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5169836 Inhibitors of platelet binding  
Peptides comprising the tripeptide sequence of arginine-tyrosine-aspartic acid, linked from amino- to carboxy-terminus, are inhibitors of fibrinogen binding, platelet aggregation, glycoprotein...
5166211 Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina  
The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT2 antagonists.
5158777 Captopril formulation providing increased duration of activity  
A formulation comprising captopril within an enteric or delayed release coated pH stable core combined with additional captopril that is available for immediate release following administration.
5151434 Controlled-release composition and the preparation thereof  
A controlled-release pharmaceutical preparation of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine. The controlled-release preparation is in the form of powder or granule containing...
5145852 Vaso-active medicament to treat impotence  
The invention pertains to the field of vasoactive medicines.The vasoactive medicine, of the type composed of a combination of main active ingredients with papaverine, is characterized by the fact...
5122384 Oral once-per-day organic nitrate formulation which does not induce tolerance  
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core...
5114918 Endothelin antagonistic cyclic pentapeptides  
Cyclic pentapeptides of the formula: cyclo (-X1 -X2 -X3 -X4 -X5 -) (I)wherein Xn (n=1-5) represents amino acid residues. These compounds are useful as hypotensive drugs.
5112596 Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability  
The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist...
5112807 Compound "Leualacin", its preparation and its use in the treatment of cardiovascular disorders  
A new compound, which we have named "Leualacin" has the formula (I): ##STR1## and may be prepared by cultivation of a microorganism of the genus Hapsidospora, especially Hapsidospora irregularis....
5096697 Method of stimulating hair growth with aliphatic alcohols  
Cell-stimulating composition having hair-growing effect and skin-vivifying effect. The composition comprising as an effective ingredient an aliphatic alcohol having odd number of carbon atoms or a...
5079237 Inclusion complex of nicardipine or its hydrochloride with beta-cyclodextrin and a sustained release pharmaceutical preparation containing the same  
There is described a new inclusion complex of nicardipine or its hydrochloride with beta-cyclohdextrin, which is prepared by admixing nicardipine or its hydrochloride with beta-cyclodextrin in a...
5071868 Process for the preparation of optically-active carbazole derivatives, new R- and S-carbazole derivatives and pharmaceutical compositions containing these compounds  
A process for the preparation of S- or R-carbazole derivatives of the general formula: ##STR1## in which R is an unsubstituted or substituted amino radical and pharmacologically acceptable salts,...
5069898 Hair enrichment composition and method of use  
This invention provides a hair enrichment composition which includes a hair-sorbable bulking agent, a blood vessel dilator, and a scalp stimulant, together with a method of using the composition.
5055302 Neuropeptide control of ocular growth  
A method and composition for inhibition of abnormal postnatal ocular growth are disclosed. The composition comprises vasoactive intestinal peptide (VIP), PHI or a analogue of these peptides. The...
5041437 Pharmaceutical preparation for percutaneous administration containing bunazosin or its salt  
A pharmaceutical composition comprises (a) a pharmacologically effective amount of bunazosin or a pharmacologically acceptable salt thereof and (b) a monoglyceride of a fatty acid having 8 to 12...
5036107 1,7-substituted heptyn-2-ones and use  
1-Phenyl-7-substituted-hept-5-yn-2-ones substituted with a C1 to C7 alkyl, C3 to C6 cycloalkyl, aryl, heteroaryl or heterocycloalkyl group at the 1-position and an amino, a dialkylamino, a...
5030656 Methods of using compositions comprising (s)-emopamil for use in treating spinal cord trauma  
A method of treating injuries in a patient associated with spinal cord trauma is disclosed. The method comprises administering to the patient a therapeutically effective amount of (S)-emopamil or...
5015654 Pharmaceutical compositions  
A pharmaceutical composition which comprises a mixture of an alpha-2 adrenoceptor antagonist, preferably idazoxan, or a pharmaceutically acceptable salt thereof, and either a catecholamine...
5002972 Compound and composition of substituted hexenoic acid derivatives useful for treating thromboxane A2 mediated diseases  
Pharmaceutical compounds and compositions for injectable use in the treatment of thromboxane A2 mediating diseases, comprising a pharmaceutical carrier and a pharmacologically effective amount of...
4996061 Pharmaceutical composition for piperidinoalkanol-decongestant combination  
The present invention relates to a pharmaceutical composition in the form of a multiple-compression tablet comprising (a) a discrete zone made with Formulation (A) which comprises a carrier base...
4954346 Orally administrable nifedipine solution in a solid light resistant dosage form  
A solid dosage form having a fill composition encased in a shell composition; the fill composition comprising (a) 5-60 mg of nifedipine; (b) a 5-7 membered cyclic pharmaceutically acceptable...
4954344 Method for treating nocturnal angina  
A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
4874774 Nifedipine compositions and the production thereof  
Nifedipine is formulated into a reactally administrable composition for administration to humans and animals to effect coronary dilation and for hypotensive effect.
4869904 Sustained release drug preparation  
Now is provided a new sustained release drug preparation comprising such an inclusion complex of a medical compound with a hydrophobic cyclodextrin derivative, e.g. ethylated cyclodextrins, which...
4859665 Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine  
Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group...
4855300 Pharmaceutical composition for the treatment of circulatory disturbances  
A pharmaceutical combination preparation and method for the treatment of circulatory disturbances comprising a dihydropyridine of the formula ##STR1## in which --R1, is a CH3 --O--CH2 --CH2 -- or...
4851450 Compounds for inhibition of platelet activating factor activity  
The present invention is a group of biologically active agents, di-hydroxy alkyl glycerols with vicinal hydroxyl groups and their acetyl-derivatives having the general formula: ##STR1## where R is...
4849226 Method for increasing oxygen supply by administering vasodilator  
A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
4849404 Therapeutic and prophylactic agent for gastrointestinal ulcers  
Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH...
4812313 Method for lessening the incidence of anginal attacks  
A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
4780560 Nitrate derivatives and vasodilators containing the same  
Novel nitrate derivatives are disclosed. As examples of said nitrate derivative are described N-(β-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)2,4-pentadienoi c acid amide nitrate,...
4774241 Derivative of benzoquinonylphenyl alkanoic acid amide  
A derivative of benzoquinonylphenyl alkanoic acid amide having the formula: ##STR1## wherein X represents an oxygen atom, sulfur atom, or methylated nitrogen atom, Me represents methyl, and n is 2...
4731241 Percutaneous pharmaceuticals preparation for external use  
A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of...
4728660 Method of treating diseases arising from platelet hyperactivation  
Calcium (Ca2+) channel blockers, such as nifedipine and verapamil, are used in the treatment of thromboembolic diseases such as stroke and peripheral vascular occlusive diseases, especially...
4725272 Novel bandage for administering beneficial drug  
A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
4721713 Process for inhibiting blood platelet aggregation and promoting vasodilation  
A method for inhibiting blood platelet aggregation in humans, and promoting vasodilation in humans, by administering to a human in need of the same an effective amount of...
4713238 Water soluble complex of a poly (vinyl lactam) and chlorothiazide and process for producing same  
The invention relates to the novel water soluble chlorothiazide in a complexed state which is derived from the reaction between and N-Vinyl actam polymer and chlorothiazide in alkaline media and...
4707477 Treating and preventing agent for ischemic cardiac disease and arrhythmia  
A quinazoline compound having the below shown formula or a pharmaceutically acceptable salt thereof is useful for treatment and prevention of ischemic cardiac disease or arrhythmia. ##STR1## in...
4705795 (2,4,6-trimethoxyphenyl)-(3-piperidinopropyl)-ketone derivatives  
The present invention relates to new derivatives of (2,4,6-trimethoxyphenyl)-(3-piperidinopropyl)-ketone which are selected from the group consisting of: (i)...
4678660 Thermoplastic polyurethane anticoagulant alloy coating  
An antithrombogenic thermoplastic polyurethane product and process for preparing the same which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a...
4677101 Substituted dihydroazepines useful as calcium channel blockers  
Substituted dihydroazepines, their preparation, and the use thereof as calcium channel blockers are disclosed.
4657906 Heterocyclic compounds having inotropic activity  
This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds has inotropic activity. One specific...
4652563 Vasodilators and β-adrenoceptor antagonists  
This invention relates to dihydropyridazinone compounds having a cyclopropylmethoxyethyl group in the 6-substituent. These compounds are vasodilators and β-adrenoceptor antagonists. A particular...
4636502 Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines  
This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
4632930 Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives  
Antihypertensive alkyl-arylheterocycle methanol or methanamine derivatives are useful in the treatment of hypertension.
4614744 Use of fenpyramin as platelet-antiaggregating, vasodilating, antithrombotic and antianginous medicine  
A new use of N-(4'-pyridyl)-3,3-diphenylpropyl amine, known as fenpyramin, as platelet aggregation-inhibiting medicine and antithrombotic agent as well as vasodilating and antianginous medicine is...
4595675 Bicyclic α-iminocarboxylic acid compounds having hypotensive activity  
What are disclosed are indole, quinoline and isoquinoline compounds of the formula ##STR1## in which n denotes 0 or 1, m denotes 1 or 2, but (n+m)≤2, A together with the bridgehead carbon atoms...
4584315 Method of treating ischemic states  
The present invention relates to novel methods of use for known pharmacological anti-allergenic agents including disodiumchromoglycate (DSCG) and related compounds thereof, including generally bis...
4571403 Antianginal medicated compound  
The anginal medicated compound according to the present invention comprises the active principle 2,4,6,8-tetramethyl-2,4,6,8-tetraazobicyclo-/3,3,0/-octanedi one-3,7 of the formula: ##STR1## in...
4568689 Pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction  
A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-1-io-4-yl)acetate of...