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7553981 |
Natural semi-synthetic and synthetic lipid derivatives of ceramide and sphingosine groups, drugs and the medical use thereof in the form of therapeutic agents in particular for dermatology
The subject of the present invention is new substances which are derived from naturally occurring ceramides and sphingosine and also from synthetic compounds with principally the same structure in...
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7473684 |
Bisphosphonate formulation
A bisphosphonate for treatment of osteoporosis is formulated with an amount of an antifoaming agent effective for reducing foaming in the stomach, leading to reduced reflux and oesophageal...
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7470660 |
Treatment for dark adaptation
The present invention addresses the treatment of age-related macular degeneration, and treatment of individuals with impaired visual function such as impaired dark adaptation, using regulation of...
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7470659 |
Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions...
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7465817 |
Inositolized phospholipids
The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol...
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7465717 |
Process for releasing and extracting phosphatides from a phosphatide-containing matrix
A process for releasing and extracting phosphatides from a phosphatide-containing matrix. The process includes (i) contacting the phosphatide-containing matrix with a solvent and a metal salt to...
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7456223 |
Treatment of bruxism
A composition and its use for local percutaneous delivery of a drug, in particular a muscle relaxant, more particularly cyclobenzaprine present in an amount of about 1 to about 10% by weight of the...
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7455855 |
Delivering substance and drug delivery system using the same
An object of the present invention is to prepare substances which are excellent in delivery and enable drugs to be retained in a body effectively over a long period and to construct a drug delivery...
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7354906 |
Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human
The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated...
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7351428 |
Phosphatidyl oligoglycerols
In order to form liposomes with a longer half-life in blood, use is made of defined formula (A)
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7344720 |
Vaccine composition
The present invention relates to a pharmaceutical composition comprising at least one vaccine antigen, which also comprises at least one phosphoric ester derivative of phosphatidylcholine having...
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7273604 |
Anti-asthmatic combinations comprising surface active phospholipids
Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine...
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7199112 |
Use of phospholipid arachidonic acids for increasing muscle mass in humans
This invention discloses a method of increasing muscle mass comprising administering phospholipid arachidonic acid to a human in need thereof.
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7182956 |
Stable topical drug delivery compositions
A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
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7141554 |
Method of treating irritable bowel syndrome
A nutritional composition is disclosed which comprises synergistic functional carbohydrates for preventing or treating infection by pathogenic bacteria and/or promoting gut flora balance and...
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7060290 |
Phosphocholine linked prodrug derivatives
Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or...
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6991776 |
Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described,...
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6979459 |
Treatment of skin damage using polyenylphosphatidycholine
Polyenylphosphatidylcholine is topically applied to treat skin damage, such as contact dermatitis (particularly diaper area dermatitis), atopic dermatitis, xerosis, eczema (including severe hand...
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6933291 |
Cholesterol lowering supplement
The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as suitable composition comprising...
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6932963 |
Treatment of skin wounds using polyenylphosphatidylcholine and alkanolamines
Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minmize scar formation. Typical compositions contain from about...
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6894032 |
Use of CDP-choline for the treatment of alcohol withdrawal syndrome
The invention relates to the use of CDP-Choline or its pharmaceutically acceptable salts for the preparation of a medicinal product for the treatment of alcohol withdrawal syndrome at daily doses...
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6858421 |
Cytosolic phospholipase A2-beta enzymes
The invention provides a novel calcium-independent cytosolic phospholipase A 2 -Beta enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6780430 |
Stabilzation method of nano-sized emulsion using tocopheryl derivatives and external application for skin containing the same
Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula (I) and (Wherein, R 1 , R 2 and R 3 are H or...
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6683066 |
Composition and treatment method for brain and spinal cord injuries
After interruption of blood supply to central nervous system tissue, cerebral edema sets in. It has been shown that restoring blood flow to injured areas of the central nervous system after the...
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6677319 |
Phosphatidylcholine as medication with protective effect large intestinal mucosa
The presented invention relates to a medication containing a therapeutically effective amount of phosphatidylcholine as active substrate for treatment of disease where phosphatidylcholine has an...
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6627211 |
Transnasal anticonvulsive compositions and modulated process
A method of vehicle modulated administration of an anticonvulsive agent to the nasal mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier...
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6602861 |
Acylated phospholipid drugs
This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the...
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6585991 |
Termite bait matrix
Termite foods mixed together in a matrix suitable to be used as baits and attractants for termites are provided. This termite matrix is preferred by termites over naturally-occurring foods such as...
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6576625 |
Targeted vesicular constructs for cytoprotection and treatment of H. pylori infections
A composition for targeted vesicular for treatment of H - Pylori infections and for protection of the cell. The composition contains lectins, phospholipids, sterols, and one or more drugs. The...
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6576266 |
Plant extract based on glycerides, a method for the preparation of this extract and a cosmetic composition containing the same
The present invention is concerned with a plant extract comprising a mixture of di-O-D-galactosyl-di-O-acylglyceride with phytosphingolipids and phospholipids, as well as with a method for the...
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6548085 |
Insecticidal compositions and method of controlling insect pests using same
A synergistic insecticide is provided by the addition of sodium lauryl sulfate or lecithin to an essential oil, preferably an essential oil which has been deregulated by the Environmental...
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6544966 |
Agents promoting laminin production in skin cells
Disclosed are compositions for promoting the production of laminin 5 in epidermic cells which contain a lysophospholipid having a C 14-22 fatty acid residue or a preparation derived from soybeans...
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6541462 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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6500810 |
Method of regulating expression of adhesion molecules on circulating leukocytes
A method to inhibit inflammation in a mammal is disclosed. The method includes administering to the mammal a composition comprising a phospholipid, which can be lysophosphatidic acid. The...
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6489369 |
Phosphocholine surfactants and their use
A pharmaceutical formulation comprising a pharmaceutically active agent, which is insoluble or sparingly soluble in water and a sterol phosphocholine surfactant.
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6465442 |
Topical application of muscarinic and opioid agents for treatment of tinnitus
The present invention relates to a compositions and methods for treating tinnitus. In preferred embodiments of the invention, muscurinic and/or opioid agents are administered to the affected ear in...
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6458854 |
Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
Phospholipid-HETE derivatives, compositions and methods of use are disclosed. The compounds are particularly useful for treating dry eye.
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6440950 |
Selective and non-invasive visualization or treatment of vasculature
Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as...
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6429202 |
Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents
The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more...
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6428807 |
Chelating immunostimulating complexes
An immunostimulating complex matrix comprising a saponin preparation, a sterol and a phospholipid, the matrix further comprising a metal-chelating moiety capable of binding a protein or polypeptide...
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6395305 |
Reduction of sperm sensitivity to chilling
Cryopreserved boar spermatozoa is much less fertile than that of other species, which could be due to damage to sperm membrane lipids during the cryopreservation process. Incorporation of selected...
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6395295 |
Use of surface active agent for the manufacture of a medicament for treatment of disorders of the middle ear
The invention relates to the treatment of serous otitis media (glue ear). A medicament is disclosed which comprises a surface active phospholipid (SAPL) which is instilled as a powder into the...
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6387876 |
Covalent polar lipid-conjugates with biologically active compounds for use in salves
This invention herein describes a method of facilitating the entry of drugs into cells and tissues at pharmokinetically useful levels and also a method of targeting drugs to specific organelles...
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6387401 |
Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process
Lipids are used as aids in the production of solid drug forms by melt extrusion.
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6352716 |
Steroidal liposomes
Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such...
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6348213 |
Method for reversing age-related changes in heart muscle cells
A method of-treating a relatively aged animal to reverse age-related changes in the lipid composition of organ and tissue cells, such as heart muscle cells, and the ability of the animal to...
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6333057 |
Composition and method for topical treatment of androgenic alopecia
This invention relates to the topical and oral treatment of hair loss, especially androgenic alopecia, by providing formulations that include anti-androgens, especially extracts of the saw palmetto...
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