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7105167 |
Methods for treating clinical manifestations of GH/GF axis dysregulation by administration of an IGF-I variant
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder...
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7087577 |
Method of promoting natural bypass
An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The...
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7074397 |
Method for enhancing proliferation or differentiation of a cell using ob protein
Uses for WSX ligands in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for stimulating hematopoiesis (e.g., myelopoiesis, erythropoiesis and especially, lymphopoiesis)...
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7071162 |
Combined use of cementum attachment protein and cyclosporin a for improved attachment of dental and orthopedic implants
A method is described for inducing the formation of cementum and a periodontal ligament between a dental implant and bone by administering cementum attachment protein (CAP) together with a...
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6974681 |
Cell culture performance with vanadate
The invention provides methods and compositions for improved in vitro culture of cells that make use of vanadate. The methods enhance cell survival thereby recovery of the polypeptide of interest...
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6946443 |
Biomaterial based on an insolubilized dextran derivative and a growth factor
The invention concerns a biologically active material essentially comprising at least an insolubilized dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an...
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6927204 |
Treatment of inner ear hair cells
Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are...
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6881398 |
Therapeutic dry powder preparation
A therapeutic dry powder preparation and a method of administering such a preparation are disclosed for effectively de-aggregating and dispersing into air a dose of medication powder in an...
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6852687 |
Method for inhibiting apoptosis
The present invention relates to a method for treating a subject having a condition or disease involving apoptosis, which comprises administering an effective amount of albumin to the subject. The...
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6723344 |
Controlled release of non heparin-binding growth factors from heparin-containing matrices
Matrices that support cell adhesion and growth are disclosed that deliver low heparin-binding affinity growth factor protein peptides in a controlled manner. These matrices comprise covalently or...
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6677500 |
Ungulates expressing exogenous IGF-I in their milk
The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also...
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6645945 |
Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors
A composition is provided for treating diseased, injured or diseased cartilage comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to...
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6610302 |
Anti-tumor activity of Ea-2 and Ea-4-peptide of pro-IGF-I
Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.
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6565842 |
Crosslinkable polypeptide compositions
In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to...
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6528479 |
Dominant negative mutants of IRS-1 and uses thereof
Dominant negative mutants of mammalian IRS-1 proteins and therapeutic compositions containing such mutants. Also featured are methods of using the dominant negative mutants to inhibit tyrosyl...
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6506727 |
Nerve regeneration
It has been found that the growth factor PDGF, when used in combination with another growth factor such as IGF-I, acts synergistically with the other factor to promote neuronal regeneration.
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6468543 |
Methods for promoting growth of bone using ZVEGF4
Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective...
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6461613 |
Methods and compositions for the selective regulation of chorionic prostanoids
Methods for inhibiting the production of specific vasoconstrictive prostanoids, such as thromboxane and prostaglandin F2α, through the addition of insulin like growth factor, particularly IGF-I or ...
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6436897 |
Pharmaceutical formulations for IGF/IGFBP
New pharmaceutical formulations for IGF/IGFBP complex are disclosed. IGF/IGFBP complex, preferably rhIGF-I/IGFBP-3 complex is formulated with bulking agents and optionally buffer salts, but without...
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6326154 |
Ligand-mediated immunofunctional hormone binding protein assay method
A ligand=mediated immunofunctional assay (LIFA) method for detecting the presence and the concentration of polypeptide hormone binding proteins which comprises capturing the binding protein with a...
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6310040 |
Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs
Disclosed is a method for promoting retinal neuronal survival in a mammal, wherein the neuronal cells are at risk of dying. The method comprises administering to the mammal an effective dose of at...
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6309633 |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
The invention provides a drug-oligomer conjugate having the following general formula: ##STR1##wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected...
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6309381 |
Use of human growth hormone to treat acute myocardial infarction
A method of treating an acute myocardial infarction (AMI) using human growth hormone to prevent most of the complications and the destructive process of cells and collagen framework which are...
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6306432 |
High and low load formulations of IGF-I in multivesicular liposomes
Disclosed are multivesicular liposomes (MVLs) containing IGF-I with substantially full bioavailability, wherein the loading of the IGF-I into the liposomes is modulated by adjusting the osmolarity...
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6284282 |
Method of spray freeze drying proteins for pharmaceutical administration
The present invention relates to the spray freeze dry preparation of dry powder formulations of therapeutic proteins suitable for administration via pulmonary delivery.
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6211142 |
Compositions comprising gas6 polypeptides and articles of manufacture comprising the same
An activator of the Rse receptor protein tyrosine kinase has been identified which is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the present invention provides compositions...
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6207640 |
Treatment of partial growth hormone insensitivity syndrome
Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering an...
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6183784 |
Method of ameliorating alimentary tract damage due to chemotherapy or radiation
A milk product extract composiiton including a plurality of cell growth stimulating factors, extracted from milk product, in concentrated form; said factors having basic to approximately neutral...
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6180606 |
Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors,...
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6180603 |
Method for administering neurologic agents to the brain
Disclosed is a method for transporting neurologic therapeutic agents to the brain by means of the olfactory neural pathway and a pharmaceutical composition useful in the treatment of brain disorders.
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6153582 |
Defined serumfree medical solution for ophthalmology
A defined serumfree medical solution for applications in Ophthalmology, that contains one or more cell nutrient supplements, and a growth factor(s) which maintains and enhances the preservation of...
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6136785 |
Protection from loss of sensory hair cells in the inner ear by administration of insulin-like growth factor and platelet derived growth factor
The invention relates to a method for protecting sensory hair cells of the inner ear from damage caused by ototoxic drugs, in particular, aminoglycoside antibiotics, by administering to a...
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6124264 |
Heterocyclic compounds
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6087090 |
Methods for predicting drug response
Methods are provided for formulating models for predicting whether subjects will respond to a particular drug or treatment regimen. Biochemical profiles are obtained (by measuring a variety or...
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6043251 |
Use of 1-(2-naphth-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyr idine for preparing drugs for treating amyotrophic lateral sclerosis
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6025368 |
Method for treating the symptoms of chronic stress-related disorders using IGF
Methods are provided for treating or alleviating the symptoms of subjects with psychological disorders, metabolic disorders, chronic stress-related disorders, sleep disorders, conditions associated...
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6024734 |
Treatment methods using homeopathic preparations of growth factors
The present invention comprises homeopathic dilutions of growth factors and methods for their use. Disorders which may be effectively treated with the compositions of the present invention include...
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5997856 |
Method and compositions for solubilization and stabilization of polypeptides, especially proteins
The invention provides a method for the solubilization and/or stabilization of polypeptides, especially proteins, using cyclodextrin selected from the group consisting of hydroxypropyl,...
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5994303 |
Use of insulin and IGF-I
A combination of insulin and an insulin-like growth factor I (IGF-I) as used in the manufacture of a medicament for counteracting a decrease in nitrogen balance and for counteracting a decrease in...
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5965520 |
Therapeutic treatment of rheumatoid arthritis and polymyalgia rheumatica
Disclosed is a therapeutic regime for treating patients with rheumatoid arthritis (RA) Supplemental growth hormone is periodically administered to raise insulin-like growth factor 1 (IGF-1) levels,...
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5951972 |
Stabilization of somatotropins and other proteins by modification of cysteine residues
The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing...
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5935940 |
Compositions and methods for modulating growth of a tissue in a mammal
Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a...
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5919459 |
Compositions and methods for treating cancer and hyperproliferative disorders
The present invention encompasses methods for reducing or inhibiting growth factor in cancer cells and tissues. More particularly immunogenic growth factor-containing compositions are administered...
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5916569 |
Human erectile dysfunction and methods of treatment
This invention is a method for treating human erectile dysfunction using therapeutic amounts of human growth hormone (GH) administered systemically. Severing the parasympathetic nerves that...
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5902799 |
Methods of modulating tissue growth and regeneration
Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a...
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5861373 |
IGF-1 to improve the neural condition
A method of treating injuries to or diseases of the central nervous system that predominantly affects glia and/or non-cholinergic neuronal cells characterized in that it comprises the step of...
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5858966 |
Fetal growth
A method of enhancing fetal growth and/or development and/or neonatal survival by the administration over a period of insulin-like growth factor (IGF-1), to either the amniotic fluid or direct to...
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5855920 |
Total hormone replacement therapy
A hormone replenishment method particularly useful in maintaining the body's neuroendocrine clock at optimal levels and combating conditions associated with advancing age is disclosed. The method...
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5843775 |
Human dorsal tissue affecting factor (noggin) and nucleic acids encoding same
Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.
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5837675 |
Synergistic effect of insulin-like growth factor-I and erythropoietin
Erythropoietin (EPO) and insulin-like growth factor (IGF); pharmaceutical compositions thereof and therapeutic and prophylactic methods to increase the hematocrit are disclosed herein. Increase in...
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