|
Match
|
Document |
Document Title |
|
|
8168159 |
Compounds for tumor diagnosis and therapy
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
|
|
|
8163719 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
|
|
|
8158153 |
Nanoparticulate bisphosphonate compositions
Nanoparticulate bisphosphonate compositions, having an effective average particle size of less than 2000 nm, are described. The compositions are useful in treating bone resorption in a mammal.
|
|
|
8129360 |
Utilization of phosphatidylserine in the treatment of attention deficit syndrome (ADHS)
The invention concerns the use of phosphatidylserine (PS), lyso-phosphatidylserine or/and a physiologically acceptable salt thereof for the treatment of the attention deficit syndrome (ADHS) in...
|
|
|
8084443 |
Biological specimen collection and transport system and methods of use
Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step...
|
|
|
8084052 |
Chemical composition for controlling insects
The invention herein provides for an improved pesticide that includes at least one attractant, at least one plant growth stimulator and an insecticide. The pesticide eradicates fire ants and...
|
|
|
8076315 |
Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists
This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or...
|
|
|
8044037 |
Modified phosphocalcic compound, injectable composition containing same
A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified...
|
|
|
8030348 |
Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications
A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
|
|
|
8026278 |
Inhibitors of pyruvate kinase as therapeutic agents for cancer
The present invention relates to compounds for the inhibition of pyruvate kinase and ATP production which are capable of inhibiting cancer cells proliferation.
|
|
|
7968529 |
Use of sphingolipids for reducing high plasma cholesterol and high triacylglycerol levels
The present invention is in the field of cholesterol and triglyceride-lowering methods and compositions. In particular, the present invention relates to the use of sphingolipids, more preferably...
|
|
|
7959904 |
Delivery of medicaments to the nail
The present invention includes a method for delivering a medicament to a nail plate or nail bed that comprises providing a therapeutically effective amount of a medicament, etching the surface of...
|
|
|
7943118 |
Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections
A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of...
|
|
|
7943588 |
Method for preventing or treating neuropathic pain
The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is...
|
|
|
7932239 |
Methods of and compositions for reducing neuronal cell death
Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing...
|
|
|
7883715 |
Pesticide compositions containing dicarboxylic acids
Solid and liquid pesticidal concentrate and spray compositions are described which exhibit enhanced efficacy due to the addition thereto of a compound which increases EPSPS enzyme inhibition by the...
|
|
|
7858599 |
Enhancement of urogenital function
An exemplary method of treating a urologic symptom includes administering a daily dose of creatine to an individual wherein the daily dose of creatine lies in a range from about 0.35 mg to about...
|
|
|
7820187 |
Method and mixture for protecting animals against pests
A mixture for application on an animal to provide barrier protection against insects, parasites, arachnids and/or other arthropods, and ectoparasites, and in general viruses, bacteria and/or other...
|
|
|
7816097 |
Nucleotide and protein sequence of Mammastatin and methods of use
A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in...
|
|
|
7790702 |
Lipid metabolism improving agent
The present invention relates to a protein/phospholipid or protein hydrolyzate/phospholipid complex containing 10 wt % or more of bound phospholipid, a lipid metabolism improving agent comprising...
|
|
|
7759346 |
[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain
This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I):...
|
|
|
7718197 |
Colonic purgative composition with soluble binding agent
This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as...
|
|
|
7713949 |
Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C...
|
|
|
7709464 |
Phosphatidyl oligoglycerols
In order to form liposomes with a longer half-life in blood, use is made of defined compounds with the general formula (A)
|
|
|
7700074 |
Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have...
|
|
|
7687075 |
Colonic purgative composition with soluble binding agent
This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as...
|
|
|
7683043 |
Creatine phosphate analog prodrugs, compositions and uses thereof
Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as...
|
|
|
7662577 |
Method of diagnosing cardiovascular disease
A method of and kit for diagnosing cardiovascular disease in a human involves assessing the presence and/or concentration of antibodies to platelet activating factor (PAF) in a sample of body fluid...
|
|
|
7652001 |
Pharmacologically active agents containing esterified phosphonates and methods for use thereof
Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The...
|
|
|
7629332 |
Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents
The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs...
|
|
|
7625879 |
Phosphohalohydrins, process for the production thereof and use thereof
The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH3 and —...
|
|
|
7625939 |
Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase IV inhibitors
The present invention relates to DP IV-inhibitors of formula (1) for the treatment and/or prophylaxis of diseases of mammals including cancer and tumors, metastasis and tumor colonization; and...
|
|
|
7615543 |
Treatment and prevention of tissue damage
An agent for use in medicine, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of C-reactive protein (CRP) molecules in the presence...
|
|
|
7537759 |
Modulating angiogenesis
The invention provides methods and compositions relating to Kuz involvement in angiogenesis. In various embodiments, the invention provides methods for modulating angiogenesis by specifically...
|
|
|
7534776 |
Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In...
|
|
|
7521436 |
Modified phosphocalcic compound, injectable composition containing same
The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition....
|
|
|
7517858 |
Prodrugs of pharmaceuticals with improved bioavailability
Lipid prodrugs of pharmaceutical agents and their analogs that have increased anticancer, anti-viral, anti-inflammatory, anti-proliferative activity over the parent drug, and methods for making...
|
|
|
7514413 |
In-vivo energy depleting strategies for killing drug-resistant cancer cells
This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to,...
|
|
|
7476661 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
|
|
|
7462608 |
Non nucleoside reverse transcriptase inhibitors
Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase...
|
|
|
7459444 |
Inhibitors of chymase
The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and...
|
|
|
7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
|
|
|
7432253 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3. Cat+ is an organic or inorganic cation,n is an integ...
|
|
|
7417035 |
Phospholipid derivatives of non-steroidal anti-inflammatory drugs
Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the...
|
|
|
7381713 |
Treatment of cancer by reduction of intracellular energy and pyrimidines
This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at...
|
|
|
7319095 |
Use of GABAB receptor agonists
The present invention relates to the use of GABAB receptor agonists for the treatment as well as the prevention of cough.
|
|
|
7304093 |
Ketone compounds and compositions for cholesterol management and related uses
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
|
|
|
7282514 |
Reactive probes for two-photon fluorescent imaging and sensing
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon...
|
|
|
7273604 |
Anti-asthmatic combinations comprising surface active phospholipids
Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine...
|
|
|
7259154 |
Pyrrolopyrimidines
Compounds of the formula and N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisosteres of such salts or...
|