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7547806 |
Tannate salt of rasagiline
The subject invention provides rasagiline tannate, compositions and a process for manufacture thereof.
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7273889 |
NMDA receptor antagonist formulation with reduced neurotoxicity
The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7071194 |
Method for improving respiratory function and inhibiting muscular degeneration
The present invention provides a method for improving respiratory function and inhibiting muscular degeneration (e.g., dystrophy and atrophy). Alternative embodiments of the invention provide a...
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7067524 |
Substituted phenyl naphthalenes as estrogenic agents
This invention provides estrogen receptor modulators of formula I, having the structure
wherein
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 , are as defined in the...
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7049337 |
Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differential CNS receptor activity and behavior
Aminotetralin derivatives and pharmacological analogs thereof which contain an N-propynyl group exhibit differential dopaminergenic receptor activity. The subject compounds are useful in affecting...
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7041703 |
2-aminotetralines and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or...
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6982286 |
Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO),...
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6956060 |
Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also...
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6949575 |
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R 1 and R 2 include alkyl and phenylalkyl; R 3 is...
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6927223 |
Use of serotonin agents for adjunct therapy in the treatment of cancer
The invention provides a method for the treatment of cancer comprising administering a serotonin agent. Also provided is a method for the treatment of cachexia comprising administering a serotonin...
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6890959 |
Aminomethyl-phenyl-cyclohexanone derivatives
Aminomethyl-phenyl-cyclohexanone derivatives of formula I or Ia,
their diastereomers, enantiomers and salts formed with a physiologically tolerated acid. Also disclosed are processes for...
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6878721 |
Beta2-adrenoceptor agonists
Compounds of formula
in free or salt or solvate form, where
Ar is a group of formula
Y is carbon or nitrogen and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , X, n,...
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6858652 |
Sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them
The present invention is directed to novel polymorphic Forms XI, XII, XIII, XIV, XV and XVI of sertraline hydrochloride, to processes for preparing them, methods of using them to treat disease,...
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6849663 |
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or...
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6844368 |
Compounds useful in pain management
The present invention relates to novel oxo-aminotetralin compounds of the formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are defined herein.
The compounds of formula (I) are...
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6784210 |
Compound and a novel process for their preparation
The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes...
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6710089 |
Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6703424 |
Dispersible compositions containing L-DOPA ethyl ester
The present invention relates to a dispersible pharmaceutical composition comprising a therapeutically effective amount of L-DOPA ethyl ester, a therapeutically effective amount of a decarboxylase...
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6696430 |
Use of vital dye for facilitating surgical procedures for vitreo-retinal surgery
A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal...
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6670387 |
Thrombopoietin mimetics
Non-peptide TPO mimetics are disclosed, as well as a method of treating thrombocytopenia, in a mammal, including a human, in need thereof, which comprises administering to such mammal an effective...
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6649614 |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety
The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or...
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6624201 |
HIGH PURITY (1R,2S,4R)-(−)-2-&lsqb (2′-&lcub N,N-DIMETHYLAMINO&rcub -ETHOXY)&rsqb -2-&lsqb PHENYL&rsqb -1,7,7 -TRI-&lsqb METHYL&rsqb -BICYCLO &lsqb 2.2.1&rsqb HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF AND A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE
The invention relates to high purity (1R,2S,4R)-(−)-2-[(2′-{N,N-dimethylamino}-ethoxy)]-2-[ph
enyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts...
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6613313 |
Aniline compound-containing hair dye composition and method of dyeing hair
A hair dye composition containing at least one of the following compounds: or analogues thereof; and a method for dyeing hair which comprises a step of applying to the hair the hair dye...
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6589996 |
Treatment of disorders relating to the serotonergic system
A method for the treatment of disorders relating to serotonergic system in humans, for example depression and anxiety, comprising orally administering deramciclane in a daily dosage of about 20 to...
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6576671 |
Aminotetralin derivatives for the therapy of cardiovascular diseases
The invention relates to a method of treatment of left ventricular dysfunction, by administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of...
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6552014 |
Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet...
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6541478 |
Smoking cessation treatments using naltrexone and related compounds
Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
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6518291 |
Inhibitors of IMPDH enzyme
The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and...
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6500849 |
1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino 1,3-propanediols and related compounds
Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and...
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6462056 |
Oxazolidines as 5-HT2A-antagonists
The invention relates to novel oxazolidine derivatives of the formula in which R 1 , R 2 and R 3 have the meanings stated in claim 1, their salts and processes for preparing the compounds...
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6441049 |
Method of treating neurodegenerative disorders via inhibition of amyloid beta peptide binding
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit...
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6413987 |
Dermal anesthetic agents
The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as...
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6387956 |
Methods of treating obsessive-compulsive spectrum disorders
A method of treating an obsessive-compulsive spectrum disorder comprises the step of administering an effective amount of tramadol to an individual.
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6380236 |
Method of treating onychomycosis
A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal...
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6369051 |
Combinations of SSRI and estrogenic agents
This invention comprises methods of depression, anxiety, generalized anxiety disorder (GAD), hot flush, post partum depression, premenstrual syndrome, obesity, obsessive compulsive disorder,...
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6329399 |
Antifungal amine derivatives and processing for producing the same
Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided. ##STR1## [in the formula (1, R 1 represents a C 1 -5 alkyl...
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6316469 |
Use of selective serotonin reuptake inhibitors for treatment of chest pain of non-cardiac origin and gastro-esophageal reflux disease
Selective serotonin reuptake inhibitors useful in the treatment of non-cardiac chest pain or the treatment of symptoms of gastro-esophageal reflux disease.
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6281248 |
Composition for treating asthma
A method of treating asthma that includes the step of controlling the asthma by ingesting a composition which includes a selective serotonin reuptake inhibitor that is sertraline hydrochloride....
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6251943 |
Method of treating or preventing septic shock by administering a MEK inhibitor
The present invention provides a method for treating or preventing septic shock. Specifically, the present invention provides a method of treating or preventing septic shock by administering to a...
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6245774 |
Tri-substituted phenyl or pyridine derivatives
Compounds of general formula (1) are described: ##STR1## wherein W-- is (1) C(Y)-- where Y is a halogen atom, or an alkyl or --XR a group where X is --O--, --S(O) m -- [where m is zero...
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6242497 |
Use of 6,7-substituted 2-aminotetralines suitable for preparing a pharmaceutical composition for the therapeutic treatment of inflammatory and/or autoimmune pathologies
6,7-substituted 2-aminotetralines are used to treat inflammatory and/or autoimmune conditions induced by inflammatory cytokines.
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6201025 |
N-aralkylaminotetralins as ligands for the neuropeptide Y Y5 receptor
β-Aminotetralin derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing a...
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RE37087 |
Insecticidal triffluormethyl alkane derivatives
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
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6191133 |
Treatment of depression and pharmaceutical preparations therefor
It has been found that the treatment of depression using known serotonin reuptake inhibitors (SRIs) and noradrenaline reuptake inhibitors (NRIs) may be improved by the administration therewith of...
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6169116 |
Amino-tetralines, pharmaceutical compositions containing them and their pharmaceutical uses
Compounds of formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description, are useful as pharmaceuticals.
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6169111 |
Conformationally rigid aryl prostaglandins for use in glaucoma therapy
Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
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6162815 |
RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are...
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6162805 |
Use of an NK-1 receptor antagonist and an SSRI for treating obesity
The present invention relates to the use of an NK-1 receptor antagonist and a selective serotonin reuptake inhibitor for the treatment or prevention of obesity.
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