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7468359 |
Compositions comprising oxophosphonate-based metalloproteinase inhibitors
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active...
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7354928 |
Small molecule inhibitors targeted at Bcl-2
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
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7345046 |
Heteroaryl-fused pyrimidinyl compounds as anticancer agents
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
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7268124 |
Geranylgeranyl pyrophosphate synthase inhibitors
The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
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7199111 |
Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
The present invention provides aqueous Ifosfamide compositions and a process for their preparation, in which the compositions have a reduced toxicity over and above the concomitant use of the...
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7166611 |
Pharmaceutical compositions having appetite suppressant activity
A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7045495 |
Combination of bryostatin and paclitaxel for treating cancer
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
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6770673 |
Therapeutic uses of arglabin in combination with other chemotherapy agents
Compositions and kits containing a first chemotherapeutic agent that includes arglabin or a derivative thereof and a second chemotherapeutic agent are described. The compositions and kits are...
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6762174 |
Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6737416 |
Phosphonic acid derivative having inhibitory activity against carboxypeptidase B
A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R 1 represents hydrogen atom, an alkyl group, a substituted alkyl group and...
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6703400 |
Methods for treating multidrug resistance
Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent.
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6649614 |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety
The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or...
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6500811 |
Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use
Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
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6444638 |
Combinations of PKC inhibitors and therapeutic agents for treating cancers
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
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6319953 |
Treatment of depression and anxiety with fluoxetine and an NK-1 receptor antagonist
The present invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and fluoxetine.
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6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
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6200961 |
Concentrates of organophosphorous insecticides
A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
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6156749 |
Use of NK-1 receptor antagonists for treating movement disorders
The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 antagonist for the manufacture of a medicament for oral administration for the treatment or prevention of...
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6096729 |
Use of NK-1 receptor antagonists for treating amnestic disorders
The present invention provides methods for the treatment or prevention of amnestic disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor...
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6087348 |
Use of NK-1 receptor antagonists for treating stress disorders
The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment...
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5929054 |
Use of NK-1 receptor antagonists for treating sexual dysfunctions
The present invention provides a method for the treatment or prevention of sexual dysfunctions which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor...
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5925627 |
Use of NK-1 receptor antagonists for treating movement disorders
The present invention provides a method for the treatment or prevention of movement disorders using an orally active, long acting, CNS-penetrant NK-1 antagonist and pharmaceutical compositions...
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5914351 |
Anti-viral aromatic hydrazones
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
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5880111 |
Therapeutic derivations of diphosphonates
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by...
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5854227 |
Therapeutic derivatives of diphosphonates
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are...
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5741784 |
Benzopyran derivatives and their use
This invention relates to a compound represented by the formula: ##STR1## wherein B represents a hydrogen atom or a lower alkyl group; ring A represents a benzene ring which may have one or more...
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5728687 |
Antitumour compositions containing taxane derivatives
Pharmaceutical compositions having therapeutic synergy comprising taxol or Taxotere or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
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5716942 |
Treatment of migraine with morpholine tachykinin receptor antagonists
Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma, emesis and nausea.
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5698541 |
2,4-diphosphonoglutaric acid derivatives, processes for their production and pharmaceutical agents containing these compounds
The invention concerns compounds of the general formula I ##STR1## in which R denotes a lower alkyl which can be substituted if desired by hydroxy, alkoxy, amino, dialkylamino, alkylmercapto,...
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5676978 |
Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent
The present invention provides for the use of creatine compounds and hyperplastic inhibitory agents for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The...
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5652238 |
Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
A compound of structural Formula (I) or pharmaceutically acceptable salts thereof wherein: R is --C(O)--R 1 , --PO 3 or --P(O)(OH) 2 ; R 1 is C 1 -6 alkyl, --N(R 4 ) 2 , C 1 -6 alkyl-N(R 4 )...
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5627173 |
Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders
Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and...
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5622917 |
Substituted 1H--3-aryl-pyrrolidine-2,4-dione derivatives
The invention relates to new 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, X, Y and G have the meanings given in the description, to a plurality of...
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5556614 |
Deodorant composition
This invention provides a deodorant composition comprising a phosphoric diester compound of the following formula or a pharmacologically acceptable salt thereof as an active deodorant ingredient....
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5556841 |
Thiazine or thiomorpholine derivatives
This invention relates to the compounds of the formula [I] which are useful for the treatment of cataracts, and the synthetic intermediates of the formula [II], ##STR1## wherein R 1 is hydroxy...
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5547952 |
3-oxo-1,4-benzothiazine derivatives
This invention relates to the compounds of the formula [I] which are useful for the treatment of cataracts, and the synthetic intermediates of the formula [II], ##STR1## wherein R 1 is hydroxy...
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5476847 |
Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
Phosphinic acid derivatives of the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is H, alkyl or alkanoyloxymethylene; R 1 , R 2 , R 3 and R 4 are H,...
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5472956 |
Phosphoramidates useful as antitumor agents
Cyclophosphamide analogs are provided of the general formula: ##STR1## wherein R 1 and R 2 are each (C 2 -C 6 )alkyl, substituted with a leaving group such as halo or alkylsulfonyl, R 3 and R 4...
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5447712 |
Method of reducing cyclophosphamide induced hemorrhagic cystitis
A method is provided for reducing side effects caused by chemotherapeutic agents by administering to a patient in need thereof a therapeutically effective amount of a composition including...
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5432168 |
Method of treatment of hormone-unresponsive metastatic prostate cancer
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
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5418223 |
Method for lyophilization of cyclophosphamide and product
A process for preparing a pharmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and a bulking agent which comprises freezing cyclophosphamide, a...
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5413994 |
Pharmaceutical compositions containing di-phosphonic acid amidines
Compounds of formula I ##STR1## wherein R, R 1 , R 2 and q are as defined in the description, have valuable pharmacological properties and are especially effective as calcium metabolism...
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5304550 |
Drug effect-enhancing agent for antitumor drug
Compounds of the formula (I): ##STR1## in which the nitrogen-containing hetero ring portion is 1,4-dihydropyridine ring or a pyridine ring, R 1 is only present when the nitrogen-containing hetero...
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5250522 |
Phosphono/biaryl substituted amino acid derivatives
The present invention relates to the N-phosphonomethyl-biaryl substituted amino acid derivatives of formula I ##STR1## wherein X represents a direct bond, C 1 -4 -alkylene or C 2 -C 4 ...
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5234917 |
Substituted 5-(alkyl)carboxamide imidazoles
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
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5229375 |
Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumor and antibiotic molecules
Phosphine oxide-terminated allene-ene-yne compounds are disclosed that possess DNA-cleaving, antimicobial and tumor growth-inhibiting properties. Methods of making and using those compounds are...
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5227506 |
Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
The invention relates to acyloxymethyl esters of bisphosphonic acids, halo-bisphosphonic acids and hydroxy-bisphosphonic acids which exhibit oral bioavailability and are useful in the treatment of...
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5185334 |
2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use
Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also...
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5164381 |
Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
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