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7612050 |
Drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis
A bisphosphonate for the treatment of osteonecrosis and/or osteonecrosis dissecans. The drug may further he used to prevent the onset of osteonecrosis and/or osetonecrosis dissecans and any...
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7601516 |
Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (αFSH) linked directly or indirectly to a binding partner of neonatal Fc...
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7592315 |
Peptide viral entry inhibitors
The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections.
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7576052 |
Methods and compositions for modulating adipocyte function
Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.
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7575755 |
Immunogenic compositions and uses thereof
The present invention relates generally to a method of eliciting or otherwise inducing an effective immune response to a micro-organism and compositions for use therein. More particularly, the...
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7563760 |
P-selectin ligand protein
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the...
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7563769 |
FGF variants and methods for use thereof
The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced...
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RE40849 |
Method of treatment of glutathione deficient mammals
Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent...
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7544364 |
Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a...
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7524513 |
Biofunctional fibers
The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth...
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7517850 |
Calcium phosphate nanoclusters and their applications
Artificial particles known as calcium phosphate nanoclusters are disclosed. The particles contain high concentrations of calcium, particularly for use in nutritional products, neutraceuticals, and...
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7511011 |
Synthetic lipid mixtures for the preparation of a reconstituted surfactant
The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants,...
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7504374 |
Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic...
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7491694 |
Dental restorative materials
The present invention relates to a composition for dental restoration including a dental restorative material and an effective amount of a casein phosphopeptide(CPP)-amorphous calcium phosphate...
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7488710 |
SFRP and peptide motifs that interact with SFRP and methods of their use
This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also...
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7445894 |
Compositions and methods for detection and isolation of phosphorylated molecules
The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target...
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7442686 |
Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions
The Rho family GTPases regulates axon growth and regeneration. Inactivation of Rho with C3, a toxin from Clostridium botulinum , can stimulate regeneration and sprouting of injured axons. The...
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7425549 |
Drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis
A bisphosphonate for the treatment of osteonecrosis and/or osteonecrosis dissecans. The drug may further be used to prevent the onset of osteonecrosis and/or osteonecrosis dissecans and any...
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7423011 |
Therapeutic chemokine receptor antagonists
The invention provides a variety of therapeutic uses for CXCR4 antagonists. In various embodiments, CXCR4 antagonists may be used as therapeutically as follows, or to manufacture a medicament for...
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7405193 |
Use of Acrp30 globular head to promote increases in muscle mass and muscle differentiation
The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free...
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7390791 |
Prodrugs of phosphonate nucleotide analogues
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a)
having substituent groups as...
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7378392 |
Bone and cartilage inductive proteins
Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and...
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7378388 |
Method of utilizing neurotrophins to manipulate reproductive capacity
Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins,...
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7354899 |
Methods of treating autoimmune diseases comprising administering CXCR4 antagonists
The invention provides a variety of therapeutic uses for CXCR4 antagonists. In various embodiments, CXCR4 antagonists may be used as therapeutically as follows, or to manufacture a medicament for...
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7351399 |
Prodrugs for phosphorus-containing compounds
Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described:
and pharmaceutically acceptable prodrugs and salts thereof.
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7351691 |
Glycopeptide phosphonate derivatives
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
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7348308 |
Glycogen synthase kinase-3 inhibitors
Peptide inhibitors of glycogen synthase kinase-3 (GSK-3) having an amino acid sequence motif of XZXXXS(p)X, wherein S(p)=phosphorylated serine or phosphorylated threonine, X=any amino acid, and...
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7312193 |
Calcium phosphopeptide complexes
Phosphopeptides containing the Ser(P) cluster sequence motif Ser(P)-Ser(P)-Ser(P)-Glu-Glu- can stabilize their own weight in amorphous calcium phosphate (ACP) [Ca 3 (PO 4 ) 1.87 (HPO 4 ) 0.2 xH 2...
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7303739 |
Prodrugs for liver specific drug delivery
The present invention is directed towards novel cyclic phosph(oramid)ate prodrugs of alcohol-, amine-, and thiol-containing drugs, their preparation, their synthetic intermediates, and their uses....
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7247611 |
Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
The invention includes compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator.
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RE39705 |
Method of treating glutathione deficient mammals
Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intra-cellularly either by forming a direct complex with an electrophilic agent...
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7173020 |
Phosphoramidates and methods therefor
Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable...
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7109165 |
Conjugates and compositions for cellular delivery
This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids...
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7105483 |
Phosphinic pseudopeptide derivatives for the selective inhibition of the C-terminal active site of angiotensin I converting enzyme (ACE)
The invention relates to the use of phosphinic pseudopeptide derivatives for production of a medicament for selectively inhibiting the active C-terminal site of angiotensin I converting enzyme....
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7067139 |
Method for treating autoimmune diseases
A method of treating patients having rheumatoid arthritis by administering Product R, a peptide-nucleic acid preparation, is disclosed.
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7060670 |
Stereoselective antifibrillogenic peptides and peptidomimetics thereof
The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment amyloidosis disorders. These agents include peptides, isomers...
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7049287 |
Nociceptin-based analgesics
The invention relates to a family of hexapeptide compounds exhibiting activity with regard to the ORL-1 receptor. The compounds share a general formula of Arg-Tyr-Tyr-Arg-Trp-Arg, and may be...
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7041637 |
Echinocandin/carbohydrate complexes
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also...
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7037896 |
Peptide (VIRIP) which inhibits a circulating virus in humans and the use thereof
A peptide having the following amino acid sequence:
Z 1 -LEAIPMSIPPEVKFNKPFVF-Z 2 (VIRIP)
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7033999 |
Nitrosated and nitrosylated heme proteins
Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet...
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6974681 |
Cell culture performance with vanadate
The invention provides methods and compositions for improved in vitro culture of cells that make use of vanadate. The methods enhance cell survival thereby recovery of the polypeptide of interest...
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6930085 |
G-type peptides to ameliorate atherosclerosis
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6821951 |
Processes for making pharmaceutical oral ECB formulations and compositions
A fluid bed spray process is described where one or more carbohydrates are incorporated into an echinocandin formulation to provide a significant improvement in thermal stability. The carbohydrate...
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6806252 |
Bone-strengthening agents, food compositions for strengthening bone and feed compositions for strengthening
A novel bone-strengthening agent, a bone-strengthening food composition and a bone-strengthening feed composition which aim at preventing a decrease in bone density in association with the onset or...
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6800607 |
Modified BDNF
Modified BDNF having improved pharmacological activities, pharmacokinetics and physical properties can be obtained by modifying BDNF with a 1-acyl-glycerol derivative. This BDNF being modified with...
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6793921 |
Specific antibodies for use in preparation of pharmaceutical compositions useful in the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers
The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained...
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6723694 |
Short peptides which selectively modulate intracellular signalling
Disclosed are peptides which are peptide derivatives of the HJ loop of a protein tyrosine kinase. The peptides can modulate the activity of the protein tyrosine kinase. Also disclosed are methods...
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6706685 |
Compounds and methods for stimulating β-catenin mediated gene expression and differentiation
Modulating agents for inhibiting degradation of cytoplasmic β-catenin are provided. The modulating agents comprise one or more of: (1) the peptide sequence SYLDS(PO 4 )GIHS(PO 4 )G (SEQ ID NO:1)...
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