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7598289 |
Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions
The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone...
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7595346 |
Curcumin analogues and uses thereof
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but...
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7572825 |
Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions
The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone...
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7521580 |
Non-cytotoxic synthetic analogues of (1E, 6E)-1, 7-Bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-Dione and therapeutic applications thereof in cystic fibrosis
Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,
5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered...
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7511078 |
Antiallergic agents, drugs, foods, drinks or cosmetics containing them and process for producing the same
The present invention provides an antiallergic agent comprising, as an active ingredient, at least one of a tomato extract, tomato pericarp, naringenin chalcone or its derivatives,...
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7462646 |
Osteoclastogenesis inhibitors and uses thereof
The present invention provides a method of reducing or inhibiting osteoclast development induced by the receptor for activation of nuclear factor kappa B ligand (RANKL), comprising the step of...
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7432401 |
Method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties
This patent of invention reports the method for the preparation of 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties: the sample denominated 37...
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7432303 |
Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit...
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7196105 |
Treatment of human multiple myeloma by curcumin
All multiple myeloma cell lines examined showed constitutively active IκB kinase (IKK), IκBα phosphorylation and constitutively active NF-κB. Curcumin, a chemopreventive agent, suppressed...
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7105577 |
Antimicrobial method using a hydroxydiphenyl ether compound
The present invention relates to the use of hydroxydiphenyl ether compounds as antimicrobially active substances, to certain new compounds of this type and to processes for the preparation of these...
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7105576 |
Synergistic effects of nuclear transcription factor NF-κB inhibitors and anti-neoplastic agents
The present invention provides methods of inhibiting metastasis of a tumor and methods of treating a tumor using a combination of an inhibitor of the activation of nuclear factor NF-κB and a...
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7078431 |
1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a...
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6943194 |
Synthesis of phenstatin and prodrugs thereof
A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was...
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6943196 |
NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient
An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R 1 , R 2 , and R 3 are each independently H, alkyl having 1 to 5...
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6890542 |
Leishmania vaccine
The present invention relates to the use of a live mutant Leishmania in the preparation of a vaccine and to vaccine formulations for use in immunizing mammals, such as dogs and/or humans. The...
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6887904 |
Substituted arylcycloalkanes, compositions containing them and use thereof
Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used...
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6797694 |
Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca ), and the use of such compounds for the...
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6776980 |
Photoprotective/cosmetic compositions comprising dibenzoylmethane/triazine/diphenylacrylate compounds
Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A...
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6703421 |
Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure
A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-κB inhibitor in a therapeutically...
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6696484 |
Method and compositions for regulation of 5-alpha reductase activity
Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5α-reductase inhibitor, such as natural and synthetic flavanoids,...
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6677330 |
Fluorides of 4-substituted piperidine derivatives
The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the...
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6673843 |
Curcumin and curcuminoid inhibition of angiogenesis
Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin,...
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6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
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6576660 |
Methods and compositions for regulation of 5-α-reductase activity
Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
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6521668 |
Cosmetic composition and methods of use
There are disclosed cosmetic compositions and methods for protection of keratinous tissue against environmental aggressors, such as smoke, smog and UV radiation. The compositions have as an...
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6436423 |
Product and method for improving avian health
A product and method for reducing and preventing the ingestion of substrates by avians wherein the substrates are disposed within an avian house. The product is a bird repellent in combination with...
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6395776 |
Pesticides
New pesticidal compositions which comprise at least one signal substance, at least one UV absorber which is only sparingly miscible with water, at least one unsaturated oil which is only sparingly...
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6328981 |
Composition comprising a dibenzoylmethane derivative and a polyamino polymer
Cosmetic and/or dermatalogoical compositions comprising, in a cosmetically and/or dermatologically acceptable vehicle, i) a dibenzoylmethane derivative, in particular...
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6326402 |
Methods for treating viral infections using a compound capable of inhibiting microtubules
The present invention is directed to a method for inhibiting viral replication and treating viral infections by administering a pharmaceutically effective amount of a compound capable of binding a...
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6277357 |
Ketotricyclo[5.2.1.0]decane derivatives
The invention relates to ketotricyclo[5.2.1.0]-decane derivatives of the formula I ##STR1## wherein Phe is a phenyl group which is unsubstituted or substituted by 1 to 5 hydroxyl, alkyl or...
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6258854 |
Ketone precursors for organoleptic compounds
The invention discloses ketones of formula I: ##STR1## wherein, Y is an optionally substituted alkyl, cycloalkyl, or cycloalkylalkyl, wherein each alkyl group is straight or branched and each...
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RE37087 |
Insecticidal triffluormethyl alkane derivatives
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
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6127570 |
Fungicidal substituted 2-hydroxybenzophenones
Substituted 2-hydroxybenzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.
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6127422 |
Anti-viral method
A method of inhibiting an envelope virus selected from the group consisting of influenza bovine diarrheal, hepatitis C and tick borne encephalitis virus that udergoes hemagglutinin-mediated fusion...
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6121330 |
5-Hydroxyalkyl substituted phenyls and their use in medicaments for the treatment of arteriosclerosis and hyperlipoproteinaemia
The novel 5-hydroxy-alkyl-substituted phenyls are prepared by either reacting the corresponding benzaldehydes with the Grignard compounds and subsequently reducing the other functional groups or by...
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6107334 |
Dietary control of arachidonic acid metabolism
The present invention is directed towards the control of inflammation. More specifically there are provided herein dietary fatty acid regimens that may be used to inhibit the increase of serum...
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6080791 |
Method of treating a viral condition by inhibiting membrane fusion
A method of preventing and treating a viral condition caused by an enveloped virus is described, comprising using a therapeutically effective amount of a compound selected from the group consisting...
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6075057 |
Inhibition of carbohydrates metabolism by quinone compounds
Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of α-glucosidase and α-mannosidase. Other enzymes assayed were not...
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6033649 |
Light screening agents
Photostable, cosmetic light-screening composition, comprising, in a cosmetically acceptable vehicle containing at least one fatty phase, about 0.1 to about 5%, in particular about 1 to about 3% by...
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5990170 |
Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor
The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic...
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5985935 |
Treatment and prophylaxis of diseases caused by parasites, or bacteria
Aromatic compounds, or prodrugs thereof, which contain an alkylating site and which are capable of alkylating the thiol group in N-acetyl-L-cysteine, in particular bis-aromatic α,β-unsaturated...
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5925376 |
Method for treating psoriasis using selected phosphorylase kinase inhibitor and additional compounds
An improved method of treating psoriasis involves controlling the enhanced proliferation and terminal differentiation of psoriatic epidermis through the activity of epidermal phosphorylase kinase....
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5891924 |
Curcumin (diferuloylmethane) inhibition of NFκB activation
The present invention provides a method of inhibiting the activation of the NFκB transcription factor in an animal in need of such treatment comprising the step of administering to said animal a...
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5882634 |
Compositions comprising a dibenzoylmethane derivative, a 1,3,5-triazine derivative and a dialkyl benzalmalonate, and methods of use therefor
The present invention relates to novel cosmetic and/or dermatological compositions comprising, in a cosmetically and/or dermatologically acceptable support, i) a dibenzoylmethane derivative, in...
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5882633 |
Compositions comprising a dibenzoylmethane derivative, a 1,3,5-triazine derivative and an amide compound, and methods of use therefor
The present invention relates to novel cosmetic and/or dermatological compositions comprising, in a cosmetically and/or dermatologically acceptable support, i) a dibenzoylmethane derivative, in...
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5849273 |
Skin care and sunscreen composition containing dibenzoylmethane derivative, e.g., parsol® 1789, and C.sub.12, C.sub.16, C.sub.18 branched chain hydroxybenzoate and/or C.sub.12, C.sub.16 branched chain benzoate stabilizers/solubilizers
A sunscreen composition containing a UV-A dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL® 1789), and a stabilizer/solubilizer for the...
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5788954 |
Hydrating skin care and sunscreen composition containing dibenzoylmethane derivative, E.G., parsol 1789, and C12, C16, C18 branched chain hydroxybenzoate and/or C12, C16, branched chain benzoate stabilizers/solubilizers
A sunscreen composition containing a UV-A dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL® 1789), and a stabilizer/solubilizer for the...
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5725844 |
Waterproof cosmetic or dermatological photoprotective preparations
Water-resistant cosmetic or dermatological light protection formulations in the form of O/W emulsions or hydrodispersions, comprising one or more cosmetically or pharmaceutically acceptable...
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5545399 |
Cosmetic composition
A composition for topical application to the skin in order to promote the repair of photo-damaged or aged skin and/or to reduce or prevent damaging effects of ultra-violet light on skin and/or to...
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5401500 |
Insect attractant compositions and methods for using same
Described is a method of attracting Musca domestica L. (Diptera:Muscidae) using benzoin and/or dimethyl benzyl carbinyl acetate. The attractants taken alone or in combination find utility primarily...
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