Matches 1 - 50 out of 137 1 2 3 >
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7354928 Small molecule inhibitors targeted at Bcl-2  
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
7345046 Heteroaryl-fused pyrimidinyl compounds as anticancer agents  
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
7268124 Geranylgeranyl pyrophosphate synthase inhibitors  
The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
7205001 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds  
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
7199111 Aqueous ifosfamide compositions for parenteral administration and a process for their preparations  
The present invention provides aqueous Ifosfamide compositions and a process for their preparation, in which the compositions have a reduced toxicity over and above the concomitant use of the...
7166611 Pharmaceutical compositions having appetite suppressant activity  
A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for...
7163703 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds  
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
7045495 Combination of bryostatin and paclitaxel for treating cancer  
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
6875451 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds  
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
6770673 Therapeutic uses of arglabin in combination with other chemotherapy agents  
Compositions and kits containing a first chemotherapeutic agent that includes arglabin or a derivative thereof and a second chemotherapeutic agent are described. The compositions and kits are...
6762174 Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof  
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
6737416 Phosphonic acid derivative having inhibitory activity against carboxypeptidase B  
A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R 1 represents hydrogen atom, an alkyl group, a substituted alkyl group and...
6703400 Methods for treating multidrug resistance  
Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent.
6649614 Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety  
The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or...
6500811 Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use  
Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
6444638 Combinations of PKC inhibitors and therapeutic agents for treating cancers  
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
6319953 Treatment of depression and anxiety with fluoxetine and an NK-1 receptor antagonist  
The present invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and fluoxetine.
6204245 Treatment of narcolepsy with immunosuppressants  
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
6200961 Concentrates of organophosphorous insecticides  
A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
6156749 Use of NK-1 receptor antagonists for treating movement disorders  
The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 antagonist for the manufacture of a medicament for oral administration for the treatment or prevention of...
6133272 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses  
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO n N-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such...
6117855 Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent  
The present invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of CNS-penetrant NK-1 receptor antagonists and an antidepressant or...
6114315 Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety  
The present invention provides methods for the treatment or prevention of major depressive disorder with anxiety without concomitant therapy with other anti-depressant or anti-anxiety agents which...
6096729 Use of NK-1 receptor antagonists for treating amnestic disorders  
The present invention provides methods for the treatment or prevention of amnestic disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor...
6087348 Use of NK-1 receptor antagonists for treating stress disorders  
The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment...
6054445 Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith  
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the...
6028063 Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith  
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula III having the...
6004955 Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists  
5958969 Benzo b!thiophene compounds, intermediates, formulations, and methods  
This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.
5952315 Use of NK-1 receptor antagonists for treating bipolar disorders  
The present invention provides methods for the treatment or prevention of bipolar disorder without concomitant therapy with other antidepressant or anti-anxiety agents which comprises oral...
5929054 Use of NK-1 receptor antagonists for treating sexual dysfunctions  
The present invention provides a method for the treatment or prevention of sexual dysfunctions which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor...
5925627 Use of NK-1 receptor antagonists for treating movement disorders  
The present invention provides a method for the treatment or prevention of movement disorders using an orally active, long acting, CNS-penetrant NK-1 antagonist and pharmaceutical compositions...
5914351 Anti-viral aromatic hydrazones  
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
5902804 Pharmaceutical composition for inhibiting the growth of viruses and cancers  
This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition is also effective against...
5880111 Therapeutic derivations of diphosphonates  
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by...
5854227 Therapeutic derivatives of diphosphonates  
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are...
5741784 Benzopyran derivatives and their use  
This invention relates to a compound represented by the formula: ##STR1## wherein B represents a hydrogen atom or a lower alkyl group; ring A represents a benzene ring which may have one or more...
5728687 Antitumour compositions containing taxane derivatives  
Pharmaceutical compositions having therapeutic synergy comprising taxol or Taxotere or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
5716942 Treatment of migraine with morpholine tachykinin receptor antagonists  
Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma, emesis and nausea.
5698541 2,4-diphosphonoglutaric acid derivatives, processes for their production and pharmaceutical agents containing these compounds  
The invention concerns compounds of the general formula I ##STR1## in which R denotes a lower alkyl which can be substituted if desired by hydroxy, alkoxy, amino, dialkylamino, alkylmercapto,...
5676978 Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent  
The present invention provides for the use of creatine compounds and hyperplastic inhibitory agents for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The...
5652238 Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones  
A compound of structural Formula (I) or pharmaceutically acceptable salts thereof wherein: R is --C(O)--R 1 , --PO 3  or --P(O)(OH) 2 ; R 1 is C 1 -6 alkyl, --N(R 4 ) 2 , C 1 -6 alkyl-N(R 4 )...
5627173 Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders  
Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and...
5622917 Substituted 1H--3-aryl-pyrrolidine-2,4-dione derivatives  
The invention relates to new 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, X, Y and G have the meanings given in the description, to a plurality of...
5587375 Azepinone compounds useful in the inhibition of ACE and NEP  
Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R 1 ,...
5580863 Benzopyran derivatives and their use  
This invention relates to a compound represented by the formula: ##STR1## wherein B represents a hydrogen atom or a lower alkyl group; ring A represents a benzene ring which may have one or more...
5578623 Saccharin derivative proteolytic enzyme inhibitors  
Compounds having the structural formula ##STR1## wherein L is O; L-R 1 is a leaving group, H-L-R 1 is the conjugate acid thereof and H-L-R 1 has a pK a value less than or equal to to 8; R...
5556841 Thiazine or thiomorpholine derivatives  
This invention relates to the compounds of the formula [I] which are useful for the treatment of cataracts, and the synthetic intermediates of the formula [II], ##STR1## wherein R 1 is hydroxy...
5556614 Deodorant composition  
This invention provides a deodorant composition comprising a phosphoric diester compound of the following formula or a pharmacologically acceptable salt thereof as an active deodorant ingredient....
5547952 3-oxo-1,4-benzothiazine derivatives  
This invention relates to the compounds of the formula [I] which are useful for the treatment of cataracts, and the synthetic intermediates of the formula [II], ##STR1## wherein R 1 is hydroxy...
Matches 1 - 50 out of 137 1 2 3 >