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4115401 Prostaglandin derivatives and process for preparing the same  
Prostaglandin derivatives corresponding to the general formula: ##STR1## wherein R1 represents hydrogen, methyl or ethyl, R2, R3 and R4, which are the same or different, each represent hydrogen or...
4113874 Pyrrolidones, pharmaceutical compositions therewith and processes of use thereof  
The present application relates to novel pyrrolidones which are analogous to prostaglandins as well as to a process of preparing the same.The new compounds have valuable pharmaceutical properties...
4108996 (-)-Apovincaminol lauric acid ester and cerebral vasodilatory composition thereof  
Apovincaminol ester of formula ##STR1## wherein R is an alkylcarbonyl group having 3 to 12 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
4105666 Piperidine derivatives  
(Aroylamino)-1-(aroyloxyalkyl)piperidines having the formula ##STR1## WHERE Ar1 and Ar2 are aryl (including heteroaryl) groups and n is from 2 to 6, and their pharmaceutically acceptable acid...
4100285 N-substituted trialkoxybenzyl piperazine derivatives  
N-substituted trialkoxybenzyl piperazine derivatives expressed by the following general formula (I): ##STR1## where R represents a methyl or ethyl group, and Z represents a group selected from the...
4097483 Pyrazolo 1,5-a!pyridines  
The present invention provides substituted pyrazolo 1,5-a!pyridine derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is...
4097504 11,12-Secoprostaglandins  
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4097482 5-O-Cyanobenzyl-4,5,6,7-tetrahydro-thieno 3,2-c!pyridine maleate  
The present invention relates to pyridine derivatives having the formula: ##STR1## in which: R is a radical selected from a phenyl radical mono- and polysubstituted with a group selected from the...
4096265 Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates  
Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates of the formula ##STR1## wherein R represents -C≡N, ##STR2## R1 is a lower alkyl, R2 is hydrogen or a lower alkyl and R3 is a...
4093811 2-Aryl-4-cyanomethyl-5-methylimidazoles  
Novel 2-aryl-4-cyanomethyl-5-methylimidazoles useful for their ultra-violet (U.V.) absorbing properties, and certain novel precursors therefor. The species,...
4088659 Effective substance from plants belonging to the Labiatae family  
Extraction processes are described resulting in the isolation of a pharmacologically active substance from a plant of the Labiatae family. Chemical and physical properties of this compound are...
4087435 8-Aza-9-dioxothiaprostanoic acids  
Novel 8-aza-9-dioxothiaprostanoic acid compounds, their salts, and derivatives, are prepared from ethyl 7-(3-hydroxymethyl-2-isothiazolidinyl)-5-heptynoate S,S-dioxide by first hydrogenating the...
4082843 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents  
The compounds are 3-(3-(3-substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines which have β-adrenergic blocking and vasodilator activity.
4082847 Substituted aminoethanols and pharmaceutical use  
1-(5-benzimidazolyl)-2-isopropylaminoethanol, pharmaceutically acceptable salts thereof, and their preparation are disclosed. These compounds have pharmaceutical utility e.g. as bronchodilators.
4079140 Benzothienyl aminoethyl ketones and their application in therapeutics  
Compounds having the formula ##STR1## wherein R1 and R2 are alkyls or alkenyls having 1 to 4 atoms or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, and RX is a salt-forming...
4075241 2-(Aryl)-3-(dimethylamino)butyl-3,4,5-trimethoxybenzoates  
The compounds 2-Aryl-3-amino-1-butanol derivatives of the formula ##STR1## wherein R represents hydrogen or acyl; R1 and R2 each independently represents hydrogen, phenyl lower alkyl, or lower...
4068076 5-(1-Hydroxy-2-(heterocyclic amino))ethyl-8-hydroxy-3,4-dihydrocarbostyril derivatives  
5-[1-HYDROXY-2-(HETEROCYCLIC AMINO)]ETHYL-8-HYDROXY-3,4-DIHYDROCARBOSTYRIL DERIVATIVES REPRESENTED BY THE FORMULA (I) wherein A, when taken together with the nitrogen atom to which it is attached,...
4066648 Isochroman derivatives  
New isochroman derivatives which may be represented by general formula [I] ##STR1## wherein R1 is hydrogen atom, a lower alkoxy group or hydroxyl group and R2 is a lower alkoxy group or hydroxyl...
4065458 Eburnamenine derivatives  
A heart and vasotropic pharmaceutical of the formula: ##STR1## wherein R represents a hydrogen atom or an acyl group, preferably a C1-15 alkylcarbonyl, C2-6 alkenylcarbonyl, or a phenyl-...
4065488 Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate  
The following process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate is described: acylating 1,4:3,6-dianhydro-D-glucitol with 0.5 to 1.5 molar equivalents of acetic anhydride in the...
4065575 3-Aminomethyl derivatives of 4-chromanone  
4-Chromanone derivatives of the formula: ##STR1## wherein R represents alkyl of 1 through 6 carbon atoms or alkoxyalkyl of 2 through 6 carbon atoms, are new compounds possessing pharmacological...
4061855 Pyrimidin-6-yl acethydroxamic acids  
Compounds of the formula ##STR1## IN WHICH R is aminocarbonylphenyl in which amino is --NH2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro,...
4059587 Certain thiazolidine compounds  
This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such...
4059601 8-Halo-11,12-secoprostaglandins  
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4057550 Nitrogen-containing polycyclic compounds  
New compounds of the general formula (I) ##STR1## wherein R1 stands for alkyl and R2 stands for carboxy, a functional carboxy derivative or a group convertible into carboxy group or a functional...
4057551 Indolo[2,3-a]quinolizines  
New compounds of the general formula (I) ##STR1## wherein R stands for an alkyl group, have been prepared by reducing a compound of the general formula (II) ##STR2## wherein R stands for alkyl, B...
4055597 10-Aza-11,12-secoprostaglandins  
This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4053601 3-Substituted-phenyl-6-hydrazine pyridazines  
The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have β-adrenergic blocking and vasodilator activity.
4053605 Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives  
Novel cyano substituted (3-loweralkylamino-2-acyl-O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. The pyridines are vasodilators having...
4052404 Indolo (2,3-α)quinolizines  
The invention relates to new indolo-quinolizidine derivatives of the general formula (I) or salts or optically active isomers thereof, ##STR1## wherein R stands for an alkyl group, AND...
4051141 Thieno[3,2-c]pyridine derivatives  
Thieno[3,2-c]pyridine derivatives having the formula: ##STR1## in which X is S; R is a phenyl or benzoyl radical optionally substituted with 1-3 halogen atoms or lower alkyl, lower alkoxy, hydroxy...
4049662 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
4049660 N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics  
Compounds of the formula ##STR1## wherein Z is --CH2 CH2 -- or --CHCH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino,...
4048171 1,4-Dihydropyridines  
1,4-Dihydropyridines of the formula: ##STR1## wherein R is hydrogen, straight, branched or cyclic lower alkyl, lower alkenyl, or lower alkinyl, unsubstituted or substituted; or benzyl, or...
4046902 Hypolipemiant composition and method using thiazole-5-methanols  
Novel thiazole derivatives of the formula ##STR1## wherein R is alkyl of 2 to 12 carbon atoms and R1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an...
4044012 Indolo-quinolizidine derivatives  
New compounds of the formula ##STR1## are provided wherein R1 is hydrogen, and R2 stands for an alkyl group and optically active enanthiomers and pharmaceutically acceptable salts thereof.
4038314 1-Hydroxy-1-[(4'-hydroxy-3'aminosulfonamido)-phenyl]-2-amino-ethanes and salts  
Compounds of the formula ##STR1## wherein R1 is hydrogen or methyl, and R2 is phenoxy-(alkyl of 2 to 3 carbon atoms), phenyl-(alkyl of 4 to 5 carbon atoms), hydroxyphenyl-(alkyl of 3 to 5 carbon...
4038319 Substituted phenoxyalkylamines, process for their preparation and applications thereof  
This invention relates to phenoxyalkylamines having the formula ##STR1## in which R1 is hydrogen, halogens or methyl, A is cyclohexylmethyl, propenyl, butenyl, cyclohexenylmethyl or a group...
4036841 Indolo[2,3α]quinolizine derivatives  
Compounds of the formula ##STR1## wherein R1 stands for hydrogen or an acyl group, and R2 stands for an alkyl group are disclosed.A process for making the above compounds is also disclosed. The...
4035372 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines  
4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines useful by reason of their vasodilating activity are disclosed.
4035370 Alkaloid esters  
Vasodilatory eburnamine-type alkaloid esters of the formula (I) ##STR1## and salts and quaternary derivatives thereof, wherein X.about.Y REPRESENTS A =CH=CH- or ##STR2## R represents a C1-6...
4029808 Thienyl phenyl O-(aminoalkyl)-ketone oxime and furyl phenyl O-(aminoalkyl)-ketone oxime coronary vasodilators  
The invention relates to novel thienyl phenyl O-(aminoalkyl)-ketone oximes nd to novel furyl phenyl O-(aminoalkyl)-ketone oximes.These novel compounds exhibit a coronary vasodilatatory activity...
4028365 Benz[g]indolyl compounds  
A group of benz[g]indolyl compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These are piperidine compounds linked by the nitrogen atom to a...
4024261 Compositions and methods employing tetrahydroindolizine derivatives  
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl,...
4022898 2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives  
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding...
4022776 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives  
5-[Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-carbostyril derivatives represented by the formula (I) ##STR1## wherein R1 and R2, which may be the same or different, each represents a hydrogen...
4021434 Sodium β-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihyd ropyridine-1-yl]ethyl sulfate  
Novel 1-substituted-1, 4-dihydropyridine derivatives, particularly diethyl 1-ethoxymethyl-4-(3-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-dicarboxylate are provided. The novel derivatives...
4020178 1,4-Dihydropyridine esters used as coronary dilators and anti-hypertensives  
A new class of 1,4-dihydropyridines which are characterized by the presence of ester substitutes at positions 3 and 5 of the nucleus and by the presence of an alkoxyalkyl have particular...
4016277 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-dihydropyridine  
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are...
4016154 Novel derivative of N-(3,4,5-trimethoxy cinnamoyl) piperazine, its acid addition salts, its process of preparation and its therapeutic application  
A compound having the formula ##STR1## and its pharmacologically acceptable acid addition salts. The compound is prepared by condensing N-(3,4,5-trimethoxy cinnamoyl) piperazine with...