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6608027 |
Macrocyclic peptides active against the hepatitis C virus
The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus. wherein W, R 21 , R 22 , R 3 , R 4 , D...
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6605280 |
Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs...
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6599527 |
Preparation of pharmaceutical compositions
A substantially homogeneous composition for human administration comprises a biologically active lipophilic compound dissolved in or associated with at least one micelle-forming lipid. For example,...
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6593297 |
Compounds and methods for inhibiting cancer metastasis
Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least...
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6586425 |
Cytoskeletal active agents for glaucoma therapy
Methods for the treatment of glaucoma are provided by the present invention. The compounds described cause a perturbation of the actin cytoskeleton in the trabecular meshwork or the modulation of...
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6586393 |
Antibiotics GE 23077, pharmaceutically acceptable salts and compositions, and use thereof
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any...
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6583114 |
Fracture healing using pthrp analogs
This invention provides methods of bone healing and fracture repair comprising administering to a patient in need thereof an effective amount of a polypeptide analog of parathyroid hormone related...
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6562785 |
Method for overcoming bacterial antibiotic resistance
The present invention is drawn to methods of killing bacteria, including antibiotic resistant bacteria, by contacting said bacteria with a membrane permeabilizing compound or combination of...
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6562786 |
Compounds and methods for modulating apoptosis
Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a classical cadherin cell adhesion recognition sequence HAV. Methods for using such...
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6551610 |
Multifaceted compositions for post-surgical adhesion prevention
This invention deals with an absorbable, gel-forming composition for multifaceted prevention of post-operative surgical adhesion through a plurality of physico-pharmacological modes, comprising a...
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6548478 |
Virginiamycin mixture
A mixture comprising: a) virginiamycin; b) a pharmaceutically acceptable and substantially anhydrous wetting agent including sodium lauryl sulfate; c) a sufficient amount of pharmaceutically...
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6534478 |
Cyclic azapeptides with angiogenic effect
Compounds of the formula I cyclo-(aArg-aGly-aAsp-aX-aY) I in which aArg, aGly, aAsp, aX and aY have the meanings indicated in claim 1 , and their salts, can be used as integrin inhibitors, in...
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6531139 |
Self-emulsifying formulation for lipophilic compounds
The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride...
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6531112 |
Formulations for administering calcitonin and processes for preparing the same
The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed...
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6521594 |
Method and composition for treating thrombosis
The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and...
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6521595 |
Nonimmunosuppressive &lsqb &ggr -hydroxy-methylleucine4&rsqb cyclosporin A, hair growth stimulator and external composition for skin using the same
The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [γ-hydroxy-methylleucine 4 ] cyclosporin A...
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6521593 |
Methods for inhibiting brain tumor growth
The present invention describes methods for inhibition of tumor growth in the brain, using antagonists of integrins such as α v β 3 and α v β 5 . Antagonists of the present invention can...
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6518242 |
Derivatives of glycopeptide antibacterial agents
Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of...
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6511961 |
Cyclic peptides and medicinal use thereof
Novel cyclic peptides having VLA-4 adhesion inhibiting activity, and their application as therapeutic agents for inflammatory disease, for example allergic inflammatory disease, or hepatitis....
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6506731 |
Elastin peptide analogs and methods of using same
The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated...
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6506726 |
Purification of Echinocandin cyclopeptide compounds
A method is described for separating and purifying a wide variety of fermentation cyclopeptide products containing at least one protonatable amino group (including the deacylated Echinocandin-type...
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6503948 |
Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor
A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the...
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6500809 |
Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
Neural tissue edema is treated by circulating a hyperoncotic artificial cerebrospinal fluid in the cerebrospinal fluid pathway in the vicinity of edematous tissue to cause the edematous tissue to...
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6495518 |
Method for importing biologically active molecules into cells
The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a...
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6472369 |
Anticancer compounds and methods
The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human...
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6468964 |
Control of acidic gut syndrome
According to the present invention there is provided a method for the treatment or prophylaxis of acidic gut syndrome resulting from the accumulation of acid and production of endotoxin in the...
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6468966 |
Octacyclodepsipeptides having an endoparasiticidal action
The present invention relates to compounds of the general formula (I) in which R 1 and R 12 represent the same or different radicals selected from the group of C 2-9 -alkyl, C 1-8...
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6465428 |
Pharmaceutical combinations based on dalfopristine and quinupristine, and on cefepime
The present invention relates to pharmaceutical combinations of group A and group B streptogramins, in particular to combinations of dalfopristine and quinupristine, with cefepime, which...
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6413936 |
Glycomimetics as selectin antagonists and pharmaceuticals having antiinflammatory activity
The invention relates to novel mimetics of the tetrasaccharides sialyl-Lewis-X and sialyl-Lewis-A having an improved action as inhibitors of cell adhesion, to a process for the preparation of these...
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6407059 |
Conformationally constrained backbone cyclized peptide analogs
Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building...
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6399567 |
Cyclic hexapeptides having antibiotic activity
This invention relates to new polypeptide compounds represented by the following formula (I): wherein R 1 is as defined in the description or a salt thereof which have antimicrobial activities...
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6391851 |
Hydrochlorides of vancomycin antibiotics and process for producing the same
Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to...
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6380156 |
Total synthesis of the amino hip analogue of didemnin A
Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as “AipDidemnin A” (8). These compounds have the...
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6372712 |
Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein...
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6368788 |
Method of treating complications in immunodepressed states resulting from HIV infection
Methods of treatment of subjects for decreasing cell mediated autoimmunity or humoral autoimmunity by administering an R′-Glu-Trp-R″ pharmaceutical preparation useful in subjects having...
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6346511 |
Pharmaceutical composition comprising cyclosporin
A homogenous substantially alcohol free composition of Cyclosporin which comprises a cyclosporin in a hydrophilic carrier medium comprising propylene glycol, esters of propylene glycol with C4 to...
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6337316 |
Pharmaceutical compositions thereof, and methods of using same
The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence,...
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6333307 |
Compounds and method for modulating neurite outgrowth
Modulating agents comprising cyclic peptides, and compositions comprising such modulating agents are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV....
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6331521 |
Echinocandine derivatives with antimicrobial activity
The invention relates to new polypeptide compounds represented by the following formula [I]: ##STR1## wherein R 1 is hydrogen, etc, R 2 is hydrogen, etc, R 3 is hydrogen, etc, and R...
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6329338 |
Derivatives of cyclodepsipeptide PF1022 substance
Novel derivatives of PF1022 substance, which are cyclodepsipeptides represented by the general formula (I) shown below or their salts are useful as anthelmintic agent for prevention or treatment of...
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6319512 |
Implants for controlled release of pharmaceutically active principles and method for making same
The present intention relates to an implant for the controlled release of at least one pharmaceutically active principle comprising a core containing at least one active principle and a sheath...
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6319897 |
Peptides which inhibit complement activation
Peptides capable of inhibiting complement activation are provided. Methods of inhibiting complement activation and complement-mediated tissue injury using these peptides are also provided. In...
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6319890 |
Inhibition of binding of complement Factor H
Pathogen-specific peptide chains are provided which prevent pathogens from escaping complement-mediated lysis. The peptide chains bind to known binding sites on pathogens to which complement...
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6316410 |
Parathyroid hormone analogues for the treatment of osteoporosis
The invention disclosed relates to analogues of human parathyroid hormoneh(PTH) which have increased activities in bone restoration, and increased bioavailablities. The analogues described are...
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6316405 |
Cyclosporin a conjugates and uses therefor
Disclosed are conjugates of Aβ-binding peptides and CsA analogs and conjugates of Aβ-binding peptides and FK506 Binding Peptide inhibitors. These conjugates chemically induce dimerization of...
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6306837 |
Heavy metal chelating agent for oral administration, its synthesis and its uses in medicine and health protection
The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in...
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6291426 |
Strain of bacillus for controlling plant diseases and corn rootworm
The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant of...
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6288029 |
Template associated NPY Y2-receptor agonists
The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically...
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6288033 |
Treatment of hepatitis B infection with thymosin alpha 1 in combination with lamivudine or in combination with lamivudine and famciclovir
A method of treatment of hepatitis B virus (HBV) infection in a patient by administering to the patient a drug regimen including an antiviral-effective amount of thymosin alpha 1 (Tα1), an...
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6281244 |
Therapeutic use for glycine
Glycine is indicated to prevent or treat acute or chronic graft rejection, optionally in combination with an immunosuppressant or an immunomodulating agent.
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