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7598294 3,4-methylenedioxy-substituted chalcones as therapeutic agents  
The present invention pertains to the use of a compounds for the manufacture of a medicament for use in the treatment of a proliferative condition, wherein the compounds have the following formula:...
7572831 Composition containing chalcone  
The present invention provides an MMP-inhibitory composition comprising chalcone or its derivatives. They inhibit the MMPs in collagenase subfamily as well as those in gelatinase subfamily. The MMP...
7364747 Process and product for inhibiting or preventing bacterial infections  
The combination of a polymyxin composition and a hop composition produces unexpected and synergistic activity against gram positive bacteria.
7348363 Method of controlling zoological and aquatic plant growth  
A method of controlling target aquatic microorganism pest populations by exposing the target population to an effective amount of an aquacidal compound. The aquacidal compounds are selected from...
7335384 Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith  
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
7312243 Materials and methods for treatment of gastrointestinal disorders  
The subject invention pertains to materials and methods for the prevention and treatment of gastrointestinal diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative...
7064124 NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient  
A NF-κB inhibitor represented by the following formula (I) is provided:
6949586 Synergistic composition of trans-tetracos-15-enoic acid and Apocynin and method of treatment for hepatotoxicity  
The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present...
6906076 Compounds and methods of use to treat infectious diseases  
The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby...
6822002 Use of L-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use  
The use of L-carnitine and its alkanoyl devivatives, optionally in the form of a pharmaceutically acceptable salt, as osmotic agents in the preparation of solutions for medical use, particularly...
6790463 Uses of targeted oxidative therapeutic formulation in arteriosclerosis  
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
6677376 Non-peptidic cyclophilin binding compounds and their use  
The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the...
6599530 Oral compacted composition comprising catechol derivatives  
The present invention relates to an oral compacted composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof and croscarmellose sodium. The composition is...
6579903 Klainetins and their derivatives, method for their preparation and use thereof  
The invention relates to compounds of formula I and of formula II in which R 1 , R 2 , R 3 , R 4 , R 5 , X 1 , X 2 , X 3 , X 4 , X 5 and Y are defined in the specification. The compounds of...
6498195 Use of 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl) as an anticarcinogenic agent  
Compositions and methods are provided for prevention and treatment of cancer. The compositions comprise pure hydroxylated chalcone compounds of licorice root ( Glycyrrhiza glabra ) including...
6423740 Chalcones having antiproliferative activity  
The invention relates to a novel class of compounds that have structures related to certain naturally occurring or synthetic chalcones. The invention also relates to pharmaceutical compositions...
6417233 Ubiguinone-containing composition suitable for promoting enhanced intramitochondrial transportation of ubiguinones and methods of using same  
Compositions containing as active ingredients a lipid-soluble benzoquinone, e.g. Coenzyme Q10 and at least one omega-3 polyunsaturated fatty acid selected from eicosapentaenoic acid (EPA),...
6410602 Method of increasing the production and improving the quality of semen  
A method of increasing the volume, the total sperm count and the reproductive performance of semen from human and animal males, is described. The method comprises administration of an effective...
6410265 Gene encoding a putive efflux protein for solvents/antibiotics in Pseudomonas mendocina  
This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina . The putative efflux gene is useful for probing an organism's efflux system to gain an...
6335361 Method of treating benign forgetfulness  
Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the...
6306913 Container for 4-allylanisole and analog scolytid pesticides  
A projectile can be used to administer pesticides such as one or more from the group consisting of 4-allylanisole, anisole, allylbenzene, 4-isopropylanisole, p-anisaldehyde, ethylbenzene, cumene,...
6133322 Quinone derivatives for treating or preventing diseases associated with iron overload  
A method of treating or preventing a disorder resulting from a mitochondr dysfunction induced by an iron overload including Friedreich Ataxia, hypertrophic cardiomyopathy, Hallervorden-Spatz...
6107276 Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent  
The pharmaceutical compositions including a slightly soluble drug incorporated in a water-swellable, but water-insoluble cross-linked polymer, a surface active agent, and an oil show much improved...
6090851 Use of an NADPH-oxidase inhibitor in the treatment of reperfusion injury  
The present invention is directed to a method for the prophylactic and therapeutic treatment of reperfusion injury or injury due to a distal reperfusion. The method involves the administration of...
5973004 L-carnitine, acetyl-L-carnitine, and pantothenic acid or ubiquinone, combined for prevention and treatment of syndromes related to ineffective energy metabolism  
A combination can be of L-carnitine and acetyl-L-carnitine, preferably with pantothenic acid or ubiquinone, is administered orally or as a parenteral injection in domesticated animals, especially...
5902831 Prevention of atherosclerosis using NADPH oxidase inhibitors  
A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor...
5654331 Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics  
Diaromatic compounds, characterised in that they correspond to the following general formula: ##STR1## in which: R 1 is --CH 3 , --CH 2 OH, --COR 8 or --CH 2 OCOR 9 , R 8 is H, OH, --OR 10 ,...
5637600 Phenylpyrrole derivatives and their use as dopamine D.sub.3 antagonists  
The present invention relates to pyrrole compounds, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, in particular as anti-psychotic agents.
5489614 Catechol derivatives, their physiologically acceptable salts, esters and use  
Known and new catechol derivates may be used as medicinal antioxidants in the prevention or treatment of tissue damage induced by lipid peroxidation. The conditions and diseases to be treated are...
5476876 Di-tert-butylphenol compounds useful as anti-inflammatory agents  
The subject invention relates to compounds having the structure: ##STR1## wherein (a) X is selected from hydroxy, C 1 to about C 2 alkanoxy, thiol, C 1 to about C 2 alkanylthiol, and halo; ...
5466717 Halogenated 4'-methoxyacetophenones as microbicides and preservatives  
Halogenated 4'-methoxyacetophenones of formula I: ##STR1## wherein X is a halogen; Y is a halogen; and n is 1 or 2 as microbicides for inhibiting the growth of microorganisms in aqueous systems and...
5420160 1-alkoxyhexatriene-2-carboxylates  
There are described new 1-alkoxyhexatriene-2-carboxylates of the formula (I) ##STR1## in which R represents substituted phenyl, and a plurality of processes for their preparation. The new...
5405875 Method of inhibiting neoplasia and tumor promotion  
The present invention provides a method of inhibiting neoplasia and tumor promotion. The method comprises administering to a mammal, particularly a human, in need thereof an effective amount of a...
5393776 Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia  
This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for...
5189066 Pharmaceutical compositions of tebufelone  
The subject invention involves compositions, consisting essentially of the drug active 1-3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl-5-hexyn-1-one (tebufelone) at a concentration of at least about...
5110801 Treatment of acne  
Acne is treated by administering to the subject a substance which is effective in blocking glucose entry into sebaceous cells, thereby inhibiting the production of sebum by these cells. Typically,...
5081155 Hydroxy aromatic ketones  
Novel hydroxy-aryl ketones are disclosed having a branched hydrocarbon chain on the aromatic nucleus ortho to the hydroxy group. The compounds were found to possess anti-microbial properties and...
4933165 Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors  
A pharmaceutical composition and method of counteracting HMG-CoA reductase inhibitor-associated myopathy is disclosed. The method comprises the adjunct administration of an effective amount of a...
4847303 Tert-butylphenyl compounds useful as anti-inflammatory agents  
The present invention involves compounds having the structure: ##STR1## wherein: (a) --A 1 is selected from the group consisting of --OH, --H, and --O 2 CR; (b) --A 2 is selected from the...
4708966 Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation  
The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or...
4621098 Thioethers and pharmaceutical compositions containing them  
The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy,...
4617187 Therapeutic method for treating radiation ulcers  
Cutaneous administration of ubidecarenone, for example, application of ubidecarenone in the form of an ointment has been proven to be effective for treatment of various skin disorders caused by...
4613611 Method of treating diabetes mellitus using arylglyoxals  
A method of treating diabetes mellitus using arylglyoxals which are known compounds.
4525361 Aralkyl carboxylic acid compounds in compositions for potentiating immuno activity  
Novel compounds of the formulae ##STR1## wherein R represents lower alkyl or lower alkoxy, A represents --CH 2 --, --CO-- or ##STR2## n represents an integer of 1 to 8, X represents hydrogen or...
4514420 Antifibrotic agent  
Compounds of the formula ##STR1## wherein A is methylene or carbonyl, n is an integer of 2 to 21, inclusive, and R is hydrogen or lower alkyl, are effective for the prophylaxis or treatment of...
4474810 Arylglyoxals and their pharmaceutical use  
Arylglyoxals which are new compounds, active as hypoglycemic agents.
4436753 Method for therapy of ischemic disease  
A mammal suffering from ischemic disease such as cerebral apoplexy, cardiac insufficiency, renal insufficiency due to vascular changes, etc. is remedied by administering to said mammal an effective...
4390537 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use  
1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing anti-allergic properties for use in the treatment of allergic conditions, such as asthma prepared by...
4333952 Growth promotors for ruminants  
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen, halogen or C 1 -4 alkoxy; X is oxygen; NR 3 in which R 3 is hydrogen, C 1 -4 alkyl, or -Y-R 2 ; --CO; or --CHOH; Y is --CH...
4243683 Tertiary alcohols  
Tertiary alcohols of the formula: ##STR1## wherein Y 1 represents a carbonyl or hydroxymethylene group, and either (i) A 1 represents a direct bond and R 1 represents a phenyl group which may...
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