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6261548 |
Leukaemia inhibitory factor
The present invention provides isolated DNA molecules encoding human and murine LIF and methods of producing LIF by the expression of the isolated DNA and suitable host cells. The invention further...
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6262127 |
Polymeric matrices and their uses in pharmaceutical compositions
This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are...
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6258779 |
Method of using fetuin to induce apoptosis in cancer cells
The present invention provides the methods to isolate the proteins specifically induced apoptosis (programmed cell death) in prostate cancer cells (LNCAP), leukemia cells (HL-60), and breast cancer...
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6254861 |
Hematopoietic growth factor derived from T lymphocytes
A T cell-derived colony stimulating factor ("TC-CSF") may be isolated from media conditioned with T lymphocyte cells. TC-CSF stimulates formation of colonies composed of granulocytes, macrophages,...
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6255282 |
Lytic peptides
Novel synthetic lytic and proliferative peptides were designed and constructed to encompass the structural features associated with lytic and proliferative activity. These compounds, along with the...
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6251859 |
Deepithelialized skin diffusion cell system
A deepithelialized skin cell diffusion system which can be used to select topical gel and cream formulations containing human other wound healing promoters such as plasma fibronectin. The...
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6251858 |
Derivatives of oligosides, their process of preparation and their applications
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6248365 |
Use of complement inhibitors for the preparation of a pharmaceutical for the prophylaxis and therapy of inflammatory intestinal and skin disorders as well as purpura
The invention relates to the use of complement inhibitors, especially of C1 inactivator or of factors I or H, for the preparation of a pharmaceutical and for the prophylaxis and therapy of chronic...
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6248714 |
Methods of inhibiting binding and treating Ig-mediated responses with IL-13 receptor
IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor methods of mediating-Ig-responses and methods for their identification are also disclosed.
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6248548 |
Thrombosis prophylaxis for factor Vleiden carriers
Persons having the Factor V LEIDEN mutation and a lower than average plasma level of TFPI have been found to be at elevated risk of thrombosis. Prophylactic methods for reducing the risk of...
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6245738 |
Cytokine restraining agents
The present invention provides novel cytokine restraining agents, which limit or control the biological activity of cytokines. The invention also provides pharmaceutical compositions comprising a...
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6242419 |
Compositions isolated from stromal cells and methods for their use
Isolated polynucleotides encoding polypeptides expressed in mammalian fsn -/- lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated...
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6239101 |
Thrombin binding polypeptides
Small, buffer soluble polypeptides having amino acid structures corresponding to residues 234-486, 310-486, and 407-486, of thrombomodulin and functionally equivalent analogs thereof inhibiting the...
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6239100 |
Synthetic polypeptide having fish growth hormone-like activity, nucleic acid encoding for the polypeptide and method using same
The present invention provides a novel polypeptide which has fish growth hormone-like activity and which can be widely used no matter what the species of fish is.
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6235707 |
Anticoagulant peptidyl-arginine aldehyde derivatives
The invention relates to new peptidyl-arginine aldehyde compounds of formula (I) Q-D-Xaa-Pro-Arg-H (I) wherein Q represents an acyl group of formula Q'--OCO, wherein Q' represents an...
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6235710 |
Spray dried erythropoietin
The present invention provides a method for preparing stable, spray dried rhEPO and the rhEPO powder produced thereby.
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6235709 |
Inhibitor of helicobacter pylori colonization
The present invention provides a safe and effective inhibitor of Helicobacter pylori colonization in the stomach and a food containing the inhibitor. The inhibitor of the present invention...
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6232288 |
Composition for improving pancreatic function
The present invention provides a novel composition comprising a betacellulin protein, or a fragment thereof, which is capable of promoting the differentiation of undifferentiated pancreatic cells...
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6218149 |
Antibodies having modified carbohydrate content and methods of preparation and use
This invention provides a method of altering the affinity of an antibody for the antigen to which it is directed which comprises introducing into the variable region of the antibody a carbohydrate...
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6218360 |
Collagen based biomaterials and methods of preparation and use
This invention comprises purified native state Type VI collagen/βig, Type VI-βig collagen gel, including the crosslinked gel, and the use of the gel in fibrosis limited wound healing, and methods...
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6217857 |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines...
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6218358 |
Functional expression of, and assay for, functional cellular receptors in vivo
Methods and materials for expressing and assaying functional neuronal receptors in neuronal cells, including methods for detecting particular odorant ligand specificity for particular odorant...
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6214875 |
Anticancer effects of specific branched-chain fatty acids and related production process
A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of...
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6214375 |
Phospholipid formulations
A liposome pharmaceutical composition is provided. The liposomes are comprised of a medicinally active agent, at least three phospholipids and at least two biodegradable polymers. The liposomes can...
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6207654 |
Capillary membrane stabilization and reduction of inflammation during the course of chemotherapy or antiviral treatment through the use of biodegradable macromolecules and interleukin-2
There is provided a method of treating a human subject to prevent leakage of serum proteins from capillary endothelial junctions during a period of increased capillary permeability. The method...
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6207155 |
Method of eosinophil depletion with antibody to CCR 3 receptor
Binding compositions and various methods of use of the binding compositions are provided. In particular, a method is provided which comprises administering an effective amount of the binding...
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6207656 |
Vitamin D analogues and their neuronal effects
The present invention is directed, inter alia, to methods of utilizing low calcemic vitamin D analogues. Particularly, the present invention is directed to using low calcemic vitamin D analogues to...
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6203792 |
Composition and methods using myelin-associated glycoprotein (MAG) and inhibitors thereof
This invention relates to the novel identification of myelin-associated glycoprotein ("MAG") as a potent inhibitor of neural regeneration. More particularly, this invention relates to compositions...
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6197749 |
Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of...
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6197291 |
Agent for potentiating the effect of interleukin-8
The inventors provide an agent for potentiating the effect of interleukin-8, which comprises dehydroepiandrosterone sulfate or a pharmaceutically acceptable salt thereof as an active ingredient. An...
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6193970 |
Controlled release of pharmaceutically active substances for immunotherapy
A method of stimulating a systemic immune response to a tumor cell or antigen associated with a pathogen by administering a mixture of a controlled release vehicle containing an immunopotentiating...
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6194376 |
Method for modulating inflammatory response comprising administering morphogen
The invention provides methods for alleviating immune cell mediated inflammatory responses to injury to mammalian tissue. The present methods make use of osteogenic protein 1(OP-1), which is...
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6191104 |
Methods of treating graft rejection with the IL-17 receptor
Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors can...
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6184206 |
Integrin ligand dissociators
The invention provides a method of disaggregating a ligand:integrin receptor complex. Specifically, the invention provides a method of disaggregating an existing platelet thrombus in a blood vessel...
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6180599 |
Pharmaceutical composition, containing medium-chain fatty acids as active ingredients, for dental caries and periodontal disease
The present invention relates to a new use of medium-chain fatty acids in prevention and treatment of dental caries and a pharmaceutical composition containing medium-chain fatty acids as active...
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6177085 |
Generation of immune response using immunogenic conjugate of molecules
Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus...
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6177059 |
GPIb-lipid complex and uses thereof
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6177404 |
Conjugates useful in the treatment of benign prostatic hyperplasia
Novel pharmaceutical compositions useful for the treatment of benign prostatic hyperplasia which comprises novel oligopeptides, which are selectively cleaved by enzymatically active PSA, in...
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6174529 |
Oral therapy for the treatment of allergies and method of manufacture
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and...
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6171614 |
Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a...
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6171584 |
Method of treatment with growth/differentiation factors of the TGF-β family
The invention concerns a protein of the TGF-β family, the DNA coding therefor and a pharmaceutical composition containing such protein.
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6172107 |
Entric-coated pharmaceutical compositions
This invention provides a pharmaceutical composition comprising a mycophenolate salt, the composition being adapted to release mycophenolate in the upper part of the intestinal tract.
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6172040 |
Immobilized lactoferrin antimicrobial agents and the use thereof
Disclosed is a method for treating products, such as meat products, with immobilized lactoferrin to reduce microbial contamination. The lactoferrin is immobilized on a naturally occurring...
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6169068 |
Pulmonary administration of soluble complement receptor-1 (sCR1) and its derivatives
A method is disclosed for treating diseases or disorders involving complement by pulmonary administration of complement inhibitory proteins such as soluble complement receptor type 1 (sCR1). The...
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6168785 |
Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of...
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6165459 |
Methods for suppressing myeloid cells with chemokines
Described are preferred processes and compositions for suppressing myeloid cells in mammals. Preferred processes and compositions involve the use of chemokines in synergistic combinations or while...
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6162426 |
Use of G-CSF to enhance the immune system in neonates
The invention relates to the use of Granulocyte Colony Stimulating Factor (G-CSF) to enhance the immune system in neonates by increasing the Absolute Neutrophil Count and/or increasing the Fc γ ...
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6162427 |
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of...
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6162787 |
Methods for treating arthritis using collagen type II, glucosamine chondroitin sulfate, and compositions
The invention describes compositions and methods for treatment of rheumatoid arthritis and osteoarthritis. The compositions comprise insoluble, native collagen Type II in a particular form in...
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6159711 |
DNA encoding rantes peptide fragments and methods of treatment with the fragments
Modifications to RANTES can result in the modified polypeptide acting as a RANTES or MIP-1α antagonist. Such antagonists can be used in therapy to reduce inflammation. They are also useful in...
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