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4314944 4-Aminoalkyl-7-hydroxy-2(3H)-indolones  
A new group of 2(3H)-indolones whose structures are characterized by having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus have beneficial...
4308396 Thromboxane A2 analogues  
Stable biologically active thromboxane A2 analogues having the formula ##STR1## wherein R1 is OR3, where R3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; or R1...
4303670 Bicyclic prostaglandins and process for their preparation  
Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory,...
4298734 Diazaheterocyclopurines and triazolopyrimidines  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4297368 Pharmaceutically useful 5,6-saturated PGI compounds  
Bicyclic prostaglandins and pharamaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory,...
4291174 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives  
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C1 to C4 alkanoyl or optionally...
4291175 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives  
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C1 to C4 alkanoyl or optionally...
4291015 Polymeric diffusion matrix containing a vasodilator  
A polymeric diffusion matrix containing a vasodilator is provided comprising from about 2 to about 60% of a polar plasticizer, e.g., glycerol, from about 2 to about 15% of a matrix component,...
4289707 Nitrogen heterocycles  
1,3,6-Trisubstituted piperazine-2,5-diones having biological properties related to those of the natural prostaglandins, their synthesis, compositions containing them, and their use in medicine.
4285966 Certain 15-epi-prostacyclins  
The present invention relates to 15-epi-derivatives of prostacyclin and its analogs, to a process for their preparation and to pharmaceutical and veterinary compositions containing them.
4285955 1,4-Dihydropyridinecarboxylic acids  
The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10° to...
4285950 10-halo-E-homoeburnane derivatives, a process for the preparation thereof, a process for the use thereof as vasodilators, and vasodilating compositions thereof  
The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), ##STR1## wherein R2 is a C1-6 alkyl group and X is halogen, and epimers, optically active derivatives...
4284632 3-Pyrrolin-2-one derivatives and compositions  
New 3-cyclicaminoalkoxy-4-phenyl-3-pyrrolin-2-ones are disclosed. These compounds exhibit anti-hypertensive and vasodilatory action.
4284634 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same  
1,4-dihydropyridine derivatives of the general formula ##STR1## having vasodilating and anti-hypertensive activity, processes for preparing same, and pharmaceutical compositions thereof for...
4278682 Vasodilating method of treatment using a indolo-quinolizine-monoester, diester or nitrile  
Vasodilating octahydro-indolo[2,3-a]quinolizine derivatives of the formula ##STR1## wherein Q is hydrogen or an A--CH2 --CH2 -- group and A is cyano or --COOR, wherein R is C1-6 alkyl.
4276299 1-(3-Bromo-isoxazol-5-yl)-2-tert.butylaminoethanol  
A new isoxazole derivative and the preparation thereof are disclosed. 1-(3-Bromo-isoxazol-5-yl)-2-ter.butylaminoethanol endowed with therapeutic activity, in particular bronchodilating action is...
4271158 Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones  
Racemic and optically active compounds of the formula Q--Cn H2n --NH--Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4265904 Prostacyclin analogs of the 1 series and related analogs  
This disclosure describes certain 6,9α-epoxy prostacyclines and their intermediates. These compounds are useful as bronchodilators.
4263325 β-Receptor blocking compounds and treatment of cardiovascular disorders therewith  
Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and method for treating cardiovascular disorders by blocking the β-receptors of the heart in...
4260771 Interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds  
This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds have prostaglandin-like biological activity and are...
4259244 Certain 13,14-didehydro-PGI1 compounds  
Bicyclic prostaglandins having numerous pharmaceutical and veterinary utilities including, for example, use as hypotensive, vasodilatory, anti-aggregating, cytoprotective, and bronchodilatory...
4256883 Pyridoza prostacyclin analogues and N-oxides thereof  
Stable biologically active aromatic prostacyclin analogues of the formula ##STR1## wherein X represents ##STR2## and R represents hydrogen, a pharmaceutically acceptable cation or a...
4251525 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydr oxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives  
3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tet rahydro-1H-3-be nzazepine derivatives are prepared by N-allylation of...
4230850 3-Substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones  
Novel 3-substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones are disclosed as having utility as pharmacologically active compounds, in particular vasodilatory, hypotensive, anti-ischemic and...
4225605 Ergolene or ergoline compounds for treating congestive heart failure  
A method for the treatment of congestive heart failure in animals comprises administering a therapeutically effective amount of an ergolene or ergoline having dopaminergic activity to an animal in...
4223137 Carbostyril derivatives and process for preparing the same  
Carbostyril derivative represented by the formula (I): ##STR1## wherein R1 and R2, which may be the same or different, each represents a hydrogen atom, a cycloalkylcarbonyl group, a...
4220649 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives  
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives shown by the formula ##STR1## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group or an...
4215119 Aminoalkyl-substituted benzimidazolidin-2-ones  
Racemic and optically active compounds of the formula Q-Cn H2n -NH-Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4207319 Thienyl or furyl phenyl O-hetero amino alkyl oximes and use thereof  
Aromatic compounds having the following formula are disclosed: ##STR1## in which, A in the heterocyclic group is selected from the group of O and S; R1, R2, R3 and R4, which may be identical or...
4206127 5,6-Dihydro analogues of prostaglandin I2  
Derivatives of prostaglandin I2 characterized by the generic structural formulae, ##STR1## are useful for inhibiting platelet aggregation or gastric acidity in individuals for whom such therapy is...
4199582 Piperazine containing dihydronaphthalene derivatives and compositions  
Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein A is a di-lower alkylamino group or a 5- to 7-membered cyclic amino group which may contain one oxygen atom and n is 2 or...
4183930 Amino derivatives of pyrazolo [1,5-a]s-triazine, and their therapeutic applications  
This invention relates to compounds having the general formula: ##STR1## in which: R1 represents a hydrogen atom or a (C1-4) alkyl radical, R2 represents a hydrogen atom, a (C1-4) alkyl radical, a...
4174448 Process for the preparation of thienopyridine derivatives  
This invention relates to a process for the preparation of compounds having the general formula: ##STR1## in which: R1 represents a hydrogen atom, an optionaly substituted alkyl, aryl or aralkyl...
4173636 Decahydroquinolines, pharmaceutical compositions and methods of use  
The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R1 represents an alkyl...
4173704 Dithio aminoacid derivatives  
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting...
4162321 Sulphur-containing amino-dihydropyridines, and their use as medicants  
The invention relates to new dihydropyridines which are substituted by an amino group in at least one of the 2- and 6-positions, by a sulphur-containing substituent in the 3-position, by a cyclic...
4154829 Aminoalkyl-substituted benzoxazine derivatives  
Racemic and optically active compounds of the formula Q--Cn H2n --NH--Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4152519 16-Hydroxy aspidospermidines and a process for their production  
This invention relates to novel aspidospermidines being useful in synthesis and also exhibiting interesting physiological properties. A process for the preparation of the novel compounds is...
4148897 1,2-Dihydronaphthalene derivatives and pharmaceutical composition  
Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein R1 and R2, independently of each other, are hydrogen, nitro, amino, halogen, or hydroxyl which may be protected, and R3 is...
4145432 6-Acyloryalkyl-1,4-dihydropyridine derivatives and a method of effecting vasodilation therewith  
This invention relates to 1,4-dihydropyridine derivatives. More particularly, it relates to new 1,4-dihydropyridine derivatives thereof which have vasodilating and anti-hypertensive activity, to...
4144336 2-Benzopyranone derivatives, process for their production, their use as medicaments, more especially as coronary dilators  
Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and each R individually is selected from the group...
4140777 Cerebral vasodilating 6-substituted vincamines  
The invention relates to novel derivatives of vincamine and apovincamine having the formula ##STR1## WHICH ARE ENDOWED WITH ANALOGOUS PROPERTIES AS THE VINCAMINE AND APOVINCAMINE AS WELL AS WITH...
4140770 Benzoylethers and processes for their production  
Processes for preparing benzoylethers, their acid additive salts and their quaternary ammonium salts are disclosed. These compounds have useful pharmacodynamic properties.
4140712 20-Hydroxy-prostaglandins  
The present invention relates to 20-hydroxy prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## and X represents ethylene or cis-vinylene and Y...
4139535 3-Cyano-2-pyridinyloxymethyl-oxazolidine derivatives  
Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines are vasodilators having...
4138489 Vasodilating octahydro-1,12-methano-oxymethano[2,3-a]-indoloquinolizines  
Pentacyclic derivatives of the general formula ##STR1## wherein R, R1, R2 and R3 are defined hereinbelow are useful as cerebral protectors and vasodilators.
4136187 Antihypertensive 2-amino-4,5-dihydropyridine derivatives  
4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or...
4136190 4,4-Dimethyl-3,5-pyrrolidinediones  
Compounds of formula (I): ##STR1## wherein: n is 4 to 8, X is CO, protected CO or CROH wherein R is hydrogen or C1-4 alkyl and wherein the OH moiety may be protected; R1 is hydrogen, or CO2 R1...
4127661 Piperazine alkanols  
This invention relates to variously substituted piperazine derivatives. S compounds possess therapeutically useful vasodilator properties.
4117128 Sulfonyl benzofurans and benzothiophenes having coronary vasodilator activity  
The compounds are sulfonyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris.