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7384984 |
Reactive hydrophilic oligomers
Hydrophilic compositions are described, which are prepared from a first component oligomer containing pendent hydrophilic groups and pendent reactive functional groups capable of reaction at...
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7381751 |
Antimicrobial composition for medical articles
An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a silicone resin. The antimicrobial formulation is formed from...
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7381422 |
Method for producing sterile polynucleotide based medicaments
The present invention relates to a novel method for producing formulations comprising a polynucleotide, block copolymer and cationic surfactant. The formulations produced by the current method are...
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7364752 |
Solid dispersion pharamaceutical formulations
A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved...
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7357949 |
Encapsulated inorganic antimicrobial additive for controlled release
The invention relates to a microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the...
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7348364 |
Segmented copolyesters as compliant, absorbable coatings and sealants for vascular devices
Disclosed are absorbable sealants or coatings for biomedical devices which are formulated from a segmented copolyester having a molecular weight of more than 5 kDa, a glass transition temperature...
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7342047 |
Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups
The present invention provides cross linkable compositions useful in the preparation of hydrophilic gels, and are prepared from obligers having pendent hydrophilic ploy(alkenylene oxide) groups,...
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7335675 |
Aqueous suspension formulation for foliar application fungicide
The present invention provides an aqueous suspension formulation containing (RS)-N-[2-(1,3-dimethylbutyl)thiophene-3-yl]-1-methyl-3-trif
luoromethyl-1H-pyrazole-4-carboxamide and having high rain...
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7332527 |
Cross-linked ionic core micelles
The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present...
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7326426 |
Compositions and medical devices utilizing bioabsorbable liquid polymers
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic...
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7255870 |
Composition containing a semicrystalline polymer, uses thereof, and method for making
A composition containing an aqueous phase dispersed in an oily phase, at least one emulsifier with an HLB value ranging from 1 to 8, at least one organic powder, and, in the oily phase at least one...
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7252838 |
Drug releasing elastic band and method
A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a...
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7244797 |
Organic domain/inorganic domain complex materials and use thereof
Disclosed are an organic domain/inorganic domain hybrid material comprising an organic domain comprising at least one water-soluble organic polymer having anionic and/or cationic functional groups,...
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7241455 |
Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent
An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a...
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RE39713 |
Polymerizable biodegradable polymers including carbonate or dioxanone linkages
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and...
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7229647 |
Chlorine dioxide gel and associated methods
A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that...
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7229642 |
Amino acid modulated extended release dosage form
Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an...
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7226620 |
Directly compressible tricalcium phosphate
A compressible tricalcium phosphate agglomerate comprises tricalcium phosphate particles, each having an outer surface, and a binder comprising a polyvinylpyrollidone, carrageenan, or a guar gum,...
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7223418 |
Stretchable patch
A stretch plaster comprising a support membrane having a thickness of 1 to 50 μm and a drug containing adhesive layer having a thickness of 3 to 400 μm, wherein (i) the support membrane...
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7217426 |
Coatings containing polycationic peptides for cardiovascular therapy
Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coatings include a region containing a polycationic peptide, such as, for example, the polycationic...
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7214366 |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
Water soluble activated polymers are provided containing an active ethyl sulfone moiety having a reactive site located at the second carbon from the sulfone group. In an embodiment, a poly(ethylene...
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7204997 |
Responsive microgel and methods related thereto
A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic...
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7202225 |
Therapeutic delivery compositions and methods of use thereof
The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition...
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7201915 |
Polyamide stick dispensing product and method of use
Described for the purpose of application to an inanimate laminar substantially solid surface is a substantially hydrocarbon-free functional substance-providing stick article having...
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7182951 |
Selection and treatment of seeds
A new vigor test is used to select seeds which, after appropriate polymeric coating, will perform well under adverse planting and growing conditions. For example, suitably coated hybrid corn seeds...
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7176209 |
Fungicidal formulation
Adjuvants selectes from mon/ionic water/soluble mixed polyalkoxy-lated aliphatic alcohol surfactants, non ionic water soluble ethoxylated aliphatic alcohol surfactants, amine ethoxylates, and...
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7163694 |
Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block...
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7153520 |
Composition for sustained delivery of hydrophobic drugs and process for the preparation thereof
A composition for the sustained delivery of a drug comprising an amphiphilic diblock copolymer; a poorly water-soluble drug; a biodegradable polymer; and liquid poly(ethylene glycol) or functional...
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7144922 |
Method and compound for the prophylaxis or treatment of an immunodeficiency condition, such as AIDS
A method and compound for the prophylaxis or treatment of an immunodeficiency condition, such as acquired immunodeficiency syndrome (AIDS) includes a glycol derivative. More specifically, the...
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7129276 |
Composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer
A composition comprising, in a physiologically acceptable medium, at least one liquid fatty phase structured by at least one semi-crystalline polymer having an organic structure, wherein said...
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7125562 |
Rapidly disintegrating methylcellulose tablets
The present invention relates to a rapidly disintegrating tablet for oral administration. The tablet has a first phase and a second phase blended with the first phase. The first phase has a...
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7118761 |
Method for producing a silver-containing wound care device
Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The...
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7115586 |
Non-inclusion cyclodextrin complexes
The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization...
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7112417 |
Foam composite for the repair or regeneration of tissue
The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition...
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7109166 |
Sustained release formulation of a peptide
This invention is directed to a sustained release composition comprised of Compound (A) having the formula
or a pharmaceutically acceptable salt thereof, and a copolymer comprised of...
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7101928 |
Polymeric thickeners for oil-containing compositions
Novel thickeners for oil-containing compositions are crystalline polymers, preferably side chain crystalline polymers, which (a) have a crystalline melting point, T p , and an onset of melting...
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7101840 |
Polymeric drug formulations
A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and...
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7101568 |
Methods and compositions for treating solid tumors
A biodegradable polymer composition comprising:
(a) a poly(phosphoester) biodegradable polymer and (b) at least one antineoplastic agent in an amount effective to inhibit the growth of a...
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7101564 |
Plastically deformable implant
The invention relates to a plastically deformable implant for inserting into bodily orifices of the human or animal body. Implants of this type are used, for example, in ophthalmology, in...
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7094810 |
pH-sensitive block copolymers for pharmaceutical compositions
The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl...
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7084132 |
Artemisinins with improved stability and bioavailability for therapeutic drug development and application
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation...
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7081246 |
Stable hydroalcoholic compositions
A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system...
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7074424 |
Polyalkylene glycol viscosity-enhancing polymeric formulations
Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity...
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7074412 |
Pharmaceutical composition
The present invention relates to pharmaceutical compositions containing a synergistic amount of at least one bone morphogenetic protein (BMP) and a synergistic amount of at least one pyrrolidone...
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7045552 |
Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy
Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic...
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7033603 |
Drug releasing biodegradable fiber for delivery of therapeutics
The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of...
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7019192 |
Composition for filling bone defects
The invention is directed toward a formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of...
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7018655 |
Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a...
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7015177 |
Solid formulation
A solid formulation of an agrochemical is prepared by forming a melt containing at least one agrochemical and at least one thermoplastic binder having a melting point or glass temperature of...
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7014866 |
High dose solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate and process for making same
A solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate is provided comprising amorphous nelfinavir mesylate in an amount of from about 400 mg to about 700 mg calculated as...
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