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6905669 |
Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer by reestablishing the gene expression through inhibition of DNA...
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6902720 |
Cyclic peptide structures for molecular scale electronic and photonic devices
The present invention discloses a family of cyclic peptide monomers and supramolecular cyclic peptide structures comprising chromophore residues which possess electronic and electro-optic...
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6900176 |
Pest control agents/depsipeptides
The present invention relates to the use of 24-membered cyclodepsipeptides of the formula (1)
in which R 1 and R 2 are as defined in the description,
for controlling animal pests in...
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6894026 |
Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
Methods and compositions are provided for prophylaxis and treatment of breast cancer involving administration of a therapeutically effective amount of carbetocin and/or other long-acting oxytocin...
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6884774 |
Cyclic hexapeptide derivatives
This invention relates to new polypeptide compound represented by the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description or a salt thereof which has...
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6875740 |
Combination of a cyclic hexapeptide with antifungal drugs for treatment of fungal pathogens
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention...
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6867185 |
Inhibitors of hepatitis C virus
The present invention relates to macrocyclic compounds, methods for making these compounds, pharmaceutical compositions and the therapeutic or prophylactic use of these compounds by administering...
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6864232 |
Agent for treating visual cell function disorder
The present invention provides an agent for treating retinopathy containing a tricyclo compound of formula (I)
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6864233 |
Fungicidal echinocandin derivatives and their preparation
The invention concerns compounds of general formula (I) wherein: R 1 represents a hydrogen atom, a hydroxy radical, Ob or Ncd; A represents an oxygen atom, a CH 2 radical or a NH radical; B...
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6858585 |
Cyclic depsipeptides and drugs containing the same as the active ingredient
Cyclic depsipeptides represented by the formula
wherein:
R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B,...
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6852689 |
Methods for administration of antibiotics
The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a...
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6852333 |
Agents and methods for promoting production gains in animals
The invention relates to compositions and methods for promoting production gains in animals, and of enhancing the efficacy of therapeutic agents. The gains are achieved through reduction in stress,...
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6846804 |
Construction of a structural variant of sublancin to facilitate its isolation and use in bioremediation of environmental contamination by gram-positive spore formers such as bacillus anthrasis
A sublancin peptide variant having a Gly-His peptide sequence fused to the C-terminal end of the mature sublancin peptide provides an affinity tag facilitating increased purification of the peptide...
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6846802 |
Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties
The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention...
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6844319 |
Peptide-based carrier devices for stellate cells
The present invention relates to a compound comprising a carrier molecule, said carrier molecule being linked to a further molecule, said further molecule being at least one cyclic peptide, said...
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6841533 |
Conformationally constrained backbone cyclized interleukin-6 antagonists
Novel peptides which are conformationally constrained backbone cyclized antagonists of IL-6, are disclosed. Methods for synthesizing the IL-6 antagonists are also disclosed. Furthermore,...
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6838435 |
Isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2(TC-2) or variants thereof
The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence...
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6833353 |
Use of immunosuppressants for MMP mediated diseases
A new use of immunosuppressant for treating or preventing MMp-medicated diseases is provided. The preferred immunosuppresants are tacrolimus, cyclosporing A or 33-epi-chloro-33-desoxyascomycin...
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6828300 |
Pest control agent/PF 1022-221
The present invention relates to the use of a 24-membered cyclodepsipeptide of the formula (I) for controlling animal pests in agriculture, forests and the protection of materials, and to...
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6821951 |
Processes for making pharmaceutical oral ECB formulations and compositions
A fluid bed spray process is described where one or more carbohydrates are incorporated into an echinocandin formulation to provide a significant improvement in thermal stability. The carbohydrate...
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6821950 |
Cyclic agonists and antagonists of C5a receptors and G protein-coupled receptors
The present invention relates to novel cyclic or constrained acyclic compounds which modulate the activity of G protein-coupled receptors and are useful in the treatment of conditions mediated by G...
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6818614 |
Compounds having antifungal activity
A compound of the following chemical structure (I) which exhibits antifungal activity and is useful in treating and preventing fungal infectious diseases:
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6812230 |
Non-peptide CCR1 receptor antagonists for the treatment of progressive renal fibrosis
This invention is directed to pharmaceutical compositions useful in treating progressive renal fibrosis in mammals comprising a pharmaceutically acceptable excipient and a therapeutically effective...
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6809077 |
Cyclosporin analogs for the treatment of autoimmune diseases
The present invention relates to a cyclosporin analog of the following formula (I) or a pro-drug or pharmaceutically acceptable salt thereof: In particular, residue A maybe represented by either...
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6787520 |
Inactivating process for lipid envelopped virus, and new antivirus lipopeptides
The invention relates to an extraordinarily efficient method of inactivating lipid-enveloped viruses, such as herpes or retroviruses, in biological or biotechnological—particularly...
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6774103 |
Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)
This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the...
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6774104 |
Stabilized pharmaceutical composition in lyophilized form
A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I): wherein R 1 is a hydrogen atom or an acyl group and...
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6770279 |
TNFα antagonists and cyclosporin in therapy of rheumatoid arthritis
A method for treating rheumatoid arthritis using a TNFα antagonist in combination with cyclosporin or analog thereof is disclosed.
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6743776 |
Cyclohexapeptides having antimicrobial activity
This invention relates to new polypeptide compounds represented by general formula [I]: wherein R 1 and R 2 are as defined in the description and pharmaceutically acceptable salt thereof which...
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6740636 |
Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective...
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6713580 |
Quaternary amino acids on solid supports
The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be...
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6696412 |
High purity lipopeptides, Lipopeptide micelles and processes for preparing same
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential...
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6689749 |
Neuropeptides originating in scorpion
The invention provides a peptide capable of blocking voltage-gated K + channels and inhibiting IL-2 production, which is represented by an amino acid sequence of: ...
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6683051 |
Pharmaceutical preparation containing a cyclopeptide and a chemotherapeutic agent or an angiogenesis inhibitor
The invention relates to a pharmaceutical preparation [lacuna] cyclo(Arg-Gly-Asp-D-Phe-NMe-Val) and/or one of its physiologically acceptable salts and at least one chemotherapeutic agent and/or one...
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6683048 |
Compounds and methods for stimulating gene expression and cellular differentiation
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or...
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6680045 |
Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma
A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has...
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6677116 |
Methods for treating cancer by modulating β-catenin mediated gene expression
Modulating agents for inhibiting β-catenin mediated gene expression are provided. The modulating agents comprise one or more of: (1) the peptide sequence LXXLL (SEQ ID NO:1); or (2) a peptide...
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6677376 |
Non-peptidic cyclophilin binding compounds and their use
The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the...
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6670326 |
Depsipeptide compound
This invention relates to a novel compound which has a cytotoxic activity and TGF-β like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition...
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6660725 |
Method and composition for modulating amyloidosis
Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that...
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6656905 |
Cyclic tetrapeptide compound and use thereof
A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to...
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6649592 |
Peptide inhibitors of LFA-1/ICAM-1 interaction
Cyclic peptides inhibit LFA-1 interaction with ICAM-1 and are useful in treatment of hematopoietic neoplasms and in adjunct therapy in prevention of retinoic acid syndrome and diseases involving...
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6645934 |
Peptide with radio protective effect
The invention makes available a peptide having a radioprotective effect that comprises a modified form and/or an optionally modified fragment of the Bowman-Birk protease inhibitor (BBI).
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6638910 |
Compositions and methods for controlling plant pests
The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant...
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6630123 |
Method to enhance tissue accumulation of radiolabeled compounds
Administration of a radioisotopic compound by infusion over a period of time greater than two hours, preferably greater than twelve hours, greatly increases the maximum radioactivity that...
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6624143 |
Calcium salts of lipopeptide antibiotics, method for producing same and their use
The invention relates to a calcium salt of the compound of formula (II), where R 1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms,...
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6624144 |
Matrix metalloproteinase inhibitors and down-regulators
The present invention relates to novel matrix metalloproteinase (MMP) inhibitors and down-regulators, to a process for the preparation of these inhibitors, to pharmaceutical compositions comprising...
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6620782 |
Substituted 2-aminobenzamide caspase inhibitors and the use thereof
The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: where R 1 -R 3 , X, and A—D are defined herein. The present invention also relates to...
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6613738 |
Cyclic lipopeptide from Cryptosporiopsis quercina possessing antifungal activity
A unique lipopeptide antimycotic, termed Cryptocandin, is described from Cryptosporiopsis cf quercina, an endophytic fungus. Cryptocandin with a molecular mass of 1079 contains equimolar...
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6610655 |
Pentapeptide with specific conformation, its production and use
Cyclic pentapeptides are disclosed having the following formula (I)-Cyclo(-A 1 -A 2 -A 3 -A 4 -A 5 -)-wherein A 1 , A 2 , A 3 , A 4 and A 5 are amino acid residues. The pentapeptide has amino...
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