Matches 301 - 350 out of 652 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >
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4059601 8-Halo-11,12-secoprostaglandins  
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4059587 Certain thiazolidine compounds  
This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such...
4057551 Indolo[2,3-a]quinolizines  
New compounds of the general formula (I) ##STR1## wherein R stands for an alkyl group, have been prepared by reducing a compound of the general formula (II) ##STR2## wherein R stands for alkyl, B...
4057550 Nitrogen-containing polycyclic compounds  
New compounds of the general formula (I) ##STR1## wherein R 1 stands for alkyl and R 2 stands for carboxy, a functional carboxy derivative or a group convertible into carboxy group or a...
4055597 10-Aza-11,12-secoprostaglandins  
This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4053605 Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives  
Novel cyano substituted (3-loweralkylamino-2-acyl-O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. The pyridines are vasodilators having...
4053601 3-Substituted-phenyl-6-hydrazine pyridazines  
The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have β-adrenergic blocking and vasodilator activity.
4052404 Indolo (2,3-α)quinolizines  
The invention relates to new indolo-quinolizidine derivatives of the general formula (I) or salts or optically active isomers thereof, ##STR1## wherein R stands for an alkyl group, AND...
4051141 Thieno[3,2-c]pyridine derivatives  
Thieno[3,2-c]pyridine derivatives having the formula: ##STR1## in which X is S; R is a phenyl or benzoyl radical optionally substituted with 1-3 halogen atoms or lower alkyl, lower alkoxy, hydroxy...
4049662 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
4049660 N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics  
Compounds of the formula ##STR1## wherein Z is --CH 2 CH 2 -- or --CHCH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino,...
4049658 N'-substituted derivatives of 4'-(N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2'-dioxolane (1',3') their method of preparation and their application in therapeutics  
Compounds of the formula ##STR1## wherein Z is --CH 2 CH 2 -- or --CHCH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino,...
4048171 1,4-Dihydropyridines  
1,4-Dihydropyridines of the formula: ##STR1## wherein R is hydrogen, straight, branched or cyclic lower alkyl, lower alkenyl, or lower alkinyl, unsubstituted or substituted; or benzyl, or...
4048164 N'-substituted derivatives of 4'-(N-piperazinylmethyl)spiro dibenzocycloheptadi- (or tri-) ene-5,2'-dioxolane(1',3')  
Compounds of the formula ##STR1## wherein Z is --CH 2 CH 2 -- or --CH=CH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino,...
4046902 Hypolipemiant composition and method using thiazole-5-methanols  
Novel thiazole derivatives of the formula ##STR1## wherein R is alkyl of 2 to 12 carbon atoms and R 1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an...
4044141 1,4-Dihydropyridines  
1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally...
4044012 Indolo-quinolizidine derivatives  
New compounds of the formula ##STR1## are provided wherein R 1 is hydrogen, and R 2 stands for an alkyl group and optically active enanthiomers and pharmaceutically acceptable salts thereof.
4038399 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives  
1,4-DINYDROPYRIDINE CARBOXYLIC ACID ESTERS OF THE FORMULA: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R, R 1 R 2 R 3 R 4 X and Y are defined hereinafter Are useful...
4038319 Substituted phenoxyalkylamines, process for their preparation and applications thereof  
This invention relates to phenoxyalkylamines having the formula ##STR1## in which R 1 is hydrogen, halogens or methyl, A is cyclohexylmethyl, propenyl, butenyl, cyclohexenylmethyl or a group...
4038314 1-Hydroxy-1-[(4'-hydroxy-3'aminosulfonamido)-phenyl]-2-amino-ethanes and salts  
Compounds of the formula ##STR1## wherein R 1 is hydrogen or methyl, and R 2 is phenoxy-(alkyl of 2 to 3 carbon atoms), phenyl-(alkyl of 4 to 5 carbon atoms), hydroxyphenyl-(alkyl of 3 to 5...
4036841 Indolo[2,3α]quinolizine derivatives  
Compounds of the formula ##STR1## wherein R 1 stands for hydrogen or an acyl group, and R 2 stands for an alkyl group are disclosed. A process for making the above compounds is also disclosed....
4035372 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines  
4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines useful by reason of their vasodilating activity are disclosed.
4035370 Alkaloid esters  
Vasodilatory eburnamine-type alkaloid esters of the formula (I) ##STR1## and salts and quaternary derivatives thereof, wherein X.about.Y REPRESENTS A =CH=CH- or ##STR2## R represents a C 1 -6...
4033996 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins  
This invention relates to 8-aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly...
4029808 Thienyl phenyl O-(aminoalkyl)-ketone oxime and furyl phenyl O-(aminoalkyl)-ketone oxime coronary vasodilators  
The invention relates to novel thienyl phenyl O-(aminoalkyl)-ketone oximes nd to novel furyl phenyl O-(aminoalkyl)-ketone oximes. These novel compounds exhibit a coronary vasodilatatory activity...
4028365 Benz[g]indolyl compounds  
A group of benz[g]indolyl compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These are piperidine compounds linked by the nitrogen atom to a...
4024261 Compositions and methods employing tetrahydroindolizine derivatives  
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl,...
4022898 2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives  
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding...
4022776 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives  
5-[Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-carbostyril derivatives represented by the formula (I) ##STR1## wherein R 1 and R 2 , which may be the same or different, each represents a...
4021434 Sodium β-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihyd ropyridine-1-yl]ethyl sulfate  
Novel 1-substituted-1, 4-dihydropyridine derivatives, particularly diethyl 1-ethoxymethyl-4-(3-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-dicarboxylate are provided. The novel derivatives...
4020178 1,4-Dihydropyridine esters used as coronary dilators and anti-hypertensives  
A new class of 1,4-dihydropyridines which are characterized by the presence of ester substitutes at positions 3 and 5 of the nucleus and by the presence of an alkoxyalkyl have particular...
4016277 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-dihydropyridine  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
4016176 Esters of 4-hydroxy-2,9-dioxatricyclo[4.3.1.0.sup.3,7 ] decanes and processes for their production  
Compounds consisting of esters of 4-hydroxy-2,9-dioxatricyclo[4.3.1.0 3 ,7 ] decane having the formulae: ##STR1## in which formulae R 1 is an alkyl radical having at most 4 carbon atoms, one of...
4016154 Novel derivative of N-(3,4,5-trimethoxy cinnamoyl) piperazine, its acid addition salts, its process of preparation and its therapeutic application  
A compound having the formula ##STR1## and its pharmacologically acceptable acid addition salts. The compound is prepared by condensing N-(3,4,5-trimethoxy cinnamoyl) piperazine with...
4015006 3(2H)-Isoquinolones therapeutic process  
New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action....
4015002 1-Aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, salts, pharmaceutical compositions and methods of use  
This invention relates to 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, and acid addition salts thereof. In particular, the compounds have (β-aminoethoxy- or γ-amino-propoxy)-phenyl substituents,...
4012517 Compositions and treatment  
Substituted thioxanthone and phenoxathiin compounds having bronchodilating properties, and their use in the treatment or prophylaxis of bronchoconstriction in mammals.
4011319 Pharmaceutical compositions and methods involving benzazepine derivatives  
Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal...
4011262 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series  
The 15-substituted-ω-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable...
4009174 Esters of substituted nicotinic acids  
Novel derivatives of nicotinic acid possessing vasomotor properties.
4007189 Pyrrolotriazolopyrimidine derivatives and process for the preparation thereof  
Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R 1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R 2 represents an alkyl group having...
4005095 Substituted thienyl-acetic acid esters  
Substituted thienyl-acetic acid esters of the formula: ##STR1## in which R 1 and R 2 each, independently is H, CH 3 , C 2 H 5 , C 3 H 7 , OCH 3 , SCH 3 , Cl Br or NO 2 , R 3 is phenyl or...
4002762 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension  
3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert...
4001426 Substituted benzofurans and benzothiophenes  
The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates...
4001259 3,6-Diamino-3,4-dihydro-2-pyridones  
3,6-Diamino-3,4-dihydro-2-pyridones of the formula ##SPC1## Wherein R 1 is straight or branched chain alkyl or alkenyl or said alkyl or alkenyl interrupted by 1 or 2 oxygen atoms; R 2 is...
4001252 2-Amino-3,4-dihydropyridines  
2-Amino-3,4-dihydropyridine-3-carboxylic acid ester derivatives are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid ester derivatives with an alkylating agent in the presence of...
4001238 1,3,4-Oxadiazole amides  
The 4-amino-6,7-dimethoxy-2-[4-(5-lower alkylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quina zolines are potent antihypertensive drugs which have little or no α-adrenergic blocking activity.
4000282 2-(3-Tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines  
Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically their preparation are disclosed. These pyridines are vasodilators having anti-hypertensive...
3998953 1,3,7-Trisubstitued xanthine peripheral vasodilators  
Compounds of the formula ##STR1## wherein R is methyl or ethyl, R 1 is methyl, ethyl or ##STR2## and R 2 is methyl, ethyl, ##STR3## where Alk is alkyl of 1 to 4 carbon atoms, Q is ethyl,...
3996234 1,4-Dihydropyridine carboxylic acid esters  
1,4-DIHYDROPYRIDINE CARBOXYLIC ACID ESTERS OF THE FORMULA: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, straight- or branched-chain lower alkyl, lower...
Matches 301 - 350 out of 652 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >