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6660271 |
Ubiquitin fusion-based vaccine system
Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising...
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6656466 |
Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
The present invention relates to novel process for the preparation of glycoproteins by mammalian cell culture wherein the sialic acid content of the glycoprotein produced is controlled over a broad...
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6656462 |
Interleukin-1 muteins useful as vaccine adjuvants
The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example,...
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6653286 |
Gonadotropin releasing hormone antagonist
The present invention relates to a method to prevent a premature LH surge. The method employs the administration of the gonadotropin releasing hormone antagonist ganirelix in an amount between...
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6649165 |
Method of blocking cytotoxic activity in patients with amyotrophic lateral sclerosis using soluble Fc&ggr RIII receptors
The present invention is directed to a method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using an effective amount...
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6645935 |
Synthesis of glycoconjugates of the lewis Y epitope and uses thereof
The present invention provides a method of synthesizing an allyl pentasaccharide having the structure: as well as related oligosaccharide ceramides and other glycoconjugates useful as vaccines...
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6645484 |
Method of blocking blood vessel growth using tie-2 ligand 2
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2...
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6642205 |
Methods and compositions for reducing side effects in chemotherapeutic treatments
A pharmaceutical compound and a process for making the compound is provided where the compound includes a therapeutic agent, a spacer and a galactose, the spacer being covalently linked to the...
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6641809 |
Method of regulating cellular processes mediated by B7 and CD28
The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins...
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6638906 |
Amphiphilic polymers and polypeptide conjugates comprising same
Proteins and/or peptides, such as luminal cholecystokinin releasing factor (LCRF), are conjugated with amphiphilic oligomers and polymers. Such conjugates may modulate the pharmacokinetic profile...
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6638909 |
Wound healing compositions containing alpha-1-antitrypsin
The invention provides the use of alpha-1-antitrypsin for the preparation of a composition for the treatment of a chronic wound, such as a pressure sore or a venous ulcer. The composition is...
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6635616 |
Laminin 15
The present invention features a novel member of the laminin family, i.e., laminin 15, the methods of making these molecules, and the methods of using these molecules in treating neural disorders,...
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6630457 |
Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized...
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6630148 |
Compositions comprising hedgehog proteins
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning...
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6627604 |
Memno peptides, process for their preparation and use thereof
The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and (A)n have the meaning herein, obtainable...
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6627201 |
Composition for drinking/eating and beverage/food
The composition for beverages/food of the present invention is a mixture of the AGARICUS BLAZEI MURRILL fruiting body and mycelium extract in a ratio by dry weight of 1:0.05 to 1:0.5, and chlorella...
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6620798 |
Synergistic agents for enhancing tissue repair
Methods for the repair, reconstruction and protection of tissue using compositions containing flavonoids and/or flavonols, including simultaneous administration of agents in order to obtain...
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6613741 |
Method for treating aseptic SIRS in humans and other animals
The method of the present invention provides a novel use of the iron binding protein lactoferrin to prevent or treat the insult-induced metabolic imbalance in humans and other animals. More...
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6613332 |
Oral administration of therapeutic proteins
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and...
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6613737 |
Process for the purification of a new motility-promoting protein from buffalo serum: a slaughter house waste
The present invention relates to a new motility-promoting protein macromolecule and a process for the isolation of the motility promoting protein from buffalo serum/plasma, a slaughter house waste....
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6607897 |
Recombinant proCVF
Recombinant proCVF exhibits substantially the same activity as CVF and is useful for lowering complement activity.
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6605592 |
Protein HOFNF53
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. In particular, the present application...
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6605280 |
Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs...
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6602850 |
Method of treating asthma using soluble IL-9 receptor variants
This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One...
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6599873 |
Interleukin-1 inhibitors, compositions, and methods of treatment
Interleukin-1 inhibitors are provided. Compositions comprising an interleukin-1 inhibitor are provided. Methods of treating a patient comprising administering an interleukin-1 inhibitor are provided.
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6596689 |
Therapeutic method using fucose-containing proteoglycan or acidic glycan
A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate selective proliferation of mammalian natural...
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6592862 |
Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
Described is the modulation of the growth of collateral arteries and/or other arteries from preexisting arterlolar connections. Methods are provided for enhancing the growth of collateral arteries...
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6586392 |
Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention...
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6576239 |
Angiogenic homing molecules and conjugates derived therefrom
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a...
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6573071 |
Factor X analogues with a modified protease cleavage site
Factor X analogues having a modification in the region of the natural Factor Xa activation cleavage site, said modification representing a processing site of a protease not naturally cleaving in...
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6573249 |
Topical wound therapeutic compositions
There is provided a composition for healing burns and wounds in mammals, which contains a cromolyn compound or the combination of a cromolyn compound and hyaluronic acid a corticosteroid. ...
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6569419 |
Methods for promoting production of myelin by Schwann cells
A method for promoting the expression of myelin or Protein Zero in Schwann cells using Zcyto7 or IL-17. Zcyto7 or IL-17 are further used to promote myelination of the peripheral nervous system....
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6569831 |
Recombinant lactoferrin, methods of production from plants and uses
The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a...
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6566329 |
Freeze-dried preparation of human growth hormone
A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method...
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6565842 |
Crosslinkable polypeptide compositions
In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to...
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6566331 |
Treatment of collagen related diseases
The present invention provides for the treatment of a patient suffering from a collagen related disease utilizing a serine protease inhibitor. The treatment includes the use of a corticosteroid...
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6566386 |
Immunomodulating and antiinflammatory agent
In the present invention, pharmaceutical compositions containing a histamine-added gamma-globulin as an effective component are used as an immunomodulating agent, a suppressive agent for...
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6562347 |
Chemokine-tumor antigen fusion proteins as cancer vaccines
The present invention provides a fusion polypeptide comprising a chemokine and either a tumor or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune...
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6562334 |
Canine interleukin 12 administration as an immune disease treatment
Canine interleukin 12 and a method for producing it by genetic engineering are disclosed. The canine interleukin 12 includes a protein having an amino acid sequence substantially the same as SEQ ID...
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6562820 |
Method for treatment and prevention of mastitis
The invention is directed to a method of treatment or prevention of mastitis in mammals with known oxazolidinone anti-bacterial agents, either alone or in combination with exogenous lactoferrins.
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6558687 |
Fibrin polymer structure
In accordance with the present invention a novel fibrin polymer structure is disclosed. The novel fibrin polymer structure useful, for example, as a surgical sealant, is comprised of a plurality of...
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6555105 |
Method of treatment with a RANTES antagonist polypeptide
Modifications to RANTES can result in the modified polypeptide acting as a RANTES or MIP-1α antagonist. Such antagonists can be used in therapy to reduce inflammation. They are also useful in...
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6551993 |
Partial agonists at the glycine modulatory site of the NMDA receptor for treating cognitive dysfunction
The present invention involves the use of partial glycine agonists directed at the glycine modulatory site of the NMDA receptor to treat cognitive dysfunction in mammals with Parkinson's disease or...
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6548482 |
Treatment of osteoporosis
A substantially pure complex including IGFIIE polypeptide and IGFBP2 polypeptide is described. Methods for treating an osteoporosis patient and targeting a compound to the skeletal extracellular...
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6541449 |
Increasing function of organs having reduced red blood cell flow
The present invention relates to a method of therapeutically, or prophylactically, treating a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in tissue of a vertebrate...
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6540993 |
Method of treating inflammatory bowel disease using a topical formulation of IL-11
Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease,...
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6537988 |
Synergistic methods and compositions for treating cancer
The present invention provides a synergistic method for the treatment of cancer which comprises administering to a mammalian specie in need thereof a synergistically, therapeutically effective...
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6538028 |
Method for inhibiting complement activation
A method of inhibiting complement activation, particularly by a transplanted tissue, in a warm-blooded vertebrate. The method includes administering a therapeutically effective amount of a platelet...
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6534477 |
Production and use of modified cystatins
Cystatins that have been modified by glycosylation in order to enhance stability and activity are disclosed, as are methods of making such cystatins and methods of using such cystatins to inhibit...
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6534475 |
Use of TIMP-3 inducers of TIMP-3 expression, and TIMP-3 mimetics to treat ocular neovascularization
Methods and compositions for treating ocular neovascularization with TIMP-3, TIMP-3 inducers, and TIMP-3 mimetics are disclosed.
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