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7388032 |
Sustained release compositions, process for producing the same and utilization thereof
A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition...
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7384984 |
Reactive hydrophilic oligomers
Hydrophilic compositions are described, which are prepared from a first component oligomer containing pendent hydrophilic groups and pendent reactive functional groups capable of reaction at...
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7371781 |
Tumor environment-induced ligand-expressing nanocarrier system
Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for...
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7348364 |
Segmented copolyesters as compliant, absorbable coatings and sealants for vascular devices
Disclosed are absorbable sealants or coatings for biomedical devices which are formulated from a segmented copolyester having a molecular weight of more than 5 kDa, a glass transition temperature...
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7342047 |
Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups
The present invention provides cross linkable compositions useful in the preparation of hydrophilic gels, and are prepared from obligers having pendent hydrophilic ploy(alkenylene oxide) groups,...
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7338663 |
Expandable osmotic composition and coating suspension
The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release...
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7335675 |
Aqueous suspension formulation for foliar application fungicide
The present invention provides an aqueous suspension formulation containing (RS)-N-[2-(1,3-dimethylbutyl)thiophene-3-yl]-1-methyl-3-trif
luoromethyl-1H-pyrazole-4-carboxamide and having high rain...
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7332527 |
Cross-linked ionic core micelles
The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present...
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7326425 |
Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release
A formulation containing a biologically active compound having a structure with hydrogen bonding sites blended with a first polymer having a structure with complementary hydrogen bonding sites and...
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7317070 |
Process for the preparation of polyamino acids
Among the various aspects of the present invention is an improved process for the preparation of polyamino acids generally, and more specifically, polyglutamic acid and polyaspartic acid. Another...
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7273891 |
Stable copolymers
A graft reverse thermal hydrogel which does not show substantial loss of complex viscosity at and up to 20 degrees above the transition temperature upon autoclaving or aging. Other embodiments...
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7265157 |
Sustained release compositions, process for producing the same and use thereof
Sustained release compositions containing a physiologically active substance or its salt, hydroxynaphthoic acid or its salt and a lactic acid-glycolic polymer or its salt, wherein the product of...
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7241813 |
End-capped polymers and compositions containing such compounds
End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula:
...
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7238364 |
Compliant tissue sealants
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the...
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RE39713 |
Polymerizable biodegradable polymers including carbonate or dioxanone linkages
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and...
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7214366 |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
Water soluble activated polymers are provided containing an active ethyl sulfone moiety having a reactive site located at the second carbon from the sulfone group. In an embodiment, a poly(ethylene...
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7204997 |
Responsive microgel and methods related thereto
A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic...
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7202281 |
Methods and compositions for reducing or eliminating post-surgical adhesion formation
The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably...
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7153520 |
Composition for sustained delivery of hydrophobic drugs and process for the preparation thereof
A composition for the sustained delivery of a drug comprising an amphiphilic diblock copolymer; a poorly water-soluble drug; a biodegradable polymer; and liquid poly(ethylene glycol) or functional...
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7109255 |
Bioresorbable hydrogel compositions for implantable prostheses
Crosslinked compositions formed from water-insoluble copolymers are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two cross-linkable...
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7101928 |
Polymeric thickeners for oil-containing compositions
Novel thickeners for oil-containing compositions are crystalline polymers, preferably side chain crystalline polymers, which (a) have a crystalline melting point, T p , and an onset of melting...
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7094810 |
pH-sensitive block copolymers for pharmaceutical compositions
The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl...
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7063980 |
Pretreatment kit for saliva and pretreatment method for saliva
A pretreatment kit and a pretreatment kit for saliva in identification and quantitative determination of mutans streptococci by immunochromatography utilizing an antigen-antibody reaction, which...
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7056533 |
Medicament incorporation matrix
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating...
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7053125 |
Controlled dispersion of colloidal suspension by comb polymers
Comb polymers are used as dispersants to increase the stability of colloidal suspensions containing multivalent or high concentrations of monovalent ions. Stabilized colloidal suspensions and...
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7045552 |
Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy
Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic...
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7034061 |
Non-thrombogenic and anti-thrombogenic polymers
Polymers having non-thrombogenic properties can be prepared by copolymerizing monomers of at least three classes selected from (a) monomers having sulphate groups, (b) monomers having sulphonate...
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7029688 |
Methods and compositions to prevent formation of adhesions in biological tissues
The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form...
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7005454 |
Polymeric drug formulations
Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also...
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6979455 |
Antimicrobial concentrates
An antimicrobial concentrate is manufactured from a carrier, one or more antimicrobial agents and optionally one or more modifiers, the carrier having a modified ethylene polymer and optionally an...
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6969528 |
Phosphorus-containing dendrimers as transfection agents
The invention concerns phosphorus-containing dendrimers and their uses, as gene transfection agents, in vitro and in vivo, including in the treatment of human and animal diseases. These agents or...
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6951642 |
Water-in-oil emulsions with anionic groups, compositions, and methods
Water-in-oil emulsions, compositions, and methods that include a vinyl polymer having a pKa of less than 4 that includes anionic group-containing side chains and alkyl-Y-containing side chains,...
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6949504 |
Composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer
A composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer having a low melting point and an organic structure, wherein said polymer is solid at...
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6939561 |
Methods and compositions for polyene antibiotics with reduced toxicity
Provided are methods and compositions for reducing the toxicity of certain hydrophobic therapeutic agents, especially polyene antibiotics, in particular, Amphotericin B (AmB), and therapeutics such...
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6932981 |
Rapidly disintegrating sustained release cefuroxime axetil composition
A fast disintegrating controlled release oral composition comprising a core material containing cefuroxime axetil present as controlled release form, the cefuroxime axetil being provided with an...
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6908628 |
Disinfectant and antiseptic composition
Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid...
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6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
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6824792 |
Bioadhesive composition
This invention relates to a method of producing a bioadhesive composition comprising the steps of preparing a solution of a solvent and a polymer mixture wherein the polymer mixture comprises at...
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6800663 |
Crosslinked hydrogel copolymers
The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a...
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6749869 |
Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection
The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition...
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6743439 |
Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride
Aqueous pharmaceutical solution compositions preserved with a cationic preservative and comprising a cationic drug and a sulfonated styrene/maleic anhydride copolymer are disclosed. The...
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6730311 |
Air fresheners comprising polyurethane/polyurea matrices for the delivery of fragrance agents
This invention relates to a picture frame assembly comprising (a) a frame panel comprising a sustained release fragrance material; (b) a picture panel comprising an adsorbent panel coated with a...
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6703045 |
Composition and method for maintaining blood glucose level
A composition useful for reducing serum glucose levels by an oral controlled release system and a method for treating diabetes in a human being by controlling the blood glucose level (BGL) and...
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6703039 |
Reversible gelling system for ocular drug delivery
The invention provides an ophthalmic aqueous composition for topical administration, comprising: (a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide...
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6703011 |
Application of film forming technology to fragrance control release systems; and resultant fragrance control release systems
Described is a fragrance control release system which is an emulsifier-free, single phase, nonporous, continuous, permeable polymeric film having a substantially uniform thickness of from about 1...
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6699510 |
Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection
The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly...
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6696500 |
Sustained-release preparation
A sustained-release preparation comprising a bioactive substance having an acidic group and a biodegradable polymer having an optionally protected basic group which improves the rate of...
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6689340 |
Hair composition containing a polycondensate comprising at least one polyurethane and/or polyurea unit and a polyol
The invention relates to hair compositions packaged in aerosol form and comprising, in a cosmetically acceptable medium, a polycondensate, such as a multiblock polymer, comprising at least one...
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6676971 |
Embolic compositions
Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains...
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6660281 |
Silicones for power treatment powers having surface treated with said silicones and cosmetic materials containing said powers
Powders treated with silicones represented by the following formula ( 1 ): R 1 a R 2 b R 3 c SiO (4−a−b−c)/2 ( 1 ) wherein R 1 , R 2 , R 3 a, b and c are as defined herein, are suitable...
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