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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7273604 |
Anti-asthmatic combinations comprising surface active phospholipids
Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine...
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7001896 |
Compositions for treating diabetes
The present invention provides a pharmaceutical composition for treating diabetes containing 4-diethoxyphosphinoylmethyl-N-(4-bromo-2-cyanophenyl)benzami
de, particularly a pharmaceutical...
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6794371 |
Aminoalkylenephosphonates for treatment of bone disorders
A method for preventing loss of bone mineral in mammals which method comprises administering to a mammal an amount of an aminoalkylenephosphonate which is effective to prevent or minimize loss of...
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6784168 |
Biocidal compositions and treatments
A synergistic biocide comprises a tris(hydroxymethyl)phosphine or a tetrakis (hydroxymethyl)phosphonium salt and at least one non-surfactant biopenetrant, such as a polymer or copolymer having a...
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6673378 |
Phosphatidylserine-containing muscle development diet supplement and anti-catabolic dietary nutrients
An anti-catabolic dietary supplement, phosphatidylserine, and diet and exercise programs using phosphatidylserine for lean muscle development and optimized conditioning.
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6593312 |
Cyclic α-amino-&ggr -hydroxyamide compounds
A compound of formula (I): wherein: represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R 1 and R 4 , which may be identical or different, each...
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6541462 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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6476006 |
Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
The present invention provides compacted pharmaceutical composition for oral administration to a patient which expands upon contact with gastric fluid to retain a dosage form in the patient's...
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6380174 |
Slime-removing composition for paper manufacture and method of controlling slime using the same
Disclosed is a slime-removing composition comprising polyhexamethyleneguanidine phosphate and 2-bromo-2-nitro-1, 3-propanediol, represented by the following formulas I and II, respectively. With a...
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6353022 |
Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
Compositions containing one or more HETE derivative(s) and an effective concentration of ethanol and methods of use for treating dry eye are disclosed.
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6348491 |
Oil-in-water emulsion for encapsulating paclitaxel
An oil-in-water emulsion for encapsulating paclitaxel including (a) triglyceride , (b) emulsifier including phosphatidyl choline (PC), non-ionic surfactant and polyethyleneglycol-modified disteaoyl...
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6329352 |
Method and composition for treating sleep apnea
Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea...
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6313106 |
Phospholipid derivatives of valproic acid and mixtures thereof
The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar...
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6300323 |
(Poly)ethereal ammonium salts of herbicides bearing acidic moieties and their use as herbicides
A compound ##STR1## Wherein x, y, and z are integers from 0 to 3; and the (poly)ethereal amine is at least one selected from compounds of formula II 1 through II 5 : ##STR2##
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6162427 |
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of...
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6071919 |
Zwitterionic compositions and methods as biological response modifiers
A method of treating a disease in a mammal by administering a therapeutic effective amount of an amphoteric zwitterion compound as an active ingredient. A pharmaceutical composition which comprises...
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5958977 |
Phosphoric acid-amino acid complex salt and additive composition containing the salt and used in feed for ruminant mammals
A novel phosphoric acid-amino acid complex salt is provided which manifests insolubility in a neutral or alkaline aqueous solution and solubility in an acidic aqueous solution and has a basic amino...
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5902802 |
Cationic amphiphiles
Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The...
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5897860 |
Method for controlling bleeding and microbial infections by administering thrombin, casein kinase II, and sphingosine
The present invention relates to a hemostatic composition comprising at least 0.1 NIH U/ml of thrombin, about 0.01 mU/ml of casein kinase II, and from 10 ng/ml to 100 ng/ml of sphingosine or a...
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5888405 |
Methods for controlling biofouling using amino methyl phosphonic acids
The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl...
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5753667 |
1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, their preparation and their therapeutic application
The present invention provides a compound of formula (I) ##STR1## in which R 1 represents a hydrogen atom or a (C 1 -C 4 )alkyl group, R 2 represents a hydrogen atom or a straight or branched (C...
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5716959 |
Method of treating disease with piperazine zwitterion compounds
A substituted piperazine zwitterion composition containing, for example, as an active ingredient, HEPES (N-2 Hydroxyethylpiperazine-N'-2 Ethane Sulfonic Acid), and method useful for treatment of...
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5681829 |
Class of phosphocholine derivatives having antifungal activity
Certain phosphocholine derivatives having substantial antifungal therapeutic activity are disclosed. The phosphocholine derivatives may be chemically synthesized, enzymatically prepared or...
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5654290 |
Polyunsaturated fatty acid based drugs
Drug compositions comprised of therapeutically effective amounts of at least one compound selected from the group consisting of: DHA esterified in the form of lysophosphatidyl-choline (lyso-PCDHA)...
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5643498 |
Quaternary cationic surfactants having multiple hydrophobic and hydrophilic groups
According to the invention, an improved class of quaternary cationic surfactants having two imidazolinium groups have been provided comprising compounds of the formula: ##STR1## The surfactants of...
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5624917 |
Method of inhibiting squalene synthetase
There is provided a squalene inhibitory composition containing a 1,1-bisphosphonic acid compound, a lower alkyl ester thereof, or a salt thereof, which is useful for treating hypercholesterolemia....
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5593980 |
Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents
This invention provides a new use of acids, esters, and salts of arylmethylphosphonates of Formula I, ##STR1## or a phosphonic acid of Formula II ##STR2## and derivatives as anti-inflammatory and...
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5578586 |
Dry eye treatment process and solution
A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the...
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5516798 |
Method for treating diarrhea and a composition therefor
Described is a method of treating diarrhea in a warm-blooded vertebrate animal, and a composition therefor. The method involves administering to the animal an effective amount of a methylamine,...
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5496811 |
Submicron emulsions as ocular drug delivery vehicles
An ocular drug delivery vehicle of an oil-in-water submicron emulsion comprising about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05...
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5466682 |
Acylamino-alkyliden-hydroxy-bisphosphonic acids esters and salts thereof, wherein the acyl group is derived from an acid having antiinflammatory activity
Compounds of formula (I) ##STR1## in which A is (CH 2 ) n in which n is 1-10, preferably 3 or 5, and R is the acyl group from a known anti-inflammatory agent, exhibit high anti-inflammatory...
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5451579 |
1-β-methyl-carbapenem, compositions containing same and methods of use
A carbapenem antibiotic of the formula I ##STR1## is disclosed. The variable X .crclbar . represents a counterion. Pharmaceutical compositions and methods of use are also disclosed.
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5447922 |
α-phosphonosulfinic squalene synthetase inhibitors
α-Phosphonosulfinate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 2 is OR...
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5434144 |
Methods of using cyclic polyanionic polyol derivatives for regulating skin wrinkles
The subject invention relates to methods of regulating skin wrinkles and/or atrophy in mammalian skin comprising topically applying to the skin of a mammal in need of treatment a composition...
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5407921 |
Method for suppressing bitter taste
A method for suppressing a bitter taste of material to be placed in mouth or in contact with mouth, such as foods, drinks, pharmaceuticals, comprises adding an acidic phospholipid or an acidic...
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5292497 |
Method of reducing chemotherapy toxicity using (methylaminopropylamino)propyl dihydrogen phosphorothioate
A method of decreasing the toxicity of chemical therapeutic agents administered in cancer chemotherapy including adminstration to a patient undergoing chemotherapy. This reduction in toxicity can...
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5284835 |
Use of dilinoleoylphosphatidylcholine (DLPC) for treatment and prevention of cirrhosis and fibrosis in the liver
This invention encompasses pharmaceutical compositions and a dietary supplement for treating or preventing alcoholic cirrhosis of the liver which comprises administering about 1 to 3 grams per day...
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5278151 |
Dry eye treatment solution
A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the...
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5278152 |
2-formylbenzylphosphonic acid derivatives useful for the treatment of diseases caused by viruses
The compound of the formula I ##STR1## in which R is an aldehyde group or a group which can be converted into an aldehyde, R 1 and R 2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen,...
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5262405 |
Method of improving bronchial mucus transport
A composition for use in the treatment of the obstruction of air ways comprising one or more phospholipids, alone or in association with excipients. This composition can be used in a method of...
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5229376 |
Encapsulated plant-derived phosphatidylinositol (PI) compositions for the prevention of mitogenically induced cell proliferation
Encapsulated PI compositions such as liposomes containing plant PI and th use to prevent mitogenic transformation of normal splenic lymphoid cells (including lymphocytes transformed induced by...
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5215972 |
Steroids
Steroids of the formula ##STR1## wherein R 1 to R 4 , X and n have the significance given in the description, which lower the intestinal resorption of cholesterol and plasma cholesterol and a...
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5200402 |
Anti microbial mafenide-phosphanilate compound, pharmaceutical compositions and method of use therefor
The present invention relates to a synergistic antimicrobial compound (mafenide-phosphanilate) having especially high activity for topical prophylaxis and therapy of burn wound infections. The...
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5187071 |
Method for the selective control of weeds, pests, and microbes
A novel means for identifying selective control agents for weeds, pests, and microbes is provided. Novel compositions for the selective control of weeds, pests, and microbes are also provided. The...
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5166143 |
Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after...
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5153183 |
Methylenediphosphonic acid compounds and methods of use for the treatment of rheumatism and osteophorosis
This invention relates to a methylenediphosphonic acid compound expressed by the formula (1). The compound has a marked effect as an anti-inflammatory agent or, more particularly, against...
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5139561 |
Method for protecting growing plants against fungal or microbial path pathogens
A method for protecting growing plants against fungal or microbial plant pathogens which comprises applying thereto, or to the medium on which they are growing or to be grown, a composition...
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5118674 |
3-(N-methyl-N-alkyl)-amino 2-methoxymethylene propan 1-ol derivatives, a preparation process of the same and therapeutical compositions containing them
The invention relates to 3-(N-methyl-N-alkyl)-amino 2-methoxymethylene propan 1-ol derivatives of the formula ##STR1## wherein R stands for an alkyl chain, A stands for: ##STR2## and Y represents...
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