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9023831 Methods and compositions of inhibiting complement and cellular activation with Dextran Sulfate  
A method of inhibiting the adverse effects of complement pathway, activation products in a subject comprising administering to the subject an amount of Dextran Sulfate effective to inhibit...
9006175 Potentiation of glucose elimination  
Methods related to the treatment of diabetes and improving the efficiency of insulin utilization are provided. The method enables effective control of prandial glucose levels while reducing the...
8980828 Combination of insulin with triazine derivatives and its use for treating diabetes  
The invention relates to a composition for use as a medicament comprising insulin in combination with at least one compound of formula (I) wherein the radicals R1 to R6 have the meaning according...
8975230 Method of treating ischemic injury with follistatin-like 1 polypeptide  
Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and...
8921398 N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof  
The present invention relates to compounds of general formula I, wherein R1, LP, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in...
8906901 Administration of dipeptidyl peptidase inhibitors  
Pharmaceutical compositions and methods comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro -2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile or a pharmaceutically acceptable...
8846724 Compositions for treating obesity and insulin resistance disorders  
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a...
8846758 Methods of decreasing glycosylated hemoglobin in patients with dyslipidemia  
Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically...
8829018 Method of restoring the incretin effect  
The present invention relates to methods of treating metabolic syndrome, Type 2 diabetes mellitus, atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of...
8791115 Combination of triazine derivatives and insulin sensitisers  
The present invention relates to combinations of triazine derivatives and of insulin sensitizers.
8784911 Compositions for treatment and prevention of diabetic complications using Osteomeles schwerinae  
The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that...
8758770 Alpha-MSH therapies for treatment of autoimmune disease  
Methods and compositions for the enteral treatment of autoimmune disease such a multiple sclerosis with polypeptide therapeutics. Enteral therapeutics comprise monomeric alpha-MSH polypeptides...
8668931 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative  
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is...
8658685 Methods for treatment of kallikrein-related disorders  
We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability)...
8648083 Method of treating diabetic hyperlipidemia or hyperlipidemia with carbamoyloxy arylalkanoyl arylpiperazine compounds  
A method of treating diabetic hyperlipidemia or lipidemia with carbamoyloxy arylalkanoyl arylpiperazine compounds including:
8648040 Amino acid composition for improving glucose tolerance  
Disclosed are compositions, including low-calorie beverages or liquids, comprising isoleucine, leucine, valine, cysteine, and methionine, in specified amounts, weight ratios, or both. The...
8609730 Rel inhibitors and methods of use thereof  
This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases...
8592394 Synthetic derivatives beta glycolipids and compositions thereof for the treatment of pathologic disorders  
The invention relates to novel synthetic derivatives of β-glycolipids and uses thereof as immunomodulators. More particularly, the invention relates to synthetic derivatives of β-glycolipids,...
8586036 Methods for the treatment of IL-1β related diseases  
Disclosed are methods for the treatment and/or prevention of Type 2 diabetes, insulin resistance and disease states and conditions characterized by insulin resistance, obesity, hyperglycemia,...
8552069 Method for treatment of obesity, dyslipidemia, fatty liver or insulin resistance syndrome comprising camphene as active ingredient  
Disclosed is a composition including camphene as an active ingredient for preventing or treating obesity, dyslipidemia, fatty liver or insulin resistance syndrome. The composition of the present...
8545846 Methods for treating IL-1β related diseases by administering an anti-IL-1β antibody  
Disclosed are methods for the treatment and/or prevention of Type 2 diabetes, insulin resistance and disease states and conditions characterized by insulin resistance, decreased insulin...
8541456 Roflumilast for the treatment of diabetes mellitus type 2  
The application relates to specific combinations of Roflumilast and/or Roflumilast N-Oxide and a PPAR-agonist, as well as their use in the treatment of diabetes mellitus type 2.
8541392 Polymer controlled induced viscosity fiber system and uses thereof  
The present invention relates generally to a method of blunting the postprandial glycemic response in a human by feeding an induced viscosity fiber system. The invention also relates to an induced...
8536182 Benzylpiperazine derivatives and their medical use  
The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or...
8524271 Skin wound dressing and preparing method thereof  
A skin wound dressing is disclosed. The skin wound dressing comprises Tremella polysaccharide and alginate and is used to cover on a skin wound to accelerate wound healing. The Tremella...
RE44459 Method for lowering blood glucose  
The invention disclosed comprises a method for administering the antidiabetic drug glipizide to a patient in need of glipizide in need of antidiabetic therapy.
8507462 Compositions and uses thereof  
Methods of controlling serum glucose levels in an individual are described, the methods including the step of administering to said individual a therapeutic food composition comprising a waxy...
8507557 Potentiators of insulin secretion  
The present invention relates to a recognition that an analog of αKG can increase glucose-induced insulin secretion in vitro and in vivo in animals, particularly in mammals, and more particularly...
8501812 Therapeutic methods for type I diabetes  
The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying...
8497298 Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels  
The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or...
8470368 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative  
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is...
8470808 Oxidant scavengers for treatment of type I diabetes or type II diabetes  
The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method...
8460659 Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases  
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
8455546 Medicament having promoting action on hepatocyte proliferation  
A medicament for promoting proliferation of hepatocytes and liver regeneration, which comprises a polyprenyl compound such as 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid as an active...
8455504 Inhibition of the activity of the capsaicin receptor in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance or insulin resistance  
The present invention provides a method of treating diseases or disorders benefiting from inactivating or down-regulating the activity of the capsaicin receptor in a mammal by inhibiting the...
8445508 Method of restoring the incretin effect  
The present invention relates to methods of treating metabolic syndrome, Type 2 diabetes mellitus, atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of...
8445467 Reducing risk of type 2 diabetes (T2D)  
This invention relates to methods for reducing chronic subacute inflammatory states associated with obesity and improve glycemia, thereby preventing or delaying the development of type 2 diabetes...
8440669 Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients  
The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a compound which inhibits the activity of...
8440668 Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes  
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in...
8435942 Methods for formulating stabilized insulin compositions  
A method of formulating insulin compositions comprises preparing a carrier having a phosphatidylcholine component which entraps insulin, stabilizing insulin compositions at room temperatures.
8404746 Anti-diabetes composition containing chicoric acid and/or one of the metabolites thereof  
The present invention relates to the use of chicoric acid and/or at least one of these metabolites selected among mono-caffeoyl-tartaric acid and/or m-hydroxyphenylpropionic acid, and/or...
8389574 Method useful for the prevention of type 2 diabetes and its complications in pre-diabetic patients with insulin resistance  
The present invention relates to the use of acetyl L-carnitine in combination with an anti hypertensive drug, and a statin, for the preparation of a medicament for the prevention or delay of onset...
8389470 Methods and compositions for delivering peptides  
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more...
8383650 Organic compounds  
The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a...
8343985 Methods for modulating Lyn kinase activity and treating related disorders  
The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in...
8338458 Method of treatment using fused aromatic compounds having anti-diabetic activity  
Fused aromatic compounds of Formula I are PPAR gamma agonists or partial agonists and are useful for weekly dosing in the treatment or control of type II diabetes, including hyperglycemia,...
8338480 Combination treatment of metabolic disorders  
Various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis...
8338394 Methods for treating metabolic diseases  
A pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid...
8329650 Method of treating ischemic injury with follistatin-like 1 polypeptide  
Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and...
8329637 Method for the treatment of automimmune diseases comprising administering rapamycin and IL-10  
The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of...