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8148338 |
Doxorubicin formulations for anti-cancer use
Doxorubicin block copolymer formulations for use in preparing injectable compositions for treating cancer patients which contain lactose for solubilizing the doxorubicin and block copolymers in...
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8114860 |
GABA-steroid antagonists and their use for the treatment of CNS disorders
Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial...
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8097248 |
Mite composition, use thereof, method for rearing the phytoseiid predatory mite Amblyseius sirskii, rearing system for rearing said phytoseiid mite and methods for biological pest control on a crop
The present invention relates to a novel mite composition comprising a population of the phytoseiid predatory mite species Amblyseius swirskii. and a factitious host population, which may be...
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8093286 |
Methods for treatment with bucindolol based on genetic targeting
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
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8080578 |
Methods for treatment with bucindolol based on genetic targeting
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
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8082109 |
Computer-aided discovery of biomarker profiles in complex biological systems
The invention relates to computational methods, systems and apparatus useful in the analysis of sets of biomolecules in an accessible body fluid or tissue sample from a patient, which biomolecules...
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8048413 |
Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
Compositions which deliver adsorbents, alone or in combination with active drug “degrading molecules,” in a site-specific manner to the intestine, and which eliminate or at least lower the con...
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7955828 |
Use of methionine synthase inhibitors for the treatment of fungal diseases of crops
The invention relates to the use of methionine synthase inhibitors for the treatment of fungal diseases of crops. The invention further relates to methods for treatment of crops against fungal...
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7947269 |
Mite composition, use thereof, method for rearing a phytoseiid predatory mite, rearing system for rearing said phytoseiid predatory mite and methods for biological pest control on a crop
The present invention relates to a novel mite composition comprising a population of a phytoseiid predatory mite species and a factitious host population, which may be employed for rearing said...
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7825161 |
Higher fullerenes useful as radical scavengers
Chemically functionalized fullerenes are useful in various applications as radical scavengers. These chemically functionalized fullerenes offer the advantages of preservation of the high innate...
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7820594 |
Pesticide compositions and methods for their use
This invention relates to agricultural compositions, particularly pesticidal compositions which find particular use as a fungicide or herbicide composition. The pesticidal composition can include...
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7803531 |
Method of inducing apoptosis by reducing the level of thiamin
The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of...
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7803595 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof
Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing...
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7785891 |
Device and methods for identifying and treating aspirin non-responsive patients
The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin.
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7785616 |
C-nitroso compounds and use thereof
A C-nitroso moiety derived from a carbon acid with a pKa less than about 25 is bound in a biocompatible polymer as an ester or ether to a pendant hydroxyl group, as an ester to a pendant carboxylic...
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7776577 |
Ubiquitin protease
The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3,...
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7763603 |
Manipulation of brain CDP-diacylglycerol and uses thereof
Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in...
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7741244 |
Fungicide compositions
This invention relates to agricultural compositions that find particular use as a fungicide composition. The fungicide composition can include one or more fatty acids and one or more organic acids...
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7732454 |
Inhibitors of Bruton's tyrosine kinase
Disclosed herein are imidazo[1,5-f][1,2,4]triazine compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). The imidazo[1,5-f][1,2,4]triazine compounds described are irreversible...
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7695948 |
Antibodies that bind TNF-α converting enzyme
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of ...
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7678824 |
Methods for treatment with bucindolol based on genetic targeting
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
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7622289 |
Ornithine aminotransferase (OAT): a target for anticancer drugs
Ornithine δ-aminotransferase (OAT) facilitates microtubule assembly in addition to its aminotransferase activity in mitochondria. An N-terminal proteolysis of the first 17 amino acids of OAT block ...
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7589128 |
Process for preparation of amorphous form of a drug
Provided is a process for preparation of amorphous form of an active pharmaceutical ingredient.
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7563825 |
Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation
Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-...
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7537919 |
Cytochrome P450RAI-2 and related proteins
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
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7531499 |
Medicinal composition
The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound...
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7479384 |
Nematode MDH-like sequences
Disclosed are two nucleic acid molecules from M. incognita encoding malate dehydrogenase-like (MDH-like) polypeptides. The MDH-like polypeptide sequences are also provided, as are vectors, host...
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7419814 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof
Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine...
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7354956 |
Composition containing a sapogenin and use thereof
The present invention relates to a composition containing a sapogenin, and/or a sapogenin ester, and to the use of a sapogenin and/or a sapogenin ester to manufacture a composition that is suitable...
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7335675 |
Aqueous suspension formulation for foliar application fungicide
The present invention provides an aqueous suspension formulation containing (RS)-N-[2-(1,3-dimethylbutyl)thiophene-3-yl]-1-methyl-3-trif
luoromethyl-1H-pyrazole-4-carboxamide and having high rain...
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7320959 |
Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease
The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the...
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7291494 |
Regulation of target protein activity through modifier proteins
The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides...
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7279317 |
Modulation of COP9 signalsome isopeptidase activity
Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition,...
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7256171 |
Use of core 2 G1cNAc transferase inhibitors in treating inflammation
This invention provides compounds and methods for treating inflammation. The compounds modulate the core 2 oligosaccharide-mediated binding of inflammatory cells, such as neutrophils, to...
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7211420 |
Process for oxidizing terpenes
A process for oxidizing a substrate which is an acyclic or cyclic terpene, or a cycloalkene; or a substituted derivative thereof, which process comprises oxidizing said compound with a mutant...
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7195903 |
Methods for the treatment of thrombosis
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by rec...
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7192914 |
Prevention of atherosclerosis and undesired blood clotting by reducing von Willebrand factor
This invention provides methods and compositions for treating and preventing atherosclerosis other undesired blood clotting. The methods for treating and preventing atherosclerosis and related...
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7179627 |
Cyclooxygenase variants and methods of use
The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring...
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7141401 |
COX1-interacting proteins and use thereof
Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying...
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7115641 |
Antimicrobial oxazolidine/iodopropynyl-butyl carbamate composition containing less than 0.1wt% free formaldehyde
This invention relates to a broad spectrum antimicrobial composition, effective against gram negative and gram positive bacteria and fungi, which comprises a synergistic composition comprising...
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7060476 |
27411, a novel human PGP synthase
The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the...
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6964782 |
Stable hydrogen peroxide compositions, products and methods of use
Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable...
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6953682 |
Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor
The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the...
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6949504 |
Composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer
A composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer having a low melting point and an organic structure, wherein said polymer is solid at...
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6939831 |
Pestcide and/or plant growth regulating compositions
The invention concerns pesticide and/or insecticide and/or plant growth regulating compositions comprising specific dendrimers, said compositions being, in particular, useable for agriculture...
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6933128 |
Cell-based assay for screening cox-2 inhibitors
A cell-based assay is provided for screening substances for the capacity to inhibit COX-2 activity. The assay utilizes as a screening reagent a cell line which has been engineered to achieve...
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6913899 |
Polynucleotides encoding insect ethanolamine kinase and uses thereof
The instant invention provides nucleic acid molecules encoding insect ethanolamine kinase, as well as ethanolamine kinase encoded thereby. The invention further provides methods of identifying...
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6884768 |
Medicinal compositions
The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound...
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6867013 |
Methods of screening for antagonists and agonists of polypeptides having kinase functions
The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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