Patents in Class 514/86

Matches 1 - 50 out of 209

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Match	Document	Document Title
1	7605137	Combination therapy comprising cloretazine This invention provides a method for treating tumor in a subject comprising administering to the subject an effective amount of: (1) VNP40101M, or its equivalent; and (2) a nucleoside, or a...
2	7511027	Method of treating hepatitis delta virus infection A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the...
3	7465734	Methods and compositions for overcoming resistance to biologic and chemotherapy This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous,...
4	7419967	Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
5	7273856	Linear basic compounds having NK-2 antagonist activity and formulations thereof Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of...
6	7208481	Aminodiphosphonate apolipoprotein E modulators The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease...
7	7129227	Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpesviruses, is disclosed. The method comprises administering to a subject in need of such treatment an...
8	7115592	Phosphonate substituted pyrimidine compounds and methods for therapy Novel compounds are provided having formula (I) where R 1 , R 2 , R 3 , R 4 , Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the...
9	7071176	Aryl phosphate derivatives of AZT having anti-HIV activity Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular,...
10	7018989	Chemical compounds Aryl substituted phosphoryl derivatives of the formula In which Ar is phenyl, naphthyl, or pyridyl, Y is O or S, X 1 is O, NR 3 , S, CR 3 R 4 , CR 3 W 1 or CW 1 W 2 , X 2 and X 6 are a bond...
11	6936602	Benzazepine derivatives, process for the preparation of the same and uses thereof Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R 1 is a 5- to 6-membered...
12	6919322	Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
13	6878697	Phenylamino-pyrimidines and uses thereof This invention relates to compounds of the general formula: in which R A , R B , R C , R D , w, x, y, and z are as defined herein, and to their preparation and use.
14	6835386	Collar containing a novel gel formulation to control arthropod infestation of animals The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal...
15	6818633	Antiviral compounds and methods for synthesis and therapy Novel compounds are provided having formula (I) where R 1 , R 2 , R 3 , R 4 , Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the...
16	6812247	Organometallic complex A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen,...
17	6787525	Glyceryl nucleotides, method for the production thereof and their use The invention relates to glyceryl nucleotides of the formula Ia in which a) one of the radicals A 1 , A 2 and A 3 is a hydrogen atom or a radical selected from hydroxyl, mercapto, alkyl,...
18	6756391	Antiviral compounds The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
19	6747036	Methods of treating leukemia The present invention provides a novel method for treating leukemia and more particularly acute myelogenous leukemia (AML) in a host comprising administering to the host a therapeutically effective...
20	6723711	Propanoic acid derivatives that inhibit the binding of integrins to their receptors A compound of the structure A method for the inhibition of the binding of α 4 β 1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin;...
21	6723712	Antiviral agent for use in treatment of cancer The invention relates to an antiviral agent for use in combination with an anticancer agent, for the treatment of cancer. Especially, the invention provides means for the treatment of...
22	6706698	α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a),...
23	6653296	Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula (IA) and (IB) wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat...
24	6645972	Methods of treating leukemia The present invention provides a novel method for treating leukemia in a host that has been previously treated with a Bcr-Abl tyrosine kinase inhibitor comprising administering to the host a...
25	6620796	Combinatorial library synthesis and pharmaceutically active compounds produced thereby The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications,...
26	6605602	Method of treating BK virus nephropathy Provided are oligonucleotides for the quantitation of BK virus (BKV) viral loads in a sample and methods for the diagnosis and management of BKV-associated nephropathy using PCR or QPCR methods. In...
27	6500811	Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
28	6498151	Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and...
29	6455513	Chemical compounds Aryl substituted phosphoryl derivatives of the formula In which Ar is phenyl, naphthyl, or pyridyl, Y is O or S, X 1 is O, NR 3 , S, CR 3 R 4 , CR 3 W 1 or CW 1 W 2 , X 2 and X 6 are a bond...
30	6444656	Antiviral phosphonate nucleotides The present invention relates to a novel nucleotide analogue having the general formula (I) and pharmaceutically acceptable salts, esters, or salt of such esters: wherein n, X, Q U R1′, R1, Z...
31	6407080	N-(pyrimidinyl)-aspartic acid analogs as interleukin-1β converting enzyme inhibitors Disclosed are compounds, compositions and methods for inhibiting interleukin-1β (IL-β) protease activity. The compounds, N-(pyrimidinyl)-aspartic acid α-substituted methyl ketones and aspartic...
32	6399620	Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists There are described cycloalkyl derivatives of the formula (I) R 1 —Y—A—B—D—E—F—G (I) in which R 1 , Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and...
33	6362172	Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided...
34	6329354	Methods for the treatment of osteoporosis Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said...
35	6300356	Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
36	6274589	L-β-dioxolane uridine analogs and their pharmaceutical compositions The present invention relates to the discovery that certain β-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high...
37	6218376	Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists Compounds of formula I or salts thereof ##STR1## where for example Y is a group of the formula (i) ##STR2## and R 1 is a group of formula (ii) ##STR3## are provided along with compositions...
38	6201002	Method for reducing mortality with an angiotensin II antagonist Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce...
39	6200961	Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
40	6174874	Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and...
41	6136836	Compositions for the systemic control of parasites of warm-blooded animals A composition and method for controlling warm-blooded animal parasites comprising 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phen yl]-3-(2,6,dif luorobenzoyl)urea.
42	6107299	Substituted pyridine and pyrimidine, processes for their preparation and their use as pesticides Compounds of formula I, N-oxides or salts, thereof ##STR1## in which q is 0, 1 or 2 A is CH and D is N + R×1/n Q n - or A is N and D is N + R×1/n Q n - or A is CH or N and D is N or A...
43	6040299	Cold storage stabilized organophosphorus insecticide formulation and method of making same There is disclosed a cold storage stabilized organophosphorus insecticide formulation. The formulation comprises a solid carrier and between approximately 2% and 40% by weight of the ultimate...
44	6022876	L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections The present invention relates to the discovery that certain β-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high...
45	5922695	Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R 2 ) 2 OC(O)X(R) a , wherein R 2 ...
46	5914351	Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
47	5880111	Therapeutic derivations of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by...
48	5866514	Pesticidal composition to noxious organisms A pesticidal composition to noxious organisms which comprises a diarylalkane and an active component effective for killing or repelling noxious organisms and the diarylalkane is at least one member...
49	5856314	Thio-substituted, Nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism The present invention relates to thio-substituted, nitrogen-containing heterocyclic phosphonate compounds, including bisphosphonates, phosphonoalkylphosphinates, phosphonocarboxylates, and...
50	5854227	Therapeutic derivatives of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are...

Matches 1 - 50 out of 209

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