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6075006 |
Soluble tachykinin antagonists, the preparation and use thereof
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6074636 |
Method of using cell surface receptor targeted molecules for the treatment of viral diseases
The invention features a method for treating a patient infected with a virus. The method includes administering to the patient a molecule which is capable of specifically binding to a proteinaceous...
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6069135 |
Use of hyaluronic acid or its derivatives to enhance delivery of therapeutic agents
A pharmaceutical composition is provided comprising: (1) an agent selected from a medicinal agent and a therapeutic agent and combinations thereof in a therapeutically effective amount to treat...
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6066317 |
Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune...
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6063764 |
Method for using lipoprotein associated coagulation inhibitor to treat sepsis
A method for prophylactically or therapeutically treating sepsis or septic shock is described, wherein an inhibitor to tissue factor is administered to septic patients. Additionally, a method for...
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6063371 |
Pharmaceutical compositions comprising a soluble interleukin-4 receptor
The biological activity of exogenous ligand proteins is enhanced by intravenously co-administering to a mammal the ligand and a soluble receptor protein that binds thereto. Pharmaceutical...
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6063380 |
Enhanced immunogenic vaccine
Vaccines, composed of antigens absorbed on alum or formulated in an alum-containing composition, have enhanced immunogenicity over existing vaccines. The vaccines of the invention are characterized...
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6060449 |
Neovascularization inhibitor containing tissue factor pathway inhibitor
There is provided an inhibitor of angiogenesis induced by growth of the vascular endothelial cells that comprises Tissue Factor Pathway Inhibitor (TFPI) as an active ingredient. The TFPI-containing...
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6060460 |
Use of betaglycan to reduce scarring
The present invention concerns soluble betaglycan for use in promoting the healing of wounds or fibrotic disorders with reduced scarring, together with methods for same.
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6060054 |
Product for T lymphocyte immunosuppression
The present invention relates to a product and process for suppressing an immune response using a T lymphocyte immunosuppression molecule capable of blocking cell surface molecules responsible for...
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6057131 |
Preparation and use of sialylated glycoforms of soluble complement receptor 1 (CR1)
Provided are methods of making preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms and therapeutic methods using them....
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6057292 |
Method for inhibiting growth hormone action
Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups,...
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6051553 |
Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products
The present invention provides methods of potentiating the gram-negative bactericidal activity of BPI protein products by means of administering LBP protein products.
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6051552 |
Lactobacillus therapies
The present invention is directed towards isolated lactobacillus biosurfactants and the process for producing same. The present invention is also directed to methods for preventing urogenital...
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6051556 |
Hybrid pesticidal toxins
The invention concerns novel hybrid pesticidal toxins. These toxins are expressed as the fusion protein of a chimeric gene. Specifically exemplified is a novel B.t. hybrid toxin. These novel toxins...
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6048837 |
OB polypeptides as modulators of body weight
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and...
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6048720 |
Conjugates of a polypeptide and a biocompatible polymer
Processes for improving the in vivo function of factor VIII by shielding exposed targets of the factor VIII comprise a) immobilizing the factor VIII by interaction with a group-specific adsorbent...
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6046162 |
Suppression of cell proliferation by decorin
A method of suppressing cell proliferation of a mammalian cell by contacting the cell with decorin.
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6046157 |
Modulation of TGF-β by recombinant TGF-β type II receptor polypeptides
The mammalian TGF-β type II receptor has been cloned. Recombinant TGF-β-binding receptor polypeptides are useful to alter the binding of TGF-β to its receptors and to modulate the effects of...
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6045788 |
Method of stimulation of immune response with low doses of IL-2
A method of activating the immune system of a subject comprises the chronic administration of low doses of an agent such as IL-2, fusion proteins thereof and derivatives thereof that are...
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6043216 |
Methods and composition for detecting and treating kidney diseases associated with adhesion of crystals to kidney cells
An autocrine crystal adhesion inhibitor called CAI is an anionic, sialic acid-containing glycoprotein secreted by kidney epithelial cells that blocks adhesion of calcium oxalate monohydrate (COM)...
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6042821 |
Method of treating sepsis with chemokines
The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC [SEQ ID NO: 1], groα [SEQ ID NO:2], groβ [SEQ ID NO: 3] or groγ [SEQ ID...
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6036955 |
Kits and methods for the specific coagulation of vasculature
Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor...
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6036972 |
Method of treating dilated cardiomyopathy
The invention describes to a method of treating a patient with dilated cardiomyopathy comprising administering an effective amount of Hepatocyte Growth Factor (HGF).
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6033669 |
Methods for generating cytotoxic T cells and treatment of diseases thereby
The present invention relates a novel class of biologically active compounds, to processes for their production and to their use in therapy. More particularly the invention provides immunogenic...
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6034055 |
Glycosyl-amides of 2-aminoacylamino-2-deoxy-sugars
The present invention relates to (2-aminoacylamino-2-deoxy-glycosyl)-amides, which are substituted on the nitrogen atom of the amino acid, of the general formula (I) ##STR1## in which the...
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6030947 |
Methods of treating p150,95-mediated inflammation and ICAM-1-mediated viral infection
This invention concerns the cloning of the alpha-subunit of the p150,95 leukocyte adhesion receptor molecule. The invention also concerns the alpha-subunit of p150,95, as well as fragments of this...
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6028050 |
Method for increasing platelets by administering soluble interleukin-6 receptor
A platelet-increasing preparation which comprises an effective amount of an interleukin-6 receptor and a pharmaceutically acceptable excipient. Preferably the preparation further comprises...
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6027730 |
Herpes simplex vaccine comprising HSV glycoprotein GD and 3 deacylated monophosphoryl lipid A
Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.
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6025391 |
Enteric-coated pharmaceutical compositions of mycophenolate
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6025325 |
Pegylated obese (ob) protein compositions
Polyethylene and polypropylene protein conjugates which modulate body weight of animals and humans for the treatment, prevention and control of obesity and associated diseases or conditions, and...
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6025324 |
Pegylated obese (ob) protein compositions
Polyethylene and polypropylene protein conjugates which modulate body weight of ani is and humans for the treatment, prevention and control obesity and associated diseases or conditions, and the...
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6022536 |
Combined use of interleukin 10 and cyclosporin for immunosuppression therapy
A combination of interleukin 10 and cyclosporin is used to suppress graft-versus-host disease, autoimmune diseases and tissue/graft rejection. It has been discovered that administration of a...
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6020309 |
Pharmaceuticals based on papillomaviruses
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6019965 |
Methods for treatment of pulmonary disease using GM-CSF
Methods of treatment of pulmonary disease, e.g., alveolar proteinosis, by treating a subject with an effective amount of GM-CSF.
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6019971 |
Treatment of autoimmune arthritis by oral administration of collagen
The invention is directed to a method of treating a T cell-mediated autoimmune disease in animals, including humans, by the oral administration of autoantigens, fragments of autoantigens, or...
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6020313 |
Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
The invention relates to a method for inducing bone formation via administration of an extract of devitalized, freeze dried Saos-2 cells. The extract is prepared by contacting the freeze dried...
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6017537 |
Formyl methionyl peptide vaccine adjuvant
The present invention relates to immunological adjuvants comprised of the N-formyl methionyl peptide fMLP. FMLP, when used as an adjuvant in accordance with the present invention, provides for an...
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6017876 |
Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity
The present invention broadly relates to chemical modification of biologically active proteins or analogs thereof. More specifically, the present invention describes novel methods for site-specific...
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6015828 |
Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride...
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6015678 |
Method for detection of a polynucleotide encoding protein kinase C inhibitor-homolog
The present invention provides a human protein kinase C inhibitor-like protein (IPKC-2) and polynucleotides which identify and encode IPKC-2. The invention also provides expression vectors, host...
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6013624 |
Method for inducing the proliferation and migration of endothelial cells using scatter factor
The present invention provides a novel method of inducing proliferation and migration of endothelial cells in a subject comprising administering an amount of scatter factor effective to induce the...
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6010722 |
Oral remedy for rheumatoid arthritis and functional food
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6011008 |
Conjugates of biologically active substances
A method for producing a water-soluble polysaccharide conjugate of an oxidation-sensitive substance is described. The method comprises the following steps: (a) activating the polysaccharide to a...
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6011009 |
Method for determining angiogenesis using scatter factor
The present invention provides a novel method of determining the presence of angiogenesis in a subject comprising detecting the presence of scatter factor in the subject.
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6004938 |
Inositolglycans having insulin-like action
The invention relates to inositolglycans having insulin-like action. Specific compounds are provided having the formula I A--Z--R (I) where A is...
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6004937 |
Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
Methods are provided for the modulation of the effects of GDF-8 and BMP-11, particularly on neural and muscular disorders administration of follistatin for treating neural, muscle, disorders which...
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5997863 |
Attenuation of wound healing processes
Glycosaminoglycans, including heparinases 1, 2 and 3 as well as chondroitinases AC and B from the Gram negative bacteria Flavobacterium heparinum, can be used either separately or in combination to...
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5997912 |
Method for inhibiting growth of P. aeruginosa using gallium-containing compounds
This invention relates to methods for using gallium-containing compounds to inhibit the growth of pathogenic P. aeruginosa in a mammal infected with the pathogen.
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5994086 |
Method for assessing infertility by binding of mannose to sperm cells
Methods for labeling mannose lectins on the surface of mammalian sperm cells are described, and methods of categorizing and quantifying the numbers of cells exhibiting particular labeling patterns...
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