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7576103 |
Tetralin and indane derivatives and uses thereof
Compounds of the formula I:
or pharmaceutically acceptable salts thereof,
wherein m, p, q, Ar, R 1 and R 2 are as defined herein. Also provided are methods for preparing, compositions...
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7569729 |
Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
Stable Atomoxetine hydrochloride, a process for the manufacture thereof, the use of stable Atomoxetine Hydrochloride for making a pharmaceutical formulation, a process for the preparation of any...
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7514475 |
Benzylamine analogues
A compound of the formula (I):
wherein R 1 is a C 1 -C 6 alkyl, an amino, a (C 1 -C 6 alkyl)amino, a di(C 1 -C 6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R 2 and R 3 ...
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7507769 |
Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
The present invention provides methods for treating and preventing benign breast disease by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts,...
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7482491 |
Amino alcohol derivative, addition salt thereof, and immunosuppressant
An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-
methylpentane-1-ol) exhibits strong...
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7473804 |
Polymorphs of atomoxetine hydrochloride
The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of...
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7449453 |
Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
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7439398 |
Enantiomerically pure atomoxetine and tomoxetine mandelate
The present invention provides enantiomerically pure (R)-(−)-tomoxetine (S)-(+)-mandelate and atomoxetine HCl. The present invention further provides enantiomerically pure (R)-(−)-tomoxetine...
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7439241 |
Compounds, formulations, and methods for treating or preventing rosacea
In methods, compounds, and topical formulations for treatment of rosacea incorporating compounds represented by the formulas below:
wherein each of R 1 , R 2 , and R 3 is independently...
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7427414 |
Modified release oral dosage form using co-polymer of polyvinyl acetate
Once a day modified release oral dosage form comprising of granules or pellets which are either compressed into tablet or filled inside the capsule, wherein the pellet has a core of active...
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7423181 |
Aminoalkoxy-functional chalcones
The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against...
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7393864 |
Use of ClC3 chloride channel blockers to modulate vascular tone
The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking...
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7384983 |
Inhibitor of monoamine uptake
The present invention provides compounds and methods for the inhibition of monoamine uptake in mammals.
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7368480 |
Methods and compositions with trans-clomiphene
The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with...
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7365085 |
Compounds and methods
Disclosed is a compound having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are...
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7348362 |
Bronchodilating β-agonist compositions and methods
Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a...
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7335659 |
Substituted 10-aryl-11H-benzo[b]fluorenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors
This invention provides a compound, or its possible salt, having the formula,
wherein: R e and ′R e are OH, optionally independently etherified or esterified; Z is —CH 2 CH 2 — or...
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7317023 |
Diaryl ether β2 adrenergic receptor agonists
The invention provides novel β 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat...
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7271197 |
Phenethanolamine derivatives
The present invention relates to novel compounds of formula (I),
or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical...
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7268152 |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
Compounds of Formula (IA) and Formula (IB)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt...
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7259188 |
Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators
Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors.
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7226950 |
Sodium channel modulators
The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also...
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7220783 |
Para-terphenyl compounds
The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an...
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7220782 |
Methods to reduce the sensitivity of endothelially-compromised vascular smooth muscle
The present invention discloses materials and methods useful to treat sensitivity of endothelially-compromised vascular smooth muscle. In one embodiment, CLC3 blockers, particularly compounds of...
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7217703 |
8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents
The present invention provides 8-(2-hydroxyphenoxy)octyldiethanolamine) and salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents...
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7173064 |
Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
The present invention discloses compositions and methods useful for treating wasting, especially a loss of muscle mass. The present invention also discloses compositions and methods useful for...
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7135497 |
Treating neural conditions resulting from spinal cord contusions and other causes
β 2 -agonists, such as clenbuterol and salbutamol can enhance the recovery of locomotive function and/or neuromuscular strength following spinal cord injuries or as a result of degenerative neural...
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7109198 |
Method for treating obesity
The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide...
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7098248 |
Beta-adrenergic blockade reversal of catabolism after severe burn
Provided herein is a method of method of treating an individual having a severe burn, comprising the step of administering to said individual a pharmacologically effective dose of a beta-adrenergic...
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7098198 |
Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
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7081465 |
Alpha-substituted naphthyloxy omega-substituted alky/aryl amino-substituted alkane derivatives as agent for treatment or prophylaxis of diabetes and related metabolic disorders
This invention relates to novel {overscore (ω)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular...
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7074836 |
Para-terphenyl compounds
The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an...
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7067557 |
Methods of treating androgen deficiency in men using selective antiestrogens
The administration of antiestrogens to men suffering a relative androgen deficiency stimulates the body's production of testosterone leading to a correction of the deficiency. For example, male...
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7056498 |
Composition containing aminophenol derivative, use thereof, and process for dissolving aminophenol derivative
Composition containing at least one aminophenol derivative and a solubilizing compound which is not in the form of vesicles, chosen from: (a) oxyalkylenated fatty acid esters of sorbitan, (b)...
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7045549 |
Treatment of symptoms associated with irritable bowel syndrome
Methods are provided for use in treating humans suffering from irritable bowel syndrome. In the subject methods, an effective amount of a nerve-acting agent, e.g., lidocaine, topiramate, mexiletine...
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7034036 |
Inhibitors of ABC drug transporters at the blood-brain barrier
The present invention relates to inhibitors of drug transporters of the ABC protein superfamily, particularly transporters present at the blood brain barrier. ABC transporter inhibitors identified...
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6949548 |
Combination therapy for the treatment of heart failure
A combination therapy for the treatment of heart failure comprises administering a combination of levosimendan or a pharmaceutically acceptable salt thereof and a beta-adrenergic receptor...
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6919325 |
Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
Pharmaceutical compositions and kits comprising:
(a) a tiotropium salt; and (b) a salmeterol salt having a solubility in water of 0.1 mg/mL or less,
processes for preparing them, and their...
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6875775 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula:
wherein R1 and R2, which are the same or different are
a) H, halogen, OCH 3 , OH; or...
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6844320 |
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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6828346 |
Methods for administration of paclitaxel
Methods are provided for using paclitaxel for treating diseases associated with abnormal cell proliferation and angiogenesis. In particular, methods are provided for administration of paclitaxel...
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6812244 |
Naphthyl compounds, intermediates, compositions, and methods of use
The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
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6765022 |
Cyclohexylamine derivatives as subtype selective nmda receptor antagonists
Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel...
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6730329 |
Zinc containing compositions for anti-viral use
One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one...
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6723749 |
Fatty acid synthase inhibitors
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6683114 |
Treatment of psoriasis
Norepinephrine reuptake inhibitors are used to treat psoriasis.
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6632842 |
Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
The present invention relates to a dual bronchodilator inhalation solution, system, kit and method for relieving bronchospasm in patients suffering from chronic obstructive pulmonary disease...
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6632447 |
Method for chemoprevention of prostate cancer
This invention relates to the chemoprevention of prostate cancer and, more particularly, to a method of suppressing or inhibiting latent prostate cancer comprising administering to a mammalian...
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6630454 |
Method and pharmaceutical composition for the treatment of cancer
A method of chemosensitization which comprises administering at least one chemotherapeutic agent and at least one 3-aryloxy-3-phenylpropylamine to a subject in need thereof.
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