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5225434 |
Pesticidal and herbicidal polycyclic 3-aryl-pyrrolidine-2,4-dione derivatives
Insecticidal, acaricidal and herbicidal polycyclic 3-aryl-pyrrolidine-2,4-dione derivatives of the formula ##STR1## in which A represents the radical of a bi-, tri- or polycyclic system which is...
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5215974 |
Certain pyridyl[(methylthio- or methyl sulfinyl)-2 benzimidazol-2-yl]N-methyl phosphonates useful for treating gastric-acid secretion related diseases
Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine for treating gastric acid related...
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5212163 |
Compounds
Novel compounds of formula (I) and salts, solvates and hydrates thereof, processes for their preparation and their use in the treatment of conditions in which degradation of connective tissue and...
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5208229 |
2-(1,2,3-triazolylsubstituted)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
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5208235 |
Indole- and benzimidazole-substituted imidazole derivatives
Novel compounds having the formula ##STR1## where X R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore for...
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5202322 |
Quinazolinone and pyridopyrimidine a-II antagonists
Substituted quinazolinones and pyridopyrimidines of structural formula 1 ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the reninangiotensin system (RAS)...
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5196408 |
N-sulfenylated pyrazolines, compositions and use
N-sulfenylated and N-acrylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their...
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5190929 |
Cyclophosphamide analogs useful as anti-tumor agents
Cyclophosphamides possessing anti-tumor activity and having the formula ##STR1## and salts thereof; wherein R is lower alkyl, aryl, aryl-lower alkyl or a nitrogen, sulfur or oxygen containing...
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5190942 |
Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful,...
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5187179 |
Angiotensin II antagonists incorporating a substituted imidazo [1,2-b][1,2,4]triazole
There are disclosed substituted imidazo[1,2-b][1,2,4]triazole derivatives of Formula I which are useful as angiotensin II antagonists. ##STR1##
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5182284 |
Piperazine compounds, processes for preparation thereof and medical uses thereof
Disclosed are a piperazine compound of the formula below or a pharmaceutically acceptable salt thereof, medical uses thereof, and processes for preparing the same: ##STR1## wherein each of R and R'...
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5162340 |
Substituted 1-(2H)-isoquinolinones bearing acidic functional groups as angiotensin II antagonists
Substituted 1-(2H)-isoquinolinones of the structural formula: ##STR1## are angiotensin II antagonists which are useful in the treatment of hypertension and congestive heart failure.
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5162325 |
Angiotensin II antagonists incorporating a substituted benzyl element
Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
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5157025 |
Method for lowering serum cholesterol employing a phosphorus containing ACE inhibitor alone or in combination with a cholesterol lowering drug
A method is provided for lowering serum cholesterol and thereby inhibiting fatty streak lesions of atherosclerosis by administering to a patient a phosphorus-containing ACE inhibitor, such as...
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5157033 |
2-phenanthridonyl carbapenems having cationizeable substituents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
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5153184 |
((N-heterocyclyl)carbonyl)phosphoramidothioate ester insecticides
O,S-Dailkyl ((nitrogen heterocyclyl)carbonyl)phosphoramidothioates are prepared by the reaction of O,S-dialkyl phosphoroisocyanatidothioates with selected five and six membered nitrogen...
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5145845 |
Substituted 2-carboxylindoles having pharmaceutical activity
The present invention relates to novel compounds, which are derivatives of ureas, thioureas, carbamates, sulfonylureas, sulfonamides, amides, and thioamides of 2-carboxyindoles as illustrated by...
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5143914 |
2-heteroarylphenyl-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
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5133972 |
Topically administrable pharmaceutical preparations
The invention relates to topically adminstrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein...
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5134131 |
Phosmet treatment for pig mange
Pig mange mite infestations are controlled or eradicated by application of a pour-on formulation containing phosmet. A suitable regime is to apply about 20 mg/kg of phosmet to sows shortly before...
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5128335 |
2-heteroarylphenyl-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
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5124323 |
2-(quinoliniumalkyl and isoquinoliniumalkyl) phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## In which Q + is quinolinium or isoquinolinium, are useful antibacterial agents.
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5118703 |
Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
Certain enol ethers and esters of the formula ##STR1## where X and Y are each hydrogen, fluoro or chloro; R 1 is 2-thienyl or benzyl and R is alkanoyl, cycloalkylcarbonyl, phenylalkanoyl,...
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5118675 |
Quinoxaline phosphono-amino acids
The compounds of the formula: ##STR1## in which Q is the quinoxaline nucleus; m is one of the integers 0, 1 or 2; n is one of the integers 1,2 or 3; or a pharmaceutically acceptable salt, alkyl...
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5116827 |
Quinolinecarboxylic acid derivatives as solubilized pro-drugs
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine,...
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5104863 |
Certain bicycloalkane and azabicycloalkane-1,1-diphosphonic acid derivatives useful for treating diseases associated with abnormal calcium and phosphate metabolism
This invention relates to pyrindine-diphosphonic acid derivatives which are useful in treating or preventing diseases characterized by abnormal calcium and phosphate matabolism, in particular those...
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5102875 |
Phosphonate substituted amino acids useful as antihypertensives
Hypotensive activity is exhibited by new phosphonate substituted amino or imino acids of the formula ##STR1## isomeric mixtures thereof and pharmaceutically acceptable salts thereof, wherein: X is...
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5084447 |
C-3 phosphine oxide substituted carbacephalosporins
This invention provides novel 3-phosphine oxide substituted 1-carba(1-dethia)cephalosporins useful as anti-microbial agents, and formulations and methods of use thereof.
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5077282 |
Solubilized pro-drugs
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine,...
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5073547 |
Dopamine pro-drug
A monophosphorylated L-dopa ester of formula ##STR1## (wherein the asterisk, R, R 1 , R 2 and R 3 have the meanings shown in the description), salts thereof with pharmaceutically acceptable...
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5073380 |
Oral sustained release pharmaceutical formulation and process
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a...
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5064851 |
3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
This invention relates to novel 3-(1-substituted-pyrazoyl)-2-oxindole derivatives which are inhibitors of prostaglandin H 2 synthease, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds...
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5057505 |
Substituted aminomethanediphosphonic acids and use in medicaments
Heteroarylaminomethanediphosphonic acids of the formula ##STR1## in which R 1 represents an optionally benzo- or cyclohexeno-fused 5-membered heteroaryl radical that contains, as hetero atom(s),...
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5045311 |
Plant-protective composition of increased stability containing nonionic surfactant only
The invention relates to an emulsifiable microemulsion concentrate containing a phophoric acid ester and/or thiophosphoric acid ester as active ingredient. In addition to 20 to 80% by weight of...
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5043163 |
Pesticide composition
The present invention relates to a multi-component pesticidal composition against anthropoda containing as active ingredient pyrethroides and phosphate esters and optionally piperonyl butoxide and...
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5039669 |
Heterocyclic bisphosphonic acid derivatives
A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): ##STR1## in which .circle.Het means one of the following (A) and (B): ##STR2## wherein a...
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5037820 |
Carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
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5034385 |
2-(heteroarylsubstituted)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
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5034384 |
2-(9-fluorenonyl)-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## wherein either the 2-fluoren-9-one or 3-fluoren-9-one is attached at the 2-position of the carbapenem are useful antibacterial agents.
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5025000 |
Phosphorus-containing HMG-CoA reductase inhibitor compounds
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH,...
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5004740 |
2-phenanthrenyl-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
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5002937 |
Diphosphonic acid compounds and use for calcium metabolism disorders
The present invention provides compounds of the formula: ##STR1## The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing...
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4980348 |
Carbacephem antibiotics
A heteroanellated phenylglycine-β-lactam antibiotic of the formula ##STR1## in which R 1 - stands for a radical of the formula ##STR2##
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4978659 |
2-(Heteroaryliumalkyl)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
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4975278 |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
This invention relates to a novel method for the delivery of cytotoxic drugs to tumor cells by the administration of a tumor-specific antibody-enzyme conjugate that binds to the tumor cells, and...
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4971957 |
Carboxamide compounds, processes for preparing the same and a pharmaceutical composition containing the same
Novel carboxamide compounds represented by the general formula (I) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases...
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4971958 |
Diphosphonic acid derivatives, pharmaceutical compositions and methods
The present invention provides diphosphonic acid derivatives of the general formula: ##STR1## according to claim 1. These compounds are useful for the treatment or prophylaxis of calcium metabolism...
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4962101 |
2-(Heterocyclylalkyl)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
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4948787 |
Inhibition of mercaptan odor in organothiophosphate biocides
Mercaptan odors in a thiophosphate compound or formulation are suppressed by treatment of the compound during preparation of the formulation with treatment agents selected from iodine, and alkali...
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4943307 |
Plant-protective pesticidal composition
The invention relates to a plant-protective solution containing 2.5 to 40 % by weight of one or more water-insoluble plant-protective ingredient(s) 20 to 71.5 % by weight of dimethylformamide...
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