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8173118 |
Compositions consisting essentially of TGF-β, BMP-2 FGF-4, leukemia inhibitory factor, IGF-1, IL-6 and H-α-thrombin
This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for...
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8163694 |
Method of treating diseases or abnormal conditions of periodontal or dental tissues with GDF5
The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic proteins, wherein depending on the subject matter the proteins may be dimeric or...
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8147862 |
Highly mineralized osteogenic sponge compositions and uses thereof
Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed...
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8148329 |
Osteogenic implants with combined implant materials and methods for same
Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The...
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8142781 |
Fusion proteins for blood-brain barrier delivery
The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier while allowing their activity once across the barrier to remain...
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8124130 |
Formulations and methods for recovery from dental surgery
Methods and formulations for the improvement of recovery following bone-impacting injury or surgery. The formulations of the present invention preferably include platelet-rich plasma with a...
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8114428 |
Methods for manufacturing a composition for treating bone and/or cartilage defects
The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment,...
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8110548 |
Method for treating cartilage disorders
The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting...
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8106001 |
Diagnostic markers of human female infertility
The subject invention pertains to methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility,...
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8101198 |
Osteogenic enhancer composition
An osteogenic enhancer composition for bone and cartilage repair and methods of using the same are described.
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8088732 |
Compositions comprising physiologic concentrations of cytokines
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing sol...
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8080060 |
Processes and systems for loading medical implants with simulative growth agents
Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts...
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8058066 |
Cellular factor-containing solution compositions
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing sol...
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8053412 |
NELL-1 peptides
Recombinant NELL peptides and methods of preparing the same are disclosed.
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8008074 |
Compositions and methods for improving bone mass through modulation of receptors of PTH and fragments thereof
The present invention relates to the discovery of novel receptors for the signaling of PTH and/or fragments of PTH, and the role of cPTH in bone development. The novel PTH receptors identified are...
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7981421 |
Combinations of antibodies selective for DR5 and other therapeutic agents
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and...
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7964561 |
Protein formulations for use at elevated temperatures
Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5,...
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7947649 |
Liquid buffered GDF-5 formulations
Improved formulations and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an acetate buffered solution of GDF-5 and other excipients wherein...
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7928068 |
Methods for using GEP, a chondrogenic growth factor and target in cartilage disorders
The present invention relates to the expression and regulating growth factors in chrondrocytes and developing cartilage, particularly granulin-epithelin precursor (GEP). The invention relates to...
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7923432 |
Implant depots to deliver growth factors to treat avascular necrosis
The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to...
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7902150 |
Medicaments and proteins based on TGF-β monomers for the treatment of wounds
There is provided the use of monomeric TGF-βs, or there fragments or derivatives, as medicaments. These medicaments preferably comprise monomeric TGF-β3, or fragments or derivatives thereof. The m...
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7897164 |
Compositions and methods for nucleus pulposus regeneration
Compositions for nucleus pulposus regeneration is provided. Such composition may comprise a scaffolding material and a pore creating agent dispersed within the scaffolding material. The pore...
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7897163 |
Bone graft and scaffolding materials immobilized with osteogenesis enhancing peptides on the surface
The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More...
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7884072 |
Prolactin induced increase in neural stem cell numbers
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ,...
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7851435 |
Bone morphogenetic protein 3 and osteogenic devices and pharmaceutical products containing thereof
The present invention relates to reindeer bone formation inducing protein called bone morphogenetic protein 3c (BMP-3c), nucleotide molecules encoding the protein and host cells expressing the...
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7795202 |
Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a)
The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-α polypeptides, related ...
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7790669 |
Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-α)
The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a...
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7786080 |
Mutein of a bone morphogenetic protein and use thereof
The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at...
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7763257 |
Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
The present invention relates to a composition and methods or uses thereof in the prophylaxis and treatment of psoriasis and other auto-immune inflammatory disorders. The composition may be...
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7763580 |
Methods for treating conditions associated with the accumulation of excess extracellular matrix
The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of...
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7758895 |
Methods for purifying insoluble bone gelatin
The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding...
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7754689 |
Finger-1 peptide analogs of the TGF-β superfamily
Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
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7744895 |
Methods of treating allergies using TGF-β1 and allergens
The invention provides an allergy prevention method or treatment method, diets and oral drugs enabling prevention/treatment of allergic symptoms without trouble such as systemic adverse reaction,...
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7740849 |
Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sFlt-1...
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7741283 |
Compositions and methods for inhibiting cell proliferation
Disclosed are compositions and methods useful in the regulation of cell proliferation. The invention provides TGF-β (transforming growth factor β) and IGFBP-3 (insulin like growth factor binding p...
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7737131 |
Multifunctional and biologically active matrices from multicomponent polymeric solutions
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention...
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7723291 |
Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix
A pump to deliver bone-growth factors to a carrier matrix within a patient. Pump can be internal or external. With external pumps, additional amounts of the same growth factor may be added, or the...
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7709439 |
Biomaterials for enhanced healing
The present invention relates to novel biomaterials and methods of using these new biomaterials to facilitate wound healing. The novel biomaterial may be a biocompatible polymer to which at least...
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RE41286 |
Compositions for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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7700562 |
Use of —furin—“convertase” inhibitors in the treatment of fibrosis and scarring
The present invention relates to use of convertase inhibitors for the reduction of scarring during the healing of wounds and also for reducing fibrosis in the treatment of fibrotic conditions.
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7700563 |
Synthetic heparin-binding factor analogs
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two...
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7691816 |
Pharmaceutical compositions
The invention provides pharmaceutical compositions comprising TGF-β superfamily members and sugars, the compositions allowing improved recovery and/or increased biological activity of the TGF-β s...
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7687460 |
Methods of treatment using wisp polypeptides
The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising...
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7671012 |
Formulations and methods for delivery of growth factor analogs
Formulations, kits and methods for bone or cartilage repair, including treatment of osteogenic defects, including formulations of synthetic heparin-binding growth factor analogs, non-ionic...
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7648965 |
Method for fostering bone formation and preservation
A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood...
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7638495 |
Peptides as solubilizing excipients for transforming growth factor β proteins
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension...
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7638486 |
Method for promoting hard tissue formation
Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprising two...
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7601341 |
Vascular endothelial growth factor fusion constructs used to inhibit osteoclastogenesis
The 121-amino acid isoform of vascular endothelial growth factor (VEGF121) is linked by a flexible G4S tether to a cytotoxic molecule such as toxin gelonin or granzyme B and expressed as a soluble...
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7579322 |
Compositions and methods for promoting myocardial and peripheral angiogenesis
Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD...
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7576052 |
Methods and compositions for modulating adipocyte function
Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.
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