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4002762 |
2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension
3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert...
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4001259 |
3,6-Diamino-3,4-dihydro-2-pyridones
3,6-Diamino-3,4-dihydro-2-pyridones of the formula ##SPC1## Wherein R1 is straight or branched chain alkyl or alkenyl or said alkyl or alkenyl interrupted by 1 or 2 oxygen atoms; R2 is straight or...
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4001238 |
1,3,4-Oxadiazole amides
The 4-amino-6,7-dimethoxy-2-[4-(5-lower alkylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quina
zolines are potent antihypertensive drugs which have little or no α-adrenergic blocking activity.
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4001426 |
Substituted benzofurans and benzothiophenes
The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates...
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4001252 |
2-Amino-3,4-dihydropyridines
2-Amino-3,4-dihydropyridine-3-carboxylic acid ester derivatives are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid ester derivatives with an alkylating agent in the presence of...
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4000282 |
2-(3-Tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically their preparation are disclosed. These pyridines are vasodilators having anti-hypertensive...
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3998953 |
1,3,7-Trisubstitued xanthine peripheral vasodilators
Compounds of the formula ##STR1## wherein R is methyl or ethyl, R1 is methyl, ethyl or ##STR2## and R2 is methyl, ethyl, ##STR3## where Alk is alkyl of 1 to 4 carbon atoms, Q is ethyl, propyl,...
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3995041 |
Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizines
2-Substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizi
nes of the structural formula, ##SPC1##In which R1 is a hydrogen atom or an alkanoyl group of 2 to 4 carbon atoms and each of ...
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3994891 |
Tetrahydroisoquinoline compounds
Tetrahydroisoquinoline compounds represented by the formula: ##SPC1##In which X is a hydroxy group, Y is a hydroxy group or Y taken with X is --O--CH2 --O--, Z is hydrogen or a hydroxy group, R1 is...
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3991057 |
C-Piperazino-pyridine sulfonamides
This invention relates to compounds of the formula: ##SPC1##Wherein R1 in the 3- or 5-position is preferably a substituted sulfonamido or a carboxamido group whereas R2 in the 2-, 4- or 6-position...
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3987176 |
Composition and use of 3,4-dihydropyridones as vasodilators and antihypertensive agents
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said...
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3985758 |
1,4-Dihydropyridine derivatives
There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dica
rboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester and ...
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3985896 |
Benzophenalenofurans
The compounds are benzophenalenofurans having pharmacological activity, in particular, coronary vasodilator activity.
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3985886 |
2-Amino-4,5-dihydropyridine derivatives and process for their preparation
2-Amino-4,5-dihydropyridines-3,5-dicarboxylates substituted by lower alkoxy or lower alkylthio in the 6-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted...
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3984558 |
1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators
Compounds useful in the treatment of asthma, the symptoms of allergy and in some instances in gout and hyperuricemia are described. The novel compounds are 1-substituted-1,2,4-triazoles being...
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3984413 |
Phenoxyalkanecarboxylic acid esters of hydroxyalkyltheophyllines and method for their manufacture
Phenoxyalkanecarboxylic acids are esterified with 7-(2-hydroxyethyl) theophylline or 7-(2,3-dihydroxypropyl) theophylline. The resulting esters have excellent antilipemic and anticholesterolemic...
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3981882 |
Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon...
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3979456 |
Phenoxyalkylamines, process for their preparation and applications thereof
This invention relates to phenoxyalkylamines having the formula: ##SPC1##In which n is zero or 1, R is hydrogen or a hydroxy group, R2 is hydrogen, a hydroxy group or an alkyl group, R2 being other...
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3975391 |
5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-3,4-dih ydrocarbostyril derivatives
5-[1-HYDROXY-2-SUBSTITUTED-AMINO)]ETHYL-8-HYDROXY-3,4-DIHYDR
OCARBOSTYRIL DERIVATIVES REPRESENTED BY THE FORMULA (I) ##SPC1##wherein R1 and R2, which may be the same or different, each represents a...
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3974213 |
13,14-Dihydro-15-substituted-ω-pentanorprostaglandins
The 15 aryl substituted-ω-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles ...
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3974275 |
1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives
Certain 1,4-dihydropyridine carboxylic acid esters or their pharmaceutically acceptable non toxic salts are useful as coronary vessel dilators and antihypertensives.
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3971793 |
Certain 6-(dialkylamino, pyrrolidino and piperidino)ethoxy-4,7-dimethoxy-5-(3-phenyl-1-hydroxypropyl)2,3-dihydrob enzofurans
A compound of the formula ##SPC1##In which R is hydrogen, hydroxy, halogen or alkoxy containing up to 3 carbon atoms, and ##EQU1## is dialkylamino in which the alkyls contain up to 3 carbon atoms,...
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3968102 |
S-substituted-2-thioadenosines
S-Substituted-2-thioadenosines represented by the formula (I): ##SPC1##wherein R is as defined hereinafter, useful as a platelet aggregation inhibitor and a coronary vasodilator.
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3966764 |
Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs
Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the...
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3966814 |
1-Phenyl-2-(Naphthylalkyl-amino)-ethanols and salts thereof
Compounds of the formula ##SPC1##Wherein A is alkylene of 2 to 6 carbon atoms, R1 is hydrogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, R2 is hydrogen, lower alkyl or lower...
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3966948 |
Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods
1,4-Dihydropyridines of the formula: ##SPC1##WhereinR is hydrogen, straight, branched or cyclic lower alkyl, lower alkenyl, or lower alkinyl, unsubstituted or substituted by hydroxyl or alkoxy of 1...
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3966724 |
1-(α-Aminomethylbenzyl)isoquinoline compounds
Compounds having the structure: ##SPC1##In which R1 and R2 are alkoxy groups of one to four carbon atoms, R3 and R4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R5 and R6...
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3962256 |
2-Aminomethyl benzimidazole derivatives
Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R1 and R2 each is...
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3959292 |
2-Amino-4,5-dihydropyridine derivatives
4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or...
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3959474 |
2,6-Diamino-1,4-dihydropyridine-3,5-dicarboxylic acid esters used as coronary vessel dilators and anti-hypertensive agents
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
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3959281 |
Piperazino substituted coumarin derivatives
The present invention relates to new coumarin compounds useful as coronary dilators and having the formula ##SPC1##Or the hydrochloric acid addition salts thereof, and to methods of preparing same...
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3959359 |
Phenoxyalkylamines, process for their preparation and therapeutical composition containing same
This invention relates to phenoxyalkylamines having the formula: ##SPC1##Wherein R is a radical selected from the group consisting of hydrogen and hydroxy, R2 is a radical selected from the group...
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3957995 |
Pharmaceutical composition comprising vincamine and theophylline
The herein disclosed invention is directed to pharmaceutical compositions of vincamine and theophylline having cerebral vasodilator activity.
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3957998 |
Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarboxylic acid esters for effecting coronary vessel dilation and treating hypertension
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
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3957845 |
Trifluoromethyl-substituted phenyl acetonitriles
Basically substituted phenylacetonitriles having also a trifluoromethyl substituent. The compounds are useful as coronary dilators.
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3957809 |
Certain 2-alkyl-5-oxymethylthiazoles
Novel thiazole derivatives of the formula ##EQU1## wherein R is alkyl of 2 to 12 carbon atoms and R1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an...
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3954780 |
Propionic acid derivatives
β-[Benzo(b)thienyl-3]propionic acid derivatives in the form of their amino esters (and salts thereof) are prepared. These compounds have spasmolytic, vasodilatatric, antiserotanic and local ...
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3954871 |
1-(4-Alkylthiopheny)-2-substituted amino-alcohols and their salts
The new amino-alcohols according to the invention are represented by the formula ##SPC1##Wherein: R1 represents a RS, RSO or RSO2 group in which R is a linear or branched alkyl group (C1 -C10), an...
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3953448 |
Piperazino-anilido compounds
Novel 1,4-disubstituted piperazine compounds and pharmaceutical compositions incorporating such compounds in conjunction with orally, parenterally or rectally administrable pharmaceutically...
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3951990 |
4-Aryl or hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon...
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3951994 |
Tetrahydroindolizine derivatives
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl,...
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3951991 |
4-Aryl-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon...
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3950336 |
2,6-Diamino-1,4-dihydropyridine derivatives
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
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3948923 |
Pentahydroqunolizine derivatives
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl,...
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3944549 |
Amino derivatives of 1,4-benzodioxan
1-[2-(1,4-benzodioxanyl)methyl]-4-(2-hydroxyethyl)-piperazin
e hemifumarate and the related compounds of formula: ##SPC1##In which R is hydrogen or alkyl; and A is --Z--OR1, --CH2 CHOR"1 CH2 OR'1,...
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3944551 |
N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines
Disubstituted piperazines of the formula: ##SPC1##Wherein: n is 1 or 2; X is oxygen or sulfur; R is hydrogen or lower alkyl; Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl,...
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3943140 |
2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives
1,4-Dihydropyridines bearing carboxy functions in the 3-, 5- and 6- or 2-, 3-, 5- and 6-positions and being substituted in the 4-position by phenyl, substituted phenyl, naphthyl, phenylalkyl or a...
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3936439 |
2,6-Diaminonebularine derivatives
Novel 2,6-diaminonebularine derivatives of the formula ##SPC1##Wherein R is a phenyl or cyclohexyl group which may be substituted with lower alkyl, lower alkoxy or halogen, and pharmaceutically...
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3935220 |
Tetrahydroimidazolo[1,2-a]pyridine derivatives
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl,...
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3935223 |
2-Amino-1,4-dihydropyridine derivatives
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding...
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