Matches 1 - 50 out of 148 1 2 3 >
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7625880 Inhibitors of tyrosine kinases and uses thereof  
Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions...
7510710 Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor  
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a...
7485626 Combinations of enzyme inhibitor-containing preparations and the use thereof  
The invention comprises a process wherein the DNA synthesis and, thus, the proliferation of mononuclear cells (MNZ) and of T cells as well is inhibited by the simultaneous and combined inhibition...
7476661 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
7459444 Inhibitors of chymase  
The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory...
7445794 Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors  
The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2)...
7427636 Inosine monophosphate dehydrogenase inhibitory phosphonate compounds  
The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as...
7410956 Caspase inhibitor prodrugs  
The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of...
7348318 α-Amino-N-(diaminophosphinyl)lactam derivatives  
There are disclosed a novel α-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1): wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl...
7345082 Phosphinic acids  
The present invention relates to phosphinic acid derivatives of formula I wherein R 1 , R 2 , R 3 and R 4 are described hereinabove. These compounds can be used in the treatment or prevention...
7319096 Thyroid hormone receptor antagonists for cardiac and metabolic disorders II  
This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders,...
7223746 Omega cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists  
The invention relates to the use of derivatives of E-type prostaglandins as EP 2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the...
7214701 Active substance combinations having insecticidal and acaricdal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G...
7199162 Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation  
The invention relates to the use of treosulfan as a conditioning agent before allogenic transplantation of bone marrow or haematopoietic stem cells, whereby treosulfan is administered, either as...
7199113 Pharmaceutically active compounds and methods of use thereof  
The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are...
7148210 Method of treating bone metastasis  
The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a...
7098196 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
7084126 Methods and compositions for enhancing cellular function through protection of tissue components  
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
7060290 Phosphocholine linked prodrug derivatives  
Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or...
7018988 Pharmaceutically active pyrrolidine derivatives as Bax inhibitors  
The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine...
7018987 Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof  
The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be...
6982251 Substituted 2-azetidinones useful as hypocholesterolemic agents  
Hypocholesterolemic substituted 2-azetidinone compounds of the formula: are disclosed, as well as a methods of lowering cholesterol by administering said compounds, pharmaceutical compositions...
6906074 2-phenylpiperazine derivatives  
A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof: wherein each of X 1 and X 3 is oxygen or two hydrogen...
6881732 Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements  
Compounds that demonstrate chelation affinity and selectivity for first transition series elements are administered to patients suffering from such conditions as ischemia, prolonged seizures and...
6756391 Antiviral compounds  
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
6706698 α-Substituted β-aminoethyl phosphonate derivatives  
The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a),...
6545038 Heterocyclic metalloprotease inhibitors  
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide,...
6506737 Antimicrobial phosphonium and sulfonium polyhalide compositions  
An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions...
6498150 Low molecular weight cell, bone marrow and immune stimulants  
The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
6440950 Selective and non-invasive visualization or treatment of vasculature  
Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as...
6399782 Benzimidazole inhibitors of fructose 1,6-bisphosphatase  
Novel benzimidazole compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described
6399598 Diheterocyclic metalloprotease inhibitors  
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptacle salt, or biohydrolyzable amide,...
6331293 Dimer amidopropyl dimethyl phospholipids as barrier compounds  
The present invention relates to compounds and, more particularly, to a class of compounds having specific quaternized amine based upon a dimer acid amido amine linked to specific phosphate esters....
6329354 Methods for the treatment of osteoporosis  
Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said...
6322821 Veterinary pharmaceutical composition  
A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene...
6221898 Amidino derivatives and their use as thrombin inhibitors  
There is provided compounds of formula I, ##STR1## wherein R 1 , R 2 , R 3 , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases,...
6194435 Lactams as selective factor Xa inhibitors  
Novel lactams, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of Formula I below: ##STR1## are useful in vitro or in vivo for...
6177442 Bicyclic amine derivatives  
The invention provides a compound of formula (I): ##STR1## wherein A represents a bidentate group of formula --CH 2 --X--CH 2 -- (wherein X is methylene, sulfur or oxygen), X'CCY or X'WC--CYZ...
6172050 Phospholipid derivatives  
Phospholipid derivatives of Formula X: ##STR1## wherein A is the ring system ##STR2## in which R is a linear or branched alkyl radical having 10 to 24 carbon atoms which may contain one or more...
6140324 Use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine to treat motion sickness  
The present invention relates to the use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine for the treatment or prevention of motion sickness. There is also provided...
6043223 Enhanced opening of abnormal brain tissue capillaries  
Improved compositions and methods for increasing permeability of abnormal brain tissue to pharmaceutical agents. Cyclic GMP specific phosphodiesterase inhibitors are combined with bradykinin or a...
6037334 Phosphonates, process for preparing the same and medicaments  
5994355 1, 2, 4-Triazin-3-one derivatives, production and use thereof  
The present invention provides a novel triazine derivative of the formula ##STR1## wherein ring A is an optionally substituted aromatic group; X is an oxygen or sulfur atom; R 1 and R 6 are...
5972912 Method for lyophilizing ifosfamide  
A method of lyophilizing an oxazaphosphorin and a preparation produced thereby including dissolving an oxazaphosphorin in water, adding an amino acid to a molar ratio of between 1 to 10 amino acid...
5968916 Fluoroalkenyl compounds and their use as pest control agents  
Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of...
5955452 Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments  
The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers...
5952327 Phosphonic acid-substituted benzazepinone-n-acetic acid derivatives process for their preparation and pharmaceutical compositions comprising them  
Compounds having NEP-inhibitory activity, corresponding to the formula I in which R 1 is hydrogen or a group forming a biolabile phosphonic acid ester, R 2 is hydrogen or a group forming a...
5939415 A!-annellated pyrrole derivatives and their use in pharmacology  
The present invention relates to heterocyclic compounds with the formula ##STR1## in which R 1 to R 7 , B, a, and X have the meanings indicated in the specification. These compounds can be used...
5935927 Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts  
The present invention relates generally to methods and compositions for treating amyloidogenic diseases such as Alzheimer's disease and the development of type II diabetes, in which deposition of...
5929114 Arylthio compounds  
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
Matches 1 - 50 out of 148 1 2 3 >