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9018191 Phosphonoxy quinazoline derivatives and their pharmaceutical use  
Quinazoline derivatives of formula (I): wherein A is 5-membered heteroaryl containing a nitrogen atom and one or two further nitrogen atoms; compositions containing them, processes for their...
8993542 Methods of treating viral infections  
The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an...
8969359 Gyrase and topoisomerase IV inhibitors  
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase...
8956648 Calciumphosphate-based nanoparticles as carrier-systems for photodynamic therapy  
The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic...
8957050 Bone implant materials comprising cross-linked bioactive hydrogel matrices  
The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently...
8940716 Bicyclic heteroaryl compounds as GPR119 modulators  
Novel compounds of structure Formula I: or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein A, D, Di, E, J, L, n, Q, R2 and R4 are defined herein, are provided which are...
8916545 Pharmaceutical compositions comprising POH derivatives  
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol...
8906885 Treating cancer with HSP90 inhibitory compounds  
Methods of treating cancer with a compound of formulae (I) or (1a) are disclosed. Also provided are methods of treating a cancer with a mutation in ALK or a c-MET mutation with a compound of...
8889123 Compositions and soft tissue replacement methods  
The invention relates to compositions comprising a hydrogel material that comprises a glycosaminoglycan polymer, adipose tissue and a compound of the structure where X1 and X5 are independently CH...
8883764 Formylpyrrole-based heterocycles for nucleic acid attachment to supports  
A compound has Formula I: A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, aryl, aldehyde, protected...
8883203 Solid oral dosage form containing an enhancer  
The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to enhance intestinal delivery of the bisphosphonate to the...
8754078 Compositions and methods for treatment of cancer  
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides methods of treating a cell...
8735384 Amino heteroaryl compounds as beta-secretase modulators and methods of use  
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including...
8697674 Xanthurenic acid derivative pharmaceutical compositions and methods related thereto  
The present invention relates to pharmaceutical compositions comprising xanthurenic acid derivatives, and methods of use thereof.
8673883 Pantothenate derivatives for the treatment of neurologic disorders  
The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions...
8664202 Cross-linked bioactive hydrogel matrices  
The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently...
8647830 Method for determining amino-terminal proANP in patients having a cardiac disease or being suspected of developing or having a cardiac disease  
The present invention relates to an in vitro method for medical diagnosis, prognosis and therapy follow-up for patients having a cardiac disease or being suspected of developing or having a...
8647829 Switchable affinity binders  
Methods and kits for binding and releasing biological targets, comprising, a binder comprising an environmentally reactive molecular switch that can switch between a high affinity state, to bind...
8633173 Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives  
This application relates, in part, to compounds of the general Formula I and/or salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to...
8618079 Imidazo[1,2-a] pyridinyl bisphosphonates  
Novel imidazo[1,2-α]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the...
8603980 Glutamate receptor antagonists and methods of use  
The present invention relates to methods and compositions for modulating platelet activity by inhibiting or activating glutamate receptors. The invention further relates to preventing or treating...
8592396 Glucokinase activators and methods of using same  
Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure wherein R1, R2, R3, R4, R5,...
8592395 Therapeutic compounds  
The present invention relates to compounds of Formula (I) and (Ia) useful in the treatment of CCR5-related diseases and disorders, for example, the prevention or treatment of an HIV infection, and...
8563569 Compositions and methods for inhibition of the JAK pathway  
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or...
8524691 Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections  
The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and...
8518911 Pyrazolo[1,5-a]pyridines as MARK inhibitors  
The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of...
8513219 Substituted phosphonates and their use in decreasing amyloid aggregates  
The invention relates to novel and known substituted phosphonates for use in ameliorating amyloid aggregates, particularly for use in the treatment of Alzheimer's disease.
8501713 Drug combinations for the treatment of duchenne muscular dystrophy  
Combinations comprising (or consisting essentially of) one or more compounds of formula (1) with one or more ancillary agents, to processes for preparing the combinations, and to various...
8450298 Aminoalcohol lipidoids and uses thereof  
Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting...
8440643 Inhibitors of beta-lactamase  
This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The...
8404664 Phosphonated Rifamycins and uses thereof for the prevention and treatment of bone and joint infections  
The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and...
8399433 Amino pyrimidine anticancer compounds  
Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including...
8372808 Suppression of glial fibrillary acidic protein  
Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell....
8361734 Xanthurenic acid derivative pharmaceutical compositions and methods related thereto  
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
8221737 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8207117 Methods of reducing hemorrhage due to surgical procedure  
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked...
8207146 Phenothiazine derivative having a double bond, method for the production thereof, and use thereof as a pharmaceutical  
The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
8163719 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to...
8110562 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof  
This invention provides nuclear hormone receptor binding compounds, compositions comprising the same and methods of uses thereof in treating a variety of diseases or conditions in a subject,...
8053423 Method of preparing cross-linked bioactive hydrogel matrices  
The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently...
8034576 Xanthurenic acid derivative pharmaceutical compositions and methods related thereto  
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
8008279 Compound—827  
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases,...
8003624 Functionally selective ALPHA2C adrenoreceptor agonists  
In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical...
7998946 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to...
7932240 Phosphadiazine HCV polymerase inhibitors IV  
Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formulas IV, IV′, I″, II″, or IVa, pharmaceutical compositions comprising the compounds, and processes of...
7902175 Aminopropanol derivatives  
Compounds of formula I: wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
7888336 Indole compounds bearing aryl or heteroaryl groups having sphingosine 1-phosphate (S1P) receptor biological activity  
The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as spingosine-1-phosphate agonists or antagonists. As such, the compounds described herein are useful...
7879826 Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them  
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein:A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms;R1 and R2 are,...
7879825 Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and methods of use thereof  
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided where at least one of R2 or R3 is not hydrogen. The compounds of the present invention are N-methyl-D-aspartate...
7807659 Caspase inhibitors and uses thereof  
The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these...