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7491849 |
Oligoamine compounds and derivatives thereof for cancer therapy
Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate...
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7459446 |
Treatment of diabetes with copper binding compounds
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
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7453011 |
Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds...
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7423182 |
Aminated polyamines
An aminated polyamine having the formula:
or its possible stereoisomers or a salt thereof with a pharmaceutically acceptable acid wherein:
R 1 and R 4 may be the same or different and...
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7414154 |
Polyamine compounds and compositions for use in conjunction with cancer therapy
The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered...
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7279502 |
Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as...
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7273888 |
Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the...
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7232846 |
Amines as anti-alcoholism agents
The oral administration to genetically alcoholic rats (from the strain UChB of the University of Chile) of a compound selected from endogenic polyamines (putrescine, spermidine, spermine),...
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7202280 |
Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration
Novel methods for treating and preventing acute and/or chronic pancreatitis are described. Additionally, novel methods for inducing liver regeneration are described. The methods may comprise...
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7094808 |
Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
Polyamines having the formula:
or a salt thereof with a pharmaceutically acceptable acid wherein: R 1 -R 6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally...
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7087648 |
Methods for modulating macrophage proliferation using polyamine analogs
Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or...
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7045550 |
Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
Polyamine effectors are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical...
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7008531 |
Treatment of circulating water systems
The present invention relates to a method of inhibiting the growth of killing algae, bacteria, yeast and/or fungi in a recirculating water system which comprises adding to the water a polymeric...
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6897243 |
Fructosamine oxidase: antagonists and inhibitors
The present invention relates to methods of treating an individual with diabetes mellitus by administering to said individual an effective amount of copper chelators, hydrazine compounds, and/or...
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6867237 |
DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans
Genes encoding an apoptosis-induced eukaryotic initiation Factor-5A (eIF-5A) and an apoptosis-induced deoxyhypusine synthase (DHS), whose expressions are induced by the onset of apoptosis, are...
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6849648 |
Phenylene alkyne matrix metalloproteinase inhibitors
A compound of Formula I
or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G 1 , G 2 , and B are as defined in the application, are selective inhibitors of...
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6841576 |
Anti-hypertensive composition and methods of treatment
Pharmaceutical compositions for the treatment of hypertension comprising an effective anti-hypertensive amount of at least one compound in association with a pharmaceutically acceptable,...
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6649587 |
Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as...
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6586478 |
Methods and compositions for improving sleep
Methods and compositions for improving sleep in individuals with sleep disorders or other conditions which interfere with normal sleep via administration of a NO-mimetic are provided.
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6576672 |
Polyamine treatment of neurological disorders
2,3,2 Tetramine (3,7-diazanonane-1,9-diamine) is propounded for treatment of Parkingson's Disease and dementias characterized by mitochondrial damage in view of this compound's ability to...
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6531512 |
Method of treating cancer in patients having a deficiency in p53 tumor suppressor gene
A method of treating cancer in a patient deficient in p53 tumor suppression gene is described herein by administering to a patient a therapeutically effective amount if a polyamine such as DENSPM...
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6482833 |
Immunotherapeutic anti-cancer pharmaceutical compositions
There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present...
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6464764 |
Protective agents for wood
Solvent-free coating materials and treating agents used as water-based wood or material protective agents containing emulsifiable binding agents, quaternary ammonium compounds and optional...
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6444230 |
Synergistic composition of peracetic acid and amine oxide
Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid,...
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6399662 |
Method and composition for the treatment of diarrhea and gastrointestinal spasms
Anti-diarrheal and/or gastrointestinal anti-spasmodic pharmaceutical compositions containing [A] a polyamine of the formula: R 1 —N 1 (R 2 )—(CH 2 )x—N 2 H—Q—N 3 H—(CH 2 )y—N 4 (R 3...
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6362232 |
Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
The present invention relates to anti-neoplastic and anti-psoriasis pharmaceutical compositions and methods of treatment and to insecticidal compositions and methods of controlling the growth of...
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6342534 |
Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
Polyamines having the formula: or a salt thereof with a pharmaceutically acceptable acid wherein: R 1 -R 6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally...
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6274630 |
Method of inhibiting biosynthesis of EIf5A
A method and pharmaceutical composition for inhibiting or preventing the intracellular biosynthesis of EIf5A by the administration to a human or non-human mammal in need thereof an amount of a...
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6235794 |
Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment
Polyamines having the formula: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein: R 1 -R 5 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl or...
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6217914 |
Ascorbic acid composition and method for treatment of aging or damaged skin
An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which...
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6184254 |
Methods of identifying modulators of perivascular sensory nerve Ca2+ receptors
Methods of identifying compounds that relax or stimulate arterial tension through their action on perivascular sensory nerve calcium receptors are described. Compounds identified through such...
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6168808 |
Synergistic composition of peracetic acid and amine oxide
Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic...
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6160022 |
Chemical resection of pancreas
A method of chemically resecting the exocrine portion of the pancreas of a patient in need thereof comprising administering to the patient an amount of a hydroxy polyamine or a salt thereof with a...
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6015828 |
Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride...
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6011066 |
Method for treating septic shock
A method for the treating septic shock in a patient comprises administering to the patient a therapeutically-effective amount of a composition comprising a compound having the formula (I): ##STR1##...
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5962533 |
Hydroxy polyamines
Disclosed are polyamines having the formula: ##STR1## or salts or stereoisomers thereof wherein R 1 -R 4 and ALK 1 -ALK 3 are as defined in the specification. Pharmaceutical compositions and...
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5935518 |
Swimming pool treatment
This invention relates to the treatment of pool surfaces and equipment with antimicrobial solutions which contain straight chain alkylamine compounds alone or in combination with additional...
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5929039 |
Method for treating cardiac dysfunction and pharmaceutical compositions useful therefor
The present invention relates generally to a method for, and pharmaceutical compositions useful in, the prophylaxis and/or treatment of cardiac dysfunction in a mammal by the administration of an...
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5906996 |
Tetramine treatment of neurological disorders
2,3,2 Tetramine (3,7-diazanonane-1,9-diamine) is propounded for the treatment of Parkinson's Disease and dementias characterized by mitochondrial damage in view of this compound's ability to...
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5886051 |
Methods and compositions for the treatment of neurodegeneration
Methods and pharmaceutical compositions in unit dosage form for treating neurodegeneration in a human or non-human animal afflicted therewith wherein the active agent is a therapeutically effective...
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5880161 |
Therapeutic polyamines
Therapeutic polyamines useful as a cancer chemotherapeutic agents, including molecules having a formula R 1 --NH--(CH 2 ) x --NH-- (CH 2 ) x --NH-- (CH 2 ) y --NH--(CH 2 ) z --NH--R, wherein R...
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5776352 |
Process for treatment of water and of surfaces in contact with the said water in order to prevent the attachment of and/or to remove and/or to control macroorganisms, composition and paint for the said treatment
The invention relates to a process for the treatment of water and of surfaces in contact with the said water in order to prevent the attachment and/or to, remove and/or to control macroorganisms,...
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5760092 |
Allocolchinones and uses thereof
Disclosed are allocolchinones, which are anti-mitotic agents. Allocolchinones bind to tubulin reversibly and are more effective at inhibiting microtubule formation than colchicine....
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5760091 |
Preventive agents against adhesion of marine organisms and methods of preventing such adhesion of marine organisms
A preventive agent against adhesion of a marine organism comprising: at least one amine compound represented by the following formula (I): ##STR1## , wherein R is a C 8 -22 saturated or unsaturated...
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5719193 |
Method of potentiating cell-mediated immunity utilizing polyamine derivatives
This invention relates to a method of potentiating cell-mediated immunity which comprises administering to a patient a cell-mediated immunity potentiating amount of a compound of the formula: ...
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5654287 |
Method of treating cancer by conjunctive therapy with N,N.sup.1 -bis[3-(ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of...
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5627215 |
Unsaturate amino compounds for use as anticancer and antiprotozoic agent
The invention relates to compounds of formula (I), R 1 and R 2 , each independently of the other, are selected from lower alkyl that is unsubstituted or substituted by one or more fluorine atoms...
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5614509 |
Pharmaceutical agents for preventing the development of tolerance during the treatment with benzodiazepine-receptor-binding active ingredients
The use of NMDA receptor antagonists or their physiologically compatible salts for preventing the development of tolerance during the long-term treatment with benzodiazepine-receptor-binding active...
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5554656 |
Disinfectant concentrates and disinfectants on amine and alcohol base and their use
The invention relates to a disinfectant concentrate which contains amine and alcohol wherein the alcohol component includes at least one glycol ether of limited miscibility with water and the amine...
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5498522 |
Methods for the use of spermidine/spermine N.sup.1 -acetyltransferase as a prognostic indicator and/or a tumor response marker
Disclosed is a method that relates to the measurement of determinants related to the in-vivo induction of spermidine/spermine N 1 -acetyltransferase (SSAT), subsequent to polyamine analog...
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