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5834472 |
Antifungal composition with enhanced bioavailability
A pharmaceutical composition comprising: i) an antifungal agent which is (-)-(2R-cis)-4- 4- 4- 4- -5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-t...
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5834005 |
Bioartificial devices and cellular matrices therefor
A device for the effective release of cellular moieties, including hormones, wherein a matrix containing a hormone producing cellular moiety is encapsulated with a non-immunogenic polymeric...
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5824345 |
Fragrances and flavorants
Compositions useful in the delivery of fragrances and flavorant active agents, and particularly vaporous fragrances and flavorants, are provided. These compositions include a microsphere which...
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5824322 |
Compositions and methods for growth promotion
The present invention includes compositions and methods using biologically active nonionic reverse block copolymers. The reverse copolymers have an inner core of polyoxypropylene (POP) that is...
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5817328 |
Material for buffered resorbable internal fixation devices and method for making same
A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and...
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5814330 |
Mucoadhesive emulsions containing cyclodextrin
The present invention relates to the use of a cyclodextrin or a derivative thereof as a mucoadhesive in an emulsion or aqueous solution, said cyclodextrin or derivative thereof being used in an...
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5811112 |
Oil-in-water cosmetic emulsions containing a stabilized protease
Cosmetic oil-in-water emulsions which are intended to be left on the skin after application (not rinsed off) the emulsions incorporating a stabilized protease. The cosmetic emulsions useful in...
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5811091 |
Cyanoacrylate compostions comprising an antimicrobial agent
Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ...
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5788978 |
Injectable pulsatile ivermectin composition
An injectable ivermectin composition having a programmable release rate and providing multiple concentration peaks of active ivermectin to produce a sequence of ivermectin release pulses into the...
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5780060 |
Microcapsules with a wall of crosslinked plant polyphenols and compositions containing them
Microcapsules based on crosslinked plant polyphenols are described. These microcapsules are obtained by the interfacial crosslinking of plant polyphenols, particularly flavonoids. When incorporated...
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5773023 |
Enhanced skin penetration system for improving topical delivery of drugs
The invention involves pharmaceutical compositions for topical application comprising: (a) a safe and effective amount of a pharmaceutical active; and (b) from about 0.05% to about 5% of a...
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5766550 |
Disposable reagent storage and delivery cartridge
A disposable cartridge for storage and delivery of reagents for synthesizing and labeling of synthetic oligonucleotides comprises an annular casing, an enclosed area defined by the interior surface...
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5762962 |
Antacid pharmaceutical composition
Antacid pharmaceutical compositions provide optimal buffering profiles of from 3.0 to 5.0 for immediate and long lasting relief from the symptoms of acid indigestion, sour stomach, heartburn and...
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5759583 |
Sustained release poly (lactic/glycolic) matrices
This invention provides a sustained release composition comprising a PLGA matrix, a bioactive agent, and a quaternary ammonium surfactant, in which the release profile of the bioactive agent from...
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5759532 |
Controlled release of miotic and myriatic drugs in the anterior chamber
The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and...
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5756553 |
Medical material and process for producing the same
A medical material of the present invention comprises a polymer or copolymer of a vinyl derivative having a polar group, said polymer or copolymer containing an antiplatelet agent. Since the...
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5756572 |
Silicone pressure sensitive adhesive composition containing thermoplastic multi-segmented copolymer
A pressure sensitive adhesive composition comprises a mixture of (A) a silicate resin, (B) a silicone fluid, and (C) a thermoplastic multi-segmented copolymer which is a product of the reaction...
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5747061 |
Suspension of loteprednol etabonate for ear, eye, or nose treatment
The invention provides novel compositions of matter for delivering water-insoluble steroid drugs suitable for therapeutic use. The invention also provides stable aqueous suspensions of...
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5744166 |
Drug delivery compositions
Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a...
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5733562 |
Injectable medical device and method of use
The present invention is an injectable medical device useful for replacing natural lubricating fluids in the body of humans or animals. The method and composition can be used for the treatment of...
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5733565 |
Male contraceptive implant
The present invention relates to implantable male contraceptive devices. An ethylene vinyl acetate copolymer based implant is described for delivery of an androgen and a system including an...
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5728390 |
Cosmetic composition of an alpha or beta-hydroxy acid and a polyvinylpyrrolidone complexing agent
What is described herein is a cosmetic composition of an alpha-hydroxy acid, such as lactic acid or glycolic acid, or a beta-hydroxy acid, such as salicylic acid, and a...
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5725882 |
Vinyl-silicone copolymers in cosmetics and personal care products
Cosmetic compositions are provided containing vinyl-silicone graft or block copolymers of the formula ##STR1##
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5710182 |
Ophthalmic composition
The present invention is directed to an ophthalmic composition in the form of a topical aqueous solution consisting essentially of an ophthalmologically active agent, an ion sensitive,...
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5702721 |
Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof
A transdermal therapeutic system exhibiting layered structure consists of a backing layer which is impermeable to active substances, a matrix having water-insoluble basic material and islands...
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5700478 |
Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity
Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer....
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5700486 |
Pharmaceutical compositions in the form of particles suitable for the controlled release of pharmacologically active substances and process for preparing the same compositions
Pharmaceutical compositions in the form of particles comprising a biodegradable polymer and/or a polysaccharide jellifying and/or bioadhesive polymer, an amphiphilic polymer, an agent modifying the...
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5695814 |
Method of making a powdered biocidal composition
A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core...
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5688517 |
Method for assessing sensitivity of tumor cells to cephalomannine and 10-deacetyltaxol
A method for assessing the sensitivity of a patient's tumor cells to cephalomannine and 10-deacetyltaxol in order to treat those tumor cells involves the removal of a sample of the tumor cells and...
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5686110 |
Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance
A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is...
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5681581 |
Controlled release pharmaceutical formulations of 3'-azido-3'-deoxythymidine and methods of use
This invention is directed to controlled release pharmaceutical formulations of 3'-azido-3'-deoxythymidine, also known as AZT or zidovudine and methods of use thereof. The controlled release...
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5674521 |
Enhanced loading of solutes into polymer gels and methods of use
A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically...
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5670145 |
Biologically active system for dispersion of pheromones
The present invention relates to liquid formulations containing pheromones, in particular sex pheromones of insects, as an active ingredient, supported by an inert liquid material whereby a...
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5668185 |
Method of making an amine containing biocidal composition
A process for preparing a composite including mixing a hydrophilic material containing an amine with a hydrophobic material containing an acid releasing agent, the hydrophilic and hydrophobic...
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5665367 |
Skin care compositions containing naringenin and/or quercetin and a retinoid
Quercetin and/or naringenin in combination with either retinol or retinyl ester resulted in a synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in...
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5665394 |
Matrix for sustained-release preparation
The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an...
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5662935 |
Process for preparing controlled release pharmaceutical forms and the forms thus obtained
An improved process for preparing controlled release pharmaceutical forms comprises exposing a mixture comprising one or more excipients and one or more active ingredients compatible with each...
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5663213 |
Method of improving ultraviolet radiation absorption of a composition
A method is disclosed for improving the UV radiation absorption of a composition containing a UV radiation absorbing agent by adding from about 0.1 weight percent to about 50 weight percent of...
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5660848 |
Subdermally implantable device
Disclosed is a subdermally implantable drug-delivery device, which contains: a central core extending in an axial direction and having an outer surface and opposing ends, which core includes a...
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5653972 |
Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
Disclosed are storage-stable preserved ophthalmic compositions containing acidic drugs in combination with polymeric quaternary ammonium compounds and boric acid.
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5651977 |
Adherent disinfecting compositions and methods relating thereto
Disinfecting compositions directed to the prevention of microbial infections are disclosed. The disinfecting compositions comprise a protic acid, a metal chlorite and a gelling agent which, when...
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5650446 |
Sustained release biocidal composition
A composite for retarding bacterial, fungal and viral contamination and mold growth including a hydrophobic material containing an acid releasing agent, and a hydrophilic material containing...
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5648389 |
Compositions for the treatment of dermatological disorders and methods for their use
The present invention provides compositions and methods for alleviation of both visible and non-visible, or pre-emergent, dermatological lesions associated with changes in normal keratinization,...
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5641745 |
Controlled release biodegradable micro- and nanospheres containing cyclosporin
A controlled release pharmaceutical formulation which comprises cyclosporin entrapped in a biodegradable polymer to form microspheres or nanospheres such that the cyclosporin is substantially in an...
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5637309 |
Physiologically active substance-prolonged releasing-type pharmaceutical preparation
A prolonged releasing pharmaceutical preparation is provided carrying a physiologically active substance, particularly, calcitonin gene-related peptide (CGRP) or a maxadilan (MAX). This...
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5635540 |
Stabilized topical pharmaceutical preparations
The present invention relates to stabilized topical pharmaceutical preparations. More specifically the present invention relates to a stabilized topical pharmaceutical preparation, based on the...
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5633001 |
Composition and a method for tissue augmentation
The present invention provides a biocompatible composition for tissue augmentation, comprising a pseudoplastic polymer carrier in an amount of 0.05-50% (w/w) of the total composition; and one or...
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5631300 |
Method of making a sustained release biocidal composition
A process for preparing a composite for preventing the growth of bacteria, molds, fungi and viruses by dissolving a chlorite salt in a hydrophilic material, and then mixing the hydrophilic material...
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5629350 |
Suspension formulations of ortho-phenylphenol
Stable, concentrated aqueous suspensions of ortho-phenylphenol (OPP) which contribute minimal chemical oxygen demand and methods of preparing and using said suspensions in biocidal applications...
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5620697 |
Method for preparing matrix-type pharmaceutical compositions through ultrasonic means to accomplish melting
An ultrasonic processing method by which polymer/drug composites can be quickly and efficiently molded to form matrix-type drug delivery systems is disclosed. The advantages of the method include...
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