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8173592 |
Method for a programmed controlled ovarian stimulation protocol
A method of therapeutic management of infertility by programming of controlled ovarian stimulation and assisted reproductive procedures is disclosed containing the steps of a) suppression of...
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8048848 |
Long-acting interferons and derivatives thereof and methods thereof
A polypeptide and polynucleotides encoding same comprising carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an IFN protein are disclosed. Pharmaceutical compositions...
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8048849 |
Long-acting polypeptides and methods of producing same
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal...
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7985732 |
Unitary combination of FSH and hCG
A novel ovulatory induction paradigm entails administration of hCG in combination with FSH during all stages of treatment, where the ratio of FSH to hCG is adjusted to optimize ovulatory...
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7964562 |
Unitary combinations of FSH and hCG
A novel ovulatory induction paradigm entails administration of hCG in combination with FSH during all stages of treatment, where the ratio of FSH to hCG is adjusted to optimize ovulatory...
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7956034 |
FSH glycosylation variant D3N
FSH mutant with increased glycosylation and longer half-life is described. The use of this FSH mutant for inducing folliculogenesis in human patients is also described.
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7846957 |
Aromatase inhibition to enhance assisted reproduction
The use of at least one aromatase inhibitor in the production of a medicament for improving the implantation and pregnancy rates for a female undergoing assisted reproduction treatment, which...
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7815912 |
Method of controlled ovarian hyperstimulation and pharmaceutical kit for use in such method
One aspect of the present invention is concerned with a method of controlled ovarian hyperstimulation in a mammalian female, said method comprising the co-administration to said female of —a s...
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7807620 |
Long-acting follicle stimulating hormone analogues and uses thereof
This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and...
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7754220 |
Methods of inhibiting secretion of follicle-stimulating hormone and testosterone
Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone...
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7744910 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7741268 |
Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant
The invention relates to the field of pharmaceutical formulations of follicle-stimulating hormone (FSH), luteinising hormone (LH), and mixtures of FSH and luteinising hormone (LH), and to methods...
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7740862 |
FSH mutants
FSH mutants with increased glycosylation and longer half-lives are described. The use of FSH mutants for inducing folliculogenesis in human patients is also described.
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7740884 |
Freeze-dried FSH/LH formulations
The invention relates to the field of pharmaceutical formulations of a mixture of follicle stimulating hormone (FSH) and luteinising hormone (LH), and to methods of producing such formulations.
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7727952 |
Methods for treating spinal and bulbar muscular atrophy using LHRH analogs
It is intended to provide a model animal faithfully reproducing the pathogenic conditions of spinal and bulbar muscular atrophy, a method of screening a remedy for polyglutamine disease using the...
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7691603 |
Intracellular formation of peptide conjugates
The invention includes methods and compositions for forming peptide conjugates intracellularly having a covalent linkage between a modifying group and a glycosylated or non-glycosylated peptide....
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7541328 |
Coupling proteins to a modified polysaccharide
The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a...
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7482024 |
Compositions comprising an active agent
The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention...
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7442684 |
Long-acting hormone and growth factor compositions and uses thereof
This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides...
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7405197 |
Use of hCG in controlled ovarian hyperstimulation
The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG, or a bio-analogue, is administered during the follicular phase.
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7402558 |
Method for aiding implantation or decreasing miscarriage rate
The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the...
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7393834 |
LHRH-antagonists in the treatment of fertility disorders
A method of treating infertility disorders by 1) administering an LH-RH antagonist, preferably Cetrorelix, in amounts to selectively suppress endogenous LH but not FSH secretion and 2) inducing...
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7364910 |
Methods of inducing ovulation
The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the...
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7351741 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.
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7309689 |
Sustained peptide-release formulation
A pharmaceutical and/or veterinary formulation for sustained release of a peptide agonist or analogue, comprising about 2-15% (w/w) of at least one peptide agonist or analogue other than deslorelin...
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7291593 |
Use of fish for treating infertility
The present invention relates to the use of FSH and/or a biologically-active analogue thereof in the production of a medicament for the treatment of infertility in women. The medicament is for...
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7288517 |
Treatment of dementia and neurodegenerative diseases with intermediate doses of LHRH antagonists
The present invention relates to the treatment of dementia and neurodegenerative diseases like Alzheimer's disease with intermediate doses of LHRH antagonists which do not cause a castration. A...
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7265157 |
Sustained release compositions, process for producing the same and use thereof
Sustained release compositions containing a physiologically active substance or its salt, hydroxynaphthoic acid or its salt and a lactic acid-glycolic polymer or its salt, wherein the product of...
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7235524 |
Medicaments for initiating ovulation
The invention relates to medicaments for initiating ovulation comprising LH in an administrable form which ensures an increase in LH plasma levels for a period of some 40 to 60 hours.
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7202215 |
Long-acting follicle stimulating hormone analogues and uses thereof
This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and...
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7192717 |
GASP1: a follistatin domain containing protein
The present invention relates to the use of a protein, GASP1, comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More...
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7186414 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7182956 |
Stable topical drug delivery compositions
A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
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7153824 |
Inhibitors of phosphodiesterases in infertility
The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation...
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7151083 |
Luteinizing hormone and follicle stimulating hormone for use in inducing folliculogenesis
The present invention relates to the use of gonadotrophins in the induction of folliculogenesis in anovulatory women. In particular, it relates to the use of LH (or an equivalent dosage of hCG) in...
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7138371 |
Remodeling and glycoconjugation of peptides
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying...
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7112341 |
Pulmonary administration of dry powder formulations for treating infertility
Provided are stabilized follicle stimulating protein (FSP) dry powder compositions for aerosolized delivery to the deep lung, methods of preparing and administering such compositions, and methods...
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7109171 |
Methods for treating FSH related conditions with GnRH antagonists
Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the...
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7105487 |
Method for inducing onset of the reproductive cycle of female breeding animals
A method for inducing the onset of the reproductive cycle of female breeding animals is provided. To this end, the animals are injected with an agent that contains synthetically produced FSH...
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7098183 |
Nucleotide and amino acid sequences of oocyte factors for altering ovarian follicular growth in vivo or in vitro
Aspects of the present invention relate to nucleotide and amino acid sequences of oocyte factors for altering ovarian follicular growth in vivo or in vitro. The present invention also concerns...
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7074397 |
Method for enhancing proliferation or differentiation of a cell using ob protein
Uses for WSX ligands in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for stimulating hematopoiesis (e.g., myelopoiesis, erythropoiesis and especially, lymphopoiesis)...
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7053150 |
Segmented polymers and their conjugates
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
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7022674 |
Polypeptide compositions with improved stability
The present invention provides means to improve the chemical stability of aqueous, parenteral pharmaceutical compositions comprising a polypeptide and glycerin. Reactive aldehydes are identified in...
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6881398 |
Therapeutic dry powder preparation
A therapeutic dry powder preparation and a method of administering such a preparation are disclosed for effectively de-aggregating and dispersing into air a dose of medication powder in an...
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6864229 |
G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
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6797258 |
Compositions and methods for the pulmonary delivery of aerosolized macromolecules
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible...
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6794357 |
Compositions for inhalation
Disclosed herein are dry powder compositions comprising a pharmacologically active polypeptide and a surfactant, wherein at least 50% of the total mass of the polypeptide and the surfactant...
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6693074 |
Cystine depleted glycoprotein hormones
Single-chain forms of the glycoprotein hormones LH, FSH, TSH or CG which are lacking at least one disulfide bridge in the sequence representing the α and/or β subunit are useful as agonists or a...
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6653286 |
Gonadotropin releasing hormone antagonist
The present invention relates to a method to prevent a premature LH surge. The method employs the administration of the gonadotropin releasing hormone antagonist ganirelix in an amount between...
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6630123 |
Method to enhance tissue accumulation of radiolabeled compounds
Administration of a radioisotopic compound by infusion over a period of time greater than two hours, preferably greater than twelve hours, greatly increases the maximum radioactivity that...
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