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7589127 |
Aminoalkylphenols, methods of using and making the same
The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium , particularly emerging strains of drug-resistant...
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7589056 |
Agent for the prevention and treatment of sexually transmitted diseases-I
Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted...
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7582653 |
Mercaptophenyl naphthyl methane compounds and synthesis thereof
Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications...
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7560491 |
Z-stilbenes derivatives and the pharmaceutical composition thereof
A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is...
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7538249 |
Tolterodine, compositions and uses thereof, and preparation of the same
Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.
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7531578 |
Compounds and methods for treating breast cancer and other diseases
Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety...
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7524866 |
Prevention and treatment of androgen—deprivation induced osteoporosis
This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate...
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7511070 |
Compounds and therapies for the prevention of vascular and non-vascular pathologies
The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to...
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7456222 |
Anti tubercular drug: compositions and methods
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the...
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7425580 |
(Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands
The present invention concerns compounds of formula:
where R 1 , R 2 , R 3 and R 4 are defined in the specification.
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7393874 |
Polymorphs of tolterodine tartrate
The present invention relates to novel polymorphs of tolterodine tartrate, to processes for their preparation and to pharmaceutical compositions containing them.
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7354928 |
Small molecule inhibitors targeted at Bcl-2
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
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7291648 |
3,3-diphenylpropylamines useful in therapy
Novel 3,3-diphenylpropylamines of the formula
and stereoisomers and physiologically acceptable acid addition salt thereof; wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein;...
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7268166 |
Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve...
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7259188 |
Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators
Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors.
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7253189 |
Cannabinoid receptor ligands
A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 , R 2 , L 1 , L 2 , M 1 , M 2 , n, p, q, A, D, X, Y and Z are as described in the specification;...
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7226949 |
Compounds of use in the treatment of epilepsy, seizure, and electroconvulsive disorders
The present invention provides pharmaceutical preparations and the uses thereof for preventing and/or treating seizures and other electroconvulsive disorders by administering a pharmaceutically...
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7220782 |
Methods to reduce the sensitivity of endothelially-compromised vascular smooth muscle
The present invention discloses materials and methods useful to treat sensitivity of endothelially-compromised vascular smooth muscle. In one embodiment, CLC3 blockers, particularly compounds of...
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7183323 |
Sodium channel modulators
The invention provides sodium channel modulating compounds of formula I:
wherein X, Y, Q, R 1 , w, and R 2 have any of the values defined in the specification, and salts thereof, which are...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7119121 |
3,3-diphenylpropylamines useful in therapy
Novel 3,3-diphenylpropylamines of the formula
and stereoisomers and physiologically acceptable acid addition salt thereof; wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein;...
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7084106 |
Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease
The present invention provides a novel treatment for senile dementia (Alzheimer's Type), comprising administering an anti-complement protein to a patient in need of such treatment in an amount...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7067557 |
Methods of treating androgen deficiency in men using selective antiestrogens
The administration of antiestrogens to men suffering a relative androgen deficiency stimulates the body's production of testosterone leading to a correction of the deficiency. For example, male...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7030160 |
Propanolaminotetralines, preparation thereof and compositions containing same
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that...
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6979689 |
Compositions and methods for treating upper respiratory congestion
A composition of an antitussive, a decongestant, and diphenhydramine as an antihistamine to treat upper respiratory and oral pharyngeal congestion and related symptoms in a patient. In addition to...
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6911217 |
Controlled release bead, a method of producing the same and multiple unit formulation comprising it
A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble...
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6897242 |
Non-racemic mixtures of d- and l- methadone and method of treating pain
Compositions of non-racemic mixtures of d- and l-methadone and a method of treating pain using the composition. The composition is especially useful for treating pain of mixed origin. For...
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6887888 |
Soluble compositions of triphenylethylene antiestrogens
Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid...
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6875775 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula:
wherein R1 and R2, which are the same or different are
a) H, halogen, OCH 3 , OH; or...
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6855736 |
Molecular target of neurotoxicity
The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterization and/or treatment (or management) of neuro...
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6833373 |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent.
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6767923 |
Benzhydryl derivatives
Benzhydryl derivatives of the formula I, where the index and the variables are as defined below: X is oxygen or sulfur; R 1 , R 3 are halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl,...
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6759435 |
Antidepressant drugs and methods
Novel amines are potent and selective serotonin reuptake inhibitors and as such can be used in the treatment of depression and other mental disorders.
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6699838 |
Antiangiogenic peptides
Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also...
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6696496 |
Low water-soluble venlafaxine salts
Low water soluble salts of venlafaxine, especially venlafaxine maleate, are provided. Such salts can provide a variety of dosage forms including hydrogel-based extended release dosage forms.
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6632841 |
Soluble compositions of triphenylethylene antiestrogens
Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid...
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6632447 |
Method for chemoprevention of prostate cancer
This invention relates to the chemoprevention of prostate cancer and, more particularly, to a method of suppressing or inhibiting latent prostate cancer comprising administering to a mammalian...
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6624199 |
Aminobenzophenones
The present invention relates to compounds of formula I wherein R 1 represents one or more, similar or different substituents; R 2 represents hydrogen, hydroxy, halogen, alkyl, alkoxy,...
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6620806 |
Methods and kits for improving vascular health
The present invention provides methods and kits for improving or maintaining vascular health, including preventing myocardial infarction or stroke; maintaining or improving vascular reactivity;...
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6589996 |
Treatment of disorders relating to the serotonergic system
A method for the treatment of disorders relating to serotonergic system in humans, for example depression and anxiety, comprising orally administering deramciclane in a daily dosage of about 20 to...
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6583182 |
Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or...
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6576645 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH 3 , OH; or where...
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6500838 |
Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
NMDA receptor antagonists can be used in methods of treatment, for reducing the frequency of stereotypic behaviors in animals and for reducing the frequency of analogous compulsive behaviors in...
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6495567 |
Triaryl methane compounds and their use in the treatment of diarrhea and scours
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
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6458848 |
Remedy for autoimmune diseases
Disclosed is use of nonsteroidal anti-estrogen compounds such as toremifene citrate as active ingredient for treating autoimmune diseases.
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6441048 |
Methods of treating affective disorders using derivatives of (-)-venlafaxine
Methods of preparing, and compositions comprising, derivatives of (−)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not...
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6417159 |
Method of enhancing effect of a neurotrophin with analogues of p75NTR367-379.
The present invention provides methods and compositions for enhancing the effect of a neurotrophin on a cell expressing a neurotrophin receptor. The effect is preferably neurotrophin-mediated...
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