Match Document Document Title
4016176 Esters of 4-hydroxy-2,9-dioxatricyclo[4.3.1.03,7 ] decanes and processes for their production  
Compounds consisting of esters of 4-hydroxy-2,9-dioxatricyclo[4.3.1.03,7 ] decane having the formulae: ##STR1## in which formulae R1 is an alkyl radical having at most 4 carbon atoms, one of the...
4015002 1-Aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, salts, pharmaceutical compositions and methods of use  
This invention relates to 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, and acid addition salts thereof. In particular, the compounds have (β-aminoethoxy- or γ-amino-propoxy)-phenyl substituents,...
4015006 3(2H)-Isoquinolones therapeutic process  
New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action....
4012517 Compositions and treatment  
Substituted thioxanthone and phenoxathiin compounds having bronchodilating properties, and their use in the treatment or prophylaxis of bronchoconstriction in mammals.
4011319 Pharmaceutical compositions and methods involving benzazepine derivatives  
Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal...
4011262 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series  
The 15-substituted-ω-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable...
4009174 Esters of substituted nicotinic acids  
Novel derivatives of nicotinic acid possessing vasomotor properties.
4007189 Pyrrolotriazolopyrimidine derivatives and process for the preparation thereof  
Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R2 represents an alkyl group having from...
4005095 Substituted thienyl-acetic acid esters  
Substituted thienyl-acetic acid esters of the formula: ##STR1## in which R1 and R2 each, independently is H, CH3, C2 H5, C3 H7, OCH3, SCH3, Cl Br or NO2, R3 is phenyl or cyclohexyl and R4 is H, or...
4002762 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension  
3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an...
4001252 2-Amino-3,4-dihydropyridines  
2-Amino-3,4-dihydropyridine-3-carboxylic acid ester derivatives are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid ester derivatives with an alkylating agent in the presence of...
4001426 Substituted benzofurans and benzothiophenes  
The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and...
4001259 3,6-Diamino-3,4-dihydro-2-pyridones  
3,6-Diamino-3,4-dihydro-2-pyridones of the formula ##SPC1## Wherein R1 is straight or branched chain alkyl or alkenyl or said alkyl or alkenyl interrupted by 1 or 2 oxygen atoms; R2 is straight or...
4001238 1,3,4-Oxadiazole amides  
The 4-amino-6,7-dimethoxy-2-[4-(5-lower alkylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quina zolines are potent antihypertensive drugs which have little or no α-adrenergic blocking activity.
4000282 2-(3-Tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines  
Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically their preparation are disclosed. These pyridines are vasodilators having anti-hypertensive...
3998953 1,3,7-Trisubstitued xanthine peripheral vasodilators  
Compounds of the formula ##STR1## wherein R is methyl or ethyl, R1 is methyl, ethyl or ##STR2## and R2 is methyl, ethyl, ##STR3## where Alk is alkyl of 1 to 4 carbon atoms, Q is ethyl, propyl,...
3994891 Tetrahydroisoquinoline compounds  
Tetrahydroisoquinoline compounds represented by the formula: ##SPC1##In which X is a hydroxy group, Y is a hydroxy group or Y taken with X is --O--CH2 --O--, Z is hydrogen or a hydroxy group, R1...
3995041 Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizines  
2-Substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizin es of the structural formula, ##SPC1##In which R1 is a hydrogen atom or an alkanoyl group of 2 to 4 carbon atoms and each of...
3991057 C-Piperazino-pyridine sulfonamides  
This invention relates to compounds of the formula: ##SPC1##Wherein R1 in the 3- or 5-position is preferably a substituted sulfonamido or a carboxamido group whereas R2 in the 2-, 4- or 6-position...
3987176 Composition and use of 3,4-dihydropyridones as vasodilators and antihypertensive agents  
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said...
3985896 Benzophenalenofurans  
The compounds are benzophenalenofurans having pharmacological activity, in particular, coronary vasodilator activity.
3985886 2-Amino-4,5-dihydropyridine derivatives and process for their preparation  
2-Amino-4,5-dihydropyridines-3,5-dicarboxylates substituted by lower alkoxy or lower alkylthio in the 6-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted...
3985758 1,4-Dihydropyridine derivatives  
There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dica rboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester and...
3984558 1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators  
Compounds useful in the treatment of asthma, the symptoms of allergy and in some instances in gout and hyperuricemia are described. The novel compounds are 1-substituted-1,2,4-triazoles being...
3984413 Phenoxyalkanecarboxylic acid esters of hydroxyalkyltheophyllines and method for their manufacture  
Phenoxyalkanecarboxylic acids are esterified with 7-(2-hydroxyethyl) theophylline or 7-(2,3-dihydroxypropyl) theophylline. The resulting esters have excellent antilipemic and anticholesterolemic...
3981882 Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester  
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon...
3979456 Phenoxyalkylamines, process for their preparation and applications thereof  
This invention relates to phenoxyalkylamines having the formula: ##SPC1##In which n is zero or 1, R is hydrogen or a hydroxy group, R2 is hydrogen, a hydroxy group or an alkyl group, R2 being...
3975391 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-3,4-dih ydrocarbostyril derivatives  
5-[1-HYDROXY-2-SUBSTITUTED-AMINO)]ETHYL-8-HYDROXY-3,4-DIHYDR OCARBOSTYRIL DERIVATIVES REPRESENTED BY THE FORMULA (I) ##SPC1##wherein R1 and R2, which may be the same or different, each represents...
3974275 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives  
Certain 1,4-dihydropyridine carboxylic acid esters or their pharmaceutically acceptable non toxic salts are useful as coronary vessel dilators and antihypertensives.
3974213 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins  
The 15 aryl substituted-ω-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles...
3971793 Certain 6-(dialkylamino, pyrrolidino and piperidino)ethoxy-4,7-dimethoxy-5-(3-phenyl-1-hydroxypropyl)2,3-dihydrob enzofurans  
A compound of the formula ##SPC1##In which R is hydrogen, hydroxy, halogen or alkoxy containing up to 3 carbon atoms, and ##EQU1## is dialkylamino in which the alkyls contain up to 3 carbon atoms,...
3968102 S-substituted-2-thioadenosines  
S-Substituted-2-thioadenosines represented by the formula (I): ##SPC1##wherein R is as defined hereinafter, useful as a platelet aggregation inhibitor and a coronary vasodilator.
3966948 Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods  
1,4-Dihydropyridines of the formula: ##SPC1##WhereinR is hydrogen, straight, branched or cyclic lower alkyl, lower alkenyl, or lower alkinyl, unsubstituted or substituted by hydroxyl or alkoxy of...
3966814 1-Phenyl-2-(Naphthylalkyl-amino)-ethanols and salts thereof  
Compounds of the formula ##SPC1##Wherein A is alkylene of 2 to 6 carbon atoms, R1 is hydrogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, R2 is hydrogen, lower alkyl or lower...
3966764 Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs  
Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the...
3966724 1-(α-Aminomethylbenzyl)isoquinoline compounds  
Compounds having the structure: ##SPC1##In which R1 and R2 are alkoxy groups of one to four carbon atoms, R3 and R4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R5 and R6...
3962256 2-Aminomethyl benzimidazole derivatives  
Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R1 and R2 each is...
3959359 Phenoxyalkylamines, process for their preparation and therapeutical composition containing same  
This invention relates to phenoxyalkylamines having the formula: ##SPC1##Wherein R is a radical selected from the group consisting of hydrogen and hydroxy, R2 is a radical selected from the group...
3959474 2,6-Diamino-1,4-dihydropyridine-3,5-dicarboxylic acid esters used as coronary vessel dilators and anti-hypertensive agents  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
3959292 2-Amino-4,5-dihydropyridine derivatives  
4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or...
3959281 Piperazino substituted coumarin derivatives  
The present invention relates to new coumarin compounds useful as coronary dilators and having the formula ##SPC1##Or the hydrochloric acid addition salts thereof, and to methods of preparing same...
3957809 Certain 2-alkyl-5-oxymethylthiazoles  
Novel thiazole derivatives of the formula ##EQU1## wherein R is alkyl of 2 to 12 carbon atoms and R1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an...
3957845 Trifluoromethyl-substituted phenyl acetonitriles  
Basically substituted phenylacetonitriles having also a trifluoromethyl substituent. The compounds are useful as coronary dilators.
3957995 Pharmaceutical composition comprising vincamine and theophylline  
The herein disclosed invention is directed to pharmaceutical compositions of vincamine and theophylline having cerebral vasodilator activity.
3957998 Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarboxylic acid esters for effecting coronary vessel dilation and treating hypertension  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
3954780 Propionic acid derivatives  
β-[Benzo(b)thienyl-3]propionic acid derivatives in the form of their amino esters (and salts thereof) are prepared. These compounds have spasmolytic, vasodilatatric, antiserotanic and local...
3954871 1-(4-Alkylthiopheny)-2-substituted amino-alcohols and their salts  
The new amino-alcohols according to the invention are represented by the formula ##SPC1##Wherein: R1 represents a RS, RSO or RSO2 group in which R is a linear or branched alkyl group (C1 -C10), an...
3953448 Piperazino-anilido compounds  
Novel 1,4-disubstituted piperazine compounds and pharmaceutical compositions incorporating such compounds in conjunction with orally, parenterally or rectally administrable pharmaceutically...
3951991 4-Aryl-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester  
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon...
3951990 4-Aryl or hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester  
3,4-Dihydropyridones of the formula ##SPC1##Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon...