Matches 251 - 300 out of 435 < 1 2 3 4 5 6 7 8 9 >
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5455271 Tight-binding inhibitors of leukotriene A.sub.4 hydrolase  
Inhibitors of leukotriene A 4 hydrolase are disclosed, corresponding to Formula I, below: ##STR1## wherein the depicted --NH 2 group is in the (S) configuration; --W is --CH 2 SH, --CH 2 NH 2 ...
5446069 Benzoalkano compounds and their use for tracting hyperproliferative diseases  
Disclosed are compounds of formula ##STR1## wherein F represents: ##STR2## or a pharmaceutically acceptable salt. The compounds are useful in treating hyperproliferative skin disease, allergic...
5446027 Amide derivative and external skin care preparation containing the same  
Amino derivatives represented by the following general formula (1): ##STR1## and external skin care preparations containing such an amide derivative, are useful for preventing or curing skin...
5446068 1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors  
This invention relates to 1-phenyl-3-phenyl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing...
5438056 Heterocyclic oxime carbamates  
The compounds of the present invention have the following formula: ##STR1## wherein R 1 and R 2 are independently phenyl, pyridyl, thienyl, naphthyl, substituted phenyl wherein the substituent is...
5436243 Aminoanthraquinone derivatives to combat multidrug resistance  
Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of...
5417987 Method for controlling bivalves such as zebra mussels  
A method for enhancing the effect of a toxicant such as chlorine or potassium on bivalve molluscs such as zebra mussels. Application of serotonin or a serotonin agonist in low concentrations...
5407961 α-substituted benzenemethanamine derivatives and pharmaceutical use  
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and...
5395611 Phenolic amine depigmenting and antimelanoma agents  
A composition useful for treating skin pigmentation, melasma and melanoma comprises: i) a biologically effective amount of derivatives of 4-S-cysteaminylphenyl such as...
5395853 Anti-atherosclerotic diaryl compounds  
The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1; W is hydrogen, a C 1 -16 straight, branched, or cyclic alkyl group, or a C 2 -16 straight,...
5389686 Analgesic properties of fedotozine  
Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate...
5362747 2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase  
2-Nitroaryl or 2-cyanoaryl compounds of the formula ##STR1## pharmaceutical compositions thereof, intermediates useful in the preparation of these compounds, and methods for treating disorders of...
5358970 Pharmaceutical composition containing bupropion hydrochloride and a stabilizer  
This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will...
5356934 Selected serotonin subtype receptor agonist to treat sleep apnea  
The present invention provides a method of employing (R)-fluoxetine to treat sleep Apnea.
5354780 Intraoral dosing method of administering (+)-α-4-(dimethylamino)-3-methyl-1,2-diphenyl-2-butanolpropionate  
A method of therapeutically administering certain BZ 1 specific trifluorobenzodiazepines in order to maximize the BZ 1 effects and minimize the BZ 2 effects on the human central nervous system...
5340826 Pharmaceutical agents for treatment of urinary incontinence  
The present invention relates to a method of treating or preventing urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane...
5322859 Antiglaucoma drug composition and method  
Use of sigma agonists as ophthlamic drugs for lowering intraocular pressure.
5280045 4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound useful as an anti-inflammatory agent  
The subject invention involves compositions comprising 4-(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamid e, or 4-(3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl)-4-oxobutanoi c acid and...
5274002 Trisubstituted phenyl analogs having activity for congestive heart failure  
Novel trisubstituted phenyl analogs are now found to have activity as for the treatment of congestive heart failure.
5268385 Method for treating schizophrenia  
This invention provides a method for treating the symptoms of schizophrenia by interacting selectively with presynaptic dopaminergic D 2 receptors without appreciably activating postsynaptic...
5260333 Effect of a combination of a terbutaline, diphenhydramine and ranitidine composition on gastrointestinal injury produced by nonsteroidal anti-inflammatory compositions  
Pharmaceutical composition and process for administering NSAIDs with a combination of beta-adrenergic agonist and certain H 1 -and H 2 -receptor blockers which protect against injury to the...
5256698 Treatment of psychosis using cyclohexyl-phenyl-lower alkyl amine derivatives  
The method and composition for treating psychotic disorders with psychoactive drugs which bind at the sigma binding site and act as antagonists to inhibiting psychotic action. The preferred...
5236951 Pharmaceutical compositions for the treatment of ocular disorders  
A method of prophylaxis and/or of treatment of ocular disorders, mainly of controlling intraocular hypertension and treating glaucoma, which comprises administering, preferably topically, a...
5225446 Use of 1-deprenyl for retention of specific physiological functions  
1-Deprenyl and pharmaceutically acceptable analog forms thereof are used at specific dosage levels and frequency of dosage to slow the normal age dependent deterioration of renal function, to...
5225436 Aryl substituted naphthalene derivatives  
Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic...
5212204 Antihypertensive compositions and use thereof  
This invention concerns antihypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein J...
5212173 Alkylaminoalkylamine and ether compounds, processes and intermediates for their preparation, and medicaments containing them  
Pharmacologically active compounds corresponding to the formula I ##STR1## in which n represents 2-5, m represents 2-6, R 1 denotes hydrogen or lower alkyl, R 2 represents an OR 4 group...
5169633 Continuous release phenylethanolamine derivative compositions  
The invention relates to compositions for the parenteral administration of an essentialy uniform and continuous amount of a phenylethanolamine derivative over an extended period of time. The...
5151449 Use of L-deprenyl for retention of specific physiological functions  
L-Deprenyl and pharmaceutically acceptable analog forms thereof are used at specific dosage levels and frequency of dosage to slow the normal age dependent deterioration of renal function, to...
5135955 Propanamine derivatives  
Substituted propanamines having anticoagulant or antifungal activity are disclosed. Also disclosed are methods of use involving the substituted propanamines as well as pharmaceutical compositions...
5120735 Antifungal composition  
A synergistically active antifungal composition comprising an azole compound and an arylmethylamine compound.
5086073 Composition for treating depression with aralkyl amines  
The invention concerns compounds having formula: ##STR1## or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar 1 --A 1 ; Ar and Ar 1 are the same or different aryl groups...
5059626 Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs  
A one phase, liquid composition for oral administration comprises a NSAID such as an anthranilic acid derivative plus a di- or triglyceride of a medium chain fatty acid edible oil which has the...
5055489 Method for the prevention and control of hypoxic damage resulting from cerebral ischemic events  
A method for the prevention and control of hypoxic damage resulting from stroke or other cerebral ischemic event which comprises administering pharmaceutical compositions containing 2-phenyl-1,...
5053431 Derivatives of chrysophanol as topoisomerase II inhibitors  
The present invention concerns compounds of the formula: ##STR1## wherein R 1 is hydrogen, a hydroxy group or a methoxy group; R 2 is hydrogen or a methyl group; R 3 is hydrogen or a...
5047235 Pharmaceutical preparations having an antihypertensive and cardioprotective effect  
A pharmaceutical preparation, which has an anti-hypertensive and cardio-protective effect, which coprises a pharmaceutically effective amount of a combination of...
5039706 Antiinflammatory PLA.sub.2 inhibitors  
The invention relates to benzylamine phosphilipase A 2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A 2 -mediated conditions in mammals by...
5023234 Combination male breast cancer therapy  
A method of treatment of breast cancer in susceptible male animals whose testicular hormonal secretions are blocked by surgical or chemical means, e.g., by use of an LH-RH agonist, e.g., [D-Trp 6 ,...
5021429 Pharmacologically active aminoalkylphenyl compounds and their use  
Compounds of the general formula: ##STR1## and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in which R 1 and R 2 , which may be...
5013760 Phenylethylamine derivatives and pharmaceutical use  
Phenylethylamine derivatives of the formula ##STR1## wherein D 1 represents a phenylethyl radical which is substituted with hydroxy and/or alkyl groups, R 1 and R 2 are hydrogen or alkyl, ...
5002946 Phenylethanolamine analog active compounds for the treatment of gastrointestinal diseases  
Phenylethanolamine analog active compounds, optionally substituted on the phenyl group with an halogen atom or with an alkyl or trifluoromethyl group and substituted on the amino group with a...
4996235 3,4-diphenylbutanamines  
The present invention provides 3,4-diphenylbutanamines capable of selectively inhibiting the uptake of serotonin and norepinephrine.
4988710 Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins  
A compound and method are disclosed for reducing neurotoxic effects (such as seizures and brain damage) caused by cholinergic agents such as soman (a nerve gas) and pilocarpine (a convulsant drug...
4980377 1-(aminophenyl)-2-aminopropanone derivatives  
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH 2 , Y is H or a halogen atom, Z is H or a...
4980354 Tetrahydronaphthalene and indane derivatives  
The invention relates to tetrahydronaphthalene and indane derivatives with the general formula I: ##STR1## wherein R 1 represents zero to four substituents, which may be the same or different and...
4968721 2-amino-alpha-phenylphenethylamines and method of use  
Novel 4-phenyl-1,3-benzodiazepines and 2-amino-α-phenylphenethylamines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as...
4939147 Substituted 3,4-dihydroxy phenylethylamino compounds  
Compounds of the formula, ##STR1## in which one of R 30 and R 40 represents a substituted phenylalkyl group and the other of R 30 and R 40 represents hydrogen or halogen, and R 50 and R 60 ...
4933370 1-aminophenyl-2-dimethylaminopropanone derivatives, method of preparation and use in therapy  
The present invention relates, by way of novel industrial products, to 1-(4-aminophenyl)-2-dimethylaminopropanone derivatives which are selected from: (a) the compounds having the general...
4916151 Method of treating parkinson's syndrome  
Novel nonaromatic fluoroallylamines are potent MAO inhibitors and at low dose selectively inhibit MAO-B. They are useful in the treatment of depression and co-administration with L-dopa and...
4908386 Ethanolamine derivatives  
The present invention provides compounds of general formula (I) ##STR1## wherein Ar represents an unsubstituted or substituted phenyl gorup; R 1 and R 2 each represents a hydrogen atom or a C...
Matches 251 - 300 out of 435 < 1 2 3 4 5 6 7 8 9 >