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3951994 Tetrahydroindolizine derivatives  
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl,...
3950336 2,6-Diamino-1,4-dihydropyridine derivatives  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
3948923 Pentahydroqunolizine derivatives  
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl,...
3944549 Amino derivatives of 1,4-benzodioxan  
1-[2-(1,4-benzodioxanyl)methyl]-4-(2-hydroxyethyl)-piperazin e hemifumarate and the related compounds of formula: ##SPC1##In which R is hydrogen or alkyl; and A is --Z--OR1, --CH2 CHOR"1 CH2 OR'1,...
3944551 N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines  
Disubstituted piperazines of the formula: ##SPC1##Wherein: n is 1 or 2; X is oxygen or sulfur; R is hydrogen or lower alkyl; Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl,...
3943140 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives  
1,4-Dihydropyridines bearing carboxy functions in the 3-, 5- and 6- or 2-, 3-, 5- and 6-positions and being substituted in the 4-position by phenyl, substituted phenyl, naphthyl, phenylalkyl or a...
3936439 2,6-Diaminonebularine derivatives  
Novel 2,6-diaminonebularine derivatives of the formula ##SPC1##Wherein R is a phenyl or cyclohexyl group which may be substituted with lower alkyl, lower alkoxy or halogen, and pharmaceutically...
3935223 2-Amino-1,4-dihydropyridine derivatives  
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding...
3935220 Tetrahydroimidazolo[1,2-a]pyridine derivatives  
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl,...
3933834 Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid  
Unsymmetrical esters of N-substituted 4-substituted-1,4-dihydropyridine 3,5-dicarboxylic acid substituted in the 4-position by pyridyl, thienyl, furyl and pyrryl and optionally substituted in the...
3933826 Protoberberine derivatives  
Protoberberine derivatives having the general formula: ##SPC1##Wherein R1 is a lower alkoxy group, i.e. C1 to C5 alkoxy; R2 is a lower alkyl group, i.e. C1 to C5 alkyl, pyridyl group, phenyl group...
3932646 Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate  
Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate as the active ingredient and methods of using same. The said ingredients are unsymmetrical...
3930003 Coumarine derivatives and process for the preparation thereof  
Compounds having the general formula (I) ##SPC1## and salts thereof with physiologically acceptable acids, in which R1, R2, R5 and R6 represent hydrogen atoms, straight-chain or branched-chain...
3926995 Theophylline derivatives  
7-[N-methyl-N-(β-phenylethyl)-3-aminopropyl]-theophylline compounds substituted on the phenyl nucleus by chlorine, hydroxyl or lower alkoxy and preferably also by fluorine, trifluoromethyl or...
3923833 N-[(1-cyano-2-phenyl)ethyl]carbamates  
The present disclosure relates to novel benzylimidazolidinones, with special reference to the 4-(substituted benzyl)-2-imidazolidinones, methods for their preparation and novel intermediates...
3917597 Benzodioxole compounds  
Benzodioxole compounds of the formula : ##SPC1## Wherein R1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl,...
3915998 Disubstituted carboxylic acids and disubstituted ethyl malonates for use as intermediates  
The present invention relates to substituted tetrahydrofurfuryl aminoesters. The novel tetrahydrofurfuryl dialkyl aminoesters are represented by the formula ##EQU1## in which R is a member of the...
3912741 1-(Benzo[b]thienylalkyl)piperidines  
A group of benzthienyl compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described....
3911123 Pharmaceutical compositions utilizing 2-amino-1,4-dihydropyridine derivatives and method of effecting coronary vessel dilation and treating hypertension in humans and animals utilizing said compounds  
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding...
3910937 Certain bis-(hydroxyalkyl)esters of 1,4-dihydro-2,6-diloweralkyl-4-(2-trifluoromethylphenyl)pyridine-3, 5 dicarboxylic acid and the N-methyl derivative thereof  
The compounds are 1,4-dihydropyridines having anti-hypertensive activity. A particular compound of this invention is 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)pyridine -3,5-dicarboxy lic...
3910927 3-Hydroxyisoquinoline ethers  
New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action....
3910884 S-Substituted-2-thioadenosines and process for producing the same  
Novel S-substituted-2-thioadenosines which are useful as a coronary vascular vasodilator and a platelet aggregation inhibitor, a process for producing S-substituted-2-thioadenosines by reacting...
3910932 1-Pyridylalkyl piperidines  
A group of pyridine compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These...
3907807 Benzoquinolizine derivatives and process for their preparation and use  
6,7,7a,8,9,10-Hexahydro-1H,5H-benzo?i,j!quinolizines bearing a lower alkyl, phenyl, substituted phenyl or a heterocyclic group in the 1-position and a carbonyl function in the 2-position, and...
3907864 Amino acid esters and amides of disubstituted phenethylamines  
Amino acid amides of disubstituted phenethylamines represented by the formula ##EQU1## wherein each R1 is hydrogen or benzyl; R2 is hydrogen or loweralkyl and R3 is an amino acid selected from the...
3906030 New amino ether derivatives of orthothymotic esters  
Amino ethers of the general formula: ##SPC1## In which R is a lower alkyl radical having 1-4 carbon atoms, R2 and R3 which may be the same or different are hydrogen or a lower alkyl radical or,...
3901884 Bases and salts of 2-aminomethyal-4,4-dialkyl-4H-1,3-benzoxazines and method for preparing same  
Bases and salts of 2-aminomethyl-4,4-dialkyl-4H-1,3-benzoxazine have the formula ##SPC1## Where R1 and R2 are alkyl, R3 is a radical of aliphatic primary or secondary amines, or cyclic secondary...
3901941 New oxyacetic ether derivatives of ortho-thymotic esters  
New derivatives of the formula: ##EQU1## in which R represents a lower alkyl radical having 1-4 carbon atoms; n is an integer from 1 to 4; R2 is hydrogen or a lower alkyl radical, the various R2...
3898230 Sydnone imine compounds  
Sydnone imines of general formula: ##EQU1## wherein Z is alkoxy- or alkylenedioxy phenyl, phenoxy, benzhydryl, benzodioxane or a heterocyclic radical, A is a single bond or methylenic chain, n is...
3897419 Basically substituted coumarin derivatives  
The present invention relates to new pharmacologically valuable, basically substituted derivatives of coumarin possessing specific cardiovasodilatory action and having the formula ##SPC1## Wherein...
3897558 Hypolipemiant and vasodilatatory methods of use  
Novel hypolipemiant and vasodilatatory compositions containing as the active ingredient, 2-methyl-thiazole-5-methanol which has the formula ##EQU1## and a method of use.
3897426 1-(3-(AMINO ALKYL)-2-OXO-2H-1-benzopyran-7-yl)-ureas  
Compounds having the general formula (I) ##SPC1## and salts thereof with physiologically acceptable acids, in which R1, R2, R5 and R6 represent hydrogen atoms, straight-chain or branched-chain...
3896127 Theophylline derivatives  
Theophylline compounds of the formula, ##SPC1## Wherein X is oxycarbonyl, carboxyl or carbonyl and R is a lower alkyl group containing from 1 to 5 carbon atoms which have excellent coronary...
3895030 (2,4,6-Alkoxy)(3-pyrrolidino propyl) ketones  
Novel aminoketones of general formula ##EQU1## in which each of R1, R2 and R3, which may be the same or different, represents a hydrogen atom or an alkyl group, each of R4 and R5, which may be the...
3894015 Basically substituted 1(2H)-phthalazinone derivatives  
The present invention relates to new pharmacologically valuable basically substituted 1(2H)-phthalazinone derivatives having excellent coronary dilator properties and which have the general...
3892799 Phenoxyalkylamines and their salts  
This invention relates to phenoxyalkylamines having the formula: ##SPC1## In which n is zero or 1, R is hydrogen or a hydroxy group, R2 is hydrogen, a hydroxy group or an alkyl group, R2 being...
3887554 2(4)-Anilino- 4(2)-hydroxy-6 H-s-triazino (2,1-b)-quinazoline-6-one  
Compounds having the formula ##SPC1## Which can be used as cardiovascular agents or in preparing diazo dyestuffs.
3886157 5,6,8,8B,9-Pentaazanaphth[3,2,1-d,e]anthracene derivatives  
Compounds having the formula ##SPC1## Which can be used as cardiovascular agents or in preparing the diamino derivatives which can be used in making polymers such as polyamides and polyimides.
3883521 3-Substituted-5-aminomethyl-6-carbethoxy(oxazino [5',6' E indoles).  
A compound of the formula ##SPC1## Wherein N is pyrrolidino, piperidino or piperazino N'-substituted with isopropylamino carbonyl methyl, pyrrolidino carbonyl methyl or ethylacetate, and R is a...
3882141 Benzo-(F)-1,4-thiazepines  
Biologically active imidazolino-[1,2-d]-benzo-1,4-thiazepines, their production and their acid addition salts. These compounds, especially as the pharmacologically compatible salts, are useful to...
3880891 Substituted benzofurans  
The compounds of this invention are substituted benzofurans having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of...
3879393 DERIVATIVES OF 1,3-DISUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES  
The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)-quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1-[alky(alkylamino)]-,...
3878299 PLANT EXTRACTS HAVING PERIPHERAL CORONARY DILATORY AND VASODILATORY ACTION  
Extracts from the bark of the root of Poterium Spinosum, which are polyflavanic and heterosidic in nature, have a molecular weight of 500 to 3,000 and are soluble in water have a peripheral...
3878207 Novel amine derivatives of 4,8 dimethoxy furo (3',2'-f) benzoxazole  
Compounds of the formula ##SPC1## Wherein ##SPC2## Is propylamino, phenylamino, dimethylamino, pyrrolidino, piperidino or morpholino. The compounds are prepared by reacting...
3873704 Novel tetrahydroisoquinoline compounds in a pharmaceutical composition  
A tetrahydroisoquinoline compound of the dimethoxyphenyl ##SPC1## Wherein R is a trimethoxyphenyl, dimethoxyplenyl or methylenedioxyphenyl radical, and pharmaceutically acceptable acid addition...
3873620 Phenoxyalkylamines, process for their preparation and applications thereof  
This invention relates to phenoxyalkylamines having the formula: ##SPC1## In which n is zero or 1, R is hydrogen or a hydroxy group, R2 is hydrogen, a hydroxy group or an alkyl group, R2 being...
3872130 1-HYDROXYISOQUINOLONES  
New 6,7-dialkoxy-1-hydroxy-2-methyl-3(2H)-isoquinolones are disclosed having peripheral vasodilator, hypotensive and bronchodilator properties. The compounds are also valuable as intermediates in...
3872112 Tetrahydrofurfuryl aminoesters  
The present invention relates to substituted tetrahydrofurfuryl aminoesters. The novel tetrahydrofurfuryl dialkyl aminoesters are represented by the formula ##SPC1## In which R is a member of the...
3867383 Monoanthranilatoanilino-s-triazines  
Compounds having the formula ##SPC1## Which can be used as cardiovascular agents or in preparing diazo compounds.
3867391 Cyclic n-substituted derivatives of 1,4-benzene disulphonamide  
Compounds of the formulae: ##SPC1## And ##SPC2## And the salts thereof with pharmaceutically acceptable cations wherein n and m are each two or three; X is oxygen or sulphur; R2 and R3, when taken...