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4542159 Cycloaliphatic ketoamines  
There are prepared compounds of the formula: ##STR1## wherein X is the group >CO or >CH(OH), Y is the group ##STR2## R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1 is...
4533732 3-Propionylsalicylic acid derivatives and process for the preparation of the same  
This invention relates to derivatives of 3-propionylsalicylic acid represented by the formula (1) ##STR1## wherein R represents a hydrogen atom, a lower alkyl group or a group ##STR2## (wherein R1...
4532135 Renoprotective treatments employing vasodilator compounds  
A treatment method and substances have been found to reduce the risk of incurring renal damage or failure. Vasodilators useful for the treatment of hypertension have been found to lower...
4529604 N,N-Di-(n-Propyl)dopamine derivatives  
N,N-Di-(n-propyl)dopamine derivatives having peripheral dopamine receptor agonist activity prepared by synthetic routes known for phenethylamines. The renal vasodilator effect of...
4529733 Antihypertensive 3-furoyl-1,4-dihydropyridines  
Novel 1,4-dihydropyridine derivatives have the following general Formula: ##STR1## and are calcium antagonists, useful for treating cardiovascular diseases.
4526999 Lipoxygenase inhibitors  
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit lipoxygenase, thus preventing the metabolism...
4521430 1,5-Benzothiazepin-4-one, their pharmaceutical compositoins, and methods of use  
A compound of the formula: ##STR1## wherein R1 and R2 are each lower alkyl, R3 is hydrogen, lower alkyl or hydroxy-lower alkyl, R4 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio...
4510149 N-Imidazolyl derivatives containing naphthalene or indene nucleus  
Compounds of the formula (I) ##STR1## wherein the symbol represents a single or a double bond; Z completes a single bond or is a --CH2 -- group; each of R1, R2, R3 and R4, which may be the same or...
4510307 6-Quinazolinesulfonyl derivatives and process for preparation thereof  
A 6-quinazolinesulfonyl derivative of Formula (I): ##STR1## wherein R1 is a hydrogen atom or a C1-12 alkyl group: R2 is a hydrogen atom, a C1-12 alkyl group, a C4-10 cycloalkyl group, an aryl...
4495192 1-Substituted 1,4-dihydropyridines  
A vasodilating or anti-hypertensive composition comprises a pharmaceutical carrier and an effective amount of a 1,4-dihydropyridine compound as an active ingredient. The 1,4-dihydropyridine...
4495352 Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols  
1-Aryloxy-3-[(3-indolyl)-tert.-butyl]amino-2-propanols having a heterocyclic aryl-attached substituent or aryl-fused heterocyclic ring are antihypertensive agents having vasodilator and adrenergic...
4489078 Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4482485 Method of preparation of human urine origin colony-stimulating factor and kallikrein  
Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by...
4478838 1-(3,4,5-Trimethoxycinnamoyl)-4-alkylaminocarbonylethyl piperazines  
1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substitut ed piperazine derivatives represented by general formula (I): ##STR1## wherein R is a straight- or branched-chain alkyl group having 1...
4473501 Dihydro azino isoquinolines  
The invention provides novel 1,5-substituted isoquinoline derivatives of formula I which are useful in the treatment of hypertension.
4461896 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids  
A series of 1-[acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxy lic acids and salts thereof are useful as Angiotensin I converting enzyme inhibitors.
4443453 Quinoline derivatives, pharmaceutical compositions containing such compounds, and methods for treating cardiovascular conditions with them  
The invention is concerned with novel quinoline derivatives of the formula ##STR1## or a salt thereof, in which A--B is --CH2 --CH2 --, --CHOH--CH2 --, --CH2 --CHOH--, --CH2 --C(O)--,...
4442108 Hydrogenated isoquinolines and peripheral vascular disease treating compositions thereof  
1-(3,4-Dialkoxybenzyl)-6,7-dialkoxyl-1,2,3,4-tetrahydro- and 3,4-dihydroisoquinolines wherein the alkoxy groups in the benzyl ring are different from those in the isoquinoline nucleus and one...
4440774 3-Amino-2-hydroxypropoxyaryl imidazole derivatives  
Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes...
4439442 Naftidrofuryl citrate and therapeutic applications  
The object of the invention is a new naftidrofuryl salt, naftidrofuryl citrate, which is therapeutically useful because it promotes metabolism and circulatory properties and because of its...
4438116 Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and β-blocking properties, their use and pharmaceutical compositions containing them  
An aminopropanol compound of the formula ##STR1## wherein R1 and R2 are individually selected from hydrogen and lower alkyl; or R1 and R2 together represent an alkylene radical; R3 is hydrogen or...
4434162 Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same  
A phosphonic acid ester of the formula ##STR1## exhibits calcium-antagonistic, coronary vasodilating and hypotensive activities. Pharmaceutical compositions containing the same are useful for the...
4430342 N-Acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound, process for prodction thereof, and use thereof  
An N-acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound represented by the following formula ##STR1## wherein R1 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms,...
4423045 Thiadizines  
Novel heterocyclic compounds of the formula: ##STR1## wherein either X is --CR1 R2 -- and Y is oxygen, sulphur or --NR3, wherein R1, R2 and R3, which may be the same or different, each is hydrogen...
4421754 Syndonimine derivatives, process for production thereof, and use thereof  
A 3-[4-(benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n...
4414213 Dihydropyridyl cyclic imidate esters and their pharmaceutical use  
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula ##STR1## wherein R and R1 are independently selected from hydrogen, lower alkyl or...
4382936 Cerebral vasodilator eburnane derivatives  
A compound of the formula: ##STR1## wherein R1 is a C1 -C6 alkyl group and R is a hydrogen atom or a C1 -C6 alkyl group, and their salts, which are useful as cerebral vasodilator; and a compound...
4380644 2-Oxoimidazolidine derivatives  
A 2-oxoimidazolidine derivative of the formula: ##STR1## wherein R1 is lower alkyl or phenyl-lower alkyl and R2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed. Said...
4379792 Anti-inflammatory composition  
A pharmaceutical composition containing an interphenylene 9-thia-11-oxo-12-aza prostanoic acid type renal vasodilator and a non-steroidal anti-inflammatory agent and its use are disclosed.
4366156 Antiallergic methods using diazaheterocyclopurines  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4366157 Novel polycyclic indole derivatives  
A compound of the formula, ##STR1## wherein R1 is C1 -C6 alkyl group and R2 is aryl group, which is a medicine useful to treat cerebral arteriosclerosis, senile mental indolence and cerebral...
4365064 1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and pharmaceutical compositions containing them  
The invention concerns new compounds of the formula (I) ##STR1## wherein R1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1...
4365063 Antihypertensive agents  
1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7- naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
4359420 Thieno-1,4-diazepin-5-ones and benzo-1,4-diazepin-5-ones  
Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as α and β is selected from the group consisting of ##STR2## the dotted line represents...
4352793 Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin  
A composition comprising as the pharmaceutically active ingredient bencyclane fumarate and cyclodextrin.As compared with prior bencyclane fumarate preparations, this composition can greatly...
4350696 Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof  
Compounds of the general formula: ##STR1## wherein X is a group of the formula: ##STR2## m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as...
4348395 1,4-Dihydropyridazine compounds  
The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said...
4346093 Heterocyclic oxypropanolamine compounds and pharmaceutical compositions  
The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R2 and R3,...
4345082 Process for the preparation of hydroxyamino-eburnane derivatives and octahydroindoloquinolizine intermediates  
The invention relates to new hydroxyamino-eburnane derivatives of the general formula (I), ##STR1## wherein R1 and R2 each stand for a C1-6 alkyl group, as well as to pharmaceutically acceptable...
4342691 ω-Heteroaroyl(propionyl or butyryl)-L-prolines  
This disclosure describes novel substituted ω-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
4340600 Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines  
4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon...
4340601 Dopaminergic isoquinolines  
A new series of compounds having renal vasodilating activity described. The compounds are 2-allyl-8-halo-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquin olines.
4339600 Compounds for alleviating angiotensin related hypertension  
Compounds for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprising angiotensin converting enzyme inhibitors selected from a group of mercaptoacyl aminoacids.
4338322 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same  
This invention relates to 2-or 6-cyano or cyano(lower)alkyl-4-phenyl or (substituted phenyl)1,4-dihydropyridine-3,5-dicarboxylates and derivatives which have vasodilating and hypertensive...
4336382 1,4-Disubstituted piperazine compounds  
There are disclosed compounds of the formula ##STR1## wherein R1 is selected from the group consisting of lower alkyl; R8 is selected from the group consisting of --O--(CH2)n --wherein n is 2 to...
4329338 Compositions for use as cosmetics  
The invention relates to new compositions to be used as cosmetics. The new cosmetics according to the invention contain as active agent 0.06 to 10% by weight of a reaction product of nicotinic...
4329350 1,1-Disubstituted octahydro-indolo[2,3-a]quinolizines, process for the preparation thereof and compositions containing same  
Compounds of the formula: ##STR1## wherein R is alkyl having 1 to 6 carbon atoms; A is substituted or unsubstituted alkyl having 1 to 6 carbon atoms, aralkyl having 7 to 16 carbon atoms wherein...
4328240 Certain PGI1 compounds and their pharmaceutical composition and methods  
2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of...
4328153 Dopaminergic benzazepines  
A new series of compounds having renal vasodilating activity is described. The compounds are 3-cycloalkylmethyl-7,8-dihydroxy-6-halo-1-(p-hydroxyphenyl)- 2,3,4,5-tetrah ydro-1H-3-benzazepines.
4326064 Derivatives of 1,4-dihydropyridine-3-carbothiol acids  
The present invention relates to compounds which are derivatives of 1,4-dihydropyridine-3-carbothiol acids of the formula: ##STR1## wherein R is hydrogen, an alkyl, aryl, heteryl; R' is a lower...