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7572782 |
Use of targeted oxidative therapeutic formulation in bone regeneration
A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an...
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7572798 |
Combi-molecules having signal transduction inhibitory properties and DNA damaging properties
The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as...
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7544306 |
Azeotropic fumigant compositions of methyl iodide
Azeotropic and azeotrope-like compositions of methyl iodide and at least one fluorocarbon or hydrofluorocarbon such as 1,1,1,3,3-pentafluoropropane (HFC-245fa). The compositions are present as a...
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7488854 |
Diterpenoid compounds imparting stress resistance to plants
The present invention provites a compound having the following structure:
wherein, in the formula: X is selected from the group consisting of hydroxy, substituted hydroxy, halogen, thiol,...
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7378449 |
Poly(bromoaryl)alkane additives and methods for their preparation and use
An additive mixture useful as a flame retardant is described. The mixture is comprised of (i) a poly(bromophenyl)alkane having in the molecule in the range of 13 to 60 carbon atoms and in the range...
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7220784 |
Substituted stilbenes and their reactions
The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on...
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7074434 |
Process for the separation of a mixture comprising at least one hydrofluoroalkane and hydrogen fluoride, processes for the preparation of a hydrofluoroalkane and azeotropic compositions
Process for the separation of a mixture comprising at least one hydrofluoroalkane and hydrogen fluoride, according to which a hydrofluoroalkane/hydrogen fluoride mixture is reacted with at least...
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7026359 |
Utilization of a highly fluorinated oligomeric alkane in ophthalmology
The invention relates to the utilization of a highly fluorinated oligomeric alkane as a therapeutic agent in ophthalmology, the alkane having the general formula [—R F (CH 2 ) n CR 1 —CR 2 —]...
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6927237 |
Two solvent antimicrobial compositions and methods employing them
The present invention relates to two solvent antimicrobial compositions and methods employing these two solvent compositions. The two solvent compositions typically contain a second solvent that is...
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6861451 |
Carboxylic acid fluorides as pesticides
Carboxylic acid fluorides having a boiling point of preferably less than 100° C. are suitable for use as pesticides. Acetyl fluoride is highly suitable, and Chlorodifluoroacetyl fluoride and...
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6528545 |
Preparations comprising a fluorocarbon or highly fluorinated compound and a lipophilic/fluorophilic organic compound, and their uses
Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula R F 1 —W—R H 1 (I) wherein R F 1 is a linear,...
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6465527 |
Iodinated hydrocarbon pesticide
Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of both mono-iodinated hydrocarbons and...
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6423330 |
Pesticidal composition and method
A mammalian pesticidal composition, and in particular a pesticidal composition for the control of insectivores, in which a pesticidal agent comprising one or more low molecular weight halogenated...
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6420436 |
Imaging contrast media and methods of use
This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the...
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6300378 |
Tropodegradable bromine-containing halocarbon additives to decrease flammability of refrigerants foam blowing agents solvents aerosol propellants and sterilants
A set of tropodegradable chemical additives to decrease the flammability of normally flammable refrigerants, foam blowing agents, cleaning solvents, aerosol propellants, and sterilants is...
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6267945 |
Farnesol-related calcium channel blockers
Compounds comprising a straight backbone carbon chain of 8-16C, optionally substituted with 1-5 alkyl groups (1-6C); said chain optionally functionalized at one terminus with halo, --OR,...
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6211248 |
Fluorinated alkanes and their uses
The invention concerns a partially fluorinated alkane with the general formula R F [CF 2 --CH 2 ]R H , wherein R H is a substituent of the general formula C n H x selected from the group...
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6204296 |
Patient oxygenation using stabilized fluorocarbon emulsions
Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or...
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6127428 |
Method for enhancing transport of gases to tissues
A method is disclosed for the treatment of right to left shunt. The method comprises introducing, into the blood circulation of an individual, to be treated, a therapeutically effective amount of...
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6124357 |
Iodinated fatty acid esters iodinated fatty acids and derivatives thereof produced by iodohydrination using alkylsilylated derivatives and alkaline iodides and the pharmacological activities thereof
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6028117 |
Microemulsion insect control compositions
Disclosed herein are microemulsion insecticides that do not contain conventional actives. The microemulsion form permits insects to be killed by an oil/surfactant combination.
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6008209 |
Method of using vitamin D.sub.3 analogs with bis C-20 side chains
This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin...
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5989918 |
ADME analysis of mixtures
A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test...
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5985310 |
Preservative systems for pharmaceutical compositions containing cyclodextrins
Disclosed are preservative systems useful in aqueous pharmaceutical compositions containing an active agent and a cyclodextrin. The preservative systems comprise boric acid and one or more...
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5916882 |
Povidone iodine (PVP-I) alcohol gel antimicrobial pre-operative skin preparation
The present invention provides antimicrobial skin-preparations useable to disinfect a surgical site for surgery. The antimicrobial skin-preparation formula includes iodine, alcohol and gel. The new...
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5914352 |
Methods for the use of stabilized fluorocarbon emulsions
Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or...
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5874113 |
Shelf life improvement for ethylene oxide sterilant mixes
A method of increasing the shelf life of a sterilant mixture of ethylene oxide and one or more halocarbons when the mixture is in contact with iron oxide on the surface of a storage vessel....
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5869538 |
Method for enhancing transport of gases to tissues
Disclosed are methods of using stabilized microbubbles, such as those formulated from slowly permeating gas, to deliver or remove from tissue at least one gas selected from a respiratory gas,...
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5869539 |
Emulsions of perfluoro compounds as solvents for nitric oxide (NO)
The present invention involves perfluoro compound emulsions including nitric oxide, their preparation and their use. These emulsions provide a new source of nitric oxide. Such nitric...
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5859068 |
Acceleration of tissue growth using fluorocarbon liquid
A method for the acceleration of tissue growth using continuous fluorocarbon liquid-based positive pressure is disclosed, whereby significant increase in tissue growth is achieved.
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5847009 |
Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions
Methods for preventing or ameliorating the transient adverse physiological response to particulate dispersions (TAPR response) when these dispersions are administered parenterally to a patient. The...
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5824703 |
Method of assisting normal breathing in a mammal having a lung disorder
A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder,...
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5733939 |
Fluorocarbons as anti-inflammatory agents
A method for reducing the inflammatory response in tissues of a patient, by contacting the tissue with an effective, inflammation-reducing amount of a liquid or gaseous fluorocarbon.
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5705148 |
Use of hydro- and fluorocarbon compounds in cosmetic compositions; hydro- and fluorocarbon compounds; and cosmetic compositions containing these compounds
The present invention concerns the use of hydrofluorocarbon compounds with formula (I): R F -(CH 2 ) n -X- C 3 H 5 (OH)!-Y-(CH 2 ) m -R' F ...
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5684050 |
Stable emulsions of highly fluorinated organic compounds
Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The...
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5635538 |
Fluorocarbon emulsions with reduced pulmonary gas-trapping properties
A fluorocarbon emulsion which exhibits reduced pulmonary gas-trapping properties in species-sensitive laboratory animals is disclosed. Additionally, the fluorocarbon component(s) exhibit short...
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5628930 |
Stabilization of fluorocarbon emulsions
Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or...
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5573757 |
Viscoelastic compositions containing concentrated fluorinated compounds their method of preparation and their uses
Compositions for topical application in gel form comprising a fluorocarbon or perfluorocarbon compound or mixtures thereof at a concentration of at least about 75% v/v, a minor quantity of a...
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5480914 |
Nonaqueous thixotropic drug delivery suspensions and methods of their use
Nonaqueous thixotropic drug delivery vehicles for use in aqueous physiological systems are disclosed comprising a substantially homogeneous dispersion of at least one suspending aid in a nonaqueous...
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5459126 |
Method for decreasing calcium uptake by cells using selected polycations
A method for reducing calcium overload in cells to prevent the transition from reversible to irreversible injury. The cell surface is treated with an organic polycation selected from the group...
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5439944 |
Red blood cell substitute emulsions containing alkyl- or alkylglyucerophosphoryl choline surfactants and methods of use
Oil and water emulsions containing alkylphosphoryl choline or alkylglycerophosphoryl choline surfactants are disclosed. The surfactants have the following general structures: ##STR1## In the above...
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5409688 |
Gaseous ultrasound contrast media
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles...
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5385721 |
Compositions of alkylbenzenes and cellulose derivatives for visualization of the gastrointestinal tract
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt...
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5376333 |
Ethylene oxide-carrier gas compositions having improved flammability suppressant characteristics
Compositions of ethylene oxide and monochlorotetrafluoroethane which are useful as sterilizing agents. These novel compositions are environmentally acceptable, possess improved flammability...
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5236694 |
19F labelled dextrans and antibodies as NMR imaging and spectroscopy agents
19 F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a 19 F-containing sensor moiety, and a transport polymer or substrate,...
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5234680 |
Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl...
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5141739 |
Delivery of x-ray contrast agents using receptor mediated endocytosis
The invention provides a method of targeting an x-ray contrast agent to a specific population of cells or organ. Targeting may be accomplished by forming a complex of a radiopaque label with a...
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5114707 |
Polycondensation silicone elastomer dosage forms for the controlled release of iodine values
Polycondensation silicone elastomer dosage forms adapted for the continuous and controlled release of iodine values, notably to domestic water supplies for the treatment of the various disease...
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5061484 |
Perfluorochemical emulsion with stabilized vesicles
A stable perfluorochemical emulsion is provided which comprises perfluorochemical particles in stabilized vesicles. The vesicles comprise a biocompatible polymer formed by coating the...
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4895876 |
Concentrated stable fluorochemical aqueous emulsions containing triglycerides
A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and...
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