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5182097 |
Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The...
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5179097 |
Salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids
Novel choline salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids are described. Additionally, blends of choline salts with the above carboxylic acids are...
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5171753 |
Derivatives of 2-amino-1-phenylethanol having antiulcer activity
Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted...
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5169633 |
Continuous release phenylethanolamine derivative compositions
The invention relates to compositions for the parenteral administration of an essentialy uniform and continuous amount of a phenylethanolamine derivative over an extended period of time. The...
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5166181 |
Halogenoalkylphenyl-alcohols, ketones and hydrates thereof
Halogenoalkylphenyl-alcohols, ketones and their hydrates of formula I, ##STR1## wherein R 1 to R 8 are as defined in the description, are useful as acetylcholinesterase inhibitors.
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5143938 |
Propanamines, their pharmacological properties and their application for therapeutic in particular antidiarrheal, purposes
A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted, or is a 5- or 6-membered monocyclic heteroaryl radical...
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5141961 |
Process for solubilizing difficulty soluble pharmaceutical actives
The present invention relates to a process for solubilizing at least one difficultly soluble pharmaceutical active in a mixture of polyethylene glycol and polyvinylpyrrolidone. The process does not...
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5130339 |
Phenylethanolaminomethyltetralins and pharmaceutical use
New phenylethanolaminomethyltetralins of formula (I) ##STR1## wherein E represents hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, phenyl, nitro, halogen, or trifluoromethyl, L represents...
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5124334 |
Benzylalcohol phospholipase A.sub.2 inhibitors
The invention relates to benylalcohol phospholipase A 2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A 2 -mediated conditions in mammals by...
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5116878 |
Medicinal composition for the treatment and prevention of the symptoms of heart failure, containing a vasoconstrictor alpha-stimulant agent as active principle
This medicinal composition for the treatment and prevention of the symptoms of heart failure contains, by way of active principle, at least one compound chosen from...
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5096929 |
2-amino-1,2,3,4-tetrahydronaphthalene derivatives with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them
5,6-Dimethoxy-2-[2-(4-hydroxyphenyl)-2-hydroxy-2-methylethyl
]amino- 1,2,3,4-tetrahydronaphthalene has inotropic and vasodilating activities and therefore can be used in the treatment of...
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5079253 |
Composition for the topical treatment of glaucoma or ocular hypertension
A method for the topical treatment of glaucoma or ocular hypertension which comprises contacting the surface of the eye with a composition consisting essentially of an effective intraocular...
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5073380 |
Oral sustained release pharmaceutical formulation and process
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a...
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5068233 |
Synergistic combination of azelastine and theophylline or azelastine and α-mimetics
A medicine having a synergistic activity containing a combination of azelastine and theophylline or azelastine and at least one β-mimetic.
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5068103 |
Salbutamol-containing plaster and method of producing same
A plaster, which can be used in the prevention of attacks of bronchial asthma and in the treatment of bronchitis, comprises an adhesive base composition comprising a macromolecular substance and a...
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5066678 |
Phenethandamine derivatives and pharmaceutical use thereof
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof; wherein; R 1 and R 2 each independently represent a hydrogen...
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5064863 |
Phenoxypropanolamines and pharmaceutical use
Tertiary and secondary amines of the formulas ##STR1## wherein n is the integer 1 or 2, p0 R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl, X 1 is phenoxymethyl optionally...
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5055460 |
Method for weight loss
A method for producing or maintaining weight loss by administering to a human a composition containing an effective amount of each of caffine, aspirin and ephedrine. The pharmaceutical composition...
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5049587 |
Ophthalmic solution for intraocular pressure adjustment
Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.
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5047244 |
Mucoadhesive carrier for delivery of therapeutical agent
A mucoadhesive carried suitable for a therapeutic agent is disclosed. This carrier allows controlled release of the therapeutic agent via mucosal tissue. The mucoadhesive carrier comprises a...
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5047433 |
N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same
N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline having general formula (I) ##STR1## wherein R is selected from hydrogen, ethyl, n-propyl and methyl cyclopropyl; R 1 is selected from...
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5047434 |
Method for weight gain-increasing of fodder utilization of pigs, cattle or poultry
The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of...
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5045567 |
Propanolamine derivatives having anti-diabetic effects
Propanolamine derivatives of the formula ##STR1## wherein R 1 is hydrogen or a group of formula ##STR2## n is the number 0 or 1; R 2 and R 5 are phenyl, m-halophenyl, m-trifluoromethylphenyl,...
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5043358 |
Gastroprotective process
A pharmaceutical composition and process for administering non-steroidal anti-inflammatory drugs which are protected against injury to gastrointestinal tract by beta adrenergic agonists.
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5037848 |
Aryl-cycloalkyl-alkanolamines for treatment of epilepsy
A compound and method are disclosed for reducing the effects of epilepsy, especially temporal lobe epilepsy. The treatment disclosed by the subject invention is provided by administering an...
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5036107 |
1,7-substituted heptyn-2-ones and use
1-Phenyl-7-substituted-hept-5-yn-2-ones substituted with a C 1 to C 7 alkyl, C 3 to C 6 cycloalkyl, aryl, heteroaryl or heterocycloalkyl group at the 1-position and an amino, a dialkylamino, a...
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5021457 |
Method for aiding cessation of smoking
Individuals are aided in smoking cessation by administering internally phenylpropanolamine.
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5017619 |
Phenethanolamine derivatives
The invention is directed to phenethanolamine derivatives and their pharmaceutically compatible salts, having the formula ##STR1## wherein n is the number 1 or 2; L 1 and L 2 are hydrogen, C 1 -3...
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5004613 |
Oral sustained release pharmaceutical formulation and process
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a...
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5004755 |
Pharmaceutical use of laevorotatory basic derivative of 9,10-ethanoanthracene
The present invention relates to a new laevorotatory basic derivative of 9,10-ethanoanthracene, namely R-(-)-α-[(methylamino)methyl]-9,10-ethanoanthracene-9(10H)-
ethanol of the formula I ##STR1##...
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5002973 |
Stabilized sulfite-free catecholamine compositions
Novel catecholamine solutions for physiological uses are provided at a pH in the range of 1.0-5.0, comprising catecholamine, acetylcysteine, chelating agent and buffering agents. The compositions...
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5002946 |
Phenylethanolamine analog active compounds for the treatment of gastrointestinal diseases
Phenylethanolamine analog active compounds, optionally substituted on the phenyl group with an halogen atom or with an alkyl or trifluoromethyl group and substituted on the amino group with a...
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4990505 |
Phenethanolamine compounds
The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The...
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4965065 |
Gastroprotective process and compositions
A pharmaceutical composition and process for administering non-steroidal anti-inflammatory drugs which are protected against injury to gastrointestinal tract by beta adrenergic agonists.
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4959358 |
Drug administration
Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of the human or animal physiological condition are provided. The compositions...
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4918108 |
Method of improving the absorption of injected antibacterial substances
An antibacterial substance which does not have optimum absorbability and is administered parentally into tissue, is administered to a host in conjunction with a benzylamine derivative of the...
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4908387 |
Use of beta.sub.2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis
A method of treating inflammation and joint deterioration in mammals which comprises administering a therapeutically effective amount of a selective beta 2 adrenergic receptor antagonist. The...
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4904662 |
Raising of pigs
The fat content of sows' milk is increased, thereby increasing the energy supplied to the sow's piglets, by administering one of a small group of phenethanolamines.
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4898729 |
Treatment of hypertension, compounds and compositions for antihypertension and diuresis
Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve antihypertension is insufficient to achieve...
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4885314 |
Novel HMG-CoA reductase inhibitors
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I)...
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4883660 |
Gel bases for pharmaceutical compositions
Gel bases for pharmaceutical compositions comprise from about 0.5 to about 10.0% by weight ethoxylated (2 to 30 moles of ethoxylation) behenyl alcohol and from about 90 to 99.5% of a glycol solvent...
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4880834 |
Method for administering ethanolamine derivatives to livestock
A method for treating livestock to decrease birth mortality rate and to increase post-natal survival rate by administering ethanolamine derivatives is disclosed.
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4873266 |
Menthone enhancement of transdermal drug delivery
Disclosed herein are compositions and methods for enhancing the transdermal delivery of physiologically active agents across mammalian skin or membranes and which comprise a percutaneous transfer...
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4861801 |
Treatment of depression by using a fluorophenacylamine derivative
The present invention relates to a process for the treatment of depression comprising administering to a human in need thereof an antidepressant amount of a compound selected from...
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4847077 |
Controlled release pharmaceutical preparations
Controlled release pharmaceutical preparations containing coated sulfonic acid cationic exchange resin drug complex particles, the resin particles having been treated, prior to coating, with about...
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4845127 |
Phenethanolamines, compositions containing the same and method for effecting weight control
Optically active N-3-(4-substituted phenyl)propyl-β-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese...
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4835315 |
Fluorophenacyl-amine derivatives and application thereof in therapeutics
The present invention relates to new compounds belonging to the family of fluorophenacyl-amine derivates of formula: ##STR1## [wherein A is CO or CHOH and R is CH(CH 3 ) 2 or C(CH 3 ) 3 ] and...
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4820717 |
Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them
The present invention relates to new aromatic derivatives of formula: ##STR1## wherein: Alk is an alkylene group with 1 to 10 carbon atoms, R 1 is hydrogen or an alkyl with 1 to 6 carbon atoms,...
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4818767 |
Quinate salts of antimalarial phenanthrenemethanol compounds
The compounds of formula (I) ##STR1## wherein R 1 is hydrogen or an alkyl radical containing one to six carbon atoms and R 2 is an alkyl radical containing one to six carbon atoms possess...
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4783457 |
Pest controlling agents
The invention relates to an invertebrate pest controlling composition comprising an invertebrate pest-controlling amount of a non-formamidine octopamine against having substantial activity toward...
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