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6723711 |
Propanoic acid derivatives that inhibit the binding of integrins to their receptors
A compound of the structure A method for the inhibition of the binding of α 4 β 1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin;...
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6706698 |
α-Substituted β-aminoethyl phosphonate derivatives
The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a),...
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6689759 |
Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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6677339 |
Phenylalanine derivatives
Phenylalanine derivatives of formula (1) are described: in which: Ar 1 is an aromatic or heteroaromatic group; L 1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar...
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6660724 |
Compounds and pharmaceutical compositions containing them
Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.
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6653296 |
Antiretroviral enantiomeric nucleotide analogs
Resolved enantiomers of the formula (IA) and (IB) wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat...
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6649601 |
Process for increasing the egg production and strengthening the eggshells of poultry
The present invention relates to a process for increasing the egg production and strengthening the eggshells of poultry, which comprises the administration to the animal of at least one...
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6649605 |
Treatment of tension-type headaches with NMDA receptor antagonists
NMDA receptor antagonists, especially mirtazapine, can be used to treat tension-type headaches.
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6642215 |
Method of modulating NF-kB activity
A method of modulating the level of activated, NF-κB in cells by contacting cells with a cyanoguanidine compound of general formula I wherein n is 0, 1 or 2; each R independently represents...
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6632806 |
Neurologically-active compounds
The invention provides methods for enhancing cognitive activity and stimulating memory capacity, comprising the step of administering an effective amount of a compound with GABA C receptor...
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6596709 |
6-sulphanoyl-3-quinolylphosphonic acid compounds
The invention relates to a compound of formula (I): wherein: X represents chlorine or fluorine or CF 3 , R represents hydrogen or a group and methods for using the same.
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6518258 |
6-sulphamoyl -3-quinolyphosphonic acid compounds
The invention relates to a compound of formula (I): wherein: X represents chlorine or fluorine or CF 3 , R represents hydrogen or a group and methods for using the same.
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6514952 |
Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists
Compounds of the formula I in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or...
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6500811 |
Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use
Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
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6498161 |
Pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are defined herein) which are useful as modulators of chemokine...
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6498151 |
Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and...
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6498150 |
Low molecular weight cell, bone marrow and immune stimulants
The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6485758 |
Hangover treatment
A cure for a hangover containing the active ingredient ephedrine in powdered form enclosed in a capsule. In a second embodiment this cure contains ephedrine and charcoal, while in a third...
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6479471 |
NAALADase inhibitors
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit...
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6479472 |
Methods of using therapeutic phospholipid derivatives
A method of treating protozoal and fungal diseases is described, in which an effective amount of a compound of formula I is administered to a host having a protozoal or fungal disease. Also...
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6468992 |
Phosphonic acid diester derivatives
The present invention provides novel phosphonic acid diester derivatives useful as medicines. The phosphonic acid diester derivatives are represented by the general formula: wherein R 1 ...
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6432930 |
Enhanced termiticide mixture
An improved termiticidal combination is formed by adding a liquid cellulose source to a standard liquid termiticide. The cellulose source may be a water soluble polyester such as a cellulose ether...
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6413948 |
Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors
The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical...
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6410520 |
Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through...
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6410505 |
Dimeric non-azo naphthalimides and uses for the same
A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a...
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6369042 |
Antioxidative vitamin B6 analogs
The present invention relates to novel antioxidative Vitamin B 6 analogs and their use in the cosmetic, dermatological, pharmaceutical and/or nutritional fields. Analogs can be provided in...
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6340676 |
4-aryl-1-oxa-9-thia-cyclopenta (b) fluorenes
This invention provides compounds of Formula I having the structure wherein B and D are each, independently, hydrogen, halogen, —CN, alkyl of 1-6 carbon atoms, aryl, or aralkyl of 6-12 carbon...
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6303784 |
Pharmaceutical aminophosphonic acid derivatives
Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity. ##STR1##
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6300356 |
Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
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6274570 |
Pesticidal compositions
A liquid pesticidal composition, which is substantially free of water, comprising a hydrophobic pesticide or mixture of pesticides dissolved in an organic solvent and comprising as surfactants (a)...
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6242432 |
Antithrombotic organic nitrates
Compounds or compositions containing compounds of the formula A-(X 1 --NO 2 ) to or salts thereof, for the preparation of antithrombotic medications wherein "to" is the integer 1 or 2X 1 is an...
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6235283 |
DNA encoding a cell membrane glycoprotein of a tick gut
This invention relates to an antigen isolated from the cattle tick Boophilus microplus and to the gene coding for that antigen and to the protein product of that gene. The antigen when used in part...
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6214812 |
Bisphosphonate conjugates and methods of making and using the same
Bisphosphonate conjugates capable of releasing antibacterial and/or cytotoxic components upon binding with bone tissue. Such conjugates are useful in the treatment and prevention of bone cancer,...
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6200961 |
Concentrates of organophosphorous insecticides
A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
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6194435 |
Lactams as selective factor Xa inhibitors
Novel lactams, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of Formula I below: ##STR1## are useful in vitro or in vivo for...
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6187752 |
Method for treating schizophrenia employing an ace inhibitor
A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or...
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6172050 |
Phospholipid derivatives
Phospholipid derivatives of Formula X: ##STR1## wherein A is the ring system ##STR2## in which R is a linear or branched alkyl radical having 10 to 24 carbon atoms which may contain one or more...
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6172051 |
Enhanced termiticide and method for treating termites
An improved termiticidal combination is formed by adding a liquid cellulose source to a standard liquid termiticide. The cellulose source may be a water soluble polyester such as a cellulose ether...
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6159957 |
Method of treatment or inhibition of tumors using pyridyl-substituted metal-diphosphine complexes
A method of treatment or inhibition of tumors involves administering a compound to a subject. The compound is one in which one or more of the eight phenyl substituents in the compound [M(dppe) 2 ]...
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6136836 |
Compositions for the systemic control of parasites of warm-blooded animals
A composition and method for controlling warm-blooded animal parasites comprising 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phen
yl]-3-(2,6,dif luorobenzoyl)urea.
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6121252 |
Phosphinic acid derivatives
The present invention relate to phosphinic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and...
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6121296 |
Transition-state inhibitors for nucleoside hydrolase and transferase reactions
This invention is directed to transition-state analog compounds and to the use of said compounds as inhibitors of nucleoside hydrolase and transferase enzyme activity of parasites. This invention...
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6117854 |
Enhanced performance insecticide compositions containing plant derived oil carriers and methods of using the same
A composition effective for the control of insects is disclosed, wherein the composition contains a phenyl pyrazole compound, a halopyridyl compound, or an avermectin compound, or combinations...
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6107299 |
Substituted pyridine and pyrimidine, processes for their preparation and their use as pesticides
Compounds of formula I, N-oxides or salts, thereof ##STR1## in which q is 0, 1 or 2 A is CH and D is N + R×1/n Q n - or A is N and D is N + R×1/n Q n - or A is CH or N and D is N or A...
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6100246 |
Spiro-piperidine derivatives as inhibitors of nitric oxide synthase
There are provided novel compounds of formula (I) ##STR1## wherein A represents a benzo ring; a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms; or a five membered...
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6083938 |
Pyridinylbisphosphonates for use as a therapeutical agent
The present invention relates to certain optionally ring substituted pyridinylaminomethylidene bisophosphonic acid tetralkyl esters (I) and their use for the treatment of bone diseases, such as...
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6051562 |
Stabilization and use of heterogeneous liquid compositions
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6040317 |
Sulfonamide fibrinogen receptor antagonists
A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases...
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6040299 |
Cold storage stabilized organophosphorus insecticide formulation and method of making same
There is disclosed a cold storage stabilized organophosphorus insecticide formulation. The formulation comprises a solid carrier and between approximately 2% and 40% by weight of the ultimate...
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6037334 |
Phosphonates, process for preparing the same and medicaments
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