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8183231 |
Substituted propane phosphinic acid derivatives
The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention...
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8168616 |
Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
The invention relates to a combination comprising the renin inhibitor of formula (I) or a pharmaceutically acceptable salt thereof.
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8071574 |
Implant improving local bone formation
A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase...
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7915316 |
Sulfonamides
The present invention provides R, R1, R2, R3, X, c, d, e, f, g, x, y, a, b, z and n are defined in the specification. These compounds are useful in lowering IOP and/or treating glaucoma or...
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7807659 |
Caspase inhibitors and uses thereof
The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these...
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7589081 |
Nitrogen-containing monodentate phosphines and their use in catalysis
The present invention relates to novel nitrogen-containing monodentate phosphane ligands of formula (I) and to their use in catalytic reactions, especially in the improvement of haloaromatic...
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7547685 |
Therapeutic substituted pyrrolidone compounds
Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are also...
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7468359 |
Compositions comprising oxophosphonate-based metalloproteinase inhibitors
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active...
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7410956 |
Caspase inhibitor prodrugs
The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of...
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7348318 |
α-Amino-N-(diaminophosphinyl)lactam derivatives
There are disclosed a novel α-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1): wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl ...
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7320967 |
Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
The invention relates to a cosmetic composition containing at least one 15-hydroxy-prostaglandin dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of...
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7276492 |
Use of ACE inhibitors for treatment of patients suffering from behavioral disorders
A method for the treatment of a patient suffering from an endogenous behavioral disorder in order to ameliorate at least some behavioral aspects of the disorder, the method comprising administering...
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7268124 |
Geranylgeranyl pyrophosphate synthase inhibitors
The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G are each as defined in...
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7208481 |
Aminodiphosphonate apolipoprotein E modulators
The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease...
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7109185 |
Pharmaceutical formulations comprising indolinone derivatives
The present invention is directed to formulations comprising 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Methods of treating dis...
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7084153 |
Medicaments comprising steroids and a novel anticholinergic
A pharmaceutical composition comprising: (a) a salt of formula 1 wherein:X− is an anion with a single negative charge; and(b) a steroid 2, processes for preparing such pharmaceutical composition, a...
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7045511 |
Fosinopril formulation
A pharmaceutical formulation is provided comprising fosinopril which is the prodrug of an angiotensin converting enzyme (ACE) inhibitor, fosinoprilat. The formulation is characterized by comprising...
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6979682 |
Platelet-activating factor antagonist inhibition of angiogenesis and tumor growth induced by basic fibroblast
A novel use of platelet-activating factor antagonists that bind to intracellular PAF binding sites such as BN-50730 (tetrahedra-4,7,8,10 methyl-1 (chloro-1 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9...
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6734206 |
3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
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6706698 |
α-Substituted β-aminoethyl phosphonate derivatives
The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo...
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6673780 |
Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing...
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6610682 |
Pharmaceutical compositions and methods for the treatment of arteriosclerosis
A pharmaceutical composition comprising as its active ingredients one or more drugs selected from the group consisting of angiotensin II receptor antagonists and angiotensin converting enzyme...
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6500811 |
Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use
Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes...
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6498150 |
Low molecular weight cell, bone marrow and immune stimulants
The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6492351 |
Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
The compounds of formulae IIA, the structure: whereinR1, R2, and X4, X5, n are as described in the specification.
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6472419 |
1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents
The present invention relates to new 1-H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) in whichA, B, G, X, Y and Z have the meanings given in the description, to processes for their...
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6369165 |
Method for the production of polymers from n-vinyl compounds
A process for preparing polymers of N-vinyl compounds comprises polymerizing the vinyl compounds in the presence of free radicals of the formula I where Q is NR2 or S and T is CR3R4 or S and R1,...
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6300356 |
Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
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6277833 |
Substituted triols
Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.
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6242432 |
Antithrombotic organic nitrates
Compounds or compositions containing compounds of the formula A-(X1 --NO2)to or salts thereof, for the preparation of antithrombotic medications wherein "to" is the integer 1 or 2X1 is an alkylene...
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6235727 |
Sulfonylaminophosphinic and sulfonylaminophosphinic acid derivatives, methods for their preparation and use
Compounds of the formula I ##STR1##are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
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6200961 |
Concentrates of organophosphorous insecticides
A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
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6194435 |
Lactams as selective factor Xa inhibitors
Novel lactams, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of Formula I below: ##STR1##are useful in vitro or in vivo for...
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6187752 |
Method for treating schizophrenia employing an ace inhibitor
A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or...
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6172050 |
Phospholipid derivatives
Phospholipid derivatives of Formula X: ##STR1##wherein A is the ring system ##STR2##in which R is a linear or branched alkyl radical having 10 to 24 carbon atoms which may contain one or more...
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6143776 |
Tosylproline analogs as thymidylate synthase inhibitors
Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful...
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6037334 |
Phosphonates, process for preparing the same and medicaments
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5955452 |
Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments
The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers...
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5942537 |
Method of inhibiting the transport of L-glutamate to treat CNS disorders
A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure ##STR1## wherein ##STR2##...
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5935927 |
Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts
The present invention relates generally to methods and compositions for treating amyloidogenic diseases such as Alzheimer's disease and the development of type II diabetes, in which deposition of...
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5919774 |
Pyrroles as sPLA2 inhibitors
A class of novel pyrroles is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
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5914351 |
Anti-viral aromatic hydrazones
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
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5880111 |
Therapeutic derivations of diphosphonates
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by...
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5863536 |
Phosphoramidate derivatives
The present invention includes phosphoramidate derivatives, compositions containing the same, and methods of using them as NAALADase inhibitors, particularly for the treatment of glutamate...
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5856314 |
Thio-substituted, Nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
The present invention relates to thio-substituted, nitrogen-containing heterocyclic phosphonate compounds, including bisphosphonates, phosphonoalkylphosphinates, phosphonocarboxylates, and...
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5854227 |
Therapeutic derivatives of diphosphonates
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are...
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5830826 |
Alkoxy-alkyl-substituted 1H-3-aryl-pyrrolidine-2, 4-diones used as herbicicides and pesticides
The present invention relates to novel 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, G, X, Y and Z have the meaning given in the description, to processes...
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5817691 |
Arylthio, -sulfinyl and -sulfonyl pyrrole insecticidal agents
There are provided arylthio, -sulfinyl and -sulfonyl pyrrole compounds having the structural formula I ##STR1## Further provided are compositions and methods comprising those compounds for the...
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5770586 |
Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism amd methods of treating and preventing dental calculus and plaque
The present invention relates to quaternary nitrogen-containing phosphate compounds, and the pharmaceutically-acceptable salts and esters thereof having the general structure: ##STR1## wherein: Z...
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