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5484797 |
Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis
The present invention provides a compound of formula I ##STR1## wherein R 1 is --H, --OH, --O(C 1 -C 4 alkyl), --OCOC 6 H 5 , --OCO(C 1 -C 6 alkyl), or --OSO 2 (C 4 -C 6 alkyl); R 2 is...
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5457100 |
Method for treatment of recurrent paroxysmal neuropsychiatric
Recurrent paroxysmal neuropsychiatric disorders selected from (1) acute dystonic reactions, (2) seizure disorders and (3) panic disorders may be treated by means of aerosol inhalation of (1)...
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5451609 |
Treatment of impotence
This invention is concerned with a novel anti-impotence composition and a novel method for the treatment of impotence, whereby deacetyl moxisylyte or one of its non-toxic salts is administered in a...
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5432168 |
Method of treatment of hormone-unresponsive metastatic prostate cancer
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
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5430062 |
Stilbene derivatives as anticancer agents
The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can...
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5426123 |
Method for lowering serum cholesterol with 1,1,2-triphenylbut-1-ene derivatives
The present invention provides a novel method of lowering serum cholesterol in humans comprising ##STR1## wherein R 1 and R 2 may be the same or different provided that, when R 1 and R 2 are...
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5409957 |
Phenoxyalkylamine and agricultural and horticultural bactericide
Disclosed are a phenoxyalkylamine represented by the following general formula I and a salt of said phenoxyalkylamine represented by the following general formula II: ##STR1## wherein R represents...
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5407956 |
2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described. The compounds are particularly useful in the treatment of arterial hypertension, cardiac...
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5399581 |
Method and compositions for treatment of sexual impotence
A method and compositions is described for treating sexual impotence with an oral drug regimen amenable to once a day therapy. The method combines the administration of a non-selective alpha 1 ...
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5389686 |
Analgesic properties of fedotozine
Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate...
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5384332 |
Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives
The present invention provides novel methods of inhibiting aortal smooth muscle cell proliferation, particularly restenosis, in humans, comprising administering to a human in need of treatment an...
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5380755 |
Alkyl and alkylbenzyl ethers of substituted hydroquinones
The present invention provides alkyl and alkylbenzyl ethers of substituted hydroquinones and pharmaceutical compositions containing them. The present invention further provides methods of using...
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5362756 |
Use of fedotozine in the treatment of functional states of intestinal obstructions
A process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-1[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N...
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5352707 |
Method for treating airway congestion
A method for treating airway congestion which comprises administering an effective amount of the compound of formula II which follows ##STR1## or a pharmaceutically acceptable salt thereof.
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5331011 |
N-benzyl-n-phenoxyethylamines and agricultural and horticultural bactericides
Disclosed is an N-benzyl-N-phenoxyethylamine selected from the group consisting of the N-benzyl-N-phenoxyethylamine represented by the following formula (I): ##STR1## and an agriculturally...
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5298528 |
Insect repellent
An insect repellent composition for against mosquitoes or other insects that attack man and or warm-blooded animals contains up to 5% by weight of a local anaesthetic selected from the group...
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5290815 |
Treatment of inflammation and allergy
The present invention provides a new medical use for the phenethanolamine compound 4-hydroxy-α 1 -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimetha
nol and physiologically acceptable...
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5283263 |
Method for treating certain psychiatric disorders and certain psychiatric symptoms
There is disclosed a method for treating psychiatric disorders including circadian rhythm disorders, borderline personality disorders, personality disorders, Late Luteal Phase Dysphoric Disorder,...
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5283262 |
Phenethanolamine derivatives
The invention provides compounds of the general formula (I) ##STR1## or a physiologically acceptable salt or solvate thereof, wherein Q represents a 1- or 2-naphthalenyl group. The compounds have a...
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5281624 |
N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof
This invention provides N-alkyl-3-phenyl-3-(2-substituted phenoxy)propylamines which are useful to treat neurological disorders associated with norepinephrine imbalance.
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5272144 |
Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use
Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is...
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5266599 |
Use of (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propy lamine to increase gastric discharge in a subject
(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dime
thyl-n-propylam ine of formula ##STR1## is a medicament of use in gastroenterology.
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5254594 |
Remedies for bone diseases
Remedies for bone diseases comprising, as active ingredient, droloxifene or a salt thereof.
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5252608 |
Inhibitors of lysyl oxidase
This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
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5250572 |
(R)-norfluoxetine in method for occupying serotonin IC receptors
The present invention provides (R)-norfluoxetine and pharmaceutically acceptable salts thereof capable of selectively occupying 5HT 1c receptors.
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5250571 |
(S)-norfluoxetine in method of inhibiting serotonin uptake
The present invention provides (S)-norfluoxetine and pharmaceutically acceptable salts thereof capable of inhibiting the uptake of serotonin.
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5238959 |
3-phenyloxy-3-phenyl propanamines
The present invention provides 3-(4-substitutedphenoxy)-3-phenyl propanamines capable of inhibiting the uptake of serotonin. These compounds are useful for treating many pharmacological disorders,...
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5232946 |
Phenylethanolamines, their use as pharmaceuticals and as performance enhancers in animals
The invention relates to new phenylethanolamines of general formula ##STR1## wherein A represents a straight-chained or branched alkylene group, B represents a bond, an alkylene group, a...
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5229417 |
2-(3-phenylpropyl)hydrazines and method of treating personality disorders
Novel 2-(3-phenylpropyl)hydrazines, intermediates in and processes for the preparation thereof, and a method of treating personality disorders utilizing compounds or compositions thereof are...
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5225445 |
Phenethanolamine derivatives having β.sub.2 -adrenoreceptor selective stimulant action
Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms,...
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5219548 |
High affinity halogenated-tamoxifen derivatives and uses thereof
Applicants describe the synthesis of fluorotamoxifen and iodotamoxifen analogs with the halogen atom positioned on the aliphatic chain of the tamoxifen molecule. The halogenated-tamoxifen...
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5214046 |
Substituted aminoalkoxybenzene anti-fungicidal compositions and use
The compound of the formula ##STR1## wherein each of R 1 and R 2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 to 4 carbon atoms, R 3 ...
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5212173 |
Alkylaminoalkylamine and ether compounds, processes and intermediates for their preparation, and medicaments containing them
Pharmacologically active compounds corresponding to the formula I ##STR1## in which n represents 2-5, m represents 2-6, R 1 denotes hydrogen or lower alkyl, R 2 represents an OR 4 group...
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5171753 |
Derivatives of 2-amino-1-phenylethanol having antiulcer activity
Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted...
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5166218 |
Phenoxypropanolamines and pharmaceutical compositions thereof
Tertiary and secondary amines of the formulas ##STR1## and ##STR2## wherein n is the integer 1 or 2, R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl, X 1 is phenoxymethyl optionally...
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5164406 |
Method for enhancing transdermal penetration and compositions useful therein
The present invention provides for a composition containing a pharmacologically active agent and a selected imidazole or an imidazole derivative, such composition exhibiting enhanced penetration of...
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5151448 |
Method for treating premature ejaculation
Premature ejaculation by a male human patient is treated by administration of fluoxetine.
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5135947 |
1-phenyl-3-naphthalenyloxypropanamines and their use as selective serotonin reuptake inhibitors
The present invention provides 1-phenyl-3-naphthalenyloxypropanamines which are selective inhibitors of serotonin uptake.
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5132302 |
Use of aromatic aminoalkoxy derivatives for the treatment of troubles of the cerebrovascular system
Method of treatment of affections related to a disturbance of the intra and extra cellular movements of calcium at the cerebral level, which comprises administering an aromatic aminoalkoxy...
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5106878 |
Use of substituted aminoalkoxybenzene derivatives in the control or prevention of fungal infections
The compound of the formula ##STR1## wherein each of R 1 and R 2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 or 4 carbon atoms, R 3 ...
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5098717 |
Method of treatment for pruritus
A method of treating a pruritic skin area in a mammal by application to the affected area of a gel composition containing from about 60 to about 90% ethyl alcohol, from about 0.5 to about 30%...
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5093131 |
Remedy for treatment of sleep apnea
Sleep apnea is treated by administering a therapeutically effective amount of 2-isopropyl-2,8-bis(3,4-dimethoxyphenyl)-6-methyl-6-azaoctan
e nitrile to a subject.
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5081154 |
Metoprolol succinate
The present invention relates to metoprolol succinate, a new therapeutically active compound, and pharmaceutical preparations comprising this new compound.
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5021429 |
Pharmacologically active aminoalkylphenyl compounds and their use
Compounds of the general formula: ##STR1## and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in which R 1 and R 2 , which may be...
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5017618 |
Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers
Compounds having the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein --X-- is --O--, --CH 2 -- or --; Y is O or a derivatized keto group which is...
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5006556 |
Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction
The invention provides compounds of the general formula (I) ##STR1## wherein X represents a C 1 -6 alkylene, C 2 -6 alkenylene or C 2 -6 alkynylene chain and Y represents a bond, or a C 1 -4...
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5002946 |
Phenylethanolamine analog active compounds for the treatment of gastrointestinal diseases
Phenylethanolamine analog active compounds, optionally substituted on the phenyl group with an halogen atom or with an alkyl or trifluoromethyl group and substituted on the amino group with a...
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5001161 |
Pharmaceutical composition comprising metroprolol succinate
The present invention relates to metoprolol succinate, a new therapeutically active compound, and pharmaceutical preparations comprising this new compound.
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4996225 |
Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses
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4970237 |
Use of clomiphene to increase bone mass in premenopausal women
This invention relates to the use of clomiphene in preventing osteoporosis in humans and treating human patients experiencing osteoporosis.
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