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7375086 |
Modulators of Nod2 signaling
The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying...
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7375081 |
Therapeutic combination of a pneumocandin derivative and an antifungal agent
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention...
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7375080 |
Immobilized lactoferrin (Im-LF) antimicrobial agents and uses thereof
Disclosed is a composition of matter comprising a defined dispersion of lactoferria immobilized on a naturally occuring substrate via the N-terminus region of the lactoferrin. Compositions...
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7371726 |
Neutralizing GDF8 epitope-based growth enhancing vaccine
The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new...
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7371388 |
Treatment of Sjogren's syndrome by administration of TR18 polypeptides
The present invention relates to TR18 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR18 protein. TR18 polypeptides are also provided as are vectors, host...
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7368422 |
Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the...
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7368106 |
Use of a promoter of T-cell expansion and an inducer of CD40 stimulation in the treatment or prevention of a pathologic state
The invention provides a method of treating or preventing a pathologic state in a mammal. The method comprises administering to the mammal a promoter of T-cell expansion and an inducer of CD40...
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7365053 |
Selective N-acylation of A82846 glygopeptides analogs
The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared...
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7365052 |
Tendon-inducing methods
Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related...
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7357925 |
Method for treating disorders and diseases treatable with human fibroblast interferon
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys 17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A...
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7358227 |
Pharmaceutical compositions comprising bone morphogenetic protein monomers for inhibiting bone formation
The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in...
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7354588 |
Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV
The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as...
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7354901 |
Production of recombinant BMP-2
In order to recombinantly prepare a biologically active protein of the TGF-β superfamily, a protein, whose amino terminus consists of the pro sequence of a protein of the TGF-β superfamily, or...
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7354902 |
Recombinant lactoferrins, methods of production from plants and uses thereof
The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a...
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7354899 |
Methods of treating autoimmune diseases comprising administering CXCR4 antagonists
The invention provides a variety of therapeutic uses for CXCR4 antagonists. In various embodiments, CXCR4 antagonists may be used as therapeutically as follows, or to manufacture a medicament for...
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7351691 |
Glycopeptide phosphonate derivatives
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
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7348309 |
Glycorandomization and production of novel vancomycin analogs
The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in...
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7347999 |
Methods of treatment of hematopoietic disorders
A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM), optionally comprising bone morphogenetic protein (BMP), particularly for...
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7348311 |
Derivatives of dehydrodidemnin B
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives
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7344699 |
Drug conjugate comprising an erythropoietin receptor ligand and an anticancer agent
A drug conjugate comprising a targeting agent and an anti-cancer agent, wherein said targeting agent comprises an erythropoietin receptor ligand, is described. The drug conjugate can be used in...
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7345019 |
Modulation of excitable tissue function by peripherally administered erythropoietin
Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as...
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7344858 |
Glycosylated human granulocyte colony-stimulating factor (G-CSF) isoform
Disclosed are human G-CSF isoforms having a modified amino acid sequence containing a glycosylation sequence Asn-X-Ser/Thr (N-X-S/T) at one or more specific amino acid positions according to the...
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7341999 |
Povidone-containing carriers for polypeptide growth factors
A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic...
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7341720 |
Targeting of glycoprotein therapeutics
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
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7341992 |
Lectin-like domain of thrombomodulin and its therapeutic use
The in vivo role of the N-terminal lectin-like domain of thrombomodulin was studied by using homologous recombination in murine ES cells to create mutant mice that lack this region of...
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7341993 |
Cross-linked glycopeptide—cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7338932 |
Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to...
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7338933 |
O-linked glycosylation of peptides
The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in...
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7332156 |
Methods of treating wounds using IL-23
Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods...
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7332149 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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7329643 |
Inhibition of HMGB1 release by fetuin
Methods of inhibiting HMGB1 release by a mammalian cell are provided. The methods comprise treating the cell with sufficient fetuin to inhibit HMGB1 release. Methods of inhibiting an inflammatory...
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7329642 |
β-2-glycoprotein is an inhibitor of angiogenesis
The present disclosure provides a method of inhibiting angiogenesis within a tissue of interest by providing either intact or nicked β2-Glycoprotein 1 (β2GP1) to cells associated with the tissue....
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7326411 |
Use of amino-terminally truncated RANTES to inhibit HIV viral replication
The present invention relates to amino-terminally truncated RANTES, lacking NH 2 -terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3 or 1-4 of the naturally-occurring RANTES (SEQ...
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7323440 |
De-immunized MOG (poly)peptide constructs
The present invention relates to a (poly)peptide construct consisting of at least two domains of at least two pluralities of domains wherein one of said domains or pluralities of domains comprises...
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7323171 |
Methods of treating skin conditions using inhibitors of the CD2/LFA-3 interaction
Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in...
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7323179 |
Methods and compositions for the treatment and prevention of Staphylococcus and other bacterial infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria, including in particular bacteria in...
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7323443 |
Lactoferrin in the reduction of pain
The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone...
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7318926 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7314857 |
Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
A synergistic antimicrobial composition for inhibiting biofilm formation includes an iron-sequestering glycoprotein, a cationic polypeptide and a chelating agent, or an iron-sequestering...
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7312194 |
Delivery systems
The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as...
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7309483 |
Method of treatment using Tie2 ligand2
The invention provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or...
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7309687 |
Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin
Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as...
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7306791 |
Agent for preventing and/or treating multiple organ failure
The present invention provides methods of preventing and/or treating multiple organ failure comprising the step of administering a therapeutically effective amount of agent comprising tumor...
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7307062 |
Method for treating a mental disorder
A method of treating an individual exhibiting at least one symptom of a mental disorder is provided which comprises administering to the individual an antimicrobial composition in an amount...
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7297343 |
Bioactive medical films
A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a...
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7294615 |
Compounds that associate on the intermolecular level and aggregate bodies that contain them
Compound of the general formula (I)
X(B) m (I)
wherein
X is an m-valent...
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7291593 |
Use of fish for treating infertility
The present invention relates to the use of FSH and/or a biologically-active analogue thereof in the production of a medicament for the treatment of infertility in women. The medicament is for...
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7285526 |
Interferon antagonists useful for the treatment of interferon related diseases
The present invention relates to a process for ameliorating or preventing diseases that are caused, in part, by an increased level of, and/or an abnormal responsivity to, interferon. Alzheimer's...
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7285532 |
Therapeutic method for treating bone formation diseases
Methods of treating and/or inhibiting a bone morphogenetic protein (BMP)-related disorder or condition by administering a BMP antagonist to a subject suffering from a BMP-related disorder or...
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7282481 |
Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same
A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active...
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