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4186136 Novel benzothienyl amino (propyl and butyl) ketones, a method of preparation thereof and their application to therapeutics  
Compounds having the formula ##STR1## wherein R 1 and R 2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic...
4183930 Amino derivatives of pyrazolo [1,5-a]s-triazine, and their therapeutic applications  
This invention relates to compounds having the general formula: ##STR1## in which: R 1 represents a hydrogen atom or a (C 1 -4) alkyl radical, R 2 represents a hydrogen atom, a (C 1 -4) alkyl...
4174448 Process for the preparation of thienopyridine derivatives  
This invention relates to a process for the preparation of compounds having the general formula: ##STR1## in which: R 1 represents a hydrogen atom, an optionaly substituted alkyl, aryl or aralkyl...
4173704 Dithio aminoacid derivatives  
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting...
4173636 Decahydroquinolines, pharmaceutical compositions and methods of use  
The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R 1 represents an...
4162321 Sulphur-containing amino-dihydropyridines, and their use as medicants  
The invention relates to new dihydropyridines which are substituted by an amino group in at least one of the 2- and 6-positions, by a sulphur-containing substituent in the 3-position, by a cyclic...
4156786 Amino acid derivatives  
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4154960 Amino acid derivatives  
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4154829 Aminoalkyl-substituted benzoxazine derivatives  
Racemic and optically active compounds of the formula Q--C n H 2n --NH--R wherein Q is ##STR1## where R 1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4152519 16-Hydroxy aspidospermidines and a process for their production  
This invention relates to novel aspidospermidines being useful in synthesis and also exhibiting interesting physiological properties. A process for the preparation of the novel compounds is...
4151284 Substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, antihypertensive compositions and methods containing same  
Novel cyano substituted (3-loweralkylamino-2-R 1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. The pyridines are vasodilators having...
4148897 1,2-Dihydronaphthalene derivatives and pharmaceutical composition  
Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein R 1 and R 2 , independently of each other, are hydrogen, nitro, amino, halogen, or hydroxyl which may be protected, and R 3...
4145432 6-Acyloryalkyl-1,4-dihydropyridine derivatives and a method of effecting vasodilation therewith  
This invention relates to 1,4-dihydropyridine derivatives. More particularly, it relates to new 1,4-dihydropyridine derivatives thereof which have vasodilating and anti-hypertensive activity, to...
4144336 2-Benzopyranone derivatives, process for their production, their use as medicaments, more especially as coronary dilators  
Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and each R individually is selected from the group...
4140864 Substituted acyl derivatives of amino acids  
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4140777 Cerebral vasodilating 6-substituted vincamines  
The invention relates to novel derivatives of vincamine and apovincamine having the formula ##STR1## WHICH ARE ENDOWED WITH ANALOGOUS PROPERTIES AS THE VINCAMINE AND APOVINCAMINE AS WELL AS WITH AN...
4140770 Benzoylethers and processes for their production  
Processes for preparing benzoylethers, their acid additive salts and their quaternary ammonium salts are disclosed. These compounds have useful pharmacodynamic properties.
4140712 20-Hydroxy-prostaglandins  
The present invention relates to 20-hydroxy prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## and X represents ethylene or cis-vinylene and Y...
4139535 3-Cyano-2-pyridinyloxymethyl-oxazolidine derivatives  
Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines are vasodilators having...
4138489 Vasodilating octahydro-1,12-methano-oxymethano[2,3-a]-indoloquinolizines  
Pentacyclic derivatives of the general formula ##STR1## wherein R, R 1 , R 2 and R 3 are defined hereinbelow are useful as cerebral protectors and vasodilators.
4136190 4,4-Dimethyl-3,5-pyrrolidinediones  
Compounds of formula (I): ##STR1## wherein: n is 4 to 8, X is CO, protected CO or CROH wherein R is hydrogen or C 1 -4 alkyl and wherein the OH moiety may be protected; R 1 is hydrogen, or CO 2 R...
4136187 Antihypertensive 2-amino-4,5-dihydropyridine derivatives  
4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or...
4127661 Piperazine alkanols  
This invention relates to variously substituted piperazine derivatives. S compounds possess therapeutically useful vasodilator properties.
4117128 Sulfonyl benzofurans and benzothiophenes having coronary vasodilator activity  
The compounds are sulfonyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris.
4115409 Alkanolamine derivatives  
Novel 1-aryloxy-3-carbamoylalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart...
4115401 Prostaglandin derivatives and process for preparing the same  
Prostaglandin derivatives corresponding to the general formula: ##STR1## wherein R 1 represents hydrogen, methyl or ethyl, R 2 , R 3 and R 4 , which are the same or different, each represent...
4113874 Pyrrolidones, pharmaceutical compositions therewith and processes of use thereof  
The present application relates to novel pyrrolidones which are analogous to prostaglandins as well as to a process of preparing the same. The new compounds have valuable pharmaceutical properties...
4108996 (-)-Apovincaminol lauric acid ester and cerebral vasodilatory composition thereof  
Apovincaminol ester of formula ##STR1## wherein R is an alkylcarbonyl group having 3 to 12 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
4107317 Chroman derivatives  
Derivatives of trans-3-hydroxy-4-amino-chroman and pharmaceutical compositions containing such derivatives are useful for effecting vasodilation in mammals, including humans.
4105666 Piperidine derivatives  
(Aroylamino)-1-(aroyloxyalkyl)piperidines having the formula ##STR1## WHERE Ar 1 and Ar 2 are aryl (including heteroaryl) groups and n is from 2 to 6, and their pharmaceutically acceptable acid...
4100285 N-substituted trialkoxybenzyl piperazine derivatives  
N-substituted trialkoxybenzyl piperazine derivatives expressed by the following general formula (I): ##STR1## where R represents a methyl or ethyl group, and Z represents a group selected from the...
4097504 11,12-Secoprostaglandins  
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4097483 Pyrazolo 1,5-a!pyridines  
The present invention provides substituted pyrazolo 1,5-a!pyridine derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is...
4097482 5-O-Cyanobenzyl-4,5,6,7-tetrahydro-thieno 3,2-c!pyridine maleate  
The present invention relates to pyridine derivatives having the formula: ##STR1## in which: R is a radical selected from a phenyl radical mono- and polysubstituted with a group selected from the...
4096265 Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates  
Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates of the formula ##STR1## wherein R represents -C≡N, ##STR2## R 1 is a lower alkyl, R 2 is hydrogen or a lower alkyl and R...
4093811 2-Aryl-4-cyanomethyl-5-methylimidazoles  
Novel 2-aryl-4-cyanomethyl-5-methylimidazoles useful for their ultra-violet (U.V.) absorbing properties, and certain novel precursors therefor. The species,...
4092419 Substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their preparation and use  
Novel cyano substituted (3-loweralkylamino-2-R 1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. The pyridines are vasodilators having...
4088659 Effective substance from plants belonging to the Labiatae family  
Extraction processes are described resulting in the isolation of a pharmacologically active substance from a plant of the Labiatae family. Chemical and physical properties of this compound are...
4087435 8-Aza-9-dioxothiaprostanoic acids  
Novel 8-aza-9-dioxothiaprostanoic acid compounds, their salts, and derivatives, are prepared from ethyl 7-(3-hydroxymethyl-2-isothiazolidinyl)-5-heptynoate S,S-dioxide by first hydrogenating the...
4082847 Substituted aminoethanols and pharmaceutical use  
1-(5-benzimidazolyl)-2-isopropylaminoethanol, pharmaceutically acceptable salts thereof, and their preparation are disclosed. These compounds have pharmaceutical utility e.g. as bronchodilators.
4082843 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents  
The compounds are 3-(3-(3-substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines which have β-adrenergic blocking and vasodilator activity.
4079140 Benzothienyl aminoethyl ketones and their application in therapeutics  
Compounds having the formula ##STR1## wherein R 1 and R 2 are alkyls or alkenyls having 1 to 4 atoms or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, and RX is a...
4075241 2-(Aryl)-3-(dimethylamino)butyl-3,4,5-trimethoxybenzoates  
The compounds 2-Aryl-3-amino-1-butanol derivatives of the formula ##STR1## wherein R represents hydrogen or acyl; R 1 and R 2 each independently represents hydrogen, phenyl lower alkyl, or lower...
4068076 5-(1-Hydroxy-2-(heterocyclic amino))ethyl-8-hydroxy-3,4-dihydrocarbostyril derivatives  
5-[1-HYDROXY-2-(HETEROCYCLIC AMINO)]ETHYL-8-HYDROXY-3,4-DIHYDROCARBOSTYRIL DERIVATIVES REPRESENTED BY THE FORMULA (I) wherein A, when taken together with the nitrogen atom to which it is attached,...
4066692 11,12-Secoprostaglandins  
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal...
4066648 Isochroman derivatives  
New isochroman derivatives which may be represented by general formula [I] ##STR1## wherein R 1 is hydrogen atom, a lower alkoxy group or hydroxyl group and R 2 is a lower alkoxy group or...
4065575 3-Aminomethyl derivatives of 4-chromanone  
4-Chromanone derivatives of the formula: ##STR1## wherein R represents alkyl of 1 through 6 carbon atoms or alkoxyalkyl of 2 through 6 carbon atoms, are new compounds possessing pharmacological...
4065488 Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate  
The following process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate is described: acylating 1,4:3,6-dianhydro-D-glucitol with 0.5 to 1.5 molar equivalents of acetic anhydride in the presence...
4065458 Eburnamenine derivatives  
A heart and vasotropic pharmaceutical of the formula: ##STR1## wherein R represents a hydrogen atom or an acyl group, preferably a C 1 -15 alkylcarbonyl, C 2 -6 alkenylcarbonyl, or a phenyl- (C 1...
4061855 Pyrimidin-6-yl acethydroxamic acids  
Compounds of the formula ##STR1## IN WHICH R is aminocarbonylphenyl in which amino is --NH 2 , pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro,...
Matches 251 - 300 out of 652 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >