-benzoxazines and method for preparing same
Bases and salts of 2-aminomethyl-4,4-dialkyl-4H-1,3-benzoxazine have the formula ##SPC1## Where R 1 and R 2 are alkyl, R 3 is a radical of aliphatic primary or secondary amines, or cyclic...
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3898230 |
Sydnone imine compounds
Sydnone imines of general formula: ##EQU1## wherein Z is alkoxy- or alkylenedioxy phenyl, phenoxy, benzhydryl, benzodioxane or a heterocyclic radical, A is a single bond or methylenic chain, n is 0...
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3897558 |
Hypolipemiant and vasodilatatory methods of use
Novel hypolipemiant and vasodilatatory compositions containing as the active ingredient, 2-methyl-thiazole-5-methanol which has the formula ##EQU1## and a method of use.
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3897426 |
1-(3-(AMINO ALKYL)-2-OXO-2H-1-benzopyran-7-yl)-ureas
Compounds having the general formula (I) ##SPC1## and salts thereof with physiologically acceptable acids, in which R 1 , R 2 , R 5 and R 6 represent hydrogen atoms, straight-chain or...
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3897419 |
Basically substituted coumarin derivatives
The present invention relates to new pharmacologically valuable, basically substituted derivatives of coumarin possessing specific cardiovasodilatory action and having the formula ##SPC1## Wherein...
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3896127 |
Theophylline derivatives
Theophylline compounds of the formula, ##SPC1## Wherein X is oxycarbonyl, carboxyl or carbonyl and R is a lower alkyl group containing from 1 to 5 carbon atoms which have excellent coronary...
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3895030 |
(2,4,6-Alkoxy)(3-pyrrolidino propyl) ketones
Novel aminoketones of general formula ##EQU1## in which each of R 1 , R 2 and R 3 , which may be the same or different, represents a hydrogen atom or an alkyl group, each of R 4 and R 5 , which...
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3894015 |
Basically substituted 1(2H)-phthalazinone derivatives
The present invention relates to new pharmacologically valuable basically substituted 1(2H)-phthalazinone derivatives having excellent coronary dilator properties and which have the general formula...
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3892799 |
Phenoxyalkylamines and their salts
This invention relates to phenoxyalkylamines having the formula: ##SPC1## In which n is zero or 1, R is hydrogen or a hydroxy group, R 2 is hydrogen, a hydroxy group or an alkyl group, R 2 being...
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3887554 |
2(4)-Anilino- 4(2)-hydroxy-6 H-s-triazino (2,1-b)-quinazoline-6-one
Compounds having the formula ##SPC1## Which can be used as cardiovascular agents or in preparing diazo dyestuffs.
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3886157 |
5,6,8,8B,9-Pentaazanaphth[3,2,1-d,e]anthracene derivatives
Compounds having the formula ##SPC1## Which can be used as cardiovascular agents or in preparing the diamino derivatives which can be used in making polymers such as polyamides and polyimides.
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3883521 |
3-Substituted-5-aminomethyl-6-carbethoxy(oxazino [5',6' E indoles).
A compound of the formula ##SPC1## Wherein N is pyrrolidino, piperidino or piperazino N'-substituted with isopropylamino carbonyl methyl, pyrrolidino carbonyl methyl or ethylacetate, and R is a...
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3882141 |
Benzo-(F)-1,4-thiazepines
Biologically active imidazolino-[1,2-d]-benzo-1,4-thiazepines, their production and their acid addition salts. These compounds, especially as the pharmacologically compatible salts, are useful to...
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3880891 |
Substituted benzofurans
The compounds of this invention are substituted benzofurans having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of...
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3879393 |
DERIVATIVES OF 1,3-DISUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES
The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)-quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1-[alky(alkylamino)]-,...
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3878299 |
PLANT EXTRACTS HAVING PERIPHERAL CORONARY DILATORY AND VASODILATORY ACTION
Extracts from the bark of the root of Poterium Spinosum, which are polyflavanic and heterosidic in nature, have a molecular weight of 500 to 3,000 and are soluble in water have a peripheral...
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3878207 |
Novel amine derivatives of 4,8 dimethoxy furo (3',2'-f) benzoxazole
Compounds of the formula ##SPC1## Wherein ##SPC2## Is propylamino, phenylamino, dimethylamino, pyrrolidino, piperidino or morpholino. The compounds are prepared by reacting 4,8-dimethoxy-2-mercapto...
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3873620 |
Phenoxyalkylamines, process for their preparation and applications thereof
This invention relates to phenoxyalkylamines having the formula: ##SPC1## In which n is zero or 1, R is hydrogen or a hydroxy group, R 2 is hydrogen, a hydroxy group or an alkyl group, R 2 being...
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3873704 |
Novel tetrahydroisoquinoline compounds in a pharmaceutical composition
A tetrahydroisoquinoline compound of the dimethoxyphenyl ##SPC1## Wherein R is a trimethoxyphenyl, dimethoxyplenyl or methylenedioxyphenyl radical, and pharmaceutically acceptable acid addition...
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3872130 |
1-HYDROXYISOQUINOLONES
New 6,7-dialkoxy-1-hydroxy-2-methyl-3(2H)-isoquinolones are disclosed having peripheral vasodilator, hypotensive and bronchodilator properties. The compounds are also valuable as intermediates in...
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3872112 |
Tetrahydrofurfuryl aminoesters
The present invention relates to substituted tetrahydrofurfuryl aminoesters. The novel tetrahydrofurfuryl dialkyl aminoesters are represented by the formula ##SPC1## In which R is a member of the...
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3867391 |
Cyclic n-substituted derivatives of 1,4-benzene disulphonamide
Compounds of the formulae: ##SPC1## And ##SPC2## And the salts thereof with pharmaceutically acceptable cations wherein n and m are each two or three; X is oxygen or sulphur; R 2 and R 3 , when...
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3867389 |
ALPHA-(N-BENZOYLOXY AND PHENYLAMINO ALKYL-PIPERAZINO)-BETA-BENZOYL-PROPIONIC ACID DERIVATIVES
The present invention relates to new pharmacologically valuable ketone derivatives exhibiting a distinct dilatory action on the cerebral vessels and which have the general formula ##SPC1## And...
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3867383 |
Monoanthranilatoanilino-s-triazines
Compounds having the formula ##SPC1## Which can be used as cardiovascular agents or in preparing diazo compounds.
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3865842 |
Beta-[benzo(b) thienyl-3]-alpha-allyl-propionic acid esters
β-[Benzo(b)thienyl-3] propionic acid derivatives in the form of their amino esters (and salts thereof) are prepared. These compounds have spasmolytic, vasodilatatric, antiserotonic and local...
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3864344 |
3-(Benzoyl)-2-(4'-anilino carbonyl or benzoxy-alkyl piperazino)-propionitriles
The present invention relates to new pharmacologically valuable ketone derivatives exhibiting a distinct dilatory action on the cerebral vessels and which have the general formula ##SPC1## And...
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3862176 |
DERIVATIVES OF 5-CINNAMOYL BENZOFURAN
Compounds of the formula ##SPC1## In which ##SPC2## Is dimethylamino, diethylamino, diisopropylamino, pyrrolidino, piperidino, morpholino or perhydroazepino; n is 2 or 3; and R 3 , r 4 and R 5 ,...
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3862162 |
CERTAIN-2-AMINO-1,4-DIHYDRO-4-PHENYL-6-LOWER ALKYL (OR PHENYL)-3-PYRIDINECARBOXYLATES
2-Amino-1,4 dihydropyridines bearing an ester carbonyl function in the 3-position, being optionally substituted by lower alkyl in the 5-position, and being substituted in the 4- and 6-positions by...
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3862177 |
NOVEL 1-(2'-BENZOYL ETH-1'-YL)-2-(4"-CINNAMYL PIPERAZIN-1"-YL METHYL) BENZIMIDAZOLES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION
Compounds of the formula ##SPC1## In which Ar is phenyl optionally substituted by a halogen atom, by one or two methyl groups or by 1-4 carbon alkoxy groups are provided as novel therapeutic agents...
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3856798 |
BICYCLIC DERIVATIVES OF 1, 4- DIHYDROPYRIDINE
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl,...
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3853875 |
ESTERS OF 2-ALKYL THIAZOLE 5-CARBOXYLIC ACID
New esters of 2-alkyl thiazole 5-carboxylic acid of formula I: ##SPC1## wherein n represents the whole numbers 0, 1, 2, 3, 4 or 5, n' represents the whole numbers 1, 2, 3, 4 or 5, m represents the...
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3852284 |
NOVEL SUBSTITUTED OXAZINO(5,6,E)INDOLES
Compounds of the formula Wherein R is alkyl having 2 or 3 carbon atoms, alkyl having 2 or 3 carbon atoms substituted by one or more hydroxyl and dialkylamino wherein the latter alkyl has 1 to 4...
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3852312 |
PREPARATION OF MANNICH BASES
Steroidal Mannich bases are prepared by reaction of a steroid bearing an ethynyl and a hydroxy function at any of positions 3 and 17 (or 17a) with an N,N-dialkyl substituted-amino-methanol in the...
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3846470 |
DERIVATIVES OF 3-BENZOYL-2-(β-HYDROXYPHENETHYLAMINO)-PROPIONITRILE
The present invention relates to new pharmacologically valuable ketone derivatives exhibiting a distinct dilatory action on the cerebral vessels and which have the general formula ##SPC1## And...
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3843725 |
4[2-(α-METHYL-PHENETHYLAMINO)-ETHOXY]-BENZENES
This invention relates to phenoxyalkylamines having the formula: ##SPC1## In which R 1 is hydrogen, halogen, an alkyl or an alkoxy group, A is an alkyl, alkylaryl, cycloalkyl, alkenyl,...
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3835141 |
QUINALYTHIOHYDROXIMIC ACIDS AND THEIR DERIVATIVES
Thiohydroximic acid compounds of the formula: ##SPC1## Wherein Het is pyridyl, pyrazinyl, quinolyl, isoquinolyl, or these radicals substituted by halogen, lower alkyl or lower alkoxy, and R is...
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3818015 |
1(POLYMETHOXYBENZYL) 6 HYDROXYL 1,2,3,4 TETRAHYDRO ISOQUINOLINES
A tetrahydroisoquinoline compound of the formula: ##SPC1## Wherein R is a trimethoxyphenyl, dimethoxyphenyl or methylene-dioxyphenyl radical, and pharmaceutically acceptable acid addition salts...
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3817981 |
N-(6)-ARALKYL-ADENOSINE COMPOUNDS
Novel N(6)-Aralkyl-Adenosine Compounds of the formula ##SPC1## Wherein R 1 is hydrogen, halogen or hydroxyl; R 2 is hydrogen, halogen, hydroxyl, alkyl or alkoxy; R 3 is hydroxyl, amino, alkoxy,...
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3789120 |
SULFAMOYL AZIDE PROCESS AND COMPOSITION FOR LOWERING BLOOD PRESSURE
This invention is concerned with a pharmaceutical process and pharmaceutical compositions for lowering blood pressure in mammals by the administration thereto sulfamoyl azides of the Formula R 1 R...
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