Match Document Document Title
9034359 Composition comprising biodegradable hydrating ceramics for controlled drug delivery  
The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in...
9029331 Glycopegylated granulocyte colony stimulating factor  
The invention relates to methods of preparing and purifying conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking...
9011933 Therapeutic methods and pharmaceutical compositions for treating warts with tellurium compounds  
A novel method for treating skin and mucosal membrane ailments caused by human papilloma viruses, which utilizes tellurium-containing compounds, is disclosed. Also disclosed are pharmaceutical...
9011309 Devices for thermally induced transformations controlled by irradiation of functionalized fullerenes  
An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with...
8999930 Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same  
The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently...
8999935 Treatment of osteoporosis in peri- and post-menopausal women with hepcidin  
The present invention is directed to a method of treating, preventing, or reducing the risk of bone deterioration or osteoporosis in a peri- or post-menopausal female subject. The method involves...
8999670 Long-acting polypeptides and methods of producing same  
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal...
8993521 Oral pharmaceutical composition of desmopressin  
The present invention relates to a liquid oral pharmaceutical composition of desmopressin, and its use for the treatment of central diabetes insipidus, primary nocturnal enuresis, bleeding in...
8980300 Plasticizers for coating compositions  
A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive...
8980295 Multifunctional in situ polymerized network via thiol-ene and thiol-maleimide chemistry  
Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second...
8968716 In situ-forming hydrogel for tissue adhesives and biomedical use thereof  
Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over...
8951551 Multiribbon nanocellulose as a matrix for wound healing  
The present invention includes compositions and methods for the integration of a non-allergenic nanocellulose into a wound bed. The composition may be formed into a wide variety of implants, e.g.,...
8946155 Long-acting polypeptides and methods of producing and administering same  
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical...
8945551 Biopolymer hybrid gel-depot delivery system  
The invention relates to biopolymer-gel based depot systems for prolonged and/or controlled release delivery of biologically active agents, methods for the manufacture of the biopolymer based...
8936804 Use of vanadium compounds to accelerate bone healing  
This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of...
8933028 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue  
Methods for facilitating joint immobilization or fusion using selective estrogen receptor modulator (SERM) such as raloxifene are disclosed. The SERM may be administered systemically or locally....
8916518 Coupling proteins to a modified polysaccharide  
The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a...
8912137 Method for increasing natriuresis or diuresis by isoforms of brain natriuretic peptide  
Methods and materials for diagnosing and treating heart conditions (e.g., heart failure) and kidney conditions (e.g., kidney failure) are described.
8871706 Method for inhibiting inflammation and pre-inflammatory cytokine/chemokine expression using a ghrelin analogue  
The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to...
8840877 Polysaccharide-protein conjugates reversibly coupled via imine bonds  
Method for preparing an oxidized polysaccharide-protein composition, by (a) oxidizing a polysaccharide with an oxidizing agent to form an oxidized polysaccharide where less than 20% of the...
8841250 Method for promoting muscle repair comprising administering G-CSF at the site of injury  
The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present...
8835513 Drug delivery devices  
Compositions provided by contacting a biotin-containing component and an avidin-containing component are useful as drug delivery devices. Bioactive agents may be covalently bound to the...
8828949 Aprotinin polypeptides for transporting a compound across the blood-brain barrier  
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as...
8815795 Methods for preventing or treating eye diseases using adiponectin  
A composition for preventing or treating an eye disease includes adiponectin as an active ingredient. Adiponectin as an active ingredient is eventually revealed to show prevention or therapeutic...
8802622 Composition for nasal administration and method for preparing same  
The invention provides a powdered composition for nasal administration, comprising a physiologically active peptide and cellulose acetate as the base, and having excellent nasal absorption for...
8802707 Method of treating and/or preventing cancers using Sartans and/or Statins to modulate VDR, and/or PPAR, and/or GCR and/or CB1 receptors; in conjunction with certain bacteriostatic antibiotics  
This invention is a method of killing the stealthy intra-cellular bacteria which are key to the pathogenesis Cancers. These very tiny L-form Cell-Wall-Deficient (CWD) antibiotic-resistant bacteria...
8778403 Diketopiperazine microparticles with defined specific surface areas  
Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise...
8758770 Alpha-MSH therapies for treatment of autoimmune disease  
Methods and compositions for the enteral treatment of autoimmune disease such a multiple sclerosis with polypeptide therapeutics. Enteral therapeutics comprise monomeric alpha-MSH polypeptides...
8753671 Filament based on hyaluronic acid in the form of free acid and method for obtaining it  
The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according...
8748382 Method of drug delivery for bone anabolic protein  
The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) and methods of using a PTHrP and the PTHrP compositions described herein to...
8741836 Polypeptides  
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for...
8729019 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents  
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the...
8722088 Pharmaceutical compositions and methods for the treatment of prostate cancer  
Compositions, kits, and methods are provided directed to the treatment of prostate cancer using a maintenance dose of degarelix or pharmaceutically acceptable salt thereof, an excipient, and a...
8722075 Compositions and methods for promoting bone formation  
A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising...
8703717 Growth hormone polypeptides and methods of making and using same  
The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host...
8680086 Methods for chronic pain management and treatment using HCG  
A gonadotropin is administered within a surprisingly effective narrow range for the purpose of treating chronic pain or other central sensitization sequelae. In one aspect, a recipient is provided...
8673859 GM-CSF cosmeceutical compositions and methods of use thereof  
It has been discovered that granulocyte macrophage colony stimulating factor (“GM-CSF”) promotes migration of activated (but not differentiating) keratinocytes to wound sites. It was also...
8673359 Nanoparticle compositions and methods for improved oral delivery of active agents  
Nanoparticles, compositions, and methods for the improved uptake of active agents are disclosed herein. The compositions contain a monodisperse population of nanoparticles, preferably including an...
8633158 Angiotensin in treating brain conditions  
The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or...
8623326 Ghrelin analogues  
Ghrelin analogues having high affinity for a target receptor in diseased cells are provided, as well as methods of diagnosis and treatment utilizing such analogues.
8614184 HCG formulations for achieving weight loss  
A formulation of human chorionic gonadotropin (HCG) for promoting weight loss comprising reconstituted HCG in an amount sufficient to promote weight loss; at least one vitamin selected from the...
8592378 Compound WS 727713  
The present invention relates to a new compound useful as a modulator of melanocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of...
8586532 Method for selectively modifying a protein via transglutaminase catalyzed reaction  
The present invention relates generally to a novel method of introducing property modifying groups to a protein. In particular, the present invention relates to the derivatization of lysine...
8575109 Recombinant pokeweed antiviral proteins, compositions and methods related thereto  
The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the...
8575091 Amylin analogues and pharmaceutical compositions thereof  
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for...
8551528 Diketopiperazine microparticles with defined specific surface areas  
Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise...
8530235 Medium that supports culture of an oocyte and modulation of granulosa cell apoptosis  
The present invention relates to a method of modulating apoptosis of a granulosa cell. The method includes one or more of the following steps: (i) modulating the concentration and/or activity of...
8524663 Method for site-specific polyvalent display on polymers  
The present invention relates to novel complex peptidomimetic products comprising multiple homogeneous or heterogeneous pendant groups that are site-specifically positioned along a linear oligomer...
8524665 Use of secretin in treatments of disorders associated with the amygdala  
In general, the present invention provides methods for treating disorders associated with the amygdala. The methods of treatment are based on the administration of a therapeutically effective...
8501690 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue  
Methods for facilitating joint immobilization or fusion using selective estrogen receptor modulator (SERM) such as raloxifene are disclosed. The SERM may be administered systemically or locally....