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Document Title |
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7572782 |
Use of targeted oxidative therapeutic formulation in bone regeneration
A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an...
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7432247 |
Methods of cardioprotection using dichloroacetate in combination with an inotrope
The present invention provides compositions and methods for maintaining cardiac function by administering dichloroacetate (DCA) in combination with an inotrope.
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7271197 |
Phenethanolamine derivatives
The present invention relates to novel compounds of formula (I),
or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical...
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7183323 |
Sodium channel modulators
The invention provides sodium channel modulating compounds of formula I:
wherein X, Y, Q, R 1 , w, and R 2 have any of the values defined in the specification, and salts thereof, which are...
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7081482 |
Use of β-adrenoceptor antagonists for the manufacture of a medicament for the treatment of disorders of the outer retina
The invention is directed to the use of β-adrenoceptor antagonists for the manufacture of a medicament for the treatment of disorders of the outer retina.
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7056498 |
Composition containing aminophenol derivative, use thereof, and process for dissolving aminophenol derivative
Composition containing at least one aminophenol derivative and a solubilizing compound which is not in the form of vesicles, chosen from: (a) oxyalkylenated fatty acid esters of sorbitan, (b)...
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7037943 |
Retinal treatment method
A method for treating or preventing retinal pathology or injury. The method locates and secures a retinal stimulating substance in the eye between the internal limiting membrane and the retina,...
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7030160 |
Propanolaminotetralines, preparation thereof and compositions containing same
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that...
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6844320 |
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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6756408 |
Methods and materials for protecting against myocardial cell damage related to coronary intervention by regional beta blocker therapy
Disclosed is method for reducing myocardial cell damage during and/or after percutaneous coronary intervention in a subject's coronary artery. The method includes instilling a beta blocker directly...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6635667 |
Methods of treatment using MAO-A and MAO-B inhibitors such as L-deprenyl
Effects of MAO-A or MAO-B inhibitors such as L-deprenyl on both cerebral and peripheral vasculature, on non-vascular smooth muscle, on the nervous system, and on platelets, RBC, WBC, mast cells,...
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6630454 |
Method and pharmaceutical composition for the treatment of cancer
A method of chemosensitization which comprises administering at least one chemotherapeutic agent and at least one 3-aryloxy-3-phenylpropylamine to a subject in need thereof.
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6627662 |
3-amino-propoxyphenyl derivatives (I)
Compounds of formula (Ia) as potent, β 1 -specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3′,4′-dimethoxyphenyl. R 1 is hydrogen, and R 2 is...
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6593094 |
Compositions to enhance the efficacy and safety of bio-pharmaceutical drugs
Optimal ratios of pharmaceutical compositions of β-1 and β-2 agonists with their respective antagonists. Safer, more cost-effective drugs for heart and lung therapies are made by combining...
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6569460 |
Film-coated tablet for improved upper gastrointestinal tract safety
A novel oral dosage to be delivered to the stomach comprising a safe and effective amount of an active ingredient selected from the group consisting of emepronium bromidebromide, doxycycline, and...
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6569903 |
Ophthalmic compositions
Ophthalmic compositions having negligible side effects on the heart can be obtained by using as the active ingredient an adrenergic β receptor agonist having a high selectivity toward adrenergic...
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RE38115 |
Dextromethorphan and an oxidase inhibitor for treating intractable conditions
Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising...
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6555519 |
O-glucosylated benzamide SGLT2 inhibitors and method
SGLT2 inhibiting compounds are provided having the formula wherein n is 0, 1 or 2; A is or heteroaryl which may contain 1 to 4 heteroatoms in the ring which may be selected from N, O, S, SO,...
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6541478 |
Smoking cessation treatments using naltrexone and related compounds
Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
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6486208 |
Sustained release, and comfortable opthalmic composition and method for ocular therapy
This invention relates to reduced stinging, sustained release ophthalmic formulations and the method of treatment comprising administering such formulations topically to the eye when in need thereof.
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6479523 |
Pharmacologic drug combination in vagal-induced asystole
Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of...
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6417215 |
Calcilytic compounds
Novel calcilytic compounds are provided.
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6395762 |
Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein, R 1 , R 2 , and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in...
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6358944 |
Methods and compositions for treating generalized anxiety disorder
The present invention relates to methods and compositions comprising a very low dose of cyclobenzaprine or metabolite thereof for preventing and treating Generalized Anxiety Disorder. The present...
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6313155 |
Composition and method for treating macular disorders
A method and composition for treating macular disorders. A pharmologically effective amount of a carbonic anhydrase inhibitor is combined with a pharmologically effective amount of an ocular...
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6310050 |
Therapeutic use of compounds with β3-agonist activity
The invention relates to the method of use of compounds with B 3 -agonist activity for inhibiting uterine contractions, preventing or slowing down premature labor, or for the treatment and/or...
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6284800 |
Methods and compositions for treatment of asthma
The present invention comprises methods and compositions for the treatment of bronchorestrictive disorders, including asthma, in humans or animals. The methods and compositions are effective in...
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6235793 |
Use of agonists of adrenergic β-3 receptors for preparing wound-healing medicines
The invention relates to the use of β 3 -adrenergic receptor agonists for the preparation of healing drugs and to the pharmaceutical compositions for said use.
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6218395 |
Centrally-acting beta-blockers and serotonin-enhancers for the treatment of anxiety disorders and adjustment disorders with anxiety
A combination of medicines are administered daily for the relief of the symptoms of an Anxiety Disorder or an Adjustment Disorder With Anxiety. The combination comprises a centrally-acting...
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6207674 |
Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants
Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades...
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6153654 |
Method of improving outcome of cardiopulmonary bypass surgery
This invention concerns a method for improving the outcome of cardiac surgery in patients who undergo cardiopulmonary bypass on a heart-lung machine. More specifically, this invention concerns...
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6124346 |
Estrogen agonist/antagonists treatment of atherosclerosis
A method of treating atherosclerosis, independent of lipid lowering, in mammals, including humans, in need of treatment by inhibiting progression of an atherogenic lesion or by stabilizing plaque....
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6121328 |
Racemic propranolol
Pharmaceutical formulations of mixtures of the D and L configuration of propranolol are disclosed which have antioxidant activity and reduced β blocking activity.
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6069177 |
3-Hydroxy-propanamine derived neuronal reuptake inhibitors
3-Hydroxy-propanamine derivatives and acid salts thereof having chiral centers at the C 1 and C 2 positions exhibit synaptosomal reuptake inhibition of neurotransmitters, and as such represent a...
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6066675 |
Method for treatment of retinal diseases
Methods for the stimulation of growth factor expression and for treatment of retinal diseases with alpha- and beta-adrenergic agonists are disclosed.
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6051605 |
Method of treating psychosis and schizophrenia
This invention relates to compounds that are antagonists of dopamine D4 receptors, and to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4...
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6022894 |
Method of using calcilytic compounds
The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to...
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5968918 |
Method for the prevention of coronary artery spasm
The present invention relates to the prevention of coronary artery spasm in mammals by the administration of an effective amount of an antiestrogen compound to block estrogen receptors for the...
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5965529 |
Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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5962413 |
Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase...
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5908847 |
Combination of a β-receptor blocker and an opioid
New combination of a β-receptor blocker or a pharmaceutically acceptable salt thereof, and an opioid or a pharmaceutically acceptable salt thereof, optionally in the presence of a pharmaceutically...
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5856342 |
Combination of a β-receptor blocker and a local anaesthetic
New combination of a β-receptor blocker, an enantiomer thereof, and a local anesthetic, administered simultaneously or sequentially, giving excellent pain relief. Also comprised in the invention...
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5854287 |
D-Propranolol metabolites useful for antioxidant activities
Metabolites of the D-isomer of propranolol show potent antioxidant activity, independent of β-blocker activity, that make them useful for the treatment of all conditions that can be treated by...
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5798393 |
Betaxolol hydrochloride for the treatment of anxiety disorders
The compound betaxolol has the chemical formula: 1- 4 2-cyclopropylmethoxy)ethyl!phenoxy!-3- 1-methylethyl)amino!-2-propanol . It is administered, preferably orally, once per day in 4-12 mg....
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5776930 |
Pharmaceutical preparation
A method of preventing, treating, terminating and protecting against cardiac arrhythmias, such as atrial, supraventricular and ventricular ectopy, tachycardia, flutter or fibrillation, including...
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5776985 |
Fluorinated propranolol and related methods
Fluorinated beta blockers, such as propranolol, are presented with amplified antioxidant effects and various levels of beta blocking effects. Mixtures are also presented of fluorinated antioxidant...
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5753256 |
Plaster for the treatment of nail mycoses
The invention relates to a plaster for the treatment of nail mycoses, which s characterized by an antimycotically active substance, clotrimazole and bifonazole being excluded.
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5733938 |
Combination of levobunolol and dipivefrin for topical ophthalmic use
Disclosed are pharmaceutical compositions comprising dipivefrin and levobunolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated...
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5723489 |
Aryloxypropanolamine beta 3 adrenergic agonists
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R 1 to R 9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic...
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