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RE40987 |
Cyclosporin with improved activity profile
The invention relates to a novel cyclosporin, the pharmaceutical use thereof and a pharmaceutical composition containing it.
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7612036 |
Peptoid compounds
The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to...
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7611724 |
Method of producing FR901228
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for...
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7608280 |
Method of producing FR901228
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for...
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7598221 |
Synthetic HLA binding WT-1 peptide analogues and uses thereof
The present invention is directed to a synthetic peptide comprising a sequence of amino acids containing at least a segment that is an analogue of a native peptide that specifically binds to HLA...
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7595294 |
Vasoactive intestinal polypeptide pharmaceuticals
Pharmaceutical compositions relating to vasoactive intestinal polypeptides and methods for the treatment of metabolic disorders, including diabetes, insulin resistance, metabolic acidosis and...
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7592315 |
Peptide viral entry inhibitors
The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections.
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7592308 |
F3W variants of the lantibiotic mersacidin and its use
The present invention relates to methods and products for improved production of the lantibiotic mersacidin. There is provided a method of producing a mersacidin variant which comprises introducing...
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7585839 |
Medical uses of intercellular communication facilitating compounds
Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions...
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7582604 |
Template-fixed peptidomimetics with antibacterial activity
Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depend on their positions in the chain (counted...
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7579432 |
Cyclic peptides as G-protein-coupled receptor antagonists
The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred...
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7579322 |
Compositions and methods for promoting myocardial and peripheral angiogenesis
Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD...
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7566691 |
Vasoactive intestinal polypeptide pharmaceuticals
Pharmaceutical compositions relating to vasoactive intestinal polypeptides and methods for the treatment of metabolic disorders, including diabetes, insulin resistance, metabolic acidosis and...
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7563765 |
Histidine-rich glycoprotein
The invention relates to histidine-rich glycoprotein (HRGP) polypeptides and the use of these polypeptides. The invention includes methods for the inhibition of angiogenesis by administering an...
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7560428 |
Hair growth promoting oligopeptides
The object of the present invention is to provide an oligopeptide having hair growth promoting activity. The present invention provides an oligopeptide which is represented by the formula (I):...
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7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7550430 |
Cationic antimicrobial peptides and compositions
The invention described herein relates to compositions of novel antimicrobial peptides. The peptides of the present invention exhibit high antibacterial activity and low hemolytic activity. The...
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7544364 |
Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a...
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7541336 |
Substance fki-1033 and process for producing the same
The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula:
in a medium, accumulating FKI-1033 substance in the...
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7531622 |
Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells
A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or...
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7531507 |
Acylated nonadepsipeptides containing pyridyl alanine residues
The invention relates to nonadepsipeptides and processes for their preparation, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial...
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7531506 |
Process for producing trunkamide a compounds
Trunkamide A and other cycloheptapeptides can be made by solid phase synthesis of a linear precursor.
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7517852 |
Compositions and methods for treating bacteria
The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of...
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7514442 |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7511013 |
Cyclosporin analogues and their pharmaceutical uses
The compounds of the present invention are represented by Formula I, as shown below:
or a pharmaceutically acceptable salt thereof,
with X, R 0 , R 1 , and R 2 defined herein.
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7504378 |
Macrocyclic peptides active against the hepatitis C virus
Compounds of formula (I):
wherein R 1 is (C 1-8 )alkyl, (C 3-7 )cycloalkyl, {(C 1-6 )alkyl-(C 3-7 )cycloalkyl} or Het, which are all optionally substituted from 1 to 3 times with halo, cyano,...
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7498301 |
Composition containing dipeptide of histidine and alanine for reducing uric acid and method for reducing uric acid using the dipeptide
The present invention relates to a composition comprising an effective amount or an effective amount of one or more dipeptides consisting of histidine or the functional equivalent thereof and...
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7498300 |
CRFR1 selective ligands
CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. These analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase...
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7498297 |
Medicinal uses of mu-opioid receptor agonists
The present invention provides methods for stimulating a mu-opioid receptor agonist peptide in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a...
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7498025 |
Targeted bifunctional molecules and therapies based thereon
Targeted bifunctional molecules and methods for their use are provided. The subject targeted bifunctional molecules are conjugates of a drug moiety and a targeting moiety, where these two moieties...
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7491695 |
Methods of using macrocyclic modulators of the ghrelin receptor
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue...
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7488712 |
Histone deacetylase inhibitors and methods for producing the same
Compounds represented by formula (1) have strong inhibitory activity that is selective towards HDAC1 and HDAC4. Therefore, the compounds of the present invention are useful as pharmaceutical agents...
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7479481 |
Treatment of ocular diseases and disorders using lantibiotic compositions
Compositions and methods for treating ocular diseases and disorders are provided. The composition can contain at least one lantibiotic, which can be administered topically by injection,...
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7473760 |
Cyclic peptide compositions for treatment of sexual dysfunction
A cyclic peptide of the structural formula:
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , R 6 , m, n and p are as defined. Further provided are compositions for...
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7470695 |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7470664 |
HCV NS3 protease inhibitors
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or...
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7459430 |
Methods of using ziconotide to treat overactive bladder
The invention relates to methods of using Cav2.2 subunit calcium channel modulators to treat painful and non-painful lower urinary tract disorders and the related genitourinary tract disorders...
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7452865 |
Antagonistic analogs of GH RH (2003)
There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH 2 . These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore...
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7452861 |
Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
This invention is directed to methods of administering an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent having a substituent comprising at least about 8...
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7449544 |
p21 peptides
The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides...
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7446095 |
Peptides modulating caspase activation
The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of...
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7446094 |
Cytotoxic depsipeptides
Compounds of general formula (I) wherein R 1 , R 2 , R 3 are as defined and R 4 groups are each independently selected from NR 2 , O and S; are of use in treatment of cancers.
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7446093 |
Cerebrospinal and vascular pharmaceutical composition and process for preparing the same
A cyclosporin-containing pharmaceutical preparation for cerebrospinal or vascular application is disclosed, comprising (1) at least one cyclosporin, and (2) DMSO.
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7439225 |
Substances K01-B0171 and process for producing the same
The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or...
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7432242 |
Inhibitors of RGS proteins
The present invention relates to novel inhibitors of G-protein signaling. In particular, the present invention provides peptide inhibitors of G protein signaling proteins and methods of using such...
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7429565 |
Antiviral phosphonate analogs
The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such...
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7419954 |
Staphylococcus peptides for bacterial interference
The present invention provides a cyclic peptide comprising the structure:
wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a...
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7419953 |
Selective R-cadherin antagonist and methods
An isolated peptide useful as a selective antagonist of mammalian R-cadherin comprises 3 to 30 amino acid residues, three contiguous residues of the peptide having the amino acid sequence...
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7414023 |
Peptide ligands for prostate specific antigen
The present invention relates to novel peptide ligands for prostate specific antigen (PSA) binding specifically with it and enhancing its enzyme activity, to a process for preparation of these...
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7410945 |
Treatment of inflammatory bowel disease
This invention relates to methods of treatment of inflammatory bowel disease, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability...
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