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7622506 |
Naphthalenedione compounds for treating inflammation related disorders and microbial infection
This invention relates to compositions containing a compound of formula (I) shown below:
Each variable is defined in the specification. Also disclosed are methods of using these compositions to...
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7582653 |
Mercaptophenyl naphthyl methane compounds and synthesis thereof
Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications...
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7572782 |
Use of targeted oxidative therapeutic formulation in bone regeneration
A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an...
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RE40862 |
Gossypolone for the treatment of cancer
A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone,...
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7432304 |
Small molecule antagonists of Bcl-2 family proteins
The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds...
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7417072 |
Blockade of Pin1 prevents cytokine production by activated immune cells
The invention provides pharmaceutical compositions and methods of treating immunological disorders. The invention also provides pharmaceutical compositions and methods of inducing eosinophil...
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7361691 |
Method of treating cancers using β-lapachone or analogs or derivatives thereof
Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic...
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7351744 |
Naphthalene derivatives as termite repellents and toxicants
Several derivatives of naphthalene, including 1′-acetonaphthone, 2′-acetpnaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of...
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7342046 |
Gossypol co-crystals and the use thereof
This invention relates to compositions comprising co-crystals of (−)-gossypol with a C 1-8 carboxylic acid or C 1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The...
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7279180 |
Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use
The present invention relates to stable emulsions and dry powders of mixtures of fat-soluble vitamins, and to processes for their preparation and to their use.
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7163930 |
Pharmaceutical compositions and methods relating to fucans
Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.
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6994863 |
Pharmaceutical and cosmetic carrier and composition for topical application
A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon...
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6949250 |
Selective algaecides for control of cyanochloronta
We have now discovered that certain 9,10-anthraquinone derivatives we developed possess potent activity against O. perornata while possessing a sufficiently high level of solubility in water to...
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6939896 |
Cd45 inhibitors
Substituted naphthalenediones in accord with structural diagram (I): compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune...
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6835755 |
Naphthoquinone derivatives and their use in the treatment and control of tuberculosis
Naphthoquinone derivatives of Formula (1): wherein R, represents an OH group, methyl ether, ethyl ether or a similar ether, R1 represents a methyl, ethyl or similar aliphatic hydrocarbon...
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6822003 |
Aldose reductase inhibitor and process for preparation thereof
Aldose redcutase inhibitor and pharmaceutically acceptable derivatives thereof of the formula I below derived from cultures of Aspergillus niger CFR 1046 and useful as a rat lens aldose reductase...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6777424 |
Methods for treating osteoarthritis using an estrogen agonist / antagonist
The present invention provides methods and kits for treating osteoarthritis using an estrogen agonist/antagonist.
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6761912 |
Composition for increasing bone density
A composition and a method for administering an improved supplement to prevent bone density loss. The composition combines a calcium compound with inulin, and optionally magnesium, Vitamin D 3 ,...
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6713463 |
Methods and compositions for treating and preventing mucositis
A method of reducing or inhibiting mucositis in a patient, which includes administering an inflammatory cytokine inhibitor or a mast cell inhibitor, or a combination thereof, is disclosed.
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6696484 |
Method and compositions for regulation of 5-alpha reductase activity
Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5α-reductase inhibitor, such as natural and synthetic flavanoids,...
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6677330 |
Fluorides of 4-substituted piperidine derivatives
The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the...
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6649659 |
Atovaquone pharmaceutical compositions
The invention relates to a process for the production of microfluidized particles of atovaquone having improved bioavailability.
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6613806 |
Enhancement of the efficacy of benzoylbenzenes
The invention relates to method for the enhancement of the activity and/or systemicity of fungicidal compositions containing at least one benzoylbenzene of formula I wherein R 1 through R 7 , m...
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6608107 |
Methods and compositions to treat conditions associated with neovascularization
This invention also provides a method to inhibit neovascularization in tissue by delivering to the cell or tissue an effective amount of gossypol, or a pharmaceutically acceptable salt, derivative...
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6596064 |
Biocidal-antifouling agents with low ecotoxicity index
A use of tetralin derivatives as biocidal and antifouling agents for preventing and slowing the growth of algae, molds and microorganisms. In particular, the vitamin derivatives are constituted by...
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6576660 |
Methods and compositions for regulation of 5-α-reductase activity
Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
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6436423 |
Product and method for improving avian health
A product and method for reducing and preventing the ingestion of substrates by avians wherein the substrates are disposed within an avian house. The product is a bird repellent in combination with...
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6433022 |
Spermicide
There is provided a method of contraception, comprising exposing a spermicidally sufficient quantity of an agent to spermatozoa. The agent is a quinone represented by the following formula: Each...
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6413993 |
Combination preparation for treating malaria
Methods of treatment and prevention of malarial infection caused by Plasmodium vivax , in which combinations of atovaquone, proguanil and primaquine are administered to a patient.
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6410601 |
Histochrome and its therapeutic use in acute myocardial infarction and ischemic heart disease
A pharmaceutical composition is provided, which comprises an aqeous solution containing a mixture of di- and tri-sodium salts of echinochrome in an amount of 0.90 to 1.10 g/ml (Histochrome). It...
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6342499 |
Parasitic and saprophagous mite control in beneficial insects
The present invention provides a method to control parasitic and saprophagous mites on beneficial insects such as honeybees via the application of a parasiticidally or saprophagouscidally effective...
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6313163 |
2,4-pentadienoic acid derivatives having retinoid-like biological activity
Compounds of formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cyclopropyl optionally substituted with one or two...
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6291533 |
Dietary supplements for each specific blood type
Dietary supplement compositions designed to be responsive to specific blood types, and thus most beneficial for people with specific antigenic blood types.
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6291488 |
Preventing protozoal infections
The invention relates to combinations of atovaquone and proguanil, their use in the treatment and prophylaxis of parasitic infections such as protozoal parasitic infections, e.g., malaria and...
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6197763 |
Use of metal complexes to treat gastrointestinal infections
Novel dietary complexes for gastrointestinal symptoms and gastrointestinal microbes are provided. They comprise a dietary metal and a dietary ligand wherein the dietary metal is selected from zinc,...
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RE37087 |
Insecticidal triffluormethyl alkane derivatives
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
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6169111 |
Conformationally rigid aryl prostaglandins for use in glaucoma therapy
Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
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6166046 |
Combination of atovaquone with proguanil for the treatment of protozoal infections
The invention relates to combinations of atovaquone and proguanil, their use in the treatment and prophylaxis of parasitic infections such as protozoal parasitic infections, e.g., malaria and...
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6127570 |
Fungicidal substituted 2-hydroxybenzophenones
Substituted 2-hydroxybenzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.
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6114397 |
Gossypol for the treatment of cancer
A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone,...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6100267 |
Quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
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6080791 |
Method of treating a viral condition by inhibiting membrane fusion
A method of preventing and treating a viral condition caused by an enveloped virus is described, comprising using a therapeutically effective amount of a compound selected from the group consisting...
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6075057 |
Inhibition of carbohydrates metabolism by quinone compounds
Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of α-glucosidase and α-mannosidase. Other enzymes assayed were not...
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6074634 |
Feeding attractant and stimulant for adult control of noctuid and/or other lepidopteran species
The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling...
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6048877 |
Tetralone derivatives as antiarrhythmic agents
Tetralone derivatives of the formula ##STR1## where R 1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo),...
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6017932 |
Pharmaceutical compositions containing at least one NSAID having increased bioavailability
A novel composition for increasing the bioavailability of Non-steroidal Anti-inflammatory Drugs (NSAIDs), particularly those belonging to the category which exhibits its activity by selectively...
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6001883 |
Fungicidal 2-methoxybenzophenones
Substituted benzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.
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5929109 |
Enhancing and stabilizing agent of the activity of Bifidus factor
The present invention relates to an agent for enhancing and stabilizing the activity of Bifidus factor, containing at least one member selected from the group consisting of ascorbic acid,...
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