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4346093 Heterocyclic oxypropanolamine compounds and pharmaceutical compositions  
The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R 2 and R...
4345082 Process for the preparation of hydroxyamino-eburnane derivatives and octahydroindoloquinolizine intermediates  
The invention relates to new hydroxyamino-eburnane derivatives of the general formula (I), ##STR1## wherein R 1 and R 2 each stand for a C 1 -6 alkyl group, as well as to pharmaceutically...
4342691 ω-Heteroaroyl(propionyl or butyryl)-L-prolines  
This disclosure describes novel substituted ω-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
4342690 ω-Heteroaroyl(propionyl or butyryl)-L-prolines  
This disclosure describes novel substituted ω-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
4342689 ω-Heteroaroyl(propionyl or butyryl)-L-prolines  
This disclosure describes novel substituted ω-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
4340601 Dopaminergic isoquinolines  
A new series of compounds having renal vasodilating activity described. The compounds are 2-allyl-8-halo-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquin olines.
4340600 Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines  
4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon...
4339600 Compounds for alleviating angiotensin related hypertension  
Compounds for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprising angiotensin converting enzyme inhibitors selected from a group of mercaptoacyl aminoacids.
4338322 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same  
This invention relates to 2-or 6-cyano or cyano(lower)alkyl-4-phenyl or (substituted phenyl)1,4-dihydropyridine-3,5-dicarboxylates and derivatives which have vasodilating and hypertensive activity,...
4336382 1,4-Disubstituted piperazine compounds  
There are disclosed compounds of the formula ##STR1## wherein R 1 is selected from the group consisting of lower alkyl; R 8 is selected from the group consisting of --O--(CH 2 ) n --wherein n is...
4329350 1,1-Disubstituted octahydro-indolo[2,3-a]quinolizines, process for the preparation thereof and compositions containing same  
Compounds of the formula: ##STR1## wherein R is alkyl having 1 to 6 carbon atoms; A is substituted or unsubstituted alkyl having 1 to 6 carbon atoms, aralkyl having 7 to 16 carbon atoms wherein...
4329338 Compositions for use as cosmetics  
The invention relates to new compositions to be used as cosmetics. The new cosmetics according to the invention contain as active agent 0.06 to 10% by weight of a reaction product of nicotinic...
4328240 Certain PGI.sub.1 compounds and their pharmaceutical composition and methods  
2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of...
4328153 Dopaminergic benzazepines  
A new series of compounds having renal vasodilating activity is described. The compounds are 3-cycloalkylmethyl-7,8-dihydroxy-6-halo-1-(p-hydroxyphenyl)- 2,3,4,5-tetrah ydro-1H-3-benzazepines.
4326064 Derivatives of 1,4-dihydropyridine-3-carbothiol acids  
The present invention relates to compounds which are derivatives of 1,4-dihydropyridine-3-carbothiol acids of the formula: ##STR1## wherein R is hydrogen, an alkyl, aryl, heteryl; R' is a lower...
4314944 4-Aminoalkyl-7-hydroxy-2(3H)-indolones  
A new group of 2(3H)-indolones whose structures are characterized by having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus have beneficial...
4314943 Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols  
1-Aryloxy-3-[(3-indolyl)-tert.-butyl]amino-2-propanols having a heterocyclic aryl-attached substituent or aryl-fused heterocyclic ring are antihypertensive agents having vasodilator and adrenergic...
4308396 Thromboxane A.sub.2 analogues  
Stable biologically active thromboxane A 2 analogues having the formula ##STR1## wherein R 1 is OR 3 , where R 3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group;...
4303670 Bicyclic prostaglandins and process for their preparation  
Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory,...
4298734 Diazaheterocyclopurines and triazolopyrimidines  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4297368 Pharmaceutically useful 5,6-saturated PGI compounds  
Bicyclic prostaglandins and pharamaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory,...
4291175 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives  
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C 1 to C 4 alkanoyl or optionally...
4291174 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives  
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C 1 to C 4 alkanoyl or optionally...
4291015 Polymeric diffusion matrix containing a vasodilator  
A polymeric diffusion matrix containing a vasodilator is provided comprising from about 2 to about 60% of a polar plasticizer, e.g., glycerol, from about 2 to about 15% of a matrix component, e.g.,...
4289707 Nitrogen heterocycles  
1,3,6-Trisubstituted piperazine-2,5-diones having biological properties related to those of the natural prostaglandins, their synthesis, compositions containing them, and their use in medicine.
4285966 Certain 15-epi-prostacyclins  
The present invention relates to 15-epi-derivatives of prostacyclin and its analogs, to a process for their preparation and to pharmaceutical and veterinary compositions containing them.
4285955 1,4-Dihydropyridinecarboxylic acids  
The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10° to...
4285950 10-halo-E-homoeburnane derivatives, a process for the preparation thereof, a process for the use thereof as vasodilators, and vasodilating compositions thereof  
The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), ##STR1## wherein R 2 is a C 1 -6 alkyl group and X is halogen, and epimers, optically active derivatives...
4284634 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same  
1,4-dihydropyridine derivatives of the general formula ##STR1## having vasodilating and anti-hypertensive activity, processes for preparing same, and pharmaceutical compositions thereof for...
4284632 3-Pyrrolin-2-one derivatives and compositions  
New 3-cyclicaminoalkoxy-4-phenyl-3-pyrrolin-2-ones are disclosed. These compounds exhibit anti-hypertensive and vasodilatory action.
4278682 Vasodilating method of treatment using a indolo-quinolizine-monoester, diester or nitrile  
Vasodilating octahydro-indolo[2,3-a]quinolizine derivatives of the formula ##STR1## wherein Q is hydrogen or an A--CH 2 --CH 2 -- group and A is cyano or --COOR, wherein R is C 1 -6 alkyl.
4276299 1-(3-Bromo-isoxazol-5-yl)-2-tert.butylaminoethanol  
A new isoxazole derivative and the preparation thereof are disclosed. 1-(3-Bromo-isoxazol-5-yl)-2-ter.butylaminoethanol endowed with therapeutic activity, in particular bronchodilating action is...
4271158 Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones  
Racemic and optically active compounds of the formula Q--C n H 2n --NH--R wherein Q is ##STR1## where R 1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4265904 Prostacyclin analogs of the 1 series and related analogs  
This disclosure describes certain 6,9α-epoxy prostacyclines and their intermediates. These compounds are useful as bronchodilators.
4263325 β-Receptor blocking compounds and treatment of cardiovascular disorders therewith  
Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and method for treating cardiovascular disorders by blocking the β-receptors of the heart in...
4260771 Interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds  
This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds have prostaglandin-like biological activity and are...
4259244 Certain 13,14-didehydro-PGI.sub.1 compounds  
Bicyclic prostaglandins having numerous pharmaceutical and veterinary utilities including, for example, use as hypotensive, vasodilatory, anti-aggregating, cytoprotective, and bronchodilatory...
4256883 Pyridoza prostacyclin analogues and N-oxides thereof  
Stable biologically active aromatic prostacyclin analogues of the formula ##STR1## wherein X represents ##STR2## and R represents hydrogen, a pharmaceutically acceptable cation or a...
4254267 Mercaptoacyldihydropyrazole carboxylic acid derivatives  
Hypotensive activity is exhibited by compounds having the formula ##STR1## wherein: R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R 5 is alkyl or aryl; R 2 is hydrogen, alkyl, or...
4251525 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydr oxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives  
3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tet rahydro-1H-3-be nzazepine derivatives are prepared by N-allylation of...
4230850 3-Substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones  
Novel 3-substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones are disclosed as having utility as pharmacologically active compounds, in particular vasodilatory, hypotensive, anti-ischemic and...
4225605 Ergolene or ergoline compounds for treating congestive heart failure  
A method for the treatment of congestive heart failure in animals comprises administering a therapeutically effective amount of an ergolene or ergoline having dopaminergic activity to an animal in...
4223137 Carbostyril derivatives and process for preparing the same  
Carbostyril derivative represented by the formula (I): ##STR1## wherein R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, a cycloalkylcarbonyl group, a...
4220772 Process for the preparation of oxadiazolopyrimidine derivatives  
A process for preparing oxadiazolopyrimidines of the formula ##STR1## wherein R is alkyl or alkoxyalkyl, by reacting a compound of the formula ##STR2## wherein R is as set forth above, with...
4220649 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives  
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives shown by the formula ##STR1## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group or an...
4215119 Aminoalkyl-substituted benzimidazolidin-2-ones  
Racemic and optically active compounds of the formula Q-C n H 2n -NH-R wherein Q is ##STR1## where R 1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4208423 Anticholinergic bronchodilators  
Compounds of the formula ##STR1## where R 1 and R 2 are the same or different and are C 1 to C 6 alkyl; C 5 or C 6 cycloalkyl; C 5 or C 6 cycloalkenyl; phenyl optionally substituted with a...
4207319 Thienyl or furyl phenyl O-hetero amino alkyl oximes and use thereof  
Aromatic compounds having the following formula are disclosed: ##STR1## in which, A in the heterocyclic group is selected from the group of O and S; R 1 , R 2 , R 3 and R 4 , which may be...
4206127 5,6-Dihydro analogues of prostaglandin I.sub.2  
Derivatives of prostaglandin I 2 characterized by the generic structural formulae, ##STR1## are useful for inhibiting platelet aggregation or gastric acidity in individuals for whom such therapy...
4199582 Piperazine containing dihydronaphthalene derivatives and compositions  
Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein A is a di-lower alkylamino group or a 5- to 7-membered cyclic amino group which may contain one oxygen atom and n is 2 or 3,...
Matches 201 - 250 out of 652 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >