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6169068 |
Pulmonary administration of soluble complement receptor-1 (sCR1) and its derivatives
A method is disclosed for treating diseases or disorders involving complement by pulmonary administration of complement inhibitory proteins such as soluble complement receptor type 1 (sCR1). The...
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6168785 |
Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of...
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6165459 |
Methods for suppressing myeloid cells with chemokines
Described are preferred processes and compositions for suppressing myeloid cells in mammals. Preferred processes and compositions involve the use of chemokines in synergistic combinations or while...
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6162426 |
Use of G-CSF to enhance the immune system in neonates
The invention relates to the use of Granulocyte Colony Stimulating Factor (G-CSF) to enhance the immune system in neonates by increasing the Absolute Neutrophil Count and/or increasing the Fc γ ...
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6162427 |
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of...
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6162787 |
Methods for treating arthritis using collagen type II, glucosamine chondroitin sulfate, and compositions
The invention describes compositions and methods for treatment of rheumatoid arthritis and osteoarthritis. The compositions comprise insoluble, native collagen Type II in a particular form in...
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6159711 |
DNA encoding rantes peptide fragments and methods of treatment with the fragments
Modifications to RANTES can result in the modified polypeptide acting as a RANTES or MIP-1α antagonist. Such antagonists can be used in therapy to reduce inflammation. They are also useful in...
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6159174 |
Method of using lectins for therapy of diseases transmittable by sexual contact
In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are...
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6159460 |
Method for treating interleukin-1 mediated diseases
The present invention provides methods for treating interleukin-1 mediated diseases including arthritis, inflammatory bowel disease, sepsis and septic shock, ischemia injury, reperfusion injury,...
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6159463 |
Lymphocyte chemoattractant factor
Purified DNA encoding LCF and the recombinant proteins expressed from such DNA are disclosed. In addition, the invention provides methods for suppressing an LCF-CD4 interaction and screening...
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6156301 |
Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors
Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant...
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6156300 |
Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
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6153195 |
Method of delivering drugs to cells specific for an HL-60 lectin
Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment...
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6150326 |
Means for treating autoimmune diseases and method for the treatment thereof
Trophoblastic β-I-glycoprotein (TBG) is used as a means for treating autoimmune diseases showing suppressors immunodeficit. A method of treating of autoimmune diseases comprises the administration...
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6150327 |
Conjugate of an active agent, a polyether and possibly a native protein regarded as acceptable by the body
This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation...
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6150331 |
Human growth hormone-containing aqueous pharmaceutical composition
Provided is an aqueous pharmaceutical composition comprising human growth hormone wherein said human growth hormone is dissolved in a benzalkonium chloride-containing, slightly to weakly acidic...
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6150461 |
Carriers targettable to organ
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a...
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6146658 |
Prodrugs, their preparation and use as pharmaceuticals
Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.
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6143331 |
Pharmaceutical composition which is stable during storage and contains a thymus extract
The invention concerns a process for preparing a pharmaceutical composition of thymus factors which displays immunomodulating and anti-inflammatory properties and is stable during storage. The...
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6138680 |
Method for destroying retinal pigment epithelial cells
A method for destroying retinal pigment epithelial cells in an eye in order to prevent the occurrence of proliferative vitreoretinopathy. A solution containing a basement membrane binding agent...
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6133230 |
Method and pharmaceutical composition for chondrostimulation with a prostaglandin (e.g. misoprostol) and TGF-β, optionally in combination with IGF-1
A pharmaceutical composition comprising a prostaglandin such as misoprostol and TGF-B in amounts sufficient to stimulate production of chondrocyte matrix is disclosed which exhibit therapeutic...
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6126933 |
Methods of treating inflammatory bowel diseases by administering IL-11
Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease,...
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6120760 |
Growth/differentiation factors of the TGF-β family
The invention provides DNA sequences encoding novel members of the TGF-β family of proteins. The TGF-β family comprises proteins which function as growth and/or differentiation factors and which...
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6121233 |
Methods for the inhibition of cancer metastasis mediated by endothelial adhesion molecules
Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Le a and di-sialyl Le a ,...
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6117837 |
Inhibiting proinflammatory cytokine production
There is disclosed a method for helping to prevent miscarriages during pregnancy, comprising administering an effective amount of a fetuin polypeptide.
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6110891 |
Lectin compositions and uses thereof
This invention provides methods for: the control of mucosal cell proliferation; the reduction and/or treatment of damage caused by a cell-damaging agent; and for the reduction and/or treatment of a...
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6107272 |
Modified polypeptides with altered biological activity
The invention relates to novel modified polypeptides, with or without variations in noncoding regions, with altered biological activity. The invention discloses methods of preparing the modified...
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6106832 |
Treatment of individuals exhibiting defective CD40L
There is disclosed a method of detecting a mutation in a CD40 ligand gene, comprising isolating nucleic acid from an individual, selectively amplifying nucleic acid derived from the CD40 ligand...
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6106828 |
Conjugation of polypeptides
The present invention provides polypeptide conjugates with reduced allergenicity comprising a polymeric carrier molecule having two or more polypeptide molecules coupled thereto. The invention also...
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6103234 |
Composition comprising an antibody to macrophage-derived inflammatory mediator (MIP-2)
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of...
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6100235 |
Methods of treating immune and inflammatory response with IL-17 receptors
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors...
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6096300 |
Treatment of myeloproliferative disease with exodus chemokine
The present invention provides purified and isolated chemokine protein, fragments and polypeptide analogs thereof, antibodies thereto, and materials and methods for the recombinant production...
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6096327 |
Cosmetic compositions containing human type serine protease inhibitors for revitalizing the skin
Cosmetic compositions and methods are provided for revitalizing the skin especially where it is placed in an environment which can cause injury to the skin. The compositions contain an effective...
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6096705 |
Inhibition of agonist-specific desensitization of β2 adrenergic receptors
The present invention relates to a method of inhibiting desensitization of a cell to the effects of a compound. The method comprises contacting the cell with an agent capable of inhibiting...
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6093417 |
Composition to treat ear disorders
A topical ear composition that uses penetration enhancers to diffuse the therapeutic agents through the tympanic membrane into the middle and inner ear for the purpose of reducing the inflammation...
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6093694 |
Antitumor active substances
By extracting hot water-insoluble and ethanol-insoluble components of the fruit body of Agaricus blazei Murill belonging to the genus Agaricus with 5% ammonium oxalate aqueous solution, degrading...
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6093693 |
B cell activation
A novel protein purified from bovine colostral whey and isolated nucleotide sequences encoding the protein. The isolated bovine protein has homology with human CD14 and murine CD14 and so is...
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6090776 |
Morphogen treatment of organ implants
The present invention is directed to methods and compositions for enhancing viability of organs and living tissues to be transplanted in a mammal. The methods and compositions provide a...
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6089234 |
Method for destroying residual lens epithelial cells
A method for destroying residual lens epithelial cells in an eye in order to prevent the occurrence of posterior chamber opacification. A solution containing a basement membrane binding agent...
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6090777 |
Method to reduce myocardial injury during acute myocardial infarction
A therapeutic or prophylactic treatment method of acute myocardial infarction, comprising administering exogenous C1-esterase inhibitor, alone or in combination with other drugs, to a patient with...
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6087328 |
Coupling of unmodified proteins to haloacyl or dihaloacyl derivatized polysaccharides for the preparation of protein-polysaccharide vaccines
A method for preparing a conjugate, and preferably a protein-polysaccharide conjugate, includes functionalizing a first moiety (e.g., a polysaccharide) with one or more pendant haloacyl groups....
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6087335 |
RNase-CV (Coriolus versicolor)
A method of obtaining a novel polypeptide from a crude extraction product of polysaccharide peptide Coriolus versicolor comprising: a) boiling a water soluble powder of polysaccharide peptide...
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6087329 |
CD40 ligand polypeptide
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
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6083926 |
Water soluble vitamin B.sub.12 receptor modulating agents and methods related thereto
Vitamin B 12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B 12 receptor modulating...
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6083911 |
Arenavirus receptor and methods of use
Disclosed is a method for inhibiting the binding of an arenavirus to a cellular receptor. The method involves providing, in soluble form, a reagent comprising α-dystroglycan or a portion thereof,...
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6083910 |
Therapeutic uses of resolved intact or clipped native-sequence PDGF-BB dimers
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of...
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6083906 |
Method of regulating nitric oxide production or arthritis with soluble IL-17 receptor
Methods for regulating levels of nitric oxide are disclosed. The methods utilize IL-17 receptors, which may be used in conjunction with inhibitor of IL-1 and/or TNF.
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6080589 |
Neisseria meningitidis capsular polysacchride conjugates
Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant...
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6077823 |
Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
The present invention is directed to methods and compositions for alleviating tissue destructive effects associated with the inflammatory response to tissue injury in a mammal. The methods and...
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6077822 |
Drug salts
It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide...
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