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7615543 |
Treatment and prevention of tissue damage
An agent for use in medicine, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of C-reactive protein (CRP) molecules in the presence...
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7592489 |
Anionic/cationic masonry sealing systems
A composition comprising a mixture, having a maximum molar ratio of acid to base of 0.6 and providing water repellency when applied to a substrate surface without etching of said surface, of A) an...
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7592469 |
Lipid-analogous phosphoric acid triesters
The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.
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7537759 |
Modulating angiogenesis
The invention provides methods and compositions relating to Kuz involvement in angiogenesis. In various embodiments, the invention provides methods for modulating angiogenesis by specifically...
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7534776 |
Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In...
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7521436 |
Modified phosphocalcic compound, injectable composition containing same
The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition....
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7517858 |
Prodrugs of pharmaceuticals with improved bioavailability
Lipid prodrugs of pharmaceutical agents and their analogs that have increased anticancer, anti-viral, anti-inflammatory, anti-proliferative activity over the parent drug, and methods for making...
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7514413 |
In-vivo energy depleting strategies for killing drug-resistant cancer cells
This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to,...
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7476661 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
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7470818 |
Fluoroalkyl phosphate compositions
A composition comprising a compound of formula (I) or (II):
wherein
r and q are independently integers of 1 to 3; R f is linear or branched chain perfluoroalkyl group having 1 to 6...
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7462608 |
Non nucleoside reverse transcriptase inhibitors
Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase...
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7459444 |
Inhibitors of chymase
The present invention is directed to a compound of formula (I),
methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory...
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7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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7432253 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 .
Cat+ is an organic or...
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7417035 |
Phospholipid derivatives of non-steroidal anti-inflammatory drugs
Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the...
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7381713 |
Treatment of cancer by reduction of intracellular energy and pyrimidines
This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at...
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7351428 |
Phosphatidyl oligoglycerols
In order to form liposomes with a longer half-life in blood, use is made of defined formula (A)
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7319095 |
Use of GABAB receptor agonists
The present invention relates to the use of GABA B receptor agonists for the treatment as well as the prevention of cough.
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7304093 |
Ketone compounds and compositions for cholesterol management and related uses
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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7282514 |
Reactive probes for two-photon fluorescent imaging and sensing
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon...
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7273604 |
Anti-asthmatic combinations comprising surface active phospholipids
Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine...
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7259154 |
Pyrrolopyrimidines
Compounds of the formula
and N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisosteres of such salts or...
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7252706 |
Inhibition of calcium and magnesium precipitation from wood preservatives
A wood preservative that contains a copper salt complex and a precipitation inhibitor is provided. The wood preservative may contain copper carbonate, an alkanolamine such as monoethanolamine and...
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7244718 |
Water soluble prodrugs of hindered alcohols
The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.
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7241459 |
Polymers containing bioactive glass with antimicrobial effect
The method of protecting a polymeric plastic from attack by bacteria and fungi includes providing bioactive glass particles having a mean particles size preferably less than 2 μm as an additive...
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7205285 |
Acyl phosphonate inhibitors of β-lactamases
The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not...
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7192940 |
Ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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7173049 |
Fungicidal compositions
1) Fungicidal compositions comprising:
a) at least one pyridylmethylbenzamide derivative of formula (I):
in which the various radicals are as defined in the description,...
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7173020 |
Phosphoramidates and methods therefor
Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable...
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7163932 |
Aryldifluoromethylphosphonic acids for treatment of diabetes
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme.
The invention also encompasses pharmaceutical compositions...
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7109183 |
Phosphohalohydrins, process for the production thereof and use thereof
The invention provides compounds comprising at least one phosphohalohydrin group of the formula:
where X is a halogen selected from among I, Br, Cl,
R1 is selected from among —CH 3 ...
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RE39264 |
Pharmaceutical combination
The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically...
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7098196 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7030101 |
Compositions of β-glucans and specific antibodies
Compositions and kits comprising combinations of β-glucans and specific immunoglobulins are disclosed. The compositions and kits are useful in methods of preventing or treating infection by a...
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7018987 |
Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be...
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7018986 |
Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption
The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone...
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7008645 |
Method of inhibiting restenosis using bisphosphonates
A method of inhibiting the activity or production of cytokines or growth factors associated with vascular restenosis, by administering to an individual an effective amount of an active ingredient...
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7001896 |
Compositions for treating diabetes
The present invention provides a pharmaceutical composition for treating diabetes containing 4-diethoxyphosphinoylmethyl-N-(4-bromo-2-cyanophenyl)benzami
de, particularly a pharmaceutical...
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7001605 |
Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same
A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I):
wherein R represents a lower alkyl group or a lower alkoxy group;...
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6984400 |
Method of treating restenosis using bisphosphonate nanoparticles
A method of treating or preventing restenosis by administering to an individual an effective amount of an active ingredient comprising a bisphosphonate particle or a bisphosphonate particulate. The...
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6949528 |
Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including...
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6949517 |
Method of treating inflammatory, tissue repair and infectious conditions
The present invention relates to a method of treating inflammatory, tissue repair and infectious conditions in a mammal suffering therefrom which comprises administering to a mammal in need thereof...
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6933127 |
Substrate for PP2C
The invention relates to a combination of a protein phosphatase type 2C as an enzyme and a phospho-BAD as substrate. The protein BAD is dephosphorylated in position Ser 155 . Furthermore, the...
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6927235 |
Vaccine composition comprising iron phosphate as vaccine adjuvant
The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 μm and 300 μm; it...
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6923989 |
Method for preparing a calcium phosphate pasty material for injection
A method for preparing a calcium phosphate pasty material for injection which after, setting, is designed to form an apatite material consists in: producing from water and calcium phosphates pasty...
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6852709 |
Biologically useful polyphosphates
The present invention provides biodegradable polymers, polymer compositions, particles composed thereof and methods of using same for the controlled release of a biologically active substance to a...
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6812224 |
Phosphorous organic compounds and their use
Use of phosphorous organic compounds of general formula (I) wherein B represents either an ether group of the formula (II) or a keto group of the formula (III) or is a 5 or 6 membered cyclic...
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6803057 |
Hydrogen peroxide disinfectant with increased activity
An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations...
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6777445 |
Fullerene pharmaceutical compositions for preventing or treating disorders
The present invention relates to a method for treating a disease, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a fullerene. The diseases...
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