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4443453 Quinoline derivatives, pharmaceutical compositions containing such compounds, and methods for treating cardiovascular conditions with them  
The invention is concerned with novel quinoline derivatives of the formula ##STR1## or a salt thereof, in which A--B is --CH 2 --CH 2 --, --CHOH--CH 2 --, --CH 2 --CHOH--, --CH 2 --C(O)--,...
4442108 Hydrogenated isoquinolines and peripheral vascular disease treating compositions thereof  
1-(3,4-Dialkoxybenzyl)-6,7-dialkoxyl-1,2,3,4-tetrahydro- and 3,4-dihydroisoquinolines wherein the alkoxy groups in the benzyl ring are different from those in the isoquinoline nucleus and one...
4440774 3-Amino-2-hydroxypropoxyaryl imidazole derivatives  
Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes...
4439442 Naftidrofuryl citrate and therapeutic applications  
The object of the invention is a new naftidrofuryl salt, naftidrofuryl citrate, which is therapeutically useful because it promotes metabolism and circulatory properties and because of its...
4438116 Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and β-blocking properties, their use and pharmaceutical compositions containing them  
An aminopropanol compound of the formula ##STR1## wherein R 1 and R 2 are individually selected from hydrogen and lower alkyl; or R 1 and R 2 together represent an alkylene radical; R 3 ...
4434162 Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same  
A phosphonic acid ester of the formula ##STR1## exhibits calcium-antagonistic, coronary vasodilating and hypotensive activities. Pharmaceutical compositions containing the same are useful for the...
4430342 N-Acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound, process for prodction thereof, and use thereof  
An N-acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound represented by the following formula ##STR1## wherein R 1 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms,...
4423045 Thiadizines  
Novel heterocyclic compounds of the formula: ##STR1## wherein either X is --CR 1 R 2 -- and Y is oxygen, sulphur or --NR 3 , wherein R 1 , R 2 and R 3 , which may be the same or different, each...
4421754 Syndonimine derivatives, process for production thereof, and use thereof  
A 3-[4-(benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n...
4414213 Dihydropyridyl cyclic imidate esters and their pharmaceutical use  
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula ##STR1## wherein R and R 1 are independently selected from hydrogen, lower alkyl or...
4382936 Cerebral vasodilator eburnane derivatives  
A compound of the formula: ##STR1## wherein R 1 is a C 1 -C 6 alkyl group and R is a hydrogen atom or a C 1 -C 6 alkyl group, and their salts, which are useful as cerebral vasodilator; and a...
4380644 2-Oxoimidazolidine derivatives  
A 2-oxoimidazolidine derivative of the formula: ##STR1## wherein R 1 is lower alkyl or phenyl-lower alkyl and R 2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed....
4379792 Anti-inflammatory composition  
A pharmaceutical composition containing an interphenylene 9-thia-11-oxo-12-aza prostanoic acid type renal vasodilator and a non-steroidal anti-inflammatory agent and its use are disclosed.
4366157 Novel polycyclic indole derivatives  
A compound of the formula, ##STR1## wherein R 1 is C 1 -C 6 alkyl group and R 2 is aryl group, which is a medicine useful to treat cerebral arteriosclerosis, senile mental indolence and...
4366156 Antiallergic methods using diazaheterocyclopurines  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4365063 Antihypertensive agents  
1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7- naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
4365064 1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and pharmaceutical compositions containing them  
The invention concerns new compounds of the formula (I) ##STR1## wherein R 1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1...
4359420 Thieno-1,4-diazepin-5-ones and benzo-1,4-diazepin-5-ones  
Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as α and β is selected from the group consisting of ##STR2## the dotted line represents...
4352793 Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin  
A composition comprising as the pharmaceutically active ingredient bencyclane fumarate and cyclodextrin. As compared with prior bencyclane fumarate preparations, this composition can greatly...
4350696 Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof  
Compounds of the general formula: ##STR1## wherein X is a group of the formula: ##STR2## m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as...
4348395 1,4-Dihydropyridazine compounds  
The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said...
4346093 Heterocyclic oxypropanolamine compounds and pharmaceutical compositions  
The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R 2 and R...
4345082 Process for the preparation of hydroxyamino-eburnane derivatives and octahydroindoloquinolizine intermediates  
The invention relates to new hydroxyamino-eburnane derivatives of the general formula (I), ##STR1## wherein R 1 and R 2 each stand for a C 1 -6 alkyl group, as well as to pharmaceutically...
4342691 ω-Heteroaroyl(propionyl or butyryl)-L-prolines  
This disclosure describes novel substituted ω-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
4340601 Dopaminergic isoquinolines  
A new series of compounds having renal vasodilating activity described. The compounds are 2-allyl-8-halo-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquin olines.
4340600 Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines  
4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon...
4339600 Compounds for alleviating angiotensin related hypertension  
Compounds for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprising angiotensin converting enzyme inhibitors selected from a group of mercaptoacyl aminoacids.
4338322 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same  
This invention relates to 2-or 6-cyano or cyano(lower)alkyl-4-phenyl or (substituted phenyl)1,4-dihydropyridine-3,5-dicarboxylates and derivatives which have vasodilating and hypertensive activity,...
4336382 1,4-Disubstituted piperazine compounds  
There are disclosed compounds of the formula ##STR1## wherein R 1 is selected from the group consisting of lower alkyl; R 8 is selected from the group consisting of --O--(CH 2 ) n --wherein n is...
4329338 Compositions for use as cosmetics  
The invention relates to new compositions to be used as cosmetics. The new cosmetics according to the invention contain as active agent 0.06 to 10% by weight of a reaction product of nicotinic...
4329350 1,1-Disubstituted octahydro-indolo[2,3-a]quinolizines, process for the preparation thereof and compositions containing same  
Compounds of the formula: ##STR1## wherein R is alkyl having 1 to 6 carbon atoms; A is substituted or unsubstituted alkyl having 1 to 6 carbon atoms, aralkyl having 7 to 16 carbon atoms wherein...
4328240 Certain PGI.sub.1 compounds and their pharmaceutical composition and methods  
2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of...
4328153 Dopaminergic benzazepines  
A new series of compounds having renal vasodilating activity is described. The compounds are 3-cycloalkylmethyl-7,8-dihydroxy-6-halo-1-(p-hydroxyphenyl)- 2,3,4,5-tetrah ydro-1H-3-benzazepines.
4326064 Derivatives of 1,4-dihydropyridine-3-carbothiol acids  
The present invention relates to compounds which are derivatives of 1,4-dihydropyridine-3-carbothiol acids of the formula: ##STR1## wherein R is hydrogen, an alkyl, aryl, heteryl; R' is a lower...
4314944 4-Aminoalkyl-7-hydroxy-2(3H)-indolones  
A new group of 2(3H)-indolones whose structures are characterized by having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus have beneficial...
4308396 Thromboxane A.sub.2 analogues  
Stable biologically active thromboxane A 2 analogues having the formula ##STR1## wherein R 1 is OR 3 , where R 3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group;...
4303670 Bicyclic prostaglandins and process for their preparation  
Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory,...
4298734 Diazaheterocyclopurines and triazolopyrimidines  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4297368 Pharmaceutically useful 5,6-saturated PGI compounds  
Bicyclic prostaglandins and pharamaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory,...
4291015 Polymeric diffusion matrix containing a vasodilator  
A polymeric diffusion matrix containing a vasodilator is provided comprising from about 2 to about 60% of a polar plasticizer, e.g., glycerol, from about 2 to about 15% of a matrix component, e.g.,...
4291174 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives  
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C 1 to C 4 alkanoyl or optionally...
4291175 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives  
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C 1 to C 4 alkanoyl or optionally...
4289707 Nitrogen heterocycles  
1,3,6-Trisubstituted piperazine-2,5-diones having biological properties related to those of the natural prostaglandins, their synthesis, compositions containing them, and their use in medicine.
4285966 Certain 15-epi-prostacyclins  
The present invention relates to 15-epi-derivatives of prostacyclin and its analogs, to a process for their preparation and to pharmaceutical and veterinary compositions containing them.
4285950 10-halo-E-homoeburnane derivatives, a process for the preparation thereof, a process for the use thereof as vasodilators, and vasodilating compositions thereof  
The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), ##STR1## wherein R 2 is a C 1 -6 alkyl group and X is halogen, and epimers, optically active derivatives...
4285955 1,4-Dihydropyridinecarboxylic acids  
The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10° to...
4284634 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same  
1,4-dihydropyridine derivatives of the general formula ##STR1## having vasodilating and anti-hypertensive activity, processes for preparing same, and pharmaceutical compositions thereof for...
4284632 3-Pyrrolin-2-one derivatives and compositions  
New 3-cyclicaminoalkoxy-4-phenyl-3-pyrrolin-2-ones are disclosed. These compounds exhibit anti-hypertensive and vasodilatory action.
4278682 Vasodilating method of treatment using a indolo-quinolizine-monoester, diester or nitrile  
Vasodilating octahydro-indolo[2,3-a]quinolizine derivatives of the formula ##STR1## wherein Q is hydrogen or an A--CH 2 --CH 2 -- group and A is cyano or --COOR, wherein R is C 1 -6 alkyl.
4276299 1-(3-Bromo-isoxazol-5-yl)-2-tert.butylaminoethanol  
A new isoxazole derivative and the preparation thereof are disclosed. 1-(3-Bromo-isoxazol-5-yl)-2-ter.butylaminoethanol endowed with therapeutic activity, in particular bronchodilating action is...
Matches 151 - 200 out of 560 < 1 2 3 4 5 6 7 8 9 10 11 12 >