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8138200 |
Compositions and methods for double-targeting virus infections and targeting cancer cells
The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus...
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8106032 |
Lipid analogs for combating tumors
The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an...
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7807658 |
Use of GabaB receptor agonists
Novel compounds of formula I, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; andii) (2R/S, 3R)-(3-amino-2-hydroxybutyl)phosphinic acid, having affinity to one or...
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7786077 |
Insulins combinations
A pharmaceutical association or combination comprising a therapeutic effective amount of insulin or insulin analogue, and a therapeutic effective amount of a pharmaceutically acceptable betaine, in...
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7772209 |
Antifolate combination therapies
A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
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7678764 |
Protein formulations for use at elevated temperatures
Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5,...
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7586020 |
Methods for determining effects of maternal treatments on offspring
The present invention provides animal models and methods for the evaluation of maternal treatments that could improve or compromise the epigenetic state, the imprinting, or the DNA methylation and...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7410955 |
Therapeutic use of agonist ligands specific to G2A receptor
The present invention relates to novel therapeutical use of agonist ligands specific to G2A receptor. More particularly, the present invention relates to methods for treating a disease or disorder...
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7294619 |
Lipid analogs for inhibiting the activity of hepatitis B antigen
The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an...
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7294620 |
Lipid analogs for inhibiting HIV-1 activity
The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an...
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7294621 |
Lipid analogs for combating tumors
The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an...
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7141557 |
Lipid analogs for treating viral infections
A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an...
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7135289 |
Methods and compositions for mutation analysis of polynucleotides by liquid chromatography
Methods, compositions, and kits for separating heteroduplex and homoduplex DNA molecules in a test mixture by temperature-compression denaturing high performance liquid chromatography (tcDHPLC)....
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7071232 |
Small molecules that increase the conversion of food to body weight gain
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same in the field of general health care, for example, to improve...
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7067500 |
Betaines as adjuvants to susceptibility testing and antimicrobial therapy
The present invention is directed to methods of antimicrobial therapy for a patient infected with, or suspected of being infected with a microorganism that has mycolic acid structures in its outer...
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7053065 |
Vitamin B12 and pemetrexed disodium combination therapies
A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
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6979682 |
Platelet-activating factor antagonist inhibition of angiogenesis and tumor growth induced by basic fibroblast
A novel use of platelet-activating factor antagonists that bind to intracellular PAF binding sites such as BN-50730 (tetrahedra-4,7,8,10 methyl-1 (chloro-1 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9...
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6696428 |
Use of dopamine receptor antagonists in palliative tumor therapy
The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide....
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6620794 |
Guerbet functionalized phospholipids
The present invention relates to novel compositions and, more particularly, to a class of compounds having specific quaternized amine based upon a guerbet amido amine linked to specific phosphate...
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6602861 |
Acylated phospholipid drugs
This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the...
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6583127 |
Use of etherlysophospholipids as antiinflammatory agents
The present invention relates to the use of a series of etherlysophospholipids (ELPs) for the preparation of a medicament for the treatment of an inflammatory disease without causing adverse...
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6579859 |
Control of protozoa and protozoan cysts that harbor legionella
A method of controlling protozoa trophozoite and cysts is disclosed, comprising administering a phosphonium salt of the formula: (R1)3P−R2.X−, wherein R1 is an alkyl group having from 1-8 car...
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6541680 |
Nutritional methyl supplements change DNA methylation and related characteristics of mammalian offspring
Increasing methylation of DNA in an unborn offspring of a pregnant mammal results in changing the epigenetically determined phenotype of the unborn offspring, inhibiting parasitic DNA sequences in...
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6525034 |
Clear personal care formulations containing quaternary ammonium compounds and other nitrogen-containing compounds
A composition formulated from a primary anionic surfactant; optionally a secondary surfactant and/or a resin; and a nitrogen-containing compound of the structural formula: wherein R is a saturated,...
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6500810 |
Method of regulating expression of adhesion molecules on circulating leukocytes
A method to inhibit inflammation in a mammal is disclosed. The method includes administering to the mammal a composition comprising a phospholipid, which can be lysophosphatidic acid. The...
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6489369 |
Phosphocholine surfactants and their use
A pharmaceutical formulation comprising a pharmaceutically active agent, which is insoluble or sparingly soluble in water and a sterol phosphocholine surfactant.
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6451775 |
Castor amidopropyl dimethyl phospholipids as emulsifiers
The present invention relates to novel compounds and, more particularly, to a class of compounds having specific quatenized amine based upon a castor amido amine linked to specific phosphate...
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6426069 |
Method and compositions for increasing intestinal absorption of fats
This invention provides a composition and method for increasing fat absorption from the intestine by increasing the amount of lysophosphatidylcholine in the intestine. The composition comprises...
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6399114 |
Nutritional system for nervous system disorders
A novel composition for treating nervous system disorders. The composition is formed by preparing a mixture comprising an effective amount of vitamin B-6, folic acid, vitamin C, magnesium, vitamin...
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6331293 |
Dimer amidopropyl dimethyl phospholipids as barrier compounds
The present invention relates to compounds and, more particularly, to a class of compounds having specific quaternized amine based upon a dimer acid amido amine linked to specific phosphate esters....
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6329352 |
Method and composition for treating sleep apnea
Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea...
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6322821 |
Veterinary pharmaceutical composition
A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene...
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6316434 |
Assay for emetic activity
An assay for emetic activity among inhibitors of type 4 phosphodiesterase (PDE 4) is disclosed. The assay comprises: (A) administering to a test mammal an anesthetic compound in an amount...
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6313106 |
Phospholipid derivatives of valproic acid and mixtures thereof
The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar...
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6127349 |
Phospholipid drug derivatives
Disclosed herein are methods for increasing the bioavailability of pharmaceutical agents by conjugation to phospholipids. Also disclosed are phospholipid-derivatized steroids, peptides, antibiotics...
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6080422 |
Methods of angioplasty and cardiac catheterization
The present invention provides an improved mode of operation of an apparatus for angioplasty or cardiac catheterization, apparatus for angioplasty and cardiac catheterization, and method of...
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6071919 |
Zwitterionic compositions and methods as biological response modifiers
A method of treating a disease in a mammal by administering a therapeutic effective amount of an amphoteric zwitterion compound as an active ingredient. A pharmaceutical composition which comprises...
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6069138 |
Use of phospholipids of animal origin in therapy and/or dietetics
The invention concerns a novel use of phospholipids of animal origin in therapy and/or dietetics, more particularly the use of phospholipids rich in long-chain polyunsaturated fatty acids derived...
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6034073 |
Solvent detergent emulsions having antiviral activity
Methods and pharmaceutical compositions for inactivating an envelope virus using an oil-in-water emulsion including an oil, a surfactant, and an organic phosphate-based solvent are disclosed. These...
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6030960 |
Method of treating hepatitis virus infections
A method of treating hepatitis virus infection is disclosed. The method comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of an...
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6024985 |
Bone materials
The invention provides a synthetic bone precursor material comprising amorphous calcium phosphate and a constituent that inhibits the crystallisation of calcium hydroxyapatite to amorphous calcium...
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6015798 |
Method for reducing the damaging effects of radiation therapy on animal skin and mucosa
The severity of damage caused to the skin and mucosa of animals with cancer undergoing radiation therapy is mitigated by feeding the animal a nutritionally balanced food composition containing...
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5972911 |
Composition for the delivery of orally administered drugs and other substances
A composition comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline...
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5958977 |
Phosphoric acid-amino acid complex salt and additive composition containing the salt and used in feed for ruminant mammals
A novel phosphoric acid-amino acid complex salt is provided which manifests insolubility in a neutral or alkaline aqueous solution and solubility in an acidic aqueous solution and has a basic amino...
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5958463 |
Agricultural pesticide formulations
The present invention relates generally to the method for the production of liposomal microencapsulated boron-containing products to be used for agricultural formulations. More specifically, a new...
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5916884 |
Compositions containing a mixture of phosphorus compounds and alkylglycerols
Cytotoxic therapeutic compositions contain as active ingredients compounds of the formula R--Y--POθ2 --X--R1wherein R is a saturated or unsaturated hydrocarbon radical of 12 to 14 carbon atoms ...
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5888990 |
Phosphocholine drug derivatives
Disclosed herein are methods for increasing the bioavailability of pharmaceutical agents by conjugation to phosphocholine. Also disclosed are phosphocholine-derivatized steroids, peptides and other...
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5880098 |
Therapeutic treatment
The present invention is directed to a therapy involving administering effective amounts of an organic osmolyte selected from the group consisting of polyols, amino acids and methyl amines, that...
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