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8153615 |
Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds
The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a...
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8129360 |
Utilization of phosphatidylserine in the treatment of attention deficit syndrome (ADHS)
The invention concerns the use of phosphatidylserine (PS), lyso-phosphatidylserine or/and a physiologically acceptable salt thereof for the treatment of the attention deficit syndrome (ADHS) in...
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8114440 |
Pharmaceutical compositions for the administration of aptamers
Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a...
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8093228 |
Bisphosphonate formulation
A bisphosphonate is formulated with an agent to reduce surface tension and/or reduce foaming in the stomach, leading to reduced reflux and oesophageal irritation in use and increased patient...
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8084067 |
Phospholipid complexes of olive fruits extracts having improved bioavailability
Phospholipids complexes of olive fruits extracts or compositions containing it having improved bioavailability.
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8076312 |
Use of lipid conjugates in the treatment of disease
This invention provides a method of preventing asthma, allergic rhinitis, or chronic obstructive pulmonary disease in a subject comprising the step of administering to a subject a compound...
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8052984 |
Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages
The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an...
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8052992 |
Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions
Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty...
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8017159 |
Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an...
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8017160 |
Enhancement of magnesium uptake in mammals
Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with...
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8003617 |
Methods of treating diabetes mellitus
The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
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7915237 |
Production of pure stereoisomers of tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate and medicaments therefrom
The invention relates to pharmaceutical formulations containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate, drugs containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate as active...
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7915227 |
Pharmaceutical formulations employing short-chain sphingolipids and their use
Pharmaceutical formulations containing (i) an amphiphilic drug and (ii) a short-chain sphingolipid are described and provided herein along with methods of making and using same.
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7901707 |
Biodegradable biocompatible implant and method of manufacturing same
Formulations or delivery systems are provided for controlled release of therapeutically active agents. The delivery systems are composed of polymer and lipid materials and may be prepared as a gel,...
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7842679 |
Phospholipid derivatives of DHA and methods for treating respiratory failure using the same
Taught are pharmaceutical compositions comprising at least one phospholipid having at least one docosahexaenoyl (DHA) residue, such as a lecithin-DHA-type phospholipid, and methods for treating or...
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7838511 |
Compositions and methods for treating, preventing and/or ameliorating cancers, the onset of cancers or the symptoms of cancers
Compositions and methods are disclosed for treating, preventing and/or ameliorating the symptoms of cancers such as breast cancer, colon cancer, ovarian cancer, lung cancer, leukemia, skin cancer,...
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7815933 |
Self emulsifying drug delivery system
The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) one or more NO-releasing NSAID(s);...
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7790702 |
Lipid metabolism improving agent
The present invention relates to a protein/phospholipid or protein hydrolyzate/phospholipid complex containing 10 wt % or more of bound phospholipid, a lipid metabolism improving agent comprising...
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7771711 |
Sphingolipids' polyalkylamines conjugates
The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present...
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7767658 |
Vaccine composition
The present invention relates to a pharmaceutical composition comprising at least one vaccine antigen, which also comprises at least one phosphoric ester derivative of phosphatidylcholine having...
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7759325 |
Use of lecithin as a medication for the treatment of psoriasis
Methods and compositions for the prevention and treatment of recent and old dermatitis, especially psoriasis, using lecithin or a lecithin-rich extract. According to one embodiment, phospholipids...
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7754679 |
Pharmaceutical compositions for the administration of aptamers
Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a...
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7683044 |
Sphingomyelin therapy of autoimmune disease
Autoimmune disease therapy in a patient treated with apoptosis-inducing agents is enhanced by co-administration of sphingomyelin. The combination most likely enhances an autoimmune disease cell's...
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7674782 |
Phosphorylcholine group-containing compound and method for producing same
The present invention is a phosphorylcholine-containing chemical compound represented by the following formula (1) or (2). (CH3)3N+CH2CH2PO4−CH2COOH (1) (CH3)3N+CH2CH2PO4−CH2COONa (2) The obj...
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7648714 |
Food for skin moisture retention
This invention relates to a food containing a glycosylated ceramide and diacylglycerol. This food is capable of improving and enhancing the barrier function of skin and increasing water holding...
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7473684 |
Bisphosphonate formulation
A bisphosphonate for treatment of osteoporosis is formulated with an amount of an antifoaming agent effective for reducing foaming in the stomach, leading to reduced reflux and oesophageal...
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7470660 |
Treatment for dark adaptation
The present invention addresses the treatment of age-related macular degeneration, and treatment of individuals with impaired visual function such as impaired dark adaptation, using regulation of...
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7470659 |
Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions...
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7465717 |
Process for releasing and extracting phosphatides from a phosphatide-containing matrix
A process for releasing and extracting phosphatides from a phosphatide-containing matrix. The process includes (i) contacting the phosphatide-containing matrix with a solvent and a metal salt to...
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7456223 |
Treatment of bruxism
A composition and its use for local percutaneous delivery of a drug, in particular a muscle relaxant, more particularly cyclobenzaprine present in an amount of about 1 to about 10% by weight of the...
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7455855 |
Delivering substance and drug delivery system using the same
An object of the present invention is to prepare substances which are excellent in delivery and enable drugs to be retained in a body effectively over a long period and to construct a drug delivery...
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7354906 |
Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human
The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated...
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7344720 |
Vaccine composition
The present invention relates to a pharmaceutical composition comprising at least one vaccine antigen, which also comprises at least one phosphoric ester derivative of phosphatidylcholine having...
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7273604 |
Anti-asthmatic combinations comprising surface active phospholipids
Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine...
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7199112 |
Use of phospholipid arachidonic acids for increasing muscle mass in humans
This invention discloses a method of increasing muscle mass comprising administering phospholipid arachidonic acid to a human in need thereof.
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7182956 |
Stable topical drug delivery compositions
A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
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7141554 |
Method of treating irritable bowel syndrome
A nutritional composition is disclosed which comprises synergistic functional carbohydrates for preventing or treating infection by pathogenic bacteria and/or promoting gut flora balance and...
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7060290 |
Phosphocholine linked prodrug derivatives
Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or...
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6991776 |
Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described,...
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6979459 |
Treatment of skin damage using polyenylphosphatidycholine
Polyenylphosphatidylcholine is topically applied to treat skin damage, such as contact dermatitis (particularly diaper area dermatitis), atopic dermatitis, xerosis, eczema (including severe hand...
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6933291 |
Cholesterol lowering supplement
The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as suitable composition comprising...
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6932963 |
Treatment of skin wounds using polyenylphosphatidylcholine and alkanolamines
Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minmize scar formation. Typical compositions contain from about...
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6894032 |
Use of CDP-choline for the treatment of alcohol withdrawal syndrome
The invention relates to the use of CDP-Choline or its pharmaceutically acceptable salts for the preparation of a medicinal product for the treatment of alcohol withdrawal syndrome at daily doses...
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6858421 |
Cytosolic phospholipase A2-beta enzymes
The invention provides a novel calcium-independent cytosolic phospholipase A2-Beta enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6780430 |
Stabilzation method of nano-sized emulsion using tocopheryl derivatives and external application for skin containing the same
Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula (I) and (Wherein,R1, R2 and R3 are H or methyl...
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6683066 |
Composition and treatment method for brain and spinal cord injuries
After interruption of blood supply to central nervous system tissue, cerebral edema sets in. It has been shown that restoring blood flow to injured areas of the central nervous system after the...
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6677319 |
Phosphatidylcholine as medication with protective effect large intestinal mucosa
The presented invention relates to a medication containing a therapeutically effective amount of phosphatidylcholine as active substrate for treatment of disease where phosphatidylcholine has an...
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6602861 |
Acylated phospholipid drugs
This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the...
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